Elemental formula annotation of polar and lipophilic metabolites using 13C, 15N and 34S isotope labelling, in combination with high‐resolution mass spectrometry

Name: Work Video:
Duration: 3 min 30 s
Patrick Giavalisco; Yan Li; Annemarie Matthes; Aenne Eckhardt; Hans‐Michael Hubberten; H. Hesse; Shruthi Segu; Jan Hummel; Karin Köhl; Lothar Willmitzer
{'id': 'https://openalex.org/W2091910674', 'doi': 'https://doi.org/10.1111/j.1365-313x.2011.04682.x', 'title': 'Elemental formula annotation of polar and lipophilic metabolites using <sup>13</sup>C, <sup>15</sup>N and <sup>34</sup>S isotope labelling, in combination with high‐resolution mass spectrometry', 'display_name': 'Elemental formula annotation of polar and lipophilic metabolites using <sup>13</sup>C, <sup>15</sup>N and <sup>34</sup>S isotope labelling, in combination with high‐resolution mass spectrometry', 'publication_year': 2011, 'publication_date': '2011-06-23', 'ids': {'openalex': 'https://openalex.org/W2091910674', 'doi': 'https://doi.org/10.1111/j.1365-313x.2011.04682.x', 'mag': '2091910674', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21699588'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1365-313x.2011.04682.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-313X.2011.04682.x', 'source': {'id': 'https://openalex.org/S67862205', 'display_name': 'The Plant Journal', 'issn_l': '0960-7412', 'issn': ['0960-7412', '1365-313X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-313X.2011.04682.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5013171903', 'display_name': 'Patrick Giavalisco', 'orcid': 'https://orcid.org/0000-0002-4636-1827'}, 'institutions': [{'id': 'https://openalex.org/I4210105972', 'display_name': 'Max Planck Institute of Molecular Plant Physiology', 'ror': 'https://ror.org/01fbde567', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210105972']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Patrick Giavalisco', 'raw_affiliation_strings': ['Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany', 'institution_ids': ['https://openalex.org/I4210105972']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100380328', 'display_name': 'Yan Li', 'orcid': 'https://orcid.org/0000-0002-3332-8040'}, 'institutions': [{'id': 'https://openalex.org/I4210105972', 'display_name': 'Max Planck Institute of Molecular Plant Physiology', 'ror': 'https://ror.org/01fbde567', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210105972']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Yan Li', 'raw_affiliation_strings': ['Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany', 'institution_ids': ['https://openalex.org/I4210105972']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045578274', 'display_name': 'Annemarie Matthes', 'orcid': 'https://orcid.org/0000-0001-8326-4842'}, 'institutions': [{'id': 'https://openalex.org/I4210105972', 'display_name': 'Max Planck Institute of Molecular Plant Physiology', 'ror': 'https://ror.org/01fbde567', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210105972']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Annemarie Matthes', 'raw_affiliation_strings': ['Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany', 'institution_ids': ['https://openalex.org/I4210105972']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027999384', 'display_name': 'Aenne Eckhardt', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105972', 'display_name': 'Max Planck Institute of Molecular Plant Physiology', 'ror': 'https://ror.org/01fbde567', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210105972']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Aenne Eckhardt', 'raw_affiliation_strings': ['Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany', 'institution_ids': ['https://openalex.org/I4210105972']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061355740', 'display_name': 'Hans‐Michael Hubberten', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105972', 'display_name': 'Max Planck Institute of Molecular Plant Physiology', 'ror': 'https://ror.org/01fbde567', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210105972']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Hans‐Michael Hubberten', 'raw_affiliation_strings': ['Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany', 'institution_ids': ['https://openalex.org/I4210105972']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031140842', 'display_name': 'H. Hesse', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105972', 'display_name': 'Max Planck Institute of Molecular Plant Physiology', 'ror': 