Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2091684277', 'doi': 'https://doi.org/10.1371/journal.pone.0001023', 'title': 'Primaquine Clears Submicroscopic Plasmodium falciparum Gametocytes that Persist after Treatment with Sulphadoxine-Pyrimethamine and Artesunate', 'display_name': 'Primaquine Clears Submicroscopic Plasmodium falciparum Gametocytes that Persist after Treatment with Sulphadoxine-Pyrimethamine and Artesunate', 'publication_year': 2007, 'publication_date': '2007-10-10', 'ids': {'openalex': 'https://openalex.org/W2091684277', 'doi': 'https://doi.org/10.1371/journal.pone.0001023', 'mag': '2091684277', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17925871', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1995753'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0001023', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001023&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001023&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110194647', 'display_name': 'Seif Shekalaghe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145872427', 'display_name': 'Radboud University Nijmegen', 'ror': 'https://ror.org/016xsfp80', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I145872427']}, {'id': 'https://openalex.org/I2802934949', 'display_name': 'Radboud University Medical Center', 'ror': 'https://ror.org/05wg1m734', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802934949']}, {'id': 'https://openalex.org/I4210136876', 'display_name': 'Kilimanjaro Christian Medical Centre', 'ror': 'https://ror.org/04knhza04', 'country_code': 'TZ', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136876']}], 'countries': ['NL', 'TZ'], 'is_corresponding': False, 'raw_author_name': 'Seif Shekalaghe', 'raw_affiliation_strings': ['Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands', 'Kilimanjaro Christian Medical Centre, Moshi, Tanzania'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands', 'institution_ids': ['https://openalex.org/I145872427', 'https://openalex.org/I2802934949']}, {'raw_affiliation_string': 'Kilimanjaro Christian Medical Centre, Moshi, Tanzania', 'institution_ids': ['https://openalex.org/I4210136876']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037076197', 'display_name': 'Chris Drakeley', 'orcid': 'https://orcid.org/0000-0003-4863-075X'}, 'institutions': [{'id': 'https://openalex.org/I4210136876', 'display_name': 'Kilimanjaro Christian Medical Centre', 'ror': 'https://ror.org/04knhza04', 'country_code': 'TZ', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136876']}, {'id': 'https://openalex.org/I4210089966', 'display_name': 'London School of Hygiene & Tropical Medicine', 'ror': 'https://ror.org/00a0jsq62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I4210089966']}], 'countries': ['GB', 'TZ'], 'is_corresponding': False, 'raw_author_name': 'Chris Drakeley', 'raw_affiliation_strings': ['Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, United Kingdom', 'Joint Malaria Programme, Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania'], 'affiliations': [{'raw_affiliation_string': 'Joint Malaria Programme, Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania', 'institution_ids': ['https://openalex.org/I4210136876']}, {'raw_affiliation_string': 'Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, United Kingdom', 'institution_ids': ['https://openalex.org/I4210089966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046328079', 'display_name': 'Roly Gosling', 'orcid': 'https://orcid.org/0000-0001-6291-0024'}, 'institutions': [{'id': 'https://openalex.org/I4210136876', 'display_name': 'Kilimanjaro Christian Medical Centre', 'ror': 'https://ror.org/04knhza04', 'country_code': 'TZ', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136876']}, {'id': 'https://openalex.org/I4210089966', 'display_name': 'London School of Hygiene & Tropical Medicine', 'ror': 'https://ror.org/00a0jsq62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I4210089966']}], 'countries': ['GB', 'TZ'], 'is_corresponding': False, 'raw_author_name': 'Roly Gosling', 'raw_affiliation_strings': ['Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, United Kingdom', 'Joint Malaria Programme, Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania'], 'affiliations': [{'raw_affiliation_string': 'Joint Malaria Programme, Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania', 'institution_ids': ['https://openalex.org/I4210136876']}, {'raw_affiliation_string': 'Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, United