Publication Information

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'https://openalex.org/C98539663', 'wikidata': 'https://www.wikidata.org/wiki/Q220599', 'display_name': 'Cytosol', 'level': 3, 'score': 0.06894699}], 'mesh': [{'descriptor_ui': 'D000106', 'descriptor_name': 'Acetate-CoA Ligase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000106', 'descriptor_name': 'Acetate-CoA Ligase', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D000106', 'descriptor_name': 'Acetate-CoA Ligase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000106', 'descriptor_name': 'Acetate-CoA Ligase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000085', 'descriptor_name': 'Acetates', 'qualifier_ui': '', 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purification', 'is_major_topic': False}, {'descriptor_ui': 'D018076', 'descriptor_name': 'DNA, Complementary', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016415', 'descriptor_name': 'Sequence Alignment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m008782200', 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'https://openalex.org/W2093787863', 'https://openalex.org/W2144634347', 'https://openalex.org/W2192938660', 'https://openalex.org/W2260964447', 'https://openalex.org/W2314225431', 'https://openalex.org/W2316644268', 'https://openalex.org/W2398263784', 'https://openalex.org/W2468391450', 'https://openalex.org/W3151474706', 'https://openalex.org/W4213231968', 'https://openalex.org/W57577109'], 'related_works': ['https://openalex.org/W3028970346', 'https://openalex.org/W2411326874', 'https://openalex.org/W2350146650', 'https://openalex.org/W2266553821', 'https://openalex.org/W2138721420', 'https://openalex.org/W2116623627', 'https://openalex.org/W2074435004', 'https://openalex.org/W2072274286', 'https://openalex.org/W2054427827', 'https://openalex.org/W1484886979'], 'abstract_inverted_index': {'Using': [0, 147, 2962, 3610], 'peptide': [1, 148, 1167, 2366, 2397, 2898], 'sequences': [2, 149, 2899, 3263], 'derived': [3, 150, 2906], 'from': [4, 107, 151, 254, 383, 392, 469, 720, 1086, 1281, 1338, 1792, 1828, 2247, 2503, 2648, 2662, 2727, 2829, 2907, 3010, 3545, 3571, 3585, 3704, 3731, 4766, 4881, 4910, 5001], 'bovine': [5, 17, 152, 164, 721, 725, 1187, 1282, 1320, 1370, 2830, 2869, 2925, 2935, 2960, 2978, 2997, 3265, 3572, 4264], 'cardiac': [6, 20, 153, 167, 736, 751, 786, 1310, 2936, 2979, 2998, 3012, 3074], 'acetyl-CoA': [7, 154, 294, 393, 395, 848, 4401, 4587, 4647, 4851], 'synthetase': [8, 155, 295, 300, 3109], '(AceCS),': [9, 156], 'we': [10, 157, 717, 738, 842, 1341, 2824, 2860, 2911, 2971, 3093, 3102, 3923, 4309, 4422], 'isolated': [11, 26, 158, 173, 1555, 2984, 4424], 'and': [12, 18, 50, 62, 68, 73, 103, 159, 165, 197, 209, 215, 220, 250, 325, 328, 346, 388, 391, 434, 658, 678, 686, 723, 726, 752, 762, 768, 861, 895, 897, 924, 943, 961, 978, 988, 1036, 1062, 1159, 1215, 1237, 1247, 1283, 1286, 1308, 1375, 1418, 1452, 1502, 1568, 1627, 1706, 1756, 1766, 1768, 1889, 1893, 1910, 1943, 1972, 1980, 2022, 2030, 2078, 2083, 2110, 2138, 2173, 2190, 2231, 2258, 2320, 2340, 2346, 2389, 2404, 2469, 2473, 2494, 2518, 2554, 2575, 2591, 2605, 2666, 2703, 2720, 2753, 2759, 2786, 2826, 2879, 2904, 3073, 3080, 3112, 3266, 3285, 3287, 3299, 3309, 3315, 3325, 3381, 3390, 3412, 3416, 3425, 3439, 3444, 3483, 3622, 3639, 3669, 3687, 3691, 3769, 3771, 3824, 3836, 3920, 3943, 3961, 3993, 4111, 4124, 4143, 4150, 4190, 4211, 4259, 4270, 4316, 4324, 4412, 4425, 4519, 4535, 4576, 4654, 4676, 4709, 4712, 4751, 4807, 4905, 4913, 5016, 5068, 5074, 5093], 'characterized': [13, 160, 2827, 3113, 4426], 'cDNAs': [14, 161, 728, 749, 1350, 3383, 4428], 'for': [15, 145, 162, 292, 431, 743, 853, 1010, 1026, 1186, 1267, 1318, 1416, 1476, 1484, 1576, 1584, 1907, 1915, 1950, 2515, 2539, 2686, 2711, 2958, 2977, 2989, 3664, 3693, 3708, 3745, 4402, 4599, 4648, 4730, 4935, 5046, 5052, 5088, 5096], 'a': [16, 27, 31, 92, 130, 163, 174, 178, 239, 277, 360, 419, 669, 741, 781, 830, 933, 944, 964, 984, 991, 1048, 1143, 1149, 1166, 1183, 1225, 1325, 1436, 1509, 1534, 1559, 1637, 1644, 1672, 1820, 1983, 2034, 2065, 2087, 2142, 2182, 2212, 2268, 2287, 2301, 2323, 2364, 2476, 2544, 2549, 2573, 2576, 2594, 2602, 2606, 2636, 2765, 2770, 2793, 2856, 2887, 2913, 2920, 2947, 2955, 2969, 2973, 2985, 2990, 3002, 3018, 3358, 3421, 3428, 3452, 3558, 3721, 3749, 3974, 4126, 4141, 4146, 4148, 4151, 4176, 4215, 4230, 4248, 4273, 4437, 4475, 4480, 4580, 4642, 4738, 4927], 'murine': [19, 28, 166, 175, 727, 748, 839, 1001, 1031, 1038, 1060, 1284, 1287, 1309, 1326, 1862, 2273, 2295, 2373, 2991, 3019, 3267, 3273, 3283, 3310, 3379, 4517], 'enzyme': [21, 168, 476, 777, 787, 1115, 1531, 1718, 2125, 2207, 2246, 2873, 2926, 3013, 3036, 3089, 3570, 3603, 4439, 4644], 'designated': [22, 35, 169, 182, 3078, 3105, 4434], 'AceCS2.': [23, 170, 1800, 1836], 'We': [24, 171, 1322, 2982, 3820, 4038, 5083], 'also': [25, 172, 739, 1323, 2983, 3651, 3821, 4039, 4803, 4854], 'cDNA': [29, 176, 742, 917, 1033, 1040, 1185, 1205, 1220, 1274, 1311, 1317, 1328, 2288, 2857, 2921, 2957, 2976, 2988, 3005, 3021, 3032], 'encoding': [30, 177, 729, 750, 1347, 2290, 2858, 2923, 2954, 3006, 3033, 4429], 'hepatic': [32, 179, 744, 753, 775, 1327, 3020, 3035, 3072, 4550, 4847], 'type': [33, 180, 745, 776, 3075], 'enzyme,': [34, 181, 737, 783, 2910, 4478], 'AceCS1,': [36, 183, 1920, 2267, 4435, 4661], 'identical': [37, 184, 837, 2994, 3039, 4440], 'to': [38, 66, 185, 213, 311, 417, 478, 734, 838, 990, 1133, 1181, 1203, 1231, 1683, 1714, 1982, 2026, 2033, 2086, 2141, 2211, 2277, 2300, 2342, 2368, 2400, 2490, 2542, 2564, 2571, 2600, 2642, 2696, 2918, 2995, 3040, 3091, 3095, 3097, 3302, 3396, 3673, 3739, 3789, 3934, 3958, 4278, 4399, 4409, 4441, 4889, 5063, 5075], 'one': [39, 186], 'reported': [40, 187], 'recently': [41, 188], '(Luong,': [42, 189], 'A.,': [43, 190], 'Hannah,': [44, 191], 'V.': [45, 192, 4817], 'C.,': [46, 193], 'Brown,': [47, 194], 'M.': [48, 195, 1092, 2833, 4282, 4772, 4957], 'S.,': [49, 196], 'Goldstein,': [51, 198], 'J.': [52, 55, 199, 202, 338, 404, 446, 517, 540, 592, 603, 637, 813, 874, 1102, 1735, 2426, 2615, 2843, 3055, 3121, 3144, 3196, 3207, 3241, 3495, 3800, 3873, 4292, 4455, 4621, 4836, 4868, 4967, 4980, 5008], 'L.': [53, 200], '(2000)': [54, 201], 'Biol.': [56, 203, 541, 604, 814, 1299, 1736, 3056, 3145, 3208, 3496, 3801, 3874, 4456, 4622, 4981], 'Chem.': [57, 204, 542, 605, 815, 1737, 3057, 3146, 3209, 3497, 3802, 3875, 4457, 4623, 4982], '275,': [58, 205], '26458–26466).': [59, 206], 'Murine': [60, 207], 'AceCS1': [61, 208, 1032, 1061, 1765, 1798, 1834, 1863, 2274, 2296, 3079, 3284, 3298, 3380, 3415, 3438, 