Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2091419984', 'doi': 'https://doi.org/10.1016/j.ydbio.2014.04.007', 'title': 'Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland', 'display_name': 'Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland', 'publication_year': 2014, 'publication_date': '2014-07-01', 'ids': {'openalex': 'https://openalex.org/W2091419984', 'doi': 'https://doi.org/10.1016/j.ydbio.2014.04.007', 'mag': '2091419984', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24769368', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4131199'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ydbio.2014.04.007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S136634221', 'display_name': 'Developmental Biology', 'issn_l': '0012-1606', 'issn': ['0012-1606', '1095-564X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1016/j.ydbio.2014.04.007', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018425864', 'display_name': 'Nadia Okolowsky', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Nadia Okolowsky', 'raw_affiliation_strings': ['Department of Laboratory Medicine & Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8.'], 'affiliations': [{'raw_affiliation_string': 'Department of Laboratory Medicine & Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8.', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053625755', 'display_name': 'Priscilla A. Furth', 'orcid': 'https://orcid.org/0000-0003-3883-0715'}, 'institutions': [{'id': 'https://openalex.org/I184565670', 'display_name': 'Georgetown University', 'ror': 'https://ror.org/05vzafd60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I184565670']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Priscilla A. Furth', 'raw_affiliation_strings': ['Lombardi Comprehensive Cancer Center, Departments of Oncology and Medicine, Georgetown University, Washington, DC, USA.'], 'affiliations': [{'raw_affiliation_string': 'Lombardi Comprehensive Cancer Center, Departments of Oncology and Medicine, Georgetown University, Washington, DC, USA.', 'institution_ids': ['https://openalex.org/I184565670']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5079971523', 'display_name': 'Paul A. Hamel', 'orcid': 'https://orcid.org/0000-0002-3844-8850'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Paul A. Hamel', 'raw_affiliation_strings': ['Department of Laboratory Medicine & Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8.'], 'affiliations': [{'raw_affiliation_string': 'Department of Laboratory Medicine & Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8.', 'institution_ids': ['https://openalex.org/I185261750']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3690, 'currency': 'USD', 'value_usd': 3690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.647, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.881649, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '391', 'issue': '2', 'first_page': '219', 'last_page': '229'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling in Development and Cancer', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling in Development and Cancer', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Regulation of Chromatin Structure and Function', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9921, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/smoothened', 'display_name': 'Smoothened', 'score': 0.6913938}, {'id': 'https://openalex.org/keywords/patched', 'display_name': 'Patched', 'score': 0.57702804}, {'id': 'https://openalex.org/keywords/hedgehog-signaling', 'display_name': 'Hedgehog Signaling', 'score': 0.559991}, {'id': 'https://openalex.org/keywords/estrogen-receptor-alpha', 'display_name': 'Estrogen receptor alpha', 'score': 0.47667244}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8004068}, {'id': 'https://openalex.org/C145837895', 'wikidata': 'https://www.wikidata.org/wiki/Q18031607', 'display_name': 'Smoothened', 'level': 4, 'score': 0.6913938}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5783265}, {'id': 'https://openalex.org/C2777994357', 'wikidata': 'https://www.wikidata.org/wiki/Q24781250', 'display_name': 'Patched', 'level': 4, 'score': 0.57702804}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5466949}, {'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.47891057}, {'id': 'https://openalex.org/C172313692', 'wikidata': 