Kingdom', 'institution_ids': ['https://openalex.org/I4210089966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027757830', 'display_name': 'Arnold Ndaro', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210136876', 'display_name': 'Kilimanjaro Christian Medical Centre', 'ror': 'https://ror.org/04knhza04', 'country_code': 'TZ', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136876']}], 'countries': ['TZ'], 'is_corresponding': False, 'raw_author_name': 'Arnold Ndaro', 'raw_affiliation_strings': ['Kilimanjaro Christian Medical Centre, Moshi, Tanzania'], 'affiliations': [{'raw_affiliation_string': 'Kilimanjaro Christian Medical Centre, Moshi, Tanzania', 'institution_ids': ['https://openalex.org/I4210136876']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004865615', 'display_name': 'Monique van Meegeren', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145872427', 'display_name': 'Radboud University Nijmegen', 'ror': 'https://ror.org/016xsfp80', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I145872427']}, {'id': 'https://openalex.org/I2802934949', 'display_name': 'Radboud University Medical Center', 'ror': 'https://ror.org/05wg1m734', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802934949']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Monique van Meegeren', 'raw_affiliation_strings': ['Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands', 'institution_ids': ['https://openalex.org/I145872427', 'https://openalex.org/I2802934949']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027063710', 'display_name': 'Anders Enevold', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210136876', 'display_name': 'Kilimanjaro Christian Medical Centre', 'ror': 'https://ror.org/04knhza04', 'country_code': 'TZ', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136876']}, {'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK', 'TZ'], 'is_corresponding': False, 'raw_author_name': 'Anders Enevold', 'raw_affiliation_strings': ['Institute for International Health, Immunology and Microbiology, Center for Medical Parasitology (CMP), University of Copenhagen, Copenhagen, Denmark', 'Joint Malaria Programme, Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania'], 'affiliations': [{'raw_affiliation_string': 'Joint Malaria Programme, Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania', 'institution_ids': ['https://openalex.org/I4210136876']}, {'raw_affiliation_string': 'Institute for International Health, Immunology and Microbiology, Center for Medical Parasitology (CMP), University of Copenhagen, Copenhagen, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085522877', 'display_name': 'Michael Alifrangis', 'orcid': 'https://orcid.org/0000-0002-3835-3333'}, 'institutions': [{'id': 'https://openalex.org/I4210136876', 'display_name': 'Kilimanjaro Christian Medical Centre', 'ror': 'https://ror.org/04knhza04', 'country_code': 'TZ', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136876']}, {'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK', 'TZ'], 'is_corresponding': False, 'raw_author_name': 'Michael Alifrangis', 'raw_affiliation_strings': ['Institute for International Health, Immunology and Microbiology, Center for Medical Parasitology (CMP), University of Copenhagen, Copenhagen, Denmark', 'Joint Malaria Programme, Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania'], 'affiliations': [{'raw_affiliation_string': 'Joint Malaria Programme, Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania', 'institution_ids': ['https://openalex.org/I4210136876']}, {'raw_affiliation_string': 'Institute for International Health, Immunology and Microbiology, Center for Medical Parasitology (CMP), University of Copenhagen, Copenhagen, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108527963', 'display_name': 'Frank Mosha', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210136876', 'display_name': 'Kilimanjaro Christian Medical Centre', 'ror': 'https://ror.org/04knhza04', 'country_code': 'TZ', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210136876']}], 'countries': ['TZ'], 'is_corresponding': False, 'raw_author_name': 'Frank Mosha', 'raw_affiliation_strings': ['Joint Malaria Programme, Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania', 'Kilimanjaro Christian Medical Centre, Moshi, Tanzania'], 'affiliations': [{'raw_affiliation_string': 'Kilimanjaro Christian Medical Centre, Moshi, Tanzania', 'institution_ids': ['https://openalex.org/I4210136876']}, {'raw_affiliation_string': 'Joint Malaria