3460, 3530, 3621, 3668, 3679, 3686, 3790, 3823, 3834, 3895, 3960, 4007, 4095, 4123, 4518, 4640], 'AceCS2': [63, 87, 113, 128, 141, 210, 234, 260, 275, 288, 846, 1039, 1063, 1865, 2374, 3268, 3300, 3311, 3356, 3382, 3417, 3440, 3556, 3623, 3670, 3688, 3780, 3825, 3847, 3913, 3962, 3978, 4061, 4104, 4206, 4228, 4252, 4265, 4334, 4384, 4397, 4508, 4520, 4554, 4703, 4723, 4736, 4901, 4925, 4945, 5033], 'were': [64, 118, 211, 265, 757, 766, 864, 919, 1008, 1016, 1066, 1140, 1276, 1313, 1351, 1356, 1380, 1414, 1525, 1652, 1693, 1750, 1790, 1803, 1826, 1839, 1866, 1900, 1925, 2020, 2076, 2127, 2167, 2193, 2391, 2438, 2453, 2660, 2707, 2725, 2738, 2882, 3077, 3384, 3394, 3418, 3515, 3624, 3782, 3838, 3954, 4029, 4072, 4089, 4556], 'purified': [65, 212, 718, 767, 1085, 1114, 1478, 2245, 2321, 2331, 2825, 2872, 2909, 3395, 3437, 3459, 3466, 3513, 3529, 3555, 3569, 3612, 3677, 4263], 'homogeneity': [67, 214, 3397], 'characterized.': [69, 216, 769, 1353], 'Among': [70, 217, 4154], 'C2–C5': [71, 218, 4533], 'short': [72, 219, 3638, 4534, 4570], 'medium': [74, 221, 1365, 3640, 4536], 'chain': [75, 222, 509, 929, 1177, 1257, 2932, 3107, 3617, 3641, 4537, 4571], 'fatty': [76, 223, 323, 2716, 3615, 3642, 3906, 4051, 4070, 4538, 4652, 4677, 4760], 'acids,': [77, 224], 'both': [78, 225, 3667], 'enzymes': [79, 226, 664, 765, 3076, 3393, 3514, 3649, 4525, 4595, 4606, 5073], 'preferentially': [80, 227, 4526], 'utilize': [81, 228, 3652], 'acetate': [82, 229, 308, 367, 377, 426, 3450, 3631, 3665, 4528, 4546, 4763, 4801, 4879, 4934, 4996, 5056], 'with': [83, 97, 230, 244, 309, 932, 975, 1020, 1047, 1125, 1207, 1224, 1315, 1367, 1382, 1571, 1704, 1796, 1832, 1860, 1938, 1995, 2000, 2007, 2046, 2054, 2064, 2100, 2107, 2112, 2132, 2155, 2221, 2228, 2233, 2272, 2317, 2322, 2338, 2475, 2522, 2682, 2741, 2797, 2817, 2876, 2939, 3270, 3319, 3420, 3427, 3449, 3540, 3567, 3644, 3655, 3754, 3905, 4199, 4239, 4257, 4266, 4314, 4348, 4496, 4529, 4657, 4792, 4810, 4942], 'similar': [84, 231, 2183, 3672, 4530, 4597], 'affinity.': [85, 232], 'The': [86, 110, 233, 257, 747, 1023, 1113, 1137, 1218, 1471, 1480, 1550, 1580, 1662, 1675, 1720, 1897, 1953, 2103, 2122, 2151, 2224, 2244, 2309, 2330, 2385, 2396, 2480, 2525, 2556, 2579, 2628, 3027, 3071, 3409, 3432, 3454, 3511, 3524, 3554, 3648, 3661, 4135, 4717, 4878], 'transcripts': [88, 235, 3741, 3781, 3791, 4105, 4555], 'are': [89, 104, 142, 236, 251, 289, 1759, 3671, 4106, 4542, 4727, 4764, 4802, 4997, 5061], 'expressed': [90, 237, 3747, 3916], 'in': [91, 101, 115, 238, 248, 262, 318, 363, 371, 380, 422, 438, 665, 792, 983, 1000, 1358, 1361, 1508, 1636, 1761, 1819, 1868, 1929, 1958, 2455, 2585, 2635, 2680, 2764, 2792, 2809, 2944, 3537, 3628, 3748, 3758, 3763, 3774, 3784, 3787, 3827, 3853, 3903, 3909, 3917, 3940, 3964, 3982, 4010, 4031, 4048, 4055, 4063, 4077, 4091, 4108, 4167, 4187, 4202, 4207, 4218, 4328, 4335, 4339, 4359, 4414, 4511, 4548, 4558, 4582, 4680, 4706, 4740, 4808, 4892, 4902, 4930, 4950, 5004, 5057], 'wide': [93, 240, 3750], 'range': [94, 241, 1698, 3751], 'of': [95, 112, 242, 259, 307, 366, 425, 436, 660, 673, 684, 715, 755, 799, 833, 1152, 1191, 1227, 1335, 1385, 1445, 1512, 1518, 1530, 1545, 1561, 1578, 1613, 1621, 1630, 1640, 1658, 1664, 1677, 1680, 1686, 1689, 1710, 1717, 1764, 1871, 1919, 2011, 2068, 2116, 2158, 2180, 2237, 2294, 2360, 2372, 2458, 2588, 2630, 2638, 2645, 2672, 2709, 2744, 2775, 2803, 2807, 2867, 2915, 2934, 2946, 2950, 3030, 3264, 3272, 3291, 3293, 3313, 3323, 3375, 3405, 3414, 3423, 3435, 3457, 3527, 3551, 3561, 3601, 3620, 3666, 3675, 3714, 3729, 3742, 3752, 3833, 3843, 3894, 3927, 3938, 3946, 3972, 3977, 4043, 4060, 4067, 4094, 4122, 4163, 4205, 4214, 4251, 4262, 4307, 4320, 4333, 4344, 4351, 4355, 4378, 4396, 4489, 4499, 4516, 4569, 4585, 4603, 4651, 4660, 4743, 4759, 4796, 4800, 4849, 4900, 4933, 4953, 4995, 5032, 5049, 5055, 5070, 5090], 'tissues,': [96, 243, 1002], 'the': [98, 108, 245, 255, 305, 329, 364, 372, 381, 423, 432, 475, 479, 713, 735, 763, 774, 785, 793, 797, 927, 1030, 1037, 1134, 1232, 1264, 1319, 1389, 1412, 1443, 1477, 1485, 1523, 1528, 1537, 1585, 1650, 1684, 1697, 1700, 1707, 1715, 1757, 1809, 1845, 1911, 1921, 1930, 2003, 2060, 2206, 2248, 2282, 2347, 2358, 2369, 2394, 2504, 2643, 2646, 2649, 2669, 2683, 2697, 2784, 2798, 2815, 2821, 2862, 2868, 2871, 2908, 2924, 2940, 2959, 2963, 2996, 3011, 3031, 3034, 3088, 3258, 3288, 3331, 3364, 3372, 3376, 3391, 3399, 3406, 3436, 3458, 3480, 3528, 3546, 3552, 3568, 3580, 3586, 3591, 3599, 3602, 3605, 3611, 3614, 3633, 3676, 3705, 3709, 3755, 3775, 3785, 3841, 3892, 3918, 3925, 3936, 3941, 3951, 3983, 4006, 4011, 4032, 4041, 4044, 4058, 4064, 4078, 4092, 4103, 4109, 4119, 4168, 4188, 4200, 4212, 4219, 4222, 4305, 4318, 4349, 4365, 4393, 4405, 4415, 4419, 4471, 4486, 4497, 4500, 4512, 4523, 4549, 4559, 4566, 4583, 4589, 4593, 4601, 4604, 4649, 4658, 4681, 4707, 4741, 4767, 4793, 4846, 4882, 4897, 4903, 4911, 4931, 4951, 5005, 5026, 5030, 5047, 5053, 5065, 5071, 5091], 'highest': [99, 246, 3756], 'levels': [100, 111, 247, 258, 3762, 3773, 3937, 4042, 4059, 4093, 4799], 'heart,': [102, 249, 3759], 'apparently': [105, 252, 4552], 'absent': [106, 253], 'liver.': [109, 256, 4560], 'mRNA': [114, 261, 3835, 3848, 3979, 4008, 4062, 4096], 'skeletal': [116, 263, 3766, 3921, 3944, 3994, 4012, 4065, 4112, 4710, 4906], 'muscle': [117, 264, 3945, 3995, 4013, 4066, 4113, 4711], 'increased': [119, 266, 4362, 4794, 4804], 'markedly': [120, 267], 'under': [121, 268, 855, 1263, 1330, 1814, 1850, 2678, 4114, 4714, 4745, 4856, 4884, 4917, 4938, 5036], 'ketogenic': [122, 269, 856, 4115, 4715, 4746, 4754, 4857, 4885, 4918, 4939, 5037], 'conditions.': [123, 270, 857, 1332, 3026, 4116, 4716, 4940], 'Subcellular': [124, 271, 770], 'fractionation': [125, 272, 771, 4128, 4224, 4505], 'revealed': [126, 273, 473, 772, 3737, 4521, 4721], 'that': [127, 137, 274, 284, 474, 773, 845, 849, 3041, 3271, 3297, 3355, 3465, 3541, 3590, 3674, 3718, 3891, 4102, 4227, 4392, 4442, 4507, 4522, 4639, 4645, 4673, 4722, 4726, 4735, 4924], 'is': [129, 276, 415, 780, 790, 836, 850, 1440, 3037, 3276, 3575, 3596, 3632, 3896, 3914, 4229, 4398, 4436, 4474, 4509, 4607, 4641, 4663, 4704, 4853, 4921, 4946, 5034], 'mitochondrial': [131, 278, 794, 2499, 2546, 2581, 2604, 3360, 3593, 4192, 4220, 4231, 4416, 4476, 4482, 4513, 4590], 'matrix': [132, 279, 3607, 4232, 4477], 'enzyme.': [133, 280, 731, 746, 1321, 1479, 2961, 4233], '[14C]Acetate': [134, 281], 'incorporation': [135, 282, 1420, 4319, 4354, 4368, 4380, 4719], 'indicated': [136, 283, 4506], 'acetyl-CoAs': [138, 285, 4725], 'produced': [139, 286, 368, 4998], 'by': [140, 287, 369, 385, 394, 428, 869, 