'https://www.wikidata.org/wiki/Q14902310', 'display_name': 'Estrogen receptor alpha', 'level': 5, 'score': 0.47667244}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.46979225}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4267121}, {'id': 'https://openalex.org/C108636557', 'wikidata': 'https://www.wikidata.org/wiki/Q21109354', 'display_name': 'Proto-oncogene tyrosine-protein kinase Src', 'level': 3, 'score': 0.41667727}, {'id': 'https://openalex.org/C2778539099', 'wikidata': 'https://www.wikidata.org/wiki/Q6120', 'display_name': 'Hedgehog', 'level': 3, 'score': 0.38784498}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.37526125}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.32471663}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12381911}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.11658993}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0906184}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.06777918}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D047628', 'descriptor_name': 'Estrogen Receptor alpha', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008321', 'descriptor_name': 'Mammary Glands, Animal', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': True}, {'descriptor_ui': 'D009024', 'descriptor_name': 'Morphogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004958', 'descriptor_name': 'Estradiol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004958', 'descriptor_name': 'Estradiol', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D004958', 'descriptor_name': 'Estradiol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004965', 'descriptor_name': 'Estrogen Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004965', 'descriptor_name': 'Estrogen Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D047628', 'descriptor_name': 'Estrogen Receptor alpha', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D047628', 'descriptor_name': 'Estrogen Receptor alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005348', 'descriptor_name': 'Fibrocystic Breast Disease', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005348', 'descriptor_name': 'Fibrocystic Breast Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077267', 'descriptor_name': 'Fulvestrant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008321', 'descriptor_name': 'Mammary Glands, Animal', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D008321', 'descriptor_name': 'Mammary Glands, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008321', 'descriptor_name': 'Mammary Glands, Animal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072079', 'descriptor_name': 'Patched Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072081', 'descriptor_name': 'Patched-1 Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D016392', 'descriptor_name': 'Proto-Oncogene Proteins pp60(c-src)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016392', 'descriptor_name': 'Proto-Oncogene Proteins pp60(c-src)', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011720', 'descriptor_name': 'Pyrazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072086', 'descriptor_name': 'Smoothened Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ydbio.2014.04.007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S136634221', 'display_name': 'Developmental Biology', 'issn_l': '0012-1606', 'issn': ['0012-1606', '1095-564X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4131199', 'pdf_url': 'https://europepmc.org/articles/pmc4131199?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131199', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/1807/69147', 'pdf_url': 'https://tspace.library.utoronto.ca/bitstream/1807/69147/1/Okolowsky_Nadia_A_201411_MSc_thesis.pdf', 'source': {'id': 'https://openalex.org/S4306400261', 'display_name': 'TSpace (University of Toronto)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I185261750', 'host_organization_name': 'University of Toronto', 'host_organization_lineage': ['https://openalex.org/I185261750'], 'host_organization_lineage_names': ['University of Toronto'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24769368', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ydbio.2014.04.007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S136634221', 'display_name': 'Developmental Biology', 'issn_l': '0012-1606', 