Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2092182275', 'doi': 'https://doi.org/10.1016/0006-291x(73)90836-x', 'title': 'Carbon tetrachloride activation in liver microsomes from rats induced with 3-methylcholantrene', 'display_name': 'Carbon tetrachloride activation in liver microsomes from rats induced with 3-methylcholantrene', 'publication_year': 1973, 'publication_date': '1973-01-01', 'ids': {'openalex': 'https://openalex.org/W2092182275', 'doi': 'https://doi.org/10.1016/0006-291x(73)90836-x', 'mag': '2092182275', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/4347515'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0006-291x(73)90836-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5059341698', 'display_name': 'J A Castro', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210113979', 'display_name': 'Institute of Scientific and Technical Research for Defense', 'ror': 'https://ror.org/0313pb684', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210113979']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'J.A. Castro', 'raw_affiliation_strings': ['Laboratorio de Quimica Bio-Toxicologica, CITEFA, Zufriategui y Varela, Villa Martelli, Pcia. de Buenos Aires, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Quimica Bio-Toxicologica, CITEFA, Zufriategui y Varela, Villa Martelli, Pcia. de Buenos Aires, Argentina', 'institution_ids': ['https://openalex.org/I4210113979']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100875862', 'display_name': 'Clementina Castro', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210113979', 'display_name': 'Institute of Scientific and Technical Research for Defense', 'ror': 'https://ror.org/0313pb684', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210113979']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'C.R. de Castro', 'raw_affiliation_strings': ['Laboratorio de Quimica Bio-Toxicologica, CITEFA, Zufriategui y Varela, Villa Martelli, Pcia. de Buenos Aires, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Quimica Bio-Toxicologica, CITEFA, Zufriategui y Varela, Villa Martelli, Pcia. de Buenos Aires, Argentina', 'institution_ids': ['https://openalex.org/I4210113979']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003453956', 'display_name': "N. D'Acosta", 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210113979', 'display_name': 'Institute of Scientific and Technical Research for Defense', 'ror': 'https://ror.org/0313pb684', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210113979']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': "N. D'Acosta", 'raw_affiliation_strings': ['Laboratorio de Quimica Bio-Toxicologica, CITEFA, Zufriategui y Varela, Villa Martelli, Pcia. de Buenos Aires, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Quimica Bio-Toxicologica, CITEFA, Zufriategui y Varela, Villa Martelli, Pcia. de Buenos Aires, Argentina', 'institution_ids': ['https://openalex.org/I4210113979']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054601937', 'display_name': 'M.I. Díaz Gómez', 'orcid': 'https://orcid.org/0000-0001-5123-8746'}, 'institutions': [{'id': 'https://openalex.org/I4210113979', 'display_name': 'Institute of Scientific and Technical Research for Defense', 'ror': 'https://ror.org/0313pb684', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210113979']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'M.I. Diaz Gomez', 'raw_affiliation_strings': ['Laboratorio de Quimica Bio-Toxicologica, CITEFA, Zufriategui y Varela, Villa Martelli, Pcia. de Buenos Aires, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Quimica Bio-Toxicologica, CITEFA, Zufriategui y Varela, Villa Martelli, Pcia. de Buenos Aires, Argentina', 'institution_ids': ['https://openalex.org/I4210113979']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5018717444', 'display_name': 'E.C. de Ferreyra', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210113979', 'display_name': 'Institute of Scientific and Technical Research for Defense', 'ror': 'https://ror.org/0313pb684', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210113979']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'E.C. de Ferreyra', 'raw_affiliation_strings': ['Laboratorio de Quimica Bio-Toxicologica, CITEFA, Zufriategui y Varela, Villa Martelli, Pcia. de Buenos Aires, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Quimica Bio-Toxicologica, CITEFA, Zufriategui y Varela, Villa Martelli, Pcia. de Buenos Aires, Argentina', 'institution_ids': ['https://openalex.org/I4210113979']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2770, 'currency': 'USD', 'value_usd': 2770, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.322, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 22, 'citation_normalized_percentile': {'value': 0.80674, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '50', 'issue': '2', 'first_page': '273', 'last_page': '279'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10375', 'display_name': 'Drug Metabolism and Pharmacogenomics', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10375', 'display_name': 'Drug Metabolism and Pharmacogenomics', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11465', 'display_name': 'Mechanisms of Drug-Induced Hepatotoxicity', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ccl4', 'display_name': 'CCL4', 'score': 0.8856026}, {'id': 'https://openalex.org/keywords/phenobarbital', 'display_name': 'Phenobarbital', 'score': 0.7855831}, {'id': 'https://openalex.org/keywords/glucose-6-phosphatase', 'display_name': 'Glucose 6-phosphatase', 'score': 0.5463775}, {'id': 'https://openalex.org/keywords/metabolic-regulation', 'display_name': 'Metabolic Regulation', 'score': 0.46774}, {'id': 'https://openalex.org/keywords/tetrachloride', 'display_name': 'Tetrachloride', 'score': 0.43928242}], 'concepts': [{'id': 'https://openalex.org/C2777359374', 'wikidata': 'https://www.wikidata.org/wiki/Q225045', 'display_name': 