926, 1018, 1075, 1142, 1161, 1195, 1388, 1430, 1435, 1527, 1541, 1556, 1654, 1808, 1844, 1895, 2130, 2195, 2378, 2393, 2440, 2509, 2800, 2813, 3016, 3043, 3330, 3467, 3520, 3532, 3681, 3898, 3967, 4015, 4180, 4369, 4383, 4444, 4665, 4805, 4999, 5028, 5080], 'utilized': [143, 290, 317, 851, 4527, 4728], 'mainly': [144, 291, 852, 4186, 4729], 'oxidation.AB046741AB046742': [146, 293], 'polyacrylamide': [296], 'gel': [297, 2344], 'electrophoresis': [298], 'Acetyl-CoA': [299], '(AceCS,1': [301], 'EC': [302], '6.2.1.1)': [303], 'catalyzes': [304, 4565], 'ligation': [306], 'CoA': [310, 656, 3692, 4216, 4575], 'produce': [312, 2281, 4400, 4410], 'acetyl-CoA,': [313], 'an': [314, 1290, 1432, 2008, 2113, 2234, 2265, 2355, 2361, 3007, 3472, 4160, 4181, 4340, 4947], 'essential': [315], 'molecule': [316], 'various': [319, 470, 661, 3294, 3732], 'metabolic': [320], 'pathways': [321, 5051], 'including': [322], 'acid': [324, 331, 1158, 1234, 1574, 2387, 2779, 2865, 2901, 3262, 3280, 3549, 3616, 3907, 4407, 4493, 4678], 'cholesterol': [326, 4675], 'synthesis': [327, 1206, 3908, 4650, 4679], 'tricarboxylic': [330, 4406], 'cycle': [332, 4408], '(for': [333], 'review,': [334], 'see': [335], 'Ref.': [336], '1Bremer': [337], 'Osmundsen': [339, 5009], 'H.': [340, 484, 495, 535, 537, 561, 563, 567, 569, 588, 618, 622, 624, 628, 634, 691, 701, 1096, 1294, 1395, 2414, 2418, 2420, 2837, 3139, 3141, 3165, 3167, 3171, 3173, 3192, 3222, 3226, 3228, 3232, 3238, 4286, 4961, 5010], 'Numa': [341, 1459, 5011], 'S.': [342, 577, 598, 1460, 2610, 2614, 3181, 3202, 4815, 5012], 'Fatty': [343, 5013], 'Acid': [344, 5014], 'Metabolism': [345, 5015], 'Its': [347, 5017], 'Regulation.': [348, 5018], 'Elsevier': [349, 5019], 'Science': [350, 5020], 'Publisher,': [351, 5021], 'Amsterdam1984:': [352, 5022], '113-154Google': [353, 5023], 'Scholar).': [354, 412, 467, 710, 1112, 1306, 1406, 1470, 1746, 2435, 2627, 2853, 3070, 3253, 3510, 4302, 4700, 4790, 4844, 4877, 5024], 'In': [355, 374, 732, 2820, 3000, 4004, 4174, 4375, 4418, 4701], 'ruminant': [356, 4954], 'animals,': [357], 'AceCS': [358, 414, 468, 719, 834, 1083, 1423, 2828, 2980, 3008, 3100, 4046, 4345, 4352, 4888], 'plays': [359, 4737, 4926], 'key': [361, 420, 4670, 4928], 'role': [362, 421, 714, 4306, 4581, 4739, 4929], 'catabolism': [365], 'microorganisms': [370, 471, 5000], 'rumen.': [373], 'nonruminant': [375], 'mammals,': [376], 'production': [378, 2359, 4742, 4795, 4937], 'occurs': [379], 'liver': [382, 4682, 4768, 4883], 'ethanol': [384], 'alcohol': [386], 'dehydrogenase': [387, 390, 1454, 1623], 'acetaldehyde': [389], 'hydrolase': [396, 4852], '(2Crabtree': [397], 'B.': [398], 'Souter': [399], 'M.-J.': [400], 'Anderson': [401], 'S.E.': [402], 'Biochem.': [403, 518, 638, 2427, 2616, 3122, 3242, 3339, 4779, 4835, 4869], '1989;': [405, 4823], '257:': [406], '673-678Crossref': [407], 'PubMed': [408, 451, 463, 525, 551, 582, 612, 645, 824, 1108, 1402, 1466, 1744, 2431, 2623, 2849, 3066, 3129, 3155, 3186, 3216, 3249, 3349, 3506, 3811, 3884, 4298, 4466, 4632, 4696, 4786, 4826, 4840, 4873, 4973, 4989], 'Scopus': [409, 452, 464, 526, 552, 583, 646, 825, 1109, 1303, 1403, 1467, 2432, 2624, 2850, 3067, 3130, 3156, 3187, 3250, 3350, 3507, 3812, 3885, 4299, 4467, 4633, 4697, 4787, 4827, 4841, 4874, 4974], '(26)': [410], 'Google': [411, 454, 466, 492, 503, 528, 554, 585, 613, 648, 699, 709, 827, 1111, 1305, 1405, 1469, 1745, 2434, 2626, 2852, 3069, 3132, 3158, 3189, 3217, 3252, 3352, 3509, 3814, 3887, 4301, 4469, 4635, 4699, 4789, 4829, 4843, 4876, 4976, 4990], 'Furthermore,': [413, 4845], 'postulated': [416], 'play': [418, 4579], 'recycling': [424], 'released': [427, 4765, 4880], 'acetylcholine': [429, 437], 'esterase': [430], 'formation': [433, 689, 1444, 1676], 'release': [435], 'cholinergic': [439], 'nerve': [440], 'terminals': [441], '(3Sterri': [442], 'S.H.': [443], 'Fonnum': [444], 'F.': [445, 4862], 'Neurochem.': [447], '1980;': [448], '35:': [449], '249-254Crossref': [450], '(47)': [453, 4788], 'Scholar,': [455, 493, 529, 555, 586, 614, 3133, 3159, 3190, 3218, 4830], '4Carroll': [456], 'P.T.': [457], 'Brain': [458], 'Res.': [459, 4781], '1997;': [460, 579, 3183, 4688], '753:': [461], '47-55Crossref': [462], '(20)': [465], 'has': [472], 'belongs': [477], 'firefly': [480], 'luciferase': [481], 'superfamily': [482, 667], '(5Toh': [483, 690], 'Protein': [485, 496, 692, 702, 1928], 'Sequences': [486, 497, 693, 703], 'Data': [487, 498, 694, 704], 'Anal.': [488, 499, 695, 705], '1990;': [489, 606, 696, 1399, 3210], '3:': [490, 697], '517-521PubMed': [491, 698], '6Toh': [494], '1991;': [500, 706], '4:': [501, 707], '111-117PubMed': [502, 708], 'Scholar),': [504, 649, 915, 4991], 'which': [505, 835, 1439, 3564, 4564, 5029], 'includes': [506], 'mammalian': [507], 'long': [508, 3106], 'acyl-CoA': [510, 3108], 'synthetases,': [511, 652], 'ACS1–ACS5': [512], '(7Fujino': [513, 3117], 'T.': [514, 516, 531, 539, 559, 594, 600, 602, 620, 632, 878, 1094, 1100, 1393, 1456, 2416, 2424, 2612, 2835, 2841, 3118, 3120, 3135, 3143, 3163, 3198, 3204, 3206, 3224, 3236, 4284, 4290, 4860, 4959, 4965], 'Yamamoto': [515, 538, 570, 601, 635, 1099, 2423, 2840, 3119, 3142, 3174, 3205, 3239, 4289, 4964], '(': [519, 639, 2617, 3123, 3243], 'Tokyo': [520, 640, 2618, 3124, 3244], ').': [521, 641, 2619, 3125, 3245], '1992;': [522, 3126], '111:': [523, 3127], '197-203Crossref': [524, 3128], '(121)': [527, 3131], '8Fujino': [530, 3134], 'Kang': [532, 629, 2421, 3136, 3233], 'M.J.': [533, 557, 630, 2422, 3137, 3161, 3234], 'Suzuki': [534, 619, 633, 2419, 3138, 3223, 3237], 'Iijima': [536, 568, 617, 3140, 3172, 3221], '1996;': [543, 2428, 3147], '271:': [544, 3148], '16748-16752Abstract': [545, 3149], 'Full': [546, 548, 609, 819, 821, 1741, 3061, 3063, 3150, 3152, 3213, 3344, 3346, 3501, 3503, 3806, 3808, 3879, 3881, 4461, 4463, 4627, 4629, 4691, 4693, 4986], 'Text': [547, 549, 610, 820, 822, 1742, 3062, 3064, 3151, 3153, 3214, 3345, 3347, 3502, 3504, 3807, 3809, 3880, 3882, 4462, 4464, 4628, 4630, 4692, 4694, 4987], 'PDF': [550, 611, 823, 1743, 3065, 3154, 3215, 3348, 3505, 3810, 3883, 4465, 4631, 4695, 4988], '(166)': [553, 3157], '9Kang': [556, 3160], 'Fujino': [558, 631, 1093, 2415, 2834, 3162, 3235, 4283, 4958], 'Sasano': [560, 621, 3164, 3225], 'Minekura': [562, 2417, 3166], 'Yabuki': [564, 3168], 'N.': [565, 3169], 'Nagura': [566, 627, 3170, 3231], 'T.T.': [571, 636, 3175, 3240], 'Proc.': [572, 3176], 'Natl.': [573, 3177], 'Acad.': [574, 3178], 'Sci.': [575, 3179, 3340], 'U.': [576, 3180], 'A.': [578, 626, 806, 1997, 2017, 2073, 2102, 2121, 2223, 2243, 2524, 3048, 3182, 3230, 3488, 3793, 3866, 4448, 4614, 4776], '94:': [580, 