'issn': ['0012-1606', '1095-564X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.83, 'display_name': 'Life below water', 'id': 'https://metadata.un.org/sdg/14'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 395, 'referenced_works': ['https://openalex.org/W120380775', 'https://openalex.org/W145159288', 'https://openalex.org/W1493268813', 'https://openalex.org/W1494091679', 'https://openalex.org/W1501286679', 'https://openalex.org/W1538903611', 'https://openalex.org/W1543890504', 'https://openalex.org/W1560420809', 'https://openalex.org/W1563762782', 'https://openalex.org/W1565310327', 'https://openalex.org/W1571431043', 'https://openalex.org/W1575089413', 'https://openalex.org/W1585922331', 'https://openalex.org/W1601214065', 'https://openalex.org/W1603742465', 'https://openalex.org/W1613446635', 'https://openalex.org/W1646199134', 'https://openalex.org/W1662062786', 'https://openalex.org/W1723187988', 'https://openalex.org/W1736447480', 'https://openalex.org/W1787540030', 'https://openalex.org/W180778085', 'https://openalex.org/W1820420430', 'https://openalex.org/W1826261498', 'https://openalex.org/W1895397458', 'https://openalex.org/W1964361564', 'https://openalex.org/W1964442275', 'https://openalex.org/W1964520022', 'https://openalex.org/W1966475217', 'https://openalex.org/W1968937305', 'https://openalex.org/W1970755773', 'https://openalex.org/W1971060771', 'https://openalex.org/W1971960644', 'https://openalex.org/W1972091253', 'https://openalex.org/W1972913757', 'https://openalex.org/W1973021296', 'https://openalex.org/W1973121483', 'https://openalex.org/W1973324969', 'https://openalex.org/W1974357996', 'https://openalex.org/W1974518572', 'https://openalex.org/W1974943922', 'https://openalex.org/W1975711179', 'https://openalex.org/W1976551834', 'https://openalex.org/W1977688398', 'https://openalex.org/W1977876541', 'https://openalex.org/W1978044136', 'https://openalex.org/W1978262912', 'https://openalex.org/W1979006386', 'https://openalex.org/W1979149114', 'https://openalex.org/W1979903836', 'https://openalex.org/W1980591242', 'https://openalex.org/W1981022538', 'https://openalex.org/W1981306061', 'https://openalex.org/W1981691061', 'https://openalex.org/W1982087641', 'https://openalex.org/W1982782319', 'https://openalex.org/W1982824007', 'https://openalex.org/W1983057459', 'https://openalex.org/W1983341583', 'https://openalex.org/W1984081620', 'https://openalex.org/W1984222668', 'https://openalex.org/W1985193538', 'https://openalex.org/W1986368022', 'https://openalex.org/W1987913532', 'https://openalex.org/W1988654710', 'https://openalex.org/W1989444478', 'https://openalex.org/W1989808605', 'https://openalex.org/W1991588527', 'https://openalex.org/W1992657457', 'https://openalex.org/W1993851741', 'https://openalex.org/W1994110056', 'https://openalex.org/W1994620081', 'https://openalex.org/W1995832384', 'https://openalex.org/W1996127793', 'https://openalex.org/W1996492268', 'https://openalex.org/W1996661903', 'https://openalex.org/W1997622817', 'https://openalex.org/W1997862931', 'https://openalex.org/W1998351354', 'https://openalex.org/W1998653181', 'https://openalex.org/W1998772680', 'https://openalex.org/W1998777048', 'https://openalex.org/W2000483250', 'https://openalex.org/W2000930609', 'https://openalex.org/W2003027153', 'https://openalex.org/W2003159257', 'https://openalex.org/W2005487923', 'https://openalex.org/W2005766913', 'https://openalex.org/W2006216237', 'https://openalex.org/W2007859564', 'https://openalex.org/W2008318329', 'https://openalex.org/W2008651555', 'https://openalex.org/W2009125857', 'https://openalex.org/W2009651971', 'https://openalex.org/W2010159589', 'https://openalex.org/W2010296464', 'https://openalex.org/W2010863761', 'https://openalex.org/W2011070056', 'https://openalex.org/W2011158289', 'https://openalex.org/W2012199249', 'https://openalex.org/W2012740498', 'https://openalex.org/W2013101182', 'https://openalex.org/W2014107736', 'https://openalex.org/W2015044035', 'https://openalex.org/W2015189406', 'https://openalex.org/W2015789469', 'https://openalex.org/W2017196173', 'https://openalex.org/W2018038828', 'https://openalex.org/W2018211174', 'https://openalex.org/W2018737195', 'https://openalex.org/W2018784356', 'https://openalex.org/W2019150363', 'https://openalex.org/W2019263869', 'https://openalex.org/W2019264546', 'https://openalex.org/W2019380047', 