Programme, Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania', 'institution_ids': ['https://openalex.org/I4210136876']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073424910', 'display_name': 'Robert W. Sauerwein', 'orcid': 'https://orcid.org/0000-0002-3163-7202'}, 'institutions': [{'id': 'https://openalex.org/I145872427', 'display_name': 'Radboud University Nijmegen', 'ror': 'https://ror.org/016xsfp80', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I145872427']}, {'id': 'https://openalex.org/I2802934949', 'display_name': 'Radboud University Medical Center', 'ror': 'https://ror.org/05wg1m734', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802934949']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Robert Sauerwein', 'raw_affiliation_strings': ['Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands', 'institution_ids': ['https://openalex.org/I145872427', 'https://openalex.org/I2802934949']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5036396443', 'display_name': 'Teun Bousema', 'orcid': 'https://orcid.org/0000-0003-2666-094X'}, 'institutions': [{'id': 'https://openalex.org/I145872427', 'display_name': 'Radboud University Nijmegen', 'ror': 'https://ror.org/016xsfp80', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I145872427']}, {'id': 'https://openalex.org/I2802934949', 'display_name': 'Radboud University Medical Center', 'ror': 'https://ror.org/05wg1m734', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802934949']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'Teun Bousema', 'raw_affiliation_strings': ['Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands', 'institution_ids': ['https://openalex.org/I145872427', 'https://openalex.org/I2802934949']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5036396443'], 'corresponding_institution_ids': ['https://openalex.org/I145872427', 'https://openalex.org/I2802934949'], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 7.016, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 133, 'citation_normalized_percentile': {'value': 0.938044, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '2', 'issue': '10', 'first_page': 'e1023', 'last_page': 'e1023'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10554', 'display_name': 'Hemoglobinopathies and Related Disorders', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10993', 'display_name': 'Complement system in diseases', 'score': 0.9823, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/primaquine', 'display_name': 'Primaquine', 'score': 0.8613528}, {'id': 'https://openalex.org/keywords/artesunate', 'display_name': 'Artesunate', 'score': 0.8095774}, {'id': 'https://openalex.org/keywords/sulfadoxine', 'display_name': 'Sulfadoxine', 'score': 0.57579905}], 'concepts': [{'id': 'https://openalex.org/C99389464', 'wikidata': 'https://www.wikidata.org/wiki/Q3319949', 'display_name': 'Gametocyte', 'level': 4, 'score': 0.9661001}, {'id': 'https://openalex.org/C2776793103', 'wikidata': 'https://www.wikidata.org/wiki/Q419834', 'display_name': 'Primaquine', 'level': 4, 'score': 0.8613528}, {'id': 'https://openalex.org/C2778059366', 'wikidata': 'https://www.wikidata.org/wiki/Q707939', 'display_name': 'Artesunate', 'level': 4, 'score': 0.8095774}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.73086}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.724389}, {'id': 'https://openalex.org/C2777035104', 'wikidata': 'https://www.wikidata.org/wiki/Q421072', 'display_name': 'Pyrimethamine', 'level': 4, 'score': 0.64843655}, {'id': 'https://openalex.org/C2778301690', 'wikidata': 'https://www.wikidata.org/wiki/Q411557', 'display_name': 'Sulfadoxine', 'level': 5, 'score': 0.57579905}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5560853}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.50267506}, {'id': 'https://openalex.org/C2777425658', 'wikidata': 'https://www.wikidata.org/wiki/Q422438', 'display_name': 'Chloroquine', 'level': 3, 'score': 0.46976516}, {'id': 'https://openalex.org/C2776120307', 'wikidata': 'https://www.wikidata.org/wiki/Q426921', 'display_name': 'Artemisinin', 'level': 4, 'score': 0.4165843}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.36896533}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.35393158}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.21616584}], 'mesh': [{'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D037621', 'descriptor_name': 'Artemisinins', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D016778', 'descriptor_name': 'Malaria, Falciparum', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011319', 