3184], '2880-2884Crossref': [581, 3185], '(208)': [584, 3188], '10Suzuki': [587, 3191], 'Kawarabayasi': [589, 3193], 'Y.': [590, 3194, 4864, 4866], 'Kondo': [591, 3195], 'Abe': [593, 3197], 'Nishikawa': [595, 3199], 'K.': [596, 1098, 1458, 2839, 3200, 3335, 4288, 4963], 'Kimura': [597, 3201], 'Hashimoto': [599, 2611, 3203], '265:': [607, 3211], '8681-8685Abstract': [608, 3212], '11Oikawa': [615, 3219], 'E.': [616, 900, 3220], 'Sato': [623, 3227], 'Kamataki': [625, 3229], '1998;': [642, 3246], '124:': [643, 3247], '679-685Crossref': [644, 3248], '(132)': [647, 3251], 'bacterial': [650, 2303], 'antibiotic': [651], '4-coumarate:CoA': [653], 'ligases,': [654], '4-chlorobenzoate:': [655], 'ligase,': [657], 'luciferases': [659], 'origins.': [662], 'All': [663, 1691, 1747], 'this': [666, 730, 800], 'contain': [668], 'common': [670, 680, 4274], 'sequence': [671, 2390, 2866, 3029, 3550], 'motif': [672], 'Ser-Gly-(small': [674], 'hydrophilic': [675], 'residue)2-Gly-(any': [676], 'residue)-Pro-Lys-Gly': [677], 'catalyze': [679], 'two-step': [681], 'reactions:': [682], 'adenylation': [683], 'substrates': [685], 'subsequent': [687], 'thioester': [688], 'Scholar,6Toh': [700], 'To': [711, 997, 2263, 2280, 2854, 3370, 4117, 4303], 'evaluate': [712, 4304], 'AceCS,': [716, 2859], 'heart': [722, 1087, 2831, 3573, 3919, 3942, 3984, 4033, 4110, 4708, 4904, 4952], 'cloned': [724], 'addition': [733, 1529], 'obtained': [740, 1342, 2726, 2883, 2972, 3015], 'types': [754], 'AceCSs': [756, 3292], 'introduced': [758, 3386], 'into': [759, 921, 2406, 2783, 2790, 3387, 3604, 4140, 4322, 4357, 4381, 4588], 'COS': [760, 1793, 1829, 2736, 3388, 4209, 4312, 4336], 'cells,': [761, 3389, 3845], 'resulting': [764, 1138, 1219, 1954, 2348, 3392], '(termed': [778, 788], 'AceCS1)': [779], 'cytosolic': [782, 2577, 4152, 4169, 4438, 4586, 4643, 4850], 'whereas': [784, 4025, 4086], 'AceCS2)': [789], 'located': [791, 4510], 'matrix.': [795, 4417, 4514, 4591], 'During': [796], 'preparation': [798], 'paper,': [801], 'Luong': [802, 3044, 3084, 3468, 3682, 3862, 4610], 'et': [803, 871, 3045, 3085, 3469, 3683, 3863, 4611], 'al.': [804, 872, 3046, 3086, 3470, 3684, 3864, 4446, 4612], '(12Luong': [805, 3047, 3487, 3792, 3865, 4447, 4613], 'Hannah': [807, 3049, 3489, 3794, 3867, 4449, 4615], 'V.C.': [808, 3050, 3490, 3795, 3868, 4450, 4616], 'Brown': [809, 3051, 3491, 3796, 3869, 4451, 4617], 'M.S.': [810, 3052, 3492, 3797, 3870, 4452, 4618, 4684], 'Goldstein': [811, 3053, 3493, 3798, 3871, 4453, 4619, 4685], 'J.L.': [812, 3054, 3494, 3799, 3872, 4454, 4620, 4686], '2000;': [816, 3058, 3498, 3803, 3876, 4458, 4624], '275:': [817, 3059, 3499, 3804, 3877, 4459, 4625], '26458-26466Abstract': [818, 3060, 3500, 3805, 3878, 4460, 4626], '(200)': [826, 3068, 3508, 3813, 3886, 4468, 4634], 'Scholar)': [828, 894, 3353, 3815, 3888, 4636], 'published': [829], 'molecular': [831, 859, 3321, 3525, 3543, 3559, 3582], 'characterization': [832], 'AceCS1.': [840, 3274], 'Here,': [841], 'provide': [843, 5044], 'evidence': [844, 5045], 'provides': [847, 4646], 'oxidation': [854, 1663, 1685, 3713, 4403], 'Standard': [858], 'biology': [860], 'immunochemical': [862], 'techniques': [863], 'performed': [865, 1046, 1180, 4130], 'essentially': [866, 3516], 'as': [867, 1068, 1088, 1725, 1812, 1848, 2354, 2411, 2968, 3099, 3110, 3451, 4749], 'described': [868, 1089, 1726, 1813, 1849, 2412, 3042, 3680, 4443], 'Sambrook': [870], '(13Sambrook': [873], 'Fritsch': [875], 'E.F.': [876], 'Maniatis': [877], 'Molecular': [879, 1617, 1625, 1634], 'Cloning:': [880], 'A': [881, 904, 1960, 2048, 2056, 2082, 2109, 2160, 2230, 2257, 2497, 3256], 'Laboratory': [882, 905], 'Manual.': [883, 906], '2nd': [884], 'Ed.': [885], 'Cold': [886, 890, 907, 911], 'Spring': [887, 891, 908, 912], 'Harbor': [888, 909], 'Laboratory,': [889, 910], 'Harbor,': [892, 913], 'NY1989Google': [893], 'Harlow': [896], 'Lane': [898, 901], '(14Harlow': [899], 'D.': [902], 'Antibodies:': [903], 'NY1988Google': [914], 'respectively.': [916, 3082, 3327, 3431], 'clones': [918, 1337, 1346], 'subcloned': [920], 'pBluescript': [922], 'vectors': [923], 'sequenced': [925, 1160], 'dideoxy': [928], 'termination': [930], 'method': [931, 1487, 1587, 1811, 1847], 'Bigdye': [934], 'Terminator': [935], 'Cycle': [936], 'Sequencing': [937], 'Ready': [938], 'Reaction': [939], 'kit': [940], '(PE': [941], 'Biosystems)': [942], 'DNA': [945, 1387, 1410], 'sequencer': [946, 1168], '(model': [947, 1169], '310;': [948], 'PE': [949, 1172], 'Biosystems).': [950, 1173], 'Total': [951], 'RNA': [952, 972, 999, 1193, 1280, 2938, 3730], 'was': [953, 973, 1045, 1073, 1084, 1123, 1179, 1201, 1221, 1260, 1425, 1473, 1539, 1554, 1666, 1712, 1723, 1913, 1936, 1956, 2005, 2024, 2062, 2105, 2153, 2185, 2209, 2226, 2253, 2275, 2297, 2312, 2336, 2352, 2376, 2398, 2482, 2501, 2531, 2561, 2583, 2633, 2780, 2788, 2811, 2874, 3014, 3461, 3534, 3702, 3720, 3851, 3931, 3980, 4129, 4138, 4184, 4255, 4386], 'prepared': [954, 1017, 1194, 1791, 1827, 2439, 2502], 'using': [955, 1148, 1165, 1278, 1289, 1447, 3023, 3398, 3471], 'standard': [956, 1481, 1581], 'guanidinium': [957], 'thiocyanate': [958], 'lysis': [959], 'buffer': [960, 1959, 1978, 1996, 2001, 2016, 2047, 2055, 2072, 2081, 2101, 2108, 2120, 2159, 2171, 2204, 2222, 2229, 2242, 2256, 2459, 2523, 2589, 2639, 4204], 'centrifugation': [962, 1944, 2510], 'over': [963, 4364], 'cesium': [965], 'chloride': [966], 'cushion.': [967], 'For': [968, 1055, 1917, 2178, 2357], 'Northern': [969, 1005, 1011, 1027, 3727, 3929], 'blotting,': [970], 'total': [971, 1510, 1638], 'denatured': [974], '1m': [976], 'glyoxal': [977], '50%': [979], 'dimethyl': [980], 'sulfoxide,': [981], 'fractionated': [982, 2592, 4139], '1.5%': [985], 'agarose': [986], 'gel,': [987], 'transferred': [989], 'Zeta': [992], 'Probe': [993], 'nylon': [994], 'membrane': [995], '(Bio-Rad).': [996], 'analyze': [998, 3935], 'commercially': [1003], 'available': [1004, 3952], 'blots': [1006, 1028], '(CLONTECH)': [1007], 'used': [1009, 1025, 1067, 1202, 1474, 1914, 2276, 2353], 'blot': [1012], 'analysis.': [1013], '32P-Labeled': [1014], 'probes': [1015, 1024], 'priming': [1019], 'random': [1021, 1216], 'hexanucleotides.': [1022], 'included': [1029], 'nucleotides': [1034, 1041], '154–1318': [1035], '160–1696.': [1042], 'Quantitative': [1043], 'analysis': [1044, 3329], 'bioimage': [1049], 'analyzer': [1050], '(BAS2000,': [1051], 'Fuji': [1052], 'Film,': [1053], 'Tokyo).': [1054], 'immunoblotting,': [1056], 'polyclonal': [1057], 'antibodies': [1058, 3953], 'against': [1059, 1977, 2080, 2170, 2203, 2255], '(see': [1064, 1421, 2927, 3608], 'below)': [1065], 'first': [1069], 'antibodies.': [1070], 