'https://openalex.org/W2019548983', 'https://openalex.org/W2020725121', 'https://openalex.org/W2022030433', 'https://openalex.org/W2022041752', 'https://openalex.org/W2022110250', 'https://openalex.org/W2022784397', 'https://openalex.org/W2022877314', 'https://openalex.org/W2023586989', 'https://openalex.org/W2024138902', 'https://openalex.org/W2024606555', 'https://openalex.org/W2024903228', 'https://openalex.org/W2025124261', 'https://openalex.org/W2026550373', 'https://openalex.org/W2027179411', 'https://openalex.org/W2027728353', 'https://openalex.org/W2028483852', 'https://openalex.org/W2028497134', 'https://openalex.org/W2028605407', 'https://openalex.org/W2029904063', 'https://openalex.org/W2030103375', 'https://openalex.org/W2030487990', 'https://openalex.org/W2030943228', 'https://openalex.org/W2031334916', 'https://openalex.org/W2032792789', 'https://openalex.org/W2033589407', 'https://openalex.org/W2033616764', 'https://openalex.org/W2034809706', 'https://openalex.org/W2035524441', 'https://openalex.org/W2035548935', 'https://openalex.org/W2035785296', 'https://openalex.org/W2036638605', 'https://openalex.org/W2036639816', 'https://openalex.org/W2037910321', 'https://openalex.org/W2039218081', 'https://openalex.org/W2039576757', 'https://openalex.org/W2040053707', 'https://openalex.org/W2040426656', 'https://openalex.org/W2042162210', 'https://openalex.org/W2042335929', 'https://openalex.org/W2042528863', 'https://openalex.org/W2042969420', 'https://openalex.org/W2043016657', 'https://openalex.org/W2043152231', 'https://openalex.org/W2043289157', 'https://openalex.org/W2043384567', 'https://openalex.org/W2044315923', 'https://openalex.org/W2044832154', 'https://openalex.org/W2045002276', 'https://openalex.org/W2045190445', 'https://openalex.org/W2045753558', 'https://openalex.org/W2045912291', 'https://openalex.org/W2046196246', 'https://openalex.org/W2046782155', 'https://openalex.org/W2048252195', 'https://openalex.org/W2048561091', 'https://openalex.org/W2048595449', 'https://openalex.org/W2048610237', 'https://openalex.org/W2048947179', 'https://openalex.org/W2049142811', 'https://openalex.org/W2050743111', 'https://openalex.org/W2051489991', 'https://openalex.org/W2052306492', 'https://openalex.org/W2052490065', 'https://openalex.org/W2053214539', 'https://openalex.org/W2053351302', 'https://openalex.org/W2053369836', 'https://openalex.org/W2053661133', 'https://openalex.org/W2053917977', 'https://openalex.org/W2054251345', 'https://openalex.org/W2054267961', 'https://openalex.org/W2055170266', 'https://openalex.org/W2055310245', 'https://openalex.org/W2056155028', 'https://openalex.org/W2056978878', 'https://openalex.org/W2056994384', 'https://openalex.org/W2057723597', 'https://openalex.org/W2058990871', 'https://openalex.org/W2059614045', 'https://openalex.org/W2059790042', 'https://openalex.org/W2060696024', 'https://openalex.org/W2061792764', 'https://openalex.org/W2062518278', 'https://openalex.org/W2062860706', 'https://openalex.org/W2062930347', 'https://openalex.org/W2063074414', 'https://openalex.org/W2063110155', 'https://openalex.org/W2063376449', 'https://openalex.org/W2064282853', 'https://openalex.org/W2065695059', 'https://openalex.org/W2065785294', 'https://openalex.org/W2066353824', 'https://openalex.org/W2066441904', 'https://openalex.org/W2067761409', 'https://openalex.org/W2068104926', 'https://openalex.org/W2068113812', 'https://openalex.org/W2068859044', 'https://openalex.org/W2069532898', 'https://openalex.org/W2070184849', 'https://openalex.org/W2070632651', 'https://openalex.org/W2070907292', 'https://openalex.org/W2071525868', 'https://openalex.org/W2072787342', 'https://openalex.org/W2073133361', 'https://openalex.org/W2073353512', 'https://openalex.org/W2073883348', 'https://openalex.org/W2075156716', 'https://openalex.org/W2075232957', 'https://openalex.org/W2075657886', 'https://openalex.org/W2075788654', 'https://openalex.org/W2076127338', 'https://openalex.org/W2076165083', 'https://openalex.org/W2076434038', 'https://openalex.org/W2077167049', 'https://openalex.org/W2078725182', 'https://openalex.org/W2079370988', 'https://openalex.org/W2082307535', 'https://openalex.org/W2082421654', 'https://openalex.org/W2082527135', 'https://openalex.org/W2083988049', 'https://openalex.org/W2084662109', 'https://openalex.org/W2085356690', 'https://openalex.org/W2085695506', 