'descriptor_name': 'Primaquine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D011739', 'descriptor_name': 'Pyrimethamine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D012717', 'descriptor_name': 'Sesquiterpenes', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D013413', 'descriptor_name': 'Sulfadoxine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037621', 'descriptor_name': 'Artemisinins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077332', 'descriptor_name': 'Artesunate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002675', 'descriptor_name': 'Child, Preschool', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004338', 'descriptor_name': 'Drug Combinations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016778', 'descriptor_name': 'Malaria, Falciparum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011319', 'descriptor_name': 'Primaquine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011739', 'descriptor_name': 'Pyrimethamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012717', 'descriptor_name': 'Sesquiterpenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013413', 'descriptor_name': 'Sulfadoxine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013636', 'descriptor_name': 'Tanzania', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 8, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0001023', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001023&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/f3793fcafc2c4e428164de7f952ec18d', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1995753', 'pdf_url': 'https://europepmc.org/articles/pmc1995753?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://repository.ubn.ru.nl//bitstream/handle/2066/53378/53378.pdf', 'pdf_url': 'https://repository.ubn.ru.nl//bitstream/handle/2066/53378/53378.pdf', 'source': {'id': 'https://openalex.org/S4306401067', 'display_name': 'Radboud Repository (Radboud University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I145872427', 'host_organization_name': 'Radboud University Nijmegen', 'host_organization_lineage': ['https://openalex.org/I145872427'], 'host_organization_lineage_names': ['Radboud University Nijmegen'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/2066/53378', 'pdf_url': 'https://repository.ubn.ru.nl/bitstream/handle/2066/53378/1/53378.pdf', 'source': {'id': 'https://openalex.org/S4306401067', 'display_name': 'Radboud Repository (Radboud University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I145872427', 'host_organization_name': 'Radboud University Nijmegen', 'host_organization_lineage': ['https://openalex.org/I145872427'], 'host_organization_lineage_names': ['Radboud University Nijmegen'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995753', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://researchonline.lshtm.ac.uk/id/eprint/59445/1/pone.0001023.pdf', 'pdf_url': 'https://researchonline.lshtm.ac.uk/id/eprint/59445/1/pone.0001023.pdf', 'source': {'id': 'https://openalex.org/S4377196261', 'display_name': 'LSHTM Research Online\n (London School of Hygiene & Tropical Medicine)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210089966', 'host_organization_name': 'London School of Hygiene & Tropical Medicine', 'host_organization_lineage': ['https://openalex.org/I4210089966'], 'host_organization_lineage_names': ['London School of Hygiene & Tropical Medicine'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17925871', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0001023', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001023&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.86, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1490125251', 'https://openalex.org/W1503499707', 'https://openalex.org/W1945827446', 'https://openalex.org/W1966834016', 'https://openalex.org/W1995166928', 'https://openalex.org/W2006322558', 'https://openalex.org/W2017793684', 'https://openalex.org/W2027697581', 'https://openalex.org/W2031595783', 'https://openalex.org/W2031796122', 'https://openalex.org/W2036678624', 'https://openalex.org/W2063416565', 'https://openalex.org/W2064306519', 'https://openalex.org/W2093869904', 'https://openalex.org/W2099098778', 'https://openalex.org/W2102326013', 'https://openalex.org/W2118219703', 'https://openalex.org/W2118248316', 'https://openalex.org/W2120579606', 'https://openalex.org/W2124136203', 'https://openalex.org/W2124177928', 'https://openalex.org/W2130853973', 'https://openalex.org/W2131174404', 