'https://ror.org/01fbde567', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210105972']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Holger Hesse', 'raw_affiliation_strings': ['Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany', 'institution_ids': ['https://openalex.org/I4210105972']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079445630', 'display_name': 'Shruthi Segu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105972', 'display_name': 'Max Planck Institute of Molecular Plant Physiology', 'ror': 'https://ror.org/01fbde567', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210105972']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Shruthi Segu', 'raw_affiliation_strings': ['Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany', 'institution_ids': ['https://openalex.org/I4210105972']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022358308', 'display_name': 'Jan Hummel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105972', 'display_name': 'Max Planck Institute of Molecular Plant Physiology', 'ror': 'https://ror.org/01fbde567', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210105972']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jan Hummel', 'raw_affiliation_strings': ['Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany', 'institution_ids': ['https://openalex.org/I4210105972']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111462329', 'display_name': 'Karin Köhl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105972', 'display_name': 'Max Planck Institute of Molecular Plant Physiology', 'ror': 'https://ror.org/01fbde567', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210105972']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Karin Köhl', 'raw_affiliation_strings': ['Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany', 'institution_ids': ['https://openalex.org/I4210105972']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5077689736', 'display_name': 'Lothar Willmitzer', 'orcid': 'https://orcid.org/0000-0003-3297-825X'}, 'institutions': [{'id': 'https://openalex.org/I4210105972', 'display_name': 'Max Planck Institute of Molecular Plant Physiology', 'ror': 'https://ror.org/01fbde567', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210105972']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Lothar Willmitzer', 'raw_affiliation_strings': ['Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck Institute of Molecular Plant Physiology; Am Mühlenberg 1 14476 Potsdam Germany', 'institution_ids': ['https://openalex.org/I4210105972']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4940, 'currency': 'USD', 'value_usd': 4940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 5.832, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 329, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '68', 'issue': '2', 'first_page': '364', 'last_page': '376'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10836', 'display_name': 'Metabolomics and Mass Spectrometry Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10836', 'display_name': 'Metabolomics and Mass Spectrometry Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12073', 'display_name': 'Isotope Analysis in Ecology', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2303', 'display_name': 'Ecology'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10683', 'display_name': 'Mass Spectrometry Techniques and Applications', 'score': 0.986, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C162356407', 'wikidata': 'https://www.wikidata.org/wiki/Q180809', 'display_name': 'Mass spectrometry', 'level': 2, 'score': 0.7061099}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6667534}, {'id': 'https://openalex.org/C2780523633', 'wikidata': 'https://www.wikidata.org/wiki/Q380709', 'display_name': 'Labelling', 'level': 2, 'score': 0.6277564}, {'id': 'https://openalex.org/C164304813', 'wikidata': 'https://www.wikidata.org/wiki/Q25276', 'display_name': 'Isotope', 'level': 2, 'score': 0.57262945}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.4895843}, {'id': 'https://openalex.org/C2777477808', 'wikidata': 'https://www.wikidata.org/wiki/Q407595', 'display_name': 'Metabolite', 'level': 2, 'score': 0.44404346}, {'id': 'https://openalex.org/C4725764', 'wikidata': 'https://www.wikidata.org/wiki/Q844704', 'display_name': 'Extraction (chemistry)', 'level': 2, 'score': 0.4428104}, {'id': 'https://openalex.org/C113196181', 'wikidata': 'https://www.wikidata.org/wiki/Q485223', 'display_name': 'Analytical Chemistry (journal)', 'level': 2, 'score': 