'https://openalex.org/W2087028407', 'https://openalex.org/W2087892362', 'https://openalex.org/W2088933735', 'https://openalex.org/W2089749296', 'https://openalex.org/W2089962853', 'https://openalex.org/W2090054404', 'https://openalex.org/W2090204791', 'https://openalex.org/W2090540779', 'https://openalex.org/W2090895449', 'https://openalex.org/W2091189600', 'https://openalex.org/W2091275560', 'https://openalex.org/W2091684557', 'https://openalex.org/W2091727882', 'https://openalex.org/W2091780485', 'https://openalex.org/W2092049238', 'https://openalex.org/W2093350076', 'https://openalex.org/W2093604426', 'https://openalex.org/W2094092533', 'https://openalex.org/W2095092592', 'https://openalex.org/W2095243783', 'https://openalex.org/W2096148741', 'https://openalex.org/W2097004442', 'https://openalex.org/W2097044981', 'https://openalex.org/W2097246067', 'https://openalex.org/W2097349743', 'https://openalex.org/W2098679175', 'https://openalex.org/W2099118069', 'https://openalex.org/W2099546104', 'https://openalex.org/W2100898329', 'https://openalex.org/W2101467600', 'https://openalex.org/W2101566761', 'https://openalex.org/W2101738855', 'https://openalex.org/W2103756247', 'https://openalex.org/W2104033956', 'https://openalex.org/W2106214793', 'https://openalex.org/W2106553606', 'https://openalex.org/W2107185092', 'https://openalex.org/W2107194582', 'https://openalex.org/W2107394975', 'https://openalex.org/W2107859602', 'https://openalex.org/W2108392970', 'https://openalex.org/W2108707301', 'https://openalex.org/W2109994415', 'https://openalex.org/W2109998560', 'https://openalex.org/W2110333944', 'https://openalex.org/W2110341920', 'https://openalex.org/W2110855516', 'https://openalex.org/W2110975457', 'https://openalex.org/W2111510880', 'https://openalex.org/W2111650618', 'https://openalex.org/W2111826622', 'https://openalex.org/W2113249646', 'https://openalex.org/W2114702304', 'https://openalex.org/W2114824375', 'https://openalex.org/W2114964628', 'https://openalex.org/W2114990515', 'https://openalex.org/W2115028037', 'https://openalex.org/W2117590286', 'https://openalex.org/W2118726922', 'https://openalex.org/W2118780544', 'https://openalex.org/W2119238809', 'https://openalex.org/W2119660751', 'https://openalex.org/W2120653485', 'https://openalex.org/W2120977933', 'https://openalex.org/W2121017846', 'https://openalex.org/W2121454015', 'https://openalex.org/W2121475173', 'https://openalex.org/W2121675971', 'https://openalex.org/W2121971175', 'https://openalex.org/W2122242665', 'https://openalex.org/W2123323189', 'https://openalex.org/W2125611937', 'https://openalex.org/W2126026987', 'https://openalex.org/W2126535056', 'https://openalex.org/W2127472285', 'https://openalex.org/W2128003724', 'https://openalex.org/W2128736766', 'https://openalex.org/W2130985779', 'https://openalex.org/W2131610283', 'https://openalex.org/W2131686724', 'https://openalex.org/W2132150825', 'https://openalex.org/W2132168822', 'https://openalex.org/W2132185105', 'https://openalex.org/W2132663758', 'https://openalex.org/W2133067229', 'https://openalex.org/W2133660543', 'https://openalex.org/W2134386050', 'https://openalex.org/W2134893181', 'https://openalex.org/W2136631382', 'https://openalex.org/W2137700247', 'https://openalex.org/W2138638290', 'https://openalex.org/W2138979073', 'https://openalex.org/W2139444294', 'https://openalex.org/W2139973495', 'https://openalex.org/W2140820250', 'https://openalex.org/W2141269411', 'https://openalex.org/W2141662437', 'https://openalex.org/W2141686420', 'https://openalex.org/W2142200968', 'https://openalex.org/W2142243714', 'https://openalex.org/W2142697077', 'https://openalex.org/W2144040588', 'https://openalex.org/W2148432857', 'https://openalex.org/W2149031125', 'https://openalex.org/W2149174373', 'https://openalex.org/W2149486009', 'https://openalex.org/W2150232801', 'https://openalex.org/W2151888740', 'https://openalex.org/W2152221138', 'https://openalex.org/W2152898418', 'https://openalex.org/W2153188090', 'https://openalex.org/W2153889566', 'https://openalex.org/W2154472114', 'https://openalex.org/W2154911204', 'https://openalex.org/W2155993944', 'https://openalex.org/W2156151160', 'https://openalex.org/W2156246789', 'https://openalex.org/W2156362611', 'https://openalex.org/W2157477417', 'https://openalex.org/W2158073794', 'https://openalex.org/W2158693623', 'https://openalex.org/W2159580663', 