'https://openalex.org/W2131545842', 'https://openalex.org/W2134344980', 'https://openalex.org/W2137961791', 'https://openalex.org/W2140772445', 'https://openalex.org/W2140931333', 'https://openalex.org/W2147703739', 'https://openalex.org/W2148420565', 'https://openalex.org/W2159526350', 'https://openalex.org/W2163924699', 'https://openalex.org/W2166229810', 'https://openalex.org/W2166681862', 'https://openalex.org/W2170936619', 'https://openalex.org/W2413009189'], 'related_works': ['https://openalex.org/W4021146', 'https://openalex.org/W2436584172', 'https://openalex.org/W2429268174', 'https://openalex.org/W2145436782', 'https://openalex.org/W2106819591', 'https://openalex.org/W2100026093', 'https://openalex.org/W2025872989', 'https://openalex.org/W2020361785', 'https://openalex.org/W2011178670', 'https://openalex.org/W1604768794'], 'abstract_inverted_index': {'Background': [0], 'P.': [1, 63, 84], 'falciparum': [2, 64, 85], 'gametocytes': [3, 162, 213, 221], 'may': [4], 'persist': [5], 'after': [6, 152, 207, 214], 'treatment': [7, 78, 135, 153, 181, 215], 'with': [8, 61, 66, 79, 147, 170, 182, 216], 'sulphadoxine-pyrimethamine': [9], '(SP)': [10], 'plus': [11, 26], 'artesunate': [12], '(AS)': [13], 'and': [14, 88, 130, 139, 184, 218], 'contribute': [15, 229], 'considerably': [16], 'to': [17, 76, 109, 164, 189, 199, 228, 230, 245, 255], 'malaria': [18, 53, 65, 231, 257], 'transmission.': [19, 232], 'We': [20], 'determined': [21, 96, 108], 'the': [22, 91, 157, 178, 219], 'efficacy': [23], 'of': [24, 30, 51, 156, 167, 195, 239, 243], 'SP+AS': [25, 81, 171, 217], 'a': [27, 240, 252], 'single': [28, 241], 'dose': [29, 242], 'primaquine': [31], '(PQ,': [32], '0.75': [33], 'mg/kg)': [34], 'on': [35], 'clearing': [36], 'gametocytaemia': [37], 'measured': [38], 'by': [39, 97], 'molecular': [40], 'methods.': [41], 'Methodology': [42], 'The': [43, 192], 'study': [44], 'was': [45, 126, 187], 'conducted': [46], 'in': [47, 54, 114, 144, 177], 'Mnyuzi,': [48], 'an': [49, 67, 246], 'area': [50], 'hyperendemic': [52], 'north-eastern': [55], 'Tanzania.': [56], 'Children': [57], 'aged': [58], '3–15': [59], 'years': [60], 'uncomplicated': [62], 'asexual': [68], 'parasite': [69], 'density': [70, 89, 140], 'between': [71], '500–100,000': [72], 'parasites/µL': [73], 'were': [74, 95, 107, 120, 141, 175], 'randomized': [75], 'receive': [77], 'either': [80], 'or': [82, 202], 'SP+AS+PQ.': [83, 148], 'gametocyte': [86, 124], 'prevalence': [87, 125, 138], 'during': [90], '42-day': [92], 'follow-up': [93], 'period': [94], 'real-time': [98], 'nucleic': [99], 'acid': [100], 'sequence-based': [101], 'amplification': [102], '(QT-NASBA).': [103], 'Haemoglobin': [104], 'levels': [105, 174, 194, 201], '(Hb)': [106], 'address': [110], 'concerns': [111], 'about': [112], 'haemolysis': [113], 'G6PD-deficient': [115], 'individuals.': [116], 'Results': [117], '108': [118], 'individuals': [119, 234], 'randomized.': [121], 'Pfs25': [122], 'QT-NASBA': [123], '88–91%': [127], 'at': [128, 223], 'enrolment': [129], 'decreased': [131], 'afterwards': [132], 'for': [133], 'both': [134], 'arms.': [136], 'Gametocyte': [137], 'significantly': [142], 'lower': [143], 'children': [145, 160], 'treated': [146, 159, 169], 'On': [149], 'day': [150], '14': [151], '3.9%': [154], '(2/51)': [155], 'SP+AS+PQ': [158, 183], 'harboured': [161], 'compared': [163], '62.7%': [165], '(32/51)': [166], 'those': [168], '(p<0.001).': [172], 'Hb': [173, 193], 'reduced': [176], 'week': [179], 'following': [180, 259], 'this': [185], 'reduction': [186], 'related': [188], 'G6PD': [190], 'deficiency.': [191], 'all': [196], 'patients': [197], 'recovered': [198], 'pre-treatment': [200], 'greater': [203], 'within': [204], 'one': [205], 'month': [206], 'treatment.': [208, 260], 'Conclusions': [209], 'PQ': [210, 244], 'clears': [211], 'submicroscopic': [212], 'persisting': [220], 'circulated': [222], 'densities': [224], 'that': [225], 'are': [226], 'unlikely': [227], 'For': [233], 'without': [235], 'severe': [236], 'anaemia,': [237], 'addition': [238], 'efficacious': [247], 'antimalarial': [248], 'drug': [249], 'combination': [250], 'is': [251], 'safe': [253], 'approach': [254], 'reduce': [256], 'transmission': [258], 'Trial': [261], 'Registration': [262], 'Controlled-Trials.com': [263], 'ISRCTN61534963': [264]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2091684277', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 18}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 23}], 'updated_date': '2024-12-10T21:56:28.056534', 'created_date': '2016-06-24'}