'Antibody': [1071], 'binding': [1072], 'detected': [1074, 3783, 3852, 4159, 4179, 4238, 4557], 'chemiluminescence': [1076], '(ECL,': [1077], 'Amersham': [1078], 'Pharmacia': [1079, 1987, 2038, 2092, 2199, 2307, 2328, 2447], 'Biotech)': [1080, 1988, 2039, 2093], 'kit.': [1081], 'Bovine': [1082, 1307, 3308], 'previously': [1090], '(15Ishikawa': [1091, 2832, 4281, 4956], 'Sakashita': [1095, 2836, 4285, 4960], 'Morikawa': [1097, 2838, 4287, 4962], 'Tohoku': [1101, 2673, 2690, 2842, 4291, 4966], 'Exp.': [1103, 2844, 4293, 4968], 'Med.': [1104, 2845, 4294, 4969], '1995;': [1105, 2846, 4295, 4970], '175:': [1106, 2847, 4296, 4971], '55-67Crossref': [1107, 2848, 4297, 4972], '(14)': [1110, 2851, 4300, 4975], '(specific': [1116], 'activity': [1117, 1424, 3456, 4848], '45': [1118], 'μmol/min/mg': [1119, 3446], 'at': [1120, 1427, 1520, 1647, 1668, 1753, 1805, 1841, 1902, 1940, 1945, 2175, 2260, 2511, 2534, 2668, 2689, 2761, 3363, 3479, 4485], '37': [1121, 1428, 1521, 1648, 1806, 1842, 2762], '°C)': [1122], 'digested': [1124, 2337, 2875], 'lysyl': [1126, 2877], 'endopeptidase': [1127], '(Wako': [1128], 'Pure': [1129], 'Chemicals,': [1130], 'Osaka)': [1131], 'according': [1132], "manufacturer's": [1135], 'instructions.': [1136], 'peptides': [1139, 2881], 'separated': [1141], 'C8': [1144, 2888], 'reverse': [1145, 1210, 2889], 'phase': [1146, 2890], 'column': [1147, 1989, 2004, 2040, 2061, 2094, 2104, 2146, 2152, 2215, 2225, 2326, 2891, 3485], 'linear': [1150], 'gradient': [1151, 2010, 2067, 2115, 2236, 2598], '0–80%': [1153], 'acetonitrile': [1154], 'containing': [1155, 2015, 2049, 2057, 2071, 2119, 2161, 2241, 2548, 2749, 3475], '0.1%': [1156], 'trifluoroacetic': [1157], 'automated': [1162], 'Edman': [1163], 'degradation': [1164, 4249], '470': [1170], 'A,': [1171, 1979, 2002, 2172, 2205, 3630, 3990, 4035, 4331], 'Reverse': [1174, 2930], 'transcription': [1175], 'polymerase': [1176], 'reaction': [1178, 1258, 1482, 1538, 1551, 1582, 1701, 1711, 2933, 3706, 3722], 'obtain': [1182, 2264, 2543, 2601], 'partial': [1184, 1316, 2863, 2956], 'AceCS.': [1188, 2999], '1': [1189, 1499, 1516, 1594, 1605, 1641, 1678, 1877, 1880, 1883, 1886, 1890, 1908, 1966, 1969, 2569, 2754, 3255, 3368], 'μg': [1190, 1384], 'poly(A)': [1192, 1279, 2937], 'oligo(dT)-Latex™': [1196], '(Takara': [1197, 1270], 'Shuzo,': [1198], 'Kyoto,': [1199], 'Japan)': [1200], 'prime': [1204], 'Superscript': [1208], 'II': [1209], 'transcriptase': [1211], '(Life': [1212], 'Technologies,': [1213], 'Inc.)': [1214], 'hexamers.': [1217], 'then': [1222, 2031, 2084, 2139, 2519, 2562], 'amplified': [1223, 2964], 'set': [1226, 2914], 'degenerate': [1228, 2916, 2941], 'primers': [1229, 2917, 2942], 'corresponding': [1230, 2367], 'amino': [1233, 2291, 2386, 2864, 3261, 3279, 3317, 3548, 4492], 'residues': [1235, 2902], '289–296': [1236], '471–478:': [1238], '5′-GGN': [1239], 'GTN': [1240, 1241], 'CA(C/T)': [1242], 'ACN': [1243], 'CA(A/G)': [1244], 'GCN': [1245], 'GG-3′': [1246], '5′-CT': [1248], 'NCC': [1249, 1250], '(C/T)TC': [1251], 'NAG': [1252], 'NAC': [1253], '(A/G)TT': [1254], 'NCC-3′.': [1255], 'Polymerase': [1256], 'amplification': [1259, 2945], 'carried': [1261, 1694, 1751, 1926, 3932], 'out': [1262, 1695, 1752, 3933], 'conditions': [1265, 4858, 4886, 5038], 'recommended': [1266], 'Ex': [1268], 'Taq™': [1269], 'Shuzo': [1271], 'Corp.).': [1272], 'Three': [1273], 'libraries': [1275, 1312], 'constructed': [1277], 'hearts,': [1285], 'livers': [1288], 'Okayama-Berg': [1291], 'vector': [1292, 2305], '(16Okayama': [1293], 'Berg': [1295], 'P.': [1296, 3337], 'Mol.': [1297], 'Cell.': [1298, 4687], '1983;': [1300], '2:': [1301], '161-170Crossref': [1302], '(871)': [1304], 'screened': [1314, 1324], 'library': [1329, 3022], 'reduced': [1331, 3024], 'After': [1333, 1515, 1533, 1643, 1998, 2052, 2201, 2769, 3969], 'screening': [1334, 3017], '∼105': [1336], 'each': [1339, 2631], 'library,': [1340], 'several': [1343, 2880], 'clones.': [1344], 'Representative': [1345], 'near': [1348, 2974, 2986, 3003], 'full-length': [1349, 2975, 2987, 3004], 'further': [1352, 2533], 'COS-7': [1354, 1853], 'cells': [1355, 1413, 1794, 1830, 1854, 2737, 2816, 3858, 4210, 4313, 4337, 4361, 4372], 'grown': [1357], 'monolayer': [1359], 'culture': [1360], "Dulbecco's": [1362], 'modified': [1363], "Eagle's": [1364], 'supplemented': [1366], '10%': [1368, 1973], 'fetal': [1369], 'serum,': [1371], '100': [1372, 1376, 1489, 1589], 'units/ml': [1373], 'penicillin,': [1374], 'μg/ml': [1377, 1884, 1887], 'streptomycin.': [1378], 'Cells': [1379], 'transfected': [1381, 1795, 1831, 1859, 4208], '10': [1383, 1494, 1496, 1503, 1599, 2135, 2488, 2516, 2656], 'plasmid': [1386, 3474], 'DEAE-dextran': [1390], 'procedure': [1391, 2184], '(17Takai': [1392], 'Ohmori': [1394], 'Biochim.': [1396], 'Biophys.': [1397, 4780], 'Acta.': [1398, 4822], '1048:': [1400], '105-109Crossref': [1401], '(68)': [1404], '3e': [1407], 'days': [1408, 2733], 'after': [1409, 2734, 2884], 'transfection,': [1411, 2735], 'harvested': [1415], 'purification': [1417, 1748, 1918, 1923, 2179, 3411], '[14C]acetate': [1419, 1505, 2756, 4315, 4718], 'below).': [1422, 3609], 'determined': [1426, 1724, 2812, 2861], '°C': [1429, 1807, 1843, 2763], 'either': [1431, 1797, 1833, 1861], 'isotopic': [1433, 1486, 1810, 1846], 'or': [1434, 1799, 1835, 1864, 3855], 'spectrophotometric': [1437, 1586, 3710], 'method,': [1438], 'based': [1441], 'on': [1442, 1671, 2443, 2593, 2886, 2896, 4131, 4896], 'AMP': [1446, 1681, 3719], 'adenylate': [1448, 1614, 3700], 'kinase,': [1449, 1451], 'pyruvate': [1450, 1631], 'lactate': [1453, 1622], '(18Tanaka': [1455], 'Hosaka': [1457], 'Methods': [1461], 'Enzymol.': [1462], '1981;': [1463], '71:': [1464], '334-341Crossref': [1465], '(23)': [1468], 'latter': [1472], 'only': [1475, 3277, 4387], 'mixture': [1483, 1583, 3707], 'contained': [1488, 1588], 'mm': [1490, 1497, 1500, 1504, 1590, 1597, 1602, 1606, 1609, 1660, 1873, 1878, 1881, 1962, 1967, 1970, 2163, 2462, 2471, 2751, 2755], 'Tris-HCl,': [1491, 1591, 1874, 1963, 2463], 'pH': [1492, 1592, 1875, 1964, 2464], '8.5,': [1493, 1593], 'mmMgCl2,': [1495], 'ATP,': [1498], 'CoA,': [1501], '(940': [1506, 2757], 'dpm/nmol)': [1507], 'volume': [1511, 1639, 2637, 2644], '0.2': [1513, 2470], 'ml.': [1514, 1642], 'min': [1517, 2517, 2541], 'preincubation': [1519, 1646], '°C,': [1522, 1649, 1755], 'reactions': [1524, 1651], 'initiated': [1526], 'solution.': [1532], '30-min': [1535], 'incubation,': [1536, 2772], 'terminated': [1540], 'adding': [1542, 1655], '50': [1543], 'μl': [1544, 1657, 2774], 'ice-cold': [1546], 'glacial': [1547], 'acetic': [1548], 'acid.': [1549], 'product': [1552, 