0.38553756}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16644692}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.09262821}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017360', 'descriptor_name': 'Arabidopsis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D055432', 'descriptor_name': 'Metabolomics', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': True}, {'descriptor_ui': 'D040901', 'descriptor_name': 'Proteomics', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D017360', 'descriptor_name': 'Arabidopsis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017360', 'descriptor_name': 'Arabidopsis', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002247', 'descriptor_name': 'Carbon Isotopes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002734', 'descriptor_name': 'Chlorophyll', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002734', 'descriptor_name': 'Chlorophyll', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002734', 'descriptor_name': 'Chlorophyll', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D016208', 'descriptor_name': 'Databases, Factual', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005583', 'descriptor_name': 'Fourier Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007553', 'descriptor_name': 'Isotope Labeling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008055', 'descriptor_name': 'Lipids', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D008055', 'descriptor_name': 'Lipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013058', 'descriptor_name': 'Mass Spectrometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055432', 'descriptor_name': 'Metabolomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009587', 'descriptor_name': 'Nitrogen Isotopes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010936', 'descriptor_name': 'Plant Extracts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018515', 'descriptor_name': 'Plant Leaves', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018515', 'descriptor_name': 'Plant Leaves', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D018515', 'descriptor_name': 'Plant Leaves', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018517', 'descriptor_name': 'Plant Roots', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D018517', 'descriptor_name': 'Plant Roots', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018517', 'descriptor_name': 'Plant Roots', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D040901', 'descriptor_name': 'Proteomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015203', 'descriptor_name': 'Reproducibility of Results', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013460', 'descriptor_name': 'Sulfur Isotopes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1365-313x.2011.04682.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-313X.2011.04682.x', 'source': {'id': 'https://openalex.org/S67862205', 'display_name': 'The Plant Journal', 'issn_l': '0960-7412', 'issn': ['0960-7412', '1365-313X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21699588', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1365-313x.2011.04682.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-313X.2011.04682.x', 'source': {'id': 'https://openalex.org/S67862205', 'display_name': 'The Plant Journal', 'issn_l': '0960-7412', 'issn': ['0960-7412', '1365-313X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 62, 'referenced_works': ['https://openalex.org/W1480161928', 'https://openalex.org/W1572194202', 'https://openalex.org/W1963773775', 'https://openalex.org/W1964010911', 'https://openalex.org/W1964771014', 'https://openalex.org/W1968137491', 'https://openalex.org/W1969106865', 'https://openalex.org/W1971606140', 'https://openalex.org/W1972477350', 'https://openalex.org/W1977027255', 'https://openalex.org/W1978242826', 'https://openalex.org/W1983347490', 'https://openalex.org/W1988595321', 'https://openalex.org/W1989299822', 'https://openalex.org/W1990912999', 'https://openalex.org/W1992303307', 'https://openalex.org/W1994124478', 'https://openalex.org/W1994974411', 'https://openalex.org/W2001383141', 'https://openalex.org/W2004835566', 'https://openalex.org/W2006317824', 'https://openalex.org/W2007921561', 'https://openalex.org/W2009945101', 'https://openalex.org/W2019913219', 'https://openalex.org/W2025819516', 'https://openalex.org/W2028868694', 'https://openalex.org/W2031993452', 'https://openalex.org/W2033242848', 'https://openalex.org/W2048294518', 'https://openalex.org/W2053300710', 'https://openalex.org/W2058467542', 'https://openalex.org/W2059217091', 