'Carbon tetrachloride', 'level': 2, 'score': 0.9232467}, {'id': 'https://openalex.org/C102124568', 'wikidata': 'https://www.wikidata.org/wiki/Q5009626', 'display_name': 'CCL4', 'level': 3, 'score': 0.8856026}, {'id': 'https://openalex.org/C2778793413', 'wikidata': 'https://www.wikidata.org/wiki/Q407241', 'display_name': 'Phenobarbital', 'level': 2, 'score': 0.7855831}, {'id': 'https://openalex.org/C87644729', 'wikidata': 'https://www.wikidata.org/wiki/Q547502', 'display_name': 'Microsome', 'level': 3, 'score': 0.780339}, {'id': 'https://openalex.org/C2780768313', 'wikidata': 'https://www.wikidata.org/wiki/Q408068', 'display_name': 'Cytochrome', 'level': 3, 'score': 0.72277415}, {'id': 'https://openalex.org/C2780829032', 'wikidata': 'https://www.wikidata.org/wiki/Q898539', 'display_name': 'Lipid peroxidation', 'level': 3, 'score': 0.69414353}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6797991}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5608059}, {'id': 'https://openalex.org/C2779202576', 'wikidata': 'https://www.wikidata.org/wiki/Q24785320', 'display_name': 'Glucose 6-phosphatase', 'level': 3, 'score': 0.5463775}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5417969}, {'id': 'https://openalex.org/C2778179251', 'wikidata': 'https://www.wikidata.org/wiki/Q16884418', 'display_name': 'Tetrachloride', 'level': 3, 'score': 0.43928242}, {'id': 'https://openalex.org/C178666793', 'wikidata': 'https://www.wikidata.org/wiki/Q422476', 'display_name': 'Phosphatase', 'level': 3, 'score': 0.4318088}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.38088846}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.24770442}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.1934424}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.113336414}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C525849907', 'wikidata': 'https://www.wikidata.org/wiki/Q1096', 'display_name': 'Tin', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002251', 'descriptor_name': 'Carbon Tetrachloride', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008748', 'descriptor_name': 'Methylcholanthrene', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002247', 'descriptor_name': 'Carbon Isotopes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002251', 'descriptor_name': 'Carbon Tetrachloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002251', 'descriptor_name': 'Carbon Tetrachloride', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D004790', 'descriptor_name': 'Enzyme Induction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004790', 'descriptor_name': 'Enzyme Induction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005952', 'descriptor_name': 'Glucose-6-Phosphatase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005952', 'descriptor_name': 'Glucose-6-Phosphatase', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050356', 'descriptor_name': 'Lipid Metabolism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008748', 'descriptor_name': 'Methylcholanthrene', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010634', 'descriptor_name': 'Phenobarbital', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010634', 'descriptor_name': 'Phenobarbital', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0006-291x(73)90836-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/4347515', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6', 'score': 0.5}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W140672966', 'https://openalex.org/W1893749439', 'https://openalex.org/W1953039335', 'https://openalex.org/W1972335113', 'https://openalex.org/W1995118242', 'https://openalex.org/W2008663323', 'https://openalex.org/W2012652819', 'https://openalex.org/W2031618530', 'https://openalex.org/W2042431422', 'https://openalex.org/W2043962523', 'https://openalex.org/W2045231599', 'https://openalex.org/W2055834016', 'https://openalex.org/W2056613035', 'https://openalex.org/W2066374202', 'https://openalex.org/W2066682234', 'https://openalex.org/W2075964115', 'https://openalex.org/W2079536532', 'https://openalex.org/W2092763649', 'https://openalex.org/W2171473267', 'https://openalex.org/W2411437542', 'https://openalex.org/W2992257681', 'https://openalex.org/W33316235'], 'related_works': ['https://openalex.org/W4387646365', 'https://openalex.org/W2917795919', 'https://openalex.org/W2508012606', 'https://openalex.org/W2388950289', 'https://openalex.org/W2359831249', 'https://openalex.org/W2355939533', 'https://openalex.org/W2347377923', 'https://openalex.org/W2288620160', 'https://openalex.org/W2042520936', 'https://openalex.org/W1988454503'], 'abstract_inverted_index': {'The': [0], 'irreversible': [1], 'binding': [2], 'of14C': [3], 'from14CCl4': [4], 'to': [5, 77], 'microsomal': [6], 'lipids': [7], 'is': [8, 18, 33, 46, 65], 'decreased': [9], 'in': [10, 20, 29, 37, 48, 53, 67, 71, 80, 89], 'animals': [11, 21], 'treated': [12, 31, 50, 69, 73], 'with': [13, 23], '3-methylcholantrene': [14], '(3-MC),': [15], 'while': [16], 'it': [17], 'increased': [19], 'induced': [22], 'phenobarbital': [24], '(PB).': [25], 'CCl4-induced': [26], 'lipid': [27], 'peroxidation': [28], '3-MC': [30, 49, 68], 'rats': [32, 51, 74], 'as': [34, 36], 'intense': [35], 'controls.': [38, 54, 81], 'Destruction': [39, 55], 'of': [40, 56], 'glucose': [41], '6-phosphatase': [42], '(G6P-ase)': [43], 'by': [44, 63], 'CCl4': [45, 64, 90], 'smaller': [47, 66], 'than': [52, 70, 95], 'total': [57], 'cytochrome': [58], 'P-450': [59, 86], '(P-450': [60], '+': [61], 'P1-450)': [62], 'PB': [72], 'but': [75], 'similar': [76], 'that': [78, 85], 'obtained': [79], 'Results': [82], 'would': [83, 87], 'indicate': [84], 'participate': [88], 'activation': [91], 'much': [92], 'more': [93], 'effectively': [94], 'P1-450.': [96]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2092182275', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-09T21:42:43.276929', 'created_date': '2016-06-24'}