3723, 4250], '([14C]acetyl-CoA)': [1553], 'spotting': [1557], 'onto': [1558], 'piece': [1560], 'chromatography': [1562, 2442, 3486], 'media': [1563], '(ITLC-SG': [1564], 'type,': [1565], 'Gelman': [1566], 'Sciences)': [1567], 'extensive': [1569], 'washing': [1570, 1999, 2053], 'water-saturated': [1572], 'ether/formic': [1573], '(7:1)': [1575], 'measurement': [1577], 'radioactivity.': [1579], 'mmdithiothreitol,': [1595], '15': [1596, 1951], 'MgCl2,': [1598], 'mmATP,': [1600], '0.25': [1601, 2466], 'potassium': [1603], 'phosphoenolpyruvate,': [1604], 'acetate,': [1607, 4600, 4797], '0.3': [1608], 'NADH,': [1610], '80': [1611], 'units': [1612, 1620, 1629], 'kinase': [1615, 1632, 3701], '(Roche': [1616, 1624, 1633], 'Biochemicals),': [1618], '17': [1619], 'Biochemicals)': [1626, 1635], '6': [1628], '1-min': [1645], 'started': [1653], '24': [1656], '25': [1659, 2750], 'CoA.': [1661], 'NADH': [1665, 3715], 'measured': [1667, 1804, 1840], '340': [1669], 'nm': [1670], 'recording': [1673], 'spectrophotometer.': [1674], 'mol': [1679, 1688], 'corresponds': [1682], '2': [1687, 2218], 'NADH.': [1690], 'assays': [1692], 'within': [1696], 'where': [1699, 4992], 'proceeded': [1702], 'linearly': [1703], 'time,': [1705], 'initial': [1708], 'rate': [1709], 'proportional': [1713], 'amount': [1716], 'added.': [1719], 'protein': [1721, 2271, 2311, 2335, 2444, 3837, 3850, 4178, 4949], 'content': [1722], '(19Lowry': [1727], 'O.H.': [1728], 'Rosebrough': [1729], 'N.J.': [1730], 'Farr': [1731], 'A.L.': [1732], 'Randall': [1733], 'R.J.': [1734], '1951;': [1738], '193:': [1739], '265-275Abstract': [1740], 'steps': [1749, 1924], '0–4': [1754], 'results': [1758, 4733], 'summarized': [1760], 'TableI.Table': [1762], 'IPurification': [1763], 'AceCS2Enzyme': [1767], 'stepTotal': [1769], 'proteinTotal': [1770], 'activitySpecific': [1771], 'activityRecoverymgμmol/minμmol/min/mg%AceCS1230,000': [1772], '×g1363672.710060%': [1773], '(NH4)2SO472.42663.772.7DEAE-Sepharose': [1774], 'FF23.01988.653.9Phenyl-Sepharose': [1775], 'FF6.313020.735.4Blue': [1776], 'Sepharose': [1777, 1784, 2089], 'FF1.019.620.75.3Sephacryl': [1778], 'S-2000.410.426.82.8AceCS2230,000': [1779], '×g13687.30.810060%': [1780], '(NH4)2SO430.367.62.377.4Q-Sepharose': [1781], 'FF1.06.36.67.2Phenyl-Sepharose': [1782], 'FF0.85.78.76.5Blue': [1783], 'FF0.33.811.24.32nd': [1785], 'Q-Sepharose': [1786, 2196, 2213, 2250], 'FF0.22.011.92.3Crude': [1787], 'sonicated': [1788, 1824, 3407], 'extracts': [1789, 1825, 1899], 'Enzyme': [1801, 1837], 'activities': [1802, 1838, 2126, 3434, 3695], '"Experimental': [1815, 1851, 2928], 'Procedures."': [1816, 1852], 'Open': [1817], 'table': [1818], 'new': [1821], 'tab': [1822], 'Crude': [1823], '(80': [1855], 'dishes,': [1856], '100-mm': [1857], 'diameter)': [1858], 'suspended': [1867, 1957, 2454, 2584, 2634, 2740], '30': [1869, 2456], 'ml': [1870, 2157, 2457, 2587, 2743], '20': [1872, 2540, 2586], '8.0,': [1876, 1965], 'EDTA,': [1879, 1968], 'dithiothreitol,': [1882, 1971], 'aprotinin,': [1885], 'leupeptin,': [1888], 'mmphenylmethylsulfonyl': [1891], 'fluoride': [1892], 'disrupted': [1894], 'sonication.': [1896], 'cell': [1898, 2492, 4223], 'centrifuged': [1901, 2483, 2532], '230,': [1903, 1931, 3400], '000': [1904, 1932, 1947, 2485, 3401], '×': [1905, 1933, 1948, 1991, 2042, 2096, 2148, 2217, 2486, 2506, 2513, 2528, 2537, 2558, 2567, 3402], 'g': [1906, 1934, 1949, 2507, 2514, 2529, 2538, 2559], 'h,': [1909], 'supernatant': [1912, 1935, 2508, 2530, 2560, 2647], 'purification.': [1916], 'following': [1922], 'out.': [1927], 'precipitated': [1937], '(NH4)2SO4': [1939, 2023, 2070], '60%': [1941], 'saturation': [1942, 2029], '16,': [1946], 'min.': [1952], 'precipitate': [1955], '(50': [1961], 'glycerol': [1974], '(w/v)),': [1975], 'dialyzed': [1976, 2079, 2169, 2254], 'applied': [1981, 2032, 2085, 2140, 2210], 'DEAE-Sepharose': [1984, 2188], 'FF': [1985, 2036, 2189, 2197, 2214, 2251], '(Amersham': [1986, 2037, 2091, 2198, 2306, 2327, 2446], '(1.5': [1990, 2041, 2216], '5': [1992, 2043, 2742, 4021], 'cm)': [1993, 2044, 2098, 2219], 'equilibrated': [1994, 2045, 2099, 2220], 'eluted': [2006, 2063, 2111, 2154, 2232], 'increasing': [2009, 2114, 2235], '0–0.25': [2012, 2238], 'm': [2013, 2239, 2467], 'KCl': [2014, 2118, 2240], 'Active': [2018, 2074, 2165], 'fractions': [2019, 2075, 2123, 2166, 2437, 3404, 4193], 'combined,': [2021, 2128], 'added': [2025, 2781], 'give': [2027], '30%': [2028, 2050, 2058, 2776], 'phenyl-Sepharose': [2035], '(NH4)2SO4.': [2051], '(NH4)2SO4,': [2059], 'decreasing': [2066], '30–0%': [2069], 'collected': [2077], 'blue': [2088], 'CL-6B': [2090], '(1.0': [2095], '3': [2097, 2732, 3659], 'washed': [2106, 2227, 2520], '0–1m': [2117], 'exhibiting': [2124], 'concentrated': [2129], 'ultrafiltration': [2131], 'Amicon': [2133], 'Centriplus': [2134], '(Amicon': [2136], 'Inc.),': [2137], 'Sephacryl': [2143, 2191], 'S-200': [2144, 2192], 'HR': [2145], '(1.6': [2147], '60': [2149], 'cm).': [2150], '150': [2156, 2162], 'KCl.': [2164], 'collected,': [2168], 'stored': [2174, 2259], '−80': [2176, 2261], '°C.': [2177, 2262], 'AceCS2,': [2181, 2363, 3081, 3286, 3746, 4125, 4258, 4308, 4473], 'followed': [2186], 'except': [2187], 'replaced': [2194], 'Biotech).': [2200, 2308, 2329, 2448], 'dialyzing': [2202], 'solution': [2208, 2748], 'second': [2249], 'step': [2252], 'anti-murine': [2266, 2362], 'glutathioneS-transferase': [2269], 'fusion': [2270, 2285, 2310, 2334], 'immunize': [2278], 'rabbits.': [2279], 'glutathione': [2283, 2332], 'S-transferase': [2284, 2333], 'protein,': [2286], 'fragment': [2289, 2351, 2922, 2949, 2967, 4276], 'acids': [2292, 3318, 3643, 4653], '456–600': [2293], 'ligated': [2298], 'in-frame': [2299], 'pGEX-4T': [2302], 'expression': [2304, 3473, 3893, 4899, 5031], 'induced': [2313, 4107, 4713, 4855, 5035], 'inEscherichia': [2314], 'coli': [2315], 'DH5α': [2316], 'isopropyl': [2318], 'β-d-thiogalactopyranoside': [2319], 'glutathione-Sepharose': [2324], '4B': [2325], 'thrombin': [2339], 'subjected': [2341, 2563], 'SDS-polyacrylamide': [2343], 'electrophoresis,': [2345], 'thrombin-cleaved': [2349], '16-kDa': [2350], 'antigen.': [2356], '15-residue': [2365], 'C': [2370], 'terminus': [2371, 3366, 3482, 4488], '(CSAFQKYEEQRAATN)': [2375], 'synthesized': [2377], 'Nippon': [2379, 2728], 'Gene': [2380, 2675], 'Research': [2381, 2676], 'Laboratories': [2382], '(Sendai,': [2383], 'Japan).': [2384], 'composition': [2388], 'confirmed': [2392], 'supplier.': [2395], 'coupled': [2399], 'keyhole': [2401], 'limpet': [2402], 'hemocyanin': [2403], 'injected': [2405], 'New': [2407], 'Zealand': [2408], 'White': [2409], 'rabbits': [2410], '(20Iijima': [2413], 