'https://openalex.org/W2060220140', 'https://openalex.org/W2060811342', 'https://openalex.org/W2073336413', 'https://openalex.org/W2075109094', 'https://openalex.org/W2075373098', 'https://openalex.org/W2084295516', 'https://openalex.org/W2085971050', 'https://openalex.org/W2086172588', 'https://openalex.org/W2091222115', 'https://openalex.org/W2096189572', 'https://openalex.org/W2101098894', 'https://openalex.org/W2111630085', 'https://openalex.org/W2115382253', 'https://openalex.org/W2116687544', 'https://openalex.org/W2117805596', 'https://openalex.org/W2118855982', 'https://openalex.org/W2119726180', 'https://openalex.org/W2123060905', 'https://openalex.org/W2123790683', 'https://openalex.org/W2127553917', 'https://openalex.org/W2130746685', 'https://openalex.org/W2137045089', 'https://openalex.org/W2141116784', 'https://openalex.org/W2158484824', 'https://openalex.org/W2159035756', 'https://openalex.org/W2160201278', 'https://openalex.org/W2167376541', 'https://openalex.org/W2170586643', 'https://openalex.org/W2246620632', 'https://openalex.org/W2790220528'], 'related_works': ['https://openalex.org/W4241622628', 'https://openalex.org/W2521903434', 'https://openalex.org/W2396436470', 'https://openalex.org/W2380886523', 'https://openalex.org/W2078502149', 'https://openalex.org/W2070829827', 'https://openalex.org/W1991894391', 'https://openalex.org/W1976633635', 'https://openalex.org/W1970064489', 'https://openalex.org/W1753739957'], 'abstract_inverted_index': {'The': [0, 58, 113], 'unbiased': [1], 'and': [2, 18, 45, 69, 80, 84, 88, 100, 138, 148, 152, 158, 180], 'comprehensive': [3, 34], 'analysis': [4, 132], 'of': [5, 21, 25, 66, 78, 133, 143, 166, 182], 'metabolites': [6, 87], 'in': [7, 50, 124], 'any': [8], 'organism': [9], 'presents': [10], 'a': [11, 33, 53, 93, 130, 141, 163], 'major': [12], 'challenge': [13], 'if': [14], 'proper': [15], 'peak': [16, 117], 'annotation': [17, 118], 'unambiguous': [19, 106], 'assignment': [20], 'the': [22, 26, 63, 76, 86, 134, 145, 178, 183], 'biological': [23], 'origin': [24], 'peaks': [27], 'are': [28], 'required.': [29], 'Here': [30], 'we': [31, 173], 'provide': [32], 'multi-isotope': [35], 'labelling-based': [36], 'strategy': [37], 'using': [38, 92, 154, 175], 'fully': [39], 'labelled': [40], '(13)': [41], 'C,': [42], '(15)': [43], 'N': [44], '(34)': [46], 'S': [47], 'plant': [48, 135], 'tissues,': [49], 'combination': [51], 'with': [52, 162], 'fractionated': [54], 'metabolite': [55], 'extraction': [56, 59, 65, 77], 'protocol.': [57], 'procedure': [60], 'allows': [61], 'for': [62, 75, 108], 'simultaneous': [64], 'polar,': [67], 'semi-polar': [68], 'hydrophobic': [70], 'metabolites,': [71], 'as': [72, 74], 'well': [73], 'proteins': [79], 'starch.': [81], 'After': [82], 'labelling': [83, 115], 'extraction,': [85], 'lipids': [89], 'were': [90, 150], 'analysed': [91], 'high-resolution': [94], 'mass': [95], 'spectrometer': [96], 'providing': [97, 104], 'accurate': [98], 'MS': [99], 'all-ion': [101], 'fragmentation': [102], 'data,': [103], 'an': [105, 126], 'readout': [107], 'every': [109], 'detectable': [110], 'isotope-labelled': [111], 'peak.': [112], 'isotope': [114], 'assisted': [116], 'process': [119], 'employed': [120], 'can': [121], 'be': [122], 'applied': [123, 151], 'either': [125], 'automated': [127], 'database-dependent': [128], 'or': [129], 'database-independent': [131], 'polar': [136], 'metabolome': [137], 'lipidome.': [139], 'As': [140], 'proof': [142], 'concept,': [144], 'developed': [146, 184], 'methods': [147], 'technologies': [149], 'validated': [153], 'Arabidopsis': [155], 'thaliana': [156], 'leaf': [157], 'root': [159], 'extracts.': [160], 'Along': [161], 'large': [164], 'repository': [165], 'assigned': [167], 'elemental': [168], 'compositions,': [169], 'which': [170], 'is': [171], 'provided,': [172], 'show,': [174], 'selected': [176], 'examples,': [177], 'accuracy': [179], 'reliability': [181], 'workflow.': [185]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2091910674', 'counts_by_year': [{'year': 2024, 'cited_by_count': 16}, {'year': 2023, 'cited_by_count': 24}, {'year': 2022, 'cited_by_count': 30}, {'year': 2021, 'cited_by_count': 46}, {'year': 2020, 'cited_by_count': 39}, {'year': 2019, 'cited_by_count': 30}, {'year': 2018, 'cited_by_count': 39}, {'year': 2017, 'cited_by_count': 21}, {'year': 2016, 'cited_by_count': 17}, {'year': 2015, 'cited_by_count': 18}, {'year': 2014, 'cited_by_count': 18}, {'year': 2013, 'cited_by_count': 19}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-27T14:02:48.114442', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
