Neurogenesis and aging: FGF‐2 and HB‐EGF restore neurogenesis in hippocampus and subventricular zone of aged mice

Name: Work Video:
Duration: 3 min 30 s
Kunlin Jin; Yunjuan Sun; Lin Xie; Sophie Batteur; Xiao Mao; Chris Smelick; Anna Logvinova; David A. Greenberg
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169, 177, 203, 243], 'adult': [10, 80], 'brain': [11, 38, 222], 'function': [13], 'normally': [14], 'and': [15, 56, 73, 82, 93, 104, 123, 160, 185, 195, 211], 'adapt': [16], 'disease,': [18], 'nevertheless': [19], 'declines': [20], 'with': [21, 90, 232], 'advancing': [22], 'age.': [23], 'Adult': [24], 'neurogenesis': [25, 65, 244], 'can': [26], 'be': [27], 'enhanced': [28], 'by': [29, 88, 94, 100, 105, 121, 127, 155, 161, 190], 'administration': [30], 'growth': [32, 53, 59, 61, 212, 230], 'factors,': [33], 'but': [34], 'whether': [35], 'aged': [37, 83, 110, 139, 221], 'remains': [39], 'responsive': [40], 'these': [42], 'factors': [43, 231], 'is': [44], 'unknown.': [45], 'We': [46], 'compared': [47], 'effects': [49], 'intracerebroventricular': [51], 'fibroblast': [52], 'factor': [54, 62], '(FGF)‐2': [55], 'heparin‐binding': [57], 'epidermal': [58], 'factor‐like': [60], '(HB‐EGF)': [63], 'on': [64], 'in': [66, 102, 107, 116, 136, 145, 153, 172, 179, 208, 246], 'hippocampal': [68], 'dentate': [69], 'subgranular': [70], 'zone': [71, 76], '(SGZ)': [72], 'subventricular': [75], '(SVZ)': [77], 'young': [79, 146], '(3‐month)': [81], '(20‐month)': [84], 'mice.': [85, 111, 181, 215], 'measured': [87], 'labelling': [89, 115, 152], 'bromodeoxyuridine': [91], '(BrdU)': [92], 'expression': [95], 'doublecortin,': [97], 'was': [98, 206], 'reduced': [99], '∼90%': [101], 'SGZ': [103, 117, 137], '∼50%': [106], 'SVZ': [108], 'HB‐EGF': [112, 184], 'increased': [113, 130, 187, 233], 'BrdU': [114, 151, 188], 'at': [118, 124, 157, 163, 192, 197], '3': [119, 158, 193], 'months': [120, 126, 159, 194], '∼60%': [122], '20': [125, 164, 198], '∼450%,': [128], 'number': [132, 168, 202], 'BrdU‐labelled': [134, 204], 'cells': [135, 205], 'mice': [140, 174], '∼25%': [142, 156], 'that': [144, 178, 219], 'adults.': [147], 'FGF‐2': [148, 186], 'also': [149], 'stimulated': [150], 'SGZ,': [154], '∼250%': [162], 'months,': [165, 199], 'increasing': [166], 'newborn': [170], 'neurones': [171], 'older': [173], '∼20%': [176], 'younger': [180], 'In': [182], 'SVZ,': [183], 'incorporation': [189], '∼140%': [191], '∼170%': [196], 'so': [200], 'comparable': [207], 'untreated': [209], '3‐month‐old': [210], 'factor‐treated': [213], '20‐month‐old': [214], 'These': [216], 'results': [217], 'demonstrate': [218], 'retains': [223], 'capacity': [225], 'respond': [227], 'exogenous': [229], 'neurogenesis,': [234], 'have': [237], 'implications': [238], 'for': [239], 'therapeutic': [241], 'potential': [242], 'enhancement': [245], 'age‐associated': [247], 'neurological': [248], 'disorders.': [249]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2091535724', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 17}, {'year': 2016, 'cited_by_count': 20}, {'year': 2015, 'cited_by_count': 20}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 37}, {'year': 2012, 'cited_by_count': 22}], 'updated_date': '2024-12-09T07:53:24.920886', 'created_date': '2016-06-24'}
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