'Eur.': [2425, 4867], '242:': [2429], '186-190Crossref': [2430], '(64)': [2433], 'IgG': [2436], 'affinity': [2441, 4531, 4598], 'A-Sepharose': [2445], 'Mouse': [2449], 'kidneys': [2450], '(8': [2451], 'g)': [2452], 'B': [2460, 2590, 2640], '(10': [2461], '7.5,': [2465], 'sucrose,': [2468], 'EDTA)': [2472], 'homogenized': [2474], 'glass': [2477], 'Dounce': [2478], 'homogenizer.': [2479], 'homogenate': [2481, 4137], '(1,': [2484], 'g,': [2487], 'min)': [2489], 'remove': [2491], 'debris': [2493], 'nuclear': [2495], 'pellets.': [2496], 'heavy': [2498, 4144, 4191], 'fraction': [2500, 2547, 2582, 2608, 4170], '1,000': [2505], '3,300': [2512], 'twice': [2521], '3,': [2526], '300': [2527], '12,': [2535], '500': [2536, 2773], 'crude': [2545, 2580], 'light': [2550, 2603, 4142, 4189], 'mitochondria': [2551, 3606], 'fraction,': [2552], 'peroxisomes,': [2553], 'lysosomes.': [2555], '12,500': [2557], 'ultracentrifugation': [2565, 2599], '(120,000': [2566], 'gfor': [2568], 'h)': [2570], 'yield': [2572, 3422, 3429], 'microsomal': [2574], 'fraction.': [2578, 4153], 'discontinuous': [2595], 'sucrose': [2596], 'density': [2597], 'peroxisomal': [2607], '(21Miyazawa': [2609], 'Yokota': [2613], '1985;': [2620, 4870], '98:': [2621], '723-733Crossref': [2622], '(120)': [2625], 'pellet': [2629], 'spin': [2632], 'equal': [2641], 'same': [2650], 'spin.': [2651], 'Male': [2652], 'C57BL/6J': [2653], 'mice': [2654, 2706, 3949], '(age': [2655], 'weeks,': [2657], 'individually': [2658, 3385], 'caged)': [2659], 'purchased': [2661], 'Clea': [2663], 'Japan': [2664], '(Tokyo)': [2665], 'housed': [2667], 'animal': [2670, 2687, 3910], 'laboratory': [2671], 'University': [2674], 'Center': [2677], 'protocols': [2679], 'accord': [2681], 'institutional': [2684], 'guidelines': [2685], 'experiments': [2688], 'University.': [2691], 'Animals': [2692], 'had': [2693], 'free': [2694, 4762], 'access': [2695], 'commercial': [2698], 'stock': [2699], 'diet': [2700], '(Clea': [2701], 'CE2)': [2702], 'water.': [2704], 'Fasted': [2705], 'deprived': [2708], 'food': [2710], '48': [2712, 3970], 'h.': [2713], 'Zucker': [2714, 4049, 4068], 'diabetic': [2715, 4050, 4069], 'rats': [2717, 4071], '(14-week-old': [2718], 'males)': [2719], 'their': [2721, 3694, 5081], 'normal': [2722, 4079], 'littermate': [2723], 'males': [2724], 'Experimental': [2729], 'Animal': [2730], 'Co.': [2731], 'scraped,': [2739], "Hanks'": [2745], 'balanced': [2746], 'salt': [2747], 'glucose': [2752], 'dpm/nmol),': [2758], 'incubated': [2760, 4310], 'tightly': [2766], 'sealed': [2767], 'flask.': [2768], '2-h': [2771], '(w/v)': [2777], 'trichloroacetic': [2778], 'immediately': [2782], 'flask,': [2785], '[14C]CO2': [2787], 'trapped': [2789], 'ethanolamine': [2791], 'counting': [2794], 'vial': [2795], 'connected': [2796], 'flask': [2799], 'constant': [2801], 'flow': [2802], 'N2': [2804], 'gas.': [2805], 'Incorporation': [2806], '14C': [2808, 4321, 4356, 4379], 'lipids': [2810, 4382], 'extracting': [2814], 'chloroform-methanol': [2818], '(2:1).': [2819], 'previous': [2822], 'study,': [2823, 4421], 'clone': [2855], 'enzyme:': [2870], 'endopeptidase,': [2878], 'separation': [2885], '(data': [2892, 3696, 3724, 3859], 'not': [2893, 3697, 3725, 3860, 3955], 'shown).': [2894, 3698, 3726, 3861], 'Based': [2895, 4895], 'two': [2897, 3377, 3512, 4045, 4427, 4524, 4594, 4605, 5050, 5072], '(amino': [2900], '286–296': [2903], '471–478)': [2905], 'designed': [2912], 'amplify': [2919], 'Procedures").': [2929], 'transcription-polymerase': [2931], 'resulted': [2943, 4338], 'major': [2948, 3740, 4394], '576': [2951], 'base': [2952], 'pairs': [2953], '576-base': [2965], 'pair': [2966], 'probe,': [2970], '(Fig.1).': [2981], 'ortholog': [2992], '83.5%': [2993], 'addition,': [3001], 'distinct': [3009, 4431], 'hybridization': [3025, 3738], 'nucleotide': [3028], 'completely': [3038, 3303, 4608], 'Although': [3083, 3830, 4540, 4592, 5025], 'abbreviated': [3087], 'name': [3090], 'ACS,': [3092], 'prefer': [3094], 'refer': [3096], 'it': [3098, 4254, 4662, 4920], 'because': [3101, 3950, 4253], 'have': [3103, 3889, 4423, 4637], 'already': [3104], 'ACS': [3111], 'five': [3114], 'enzymes,': [3115, 3378], 'ACS1–5': [3116], 'Fig.': [3254, 4020, 4329], 'shows': [3257], 'deduced': [3259, 3547, 3584], 'primary': [3260, 4491], 'compared': [3269], 'There': [3275], '45.8%': [3278], 'identity': [3281], 'between': [3282, 4574], 'phylogenetic': [3289], 'tree': [3290], 'origins': [3295], 'indicates': [3296], 'belong': [3301], 'different': [3304], 'groups': [3305, 4573], '(Fig.1': [3306], 'B).': [3307, 3660, 4374], 'consist': [3312], '675': [3314], '682': [3316], 'calculated': [3320, 3542, 3581, 3662], 'weights': [3322], '74,309': [3324], '74,662,': [3326], 'Sequence': [3328], 'PSORT': [3332], 'program': [3333], '(22Nakai': [3334], 'Horton': [3336], 'Trends': [3338], '1999;': [3341], '24:': [3342], '34-36Abstract': [3343], '(1838)': [3351], 'predicted': [3354], 'contains': [3357], 'potential': [3359], 'targeting': [3361, 3594, 4483], 'signal': [3362, 3595, 4484, 4502], 'N': [3365, 3481, 4487], '(Fig.': [3367, 3522, 3658, 3735, 3816, 4194, 4242], 'A).': [3369], 'compare': [3371], 'enzymatic': [3373], 'properties': [3374], 'gsupernatant': [3403], 'extracts.': [3408], 'overall': [3410], 'yields': [3413], '9.9-fold': [3419], '2.8%': [3424], '15-fold': [3426], '2.3%,': [3430], 'specific': [3433, 3455], 'were,': [3441], 'respectively,': [3442], '26.8': [3443], '11.9': [3445], 'when': [3447, 3518], 'assayed': [3448], 'substrate.': [3453], '18-fold': [3462], 'higher': [3463, 4074], 'than': [3464, 3579, 4075], 'six': [3476], 'consecutive': [3477], 'histidines': [3478], 'nickel': [3484], 'homogenous': [3517], 'analyzed': [3519, 3822, 3924, 4040, 4317], 'SDS-PAGE': [3521, 3533], '2).': [3523], 'mass': [3526, 3544, 3560, 3583], 'estimated': [3531], '∼78': [3535], 'kDa,': [3536, 3563], 'good': [3538], 'agreement': [3539], 'cDNA.': [3553, 3587], 'exhibited': [3557], '71': [3562], 'agrees': [3565], 'well': [3566], 'but': [3574, 3654], '∼3.7': [3576], 'kDa': [3577, 4165], 'smaller': [3578], 'This': [3588], 'suggests': [3589], 'putative': [3592, 4481, 4501], 'cleaved': [3597], 'during': [3598, 3840], 'transportation': [3600, 4584], 'preparation,': [3613], 'length': [3618], 'preferences': [3619], 'determined.': [3625], 'As': [3626, 4053, 4326], 'shown': [3627, 4054, 4327], 'Fig.3': [3629], 'most': [3634], 'preferred': [3635], 'substrate': [3636], 'among': [3637, 4532], '2–5': [3645], 'carbon': [3646], 'atoms.': [3647], 'can': [3650], 'propionate': [3653], 'lower': [3656, 3772], 'affinities': [3657], 'Kmvalues': [3663], 'histidine-tagged': [3678], 