Title: Water‐Soluble Polymers Coupled with Glycopeptide Antigens and T‐Cell Epitopes as Potential Antitumor Vaccines
Abstract: Angewandte Chemie International EditionVolume 52, Issue 40 p. 10652-10656 Communication Water-Soluble Polymers Coupled with Glycopeptide Antigens and T-Cell Epitopes as Potential Antitumor Vaccines† Lutz Nuhn, Lutz Nuhn Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz (Germany) These authors contributed equally to this work.Search for more papers by this authorSebastian Hartmann, Sebastian Hartmann Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz (Germany) These authors contributed equally to this work.Search for more papers by this authorBjörn Palitzsch, Björn Palitzsch Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz (Germany)Search for more papers by this authorDr. Bastian Gerlitzki, Dr. Bastian Gerlitzki University Medical Center-Institute of Immunology, Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, Geb. 708, 55101 Mainz (Germany)Search for more papers by this authorProf. Dr. Edgar Schmitt, Prof. Dr. Edgar Schmitt University Medical Center-Institute of Immunology, Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, Geb. 708, 55101 Mainz (Germany)Search for more papers by this authorProf. Dr. Rudolf Zentel, Corresponding Author Prof. Dr. Rudolf Zentel [email protected] Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz (Germany)Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz (Germany)Search for more papers by this authorProf. Dr. Horst Kunz, Corresponding Author Prof. Dr. Horst Kunz [email protected] Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz (Germany)Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz (Germany)Search for more papers by this author Lutz Nuhn, Lutz Nuhn Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz (Germany) These authors contributed equally to this work.Search for more papers by this authorSebastian Hartmann, Sebastian Hartmann Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz (Germany) These authors contributed equally to this work.Search for more papers by this authorBjörn Palitzsch, Björn Palitzsch Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz (Germany)Search for more papers by this authorDr. Bastian Gerlitzki, Dr. Bastian Gerlitzki University Medical Center-Institute of Immunology, Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, Geb. 708, 55101 Mainz (Germany)Search for more papers by this authorProf. Dr. Edgar Schmitt, Prof. Dr. Edgar Schmitt University Medical Center-Institute of Immunology, Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, Geb. 708, 55101 Mainz (Germany)Search for more papers by this authorProf. Dr. Rudolf Zentel, Corresponding Author Prof. Dr. Rudolf Zentel [email protected] Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz (Germany)Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz (Germany)Search for more papers by this authorProf. Dr. Horst Kunz, Corresponding Author Prof. Dr. Horst Kunz [email protected] Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz (Germany)Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10–14, 55128 Mainz (Germany)Search for more papers by this author First published: 26 August 2013 https://doi.org/10.1002/anie.201304212Citations: 73 † We thank Prof. Dr. Manfred Schmidt for providing access to his light-scattering setup. Moreover, L.N. is grateful to the Fonds der Chemischen Industrie and the Max Planck Graduate Center with the Johannes Gutenberg-Universität Mainz (MPGC) for financial funding. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Highly decorated: Tumor-associated MUC1 glycopeptide and tetanus toxoid T-cell epitope P2 can be attached to water-soluble poly(N-(2-hydroxypropyl)methacrylamide) carriers by orthogonal ligation techniques. Fully synthetic vaccine A with additional nanostructure-promoting domains induced antibodies that exhibit high affinity to tumor cells. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description anie_201304212_sm_miscellaneous_information.pdf10.6 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume52, Issue40September 27, 2013Pages 10652-10656 RelatedInformation
Publication Year: 2013
Publication Date: 2013-08-26
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 86
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