'Both': [3685], 'require': [3689], 'ATP': [3690, 4411], 'When': [3699], 'omitted': [3703], 'assay,': [3711], 'no': [3712, 4026, 4087, 4553], 'occurred,': [3716], 'indicating': [3717], 'blotting': [3728, 3930], 'mouse': [3733, 4132], 'tissues': [3734, 3753, 3966], '4)': [3736], '4.4': [3743], 'kilobases': [3744], 'level': [3757, 4009], 'relatively': [3760, 4366, 4756], 'high': [3761], 'spleen,': [3764], 'lung,': [3765], 'muscle,': [3767, 3922, 4907], 'kidney,': [3768], 'testis': [3770], 'brain': [3776], '(middle': [3777], 'panel).': [3778, 3819, 4003, 4037, 4098, 4173, 4197], 'No': [3779], 'liver,': [3786, 4912], 'contrast': [3788], '4,': [3817], 'top': [3818, 4172], 'mRNAs': [3826, 3939, 4047], '3T3-L1': [3828, 3844, 3857], 'cells.': [3829, 3911], 'marked': [3831, 3975, 4915], 'induction': [3832, 3976, 4343, 4350, 4377, 4916], 'seen': [3839, 3981, 4030], 'differentiation': [3842], 'neither': [3846], 'nor': [3849], 'undifferentiated': [3854], 'differentiated': [3856], 'demonstrated': [3890, 4638], 'regulated': [3897, 4664], 'sterol': [3899, 4666], 'regulatory': [3900, 4667], 'element-binding': [3901, 4668], 'proteins': [3902, 3963], 'parallel': [3904], 'Because': [3912], 'highly': [3915], 'effects': [3926], 'starvation.': [3928], 'adult': [3947], 'male': [3948], 'sufficiently': [3956], 'sensitive': [3957], 'detect': [3959], 'these': [3965, 4155, 4279], 'immunoblotting.': [3968], 'h': [3971], 'fasting,': [3973], '(2-fold,': [3985], 'p': [3986, 3997], '<': [3987, 3998, 4018, 4082], '0.01,': [3988, 3999], 'Fig.5': [3989, 4000, 4056], 'right': [3991, 4002, 4084], 'panel),': [3992, 4024, 4085], '(6.5-fold,': [3996], 'B,': [4001, 4022], 'contrast,': [4005, 4175, 4376, 4702], 'decreased': [4014], '∼50%': [4016], '(p': [4017, 4081], '0.05,': [4019, 4083], 'left': [4023, 4036], 'significant': [4027], 'changes': [4028, 4088], '(Fig.5': [4034], 'rats.': [4052], 'C,': [4057], '∼3-fold': [4073], 'those': [4076], 'littermates': [4080], 'found': [4090], '(left': [4097], 'These': [4099, 4389, 4732], 'data': [4100, 4225, 4390, 5043], 'indicate': [4101, 4226], 'determine': [4118, 5076], 'subcellular': [4120, 4127, 4504], 'distributions': [4121], 'kidney': [4133], 'homogenate.': [4134], 'tissue': [4136], 'mitochondrial,': [4145], 'peroxisomal,': [4147], 'microsomal,': [4149], 'fractions,': [4156], 'anti-AceCS1': [4157], 'antibody': [4158, 4183, 4241], 'immunoreactive': [4161], 'band': [4162, 4237], '78': [4164], 'exclusively': [4166], '(Fig.6,': [4171], '71-kDa': [4177], 'anti-AceCS2': [4182, 4240], 'present': [4185], '6,': [4195, 4243], 'middle': [4196, 4244], 'Together': [4198], 'solubility': [4201], 'hypotonic': [4203], 'presence': [4213, 4498, 5048], 'pool': [4217], 'matrix,': [4221], 'An': [4234], 'approximately': [4235, 4341], '55-kDa': [4236], 'panel)': [4245], 'may': [4246, 4578], 'be': [4247, 4890], 'colocalized': [4256], 'proteolytic': [4260], 'digestion': [4261], 'trypsin,': [4267], 'subtilisin': [4268], 'BPN′,': [4269], 'chymotrypsin': [4271], 'generated': [4272], '56-kDa': [4275], 'resistant': [4277], 'proteases': [4280], 'AceCS2-transfected': [4311, 4360], 'CO2': [4323, 4358, 4413], 'lipids.': [4325], '7': [4330], 'transfection': [4332, 4385], '4-fold': [4342], 'activity.': [4346], 'Consistent': [4347, 4495, 4656, 4791, 4941], 'activity,': [4353], 'approximately.5-fold': [4363], 'low': [4367], 'parental': [4370], 'vector-transfected': [4371], '(Fig.7': [4373], '1.6-fold.': [4388], 'suggest': [4391], 'function': [4395, 4659, 5067], 'through': [4404], 'current': [4420, 5042], 'functionally': [4430], 'AceCSs.': [4432], 'One,': [4433], 'Luonget': [4445], 'Scholar);': [4470], 'other,': [4472], 'having': [4479], 'its': [4490, 4908, 4914], 'sequence.': [4494], 'sequence,': [4503], 'Purification': [4515], 'acids.': [4539], 'there': [4541], 'numerous': [4543], 'studies': [4544, 5060], 'showing': [4545], 'utilization': [4547], 'mitochondria,': [4551], 'Hepatic': [4561], 'carnitine': [4562], 'acetyltransferase,': [4563], 'reversible': [4567], 'transfer': [4568], 'acyl': [4572], 'carnitine,': [4577], 'exhibit': [4596], 'regulation': [4602, 5069], 'different.': [4609], 'cholesterol.': [4655], 'proteins,': [4669], 'transcriptional': [4671], 'factors': [4672], 'mediate': [4674], '(23Brown': [4683], '89:': [4689], '331-340Abstract': [4690], '(3028)': [4698], 'abundant': [4705, 4898, 4948], 'study': [4720], 'produces': [4724], 'oxidation.': [4731], 'suggested': [4734, 4923], 'energy': [4744, 4936], 'conditions,': [4747, 4755, 4919], 'such': [4748], 'starvation': [4750, 4806], 'diabetes.': [4752], 'Under': [4753], 'large': [4757, 4993], 'amounts': [4758, 4994], 'acid-derived': [4761], '(24Seufert': [4769], 'C.D.': [4770], 'Graf': [4771], 'Janson': [4773], 'G.': [4774], 'Kuhn': [4775], 'Soling': [4777], 'H.D.': [4778], 'Commun.': [4782], '1974;': [4783], '57:': [4784], '901-909Crossref': [4785], 'plasma': [4798], 'patients': [4809], 'diabetes': [4811], '(25Akanji': [4812], 'A.O.': [4813], 'Humphreys': [4814], 'Thursfield': [4816], 'Hockaday': [4818], 'T.D.': [4819], 'Clin.': [4820], 'Chim.': [4821], '185:': [4824], '25-34Crossref': [4825], '(25)': [4828], '26Buckley': [4831], 'B.M.': [4832], 'Wiliamson': [4833], 'D.H.': [4834], '1977;': [4837], '166:': [4838], '539-545Crossref': [4839], '(95)': [4842], '(27Matsunaga': [4859], 'Isohashi': [4861], 'Nakanishi': [4863], 'Sakamoto': [4865], '152:': [4871], '331-336Crossref': [4872], '(24)': [4875], 'requires': [4887], 'metabolized': [4891], 'extrahepatic': [4893], 'tissues.': [4894], 'absence': [4909], 'strongly': [4922], 'metabolism': [4932, 5054], 'our': [4943, 5041], 'hypothesis,': [4944], 'mammals': [4955], 'Scholar,28Webster': [4977], 'Jr.,': [4978], 'L.T.': [4979], '1963;': [4983], '238:': [4984], '4010-4015Abstract': [4985], 'plant': [5002], 'fibers': [5003], 'rumen': [5006], '(1Bremer': [5007], 'mechanism': [5027], 'remains': [5039], 'unclear,': [5040], 'animals.': [5058], 'Further': [5059], 'necessary': [5062], 'elucidate': [5064], 'precise': [5066], 'any': [5077], 'disorders': [5078], 'caused': [5079], 'absence.': [5082], 'thank': [5084], 'Dr.': [5085], 'Ian': [5086], 'Gleadall': [5087], 'review': [5089], 'manuscript': [5092], 'Yumiko': [5094], 'Takei': [5095], 'excellent': [5097], 'technical': [5098], 'assistance.': [5099]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2091700326', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 22}, {'year': 2021, 'cited_by_count': 22}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 18}, {'year': 2014, 'cited_by_count': 18}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2024-12-13T15:46:31.941372', 'created_date': '2016-06-24'}