'https://openalex.org/W2160010535', 'https://openalex.org/W2160084272', 'https://openalex.org/W2160889747', 'https://openalex.org/W2161062193', 'https://openalex.org/W2161623422', 'https://openalex.org/W2161830534', 'https://openalex.org/W2162553503', 'https://openalex.org/W2163838718', 'https://openalex.org/W2164310262', 'https://openalex.org/W2165562833', 'https://openalex.org/W2166188229', 'https://openalex.org/W2166227031', 'https://openalex.org/W2166841567', 'https://openalex.org/W2167978187', 'https://openalex.org/W2168016965', 'https://openalex.org/W2169318796', 'https://openalex.org/W2170396713', 'https://openalex.org/W2171068118', 'https://openalex.org/W2171643283', 'https://openalex.org/W2172209768', 'https://openalex.org/W2172256092', 'https://openalex.org/W2177151394', 'https://openalex.org/W2183437149', 'https://openalex.org/W2185212728', 'https://openalex.org/W2186560096', 'https://openalex.org/W2187452737', 'https://openalex.org/W2204303744', 'https://openalex.org/W2333732234', 'https://openalex.org/W2340033494', 'https://openalex.org/W2398300326', 'https://openalex.org/W2407636133', 'https://openalex.org/W4232934018', 'https://openalex.org/W4296300797', 'https://openalex.org/W72372646', 'https://openalex.org/W8163034', 'https://openalex.org/W8541401'], 'related_works': ['https://openalex.org/W2954644901', 'https://openalex.org/W2188362237', 'https://openalex.org/W2148338861', 'https://openalex.org/W2142200968', 'https://openalex.org/W2122598160', 'https://openalex.org/W2116707180', 'https://openalex.org/W2067761409', 'https://openalex.org/W2065908983', 'https://openalex.org/W2048769012', 'https://openalex.org/W2033589407'], 'abstract_inverted_index': {'Mesenchymal': [0], 'dysplasia': [1], '(mes)': [2], 'mice': [3], 'harbour': [4], 'a': [5, 53], 'truncation': [6], 'in': [7, 96, 112, 151, 163, 191], 'the': [8, 12, 18, 45, 66, 91, 143, 152, 169, 181, 205, 214, 224], 'C-terminal': [9], 'region': [10], 'of': [11, 21, 32, 68, 73, 76, 84, 88, 138, 161, 180, 207], 'Hh-ligand': [13], 'receptor,': [14], 'Patched-1': [15], '(mPtch1).': [16], 'While': [17], 'mes': [19, 46, 97, 153, 170], 'variant': [20], 'mPtch1': [22, 35], 'binds': [23], 'to': [24, 30, 38, 55, 93, 145, 178], 'Hh-ligands': [25], 'with': [26, 100, 175], 'an': [27, 85, 110, 230], 'affinity': [28], 'similar': [29, 177], 'that': [31, 104, 118, 136, 158, 179, 187, 199, 239], 'wild': [33], 'type': [34], 'and': [36, 70, 117, 124, 198, 237], 'appears': [37], 'normally': [39], 'regulate': [40], 'canonical': [41], 'Hh-signalling': [42, 64, 232], 'via': [43], 'smoothened,': [44], 'mutation': [47], 'causes,': [48], 'among': [49], 'other': [50], 'non-lethal': [51], 'defects,': [52], 'block': [54, 92, 144], 'mammary': [56, 80, 130, 146, 165, 193, 243], 'ductal': [57, 94, 147, 173], 'elongation': [58, 95, 148], 'at': [59, 149, 246], 'puberty.': [60, 247], 'We': [61, 155, 184], 'demonstrated': [62], 'previously': [63], 'induces': [65], 'activation': [67, 201], 'Erk1/2': [69, 188], 'c-src': [71, 89, 125, 236], 'independently': [72], 'its': [74], 'control': [75], 'smo': [77], 'activity.': [78], 'Furthermore,': [79], 'epithelial': [81, 166, 194], 'cell-directed': [82], 'expression': [83, 116, 137, 160], 'activated': [86, 190], 'allele': [87], 'rescued': [90], 'mice,': [98], 'albeit': [99], 'delayed': [101], 'kinetics.': [102], 'Given': [103], 'this': [105, 200], 'rescue': [106], 'was': [107, 134], 'accompanied': [108], 'by': [109, 196, 204, 213, 223], 'induction': [111], 'estrogen': [113], 'receptor-alpha': [114], '(ERα)': [115], 'complex': [119], 'regulatory': [120], 'interactions': [121], 'between': [122], 'ERα': [123, 139, 162, 215, 238], 'are': [126], 'required': [127, 241], 'for': [128, 242], 'normal': [129], 'gland': [131, 244], 'development,': [132], 'it': [133], 'hypothesized': [135], 'would': [140], 'also': [141], 'overcome': [142], 'puberty': [150], 'mouse.': [154], 'demonstrate': [156, 185], 'here': [157], 'conditional': [159], 'luminal': [164], 'cells': [167, 195], 'on': [168], 'background': [171], 'facilitates': [172], 'morphogenesis': [174, 245], 'kinetics': [176], 'MMTV-c-srcAct': [182], 'mice.': [183], 'further': [186], 'is': [189, 202, 210, 220, 240], 'primary': [192], 'Shh-ligand': [197], 'blocked': [203, 212, 222], 'inhibitor': [206], 'c-src,': [208], 'PP2,': [209], 'partially': [211], 'inhibitor,': [216], 'ICI': [217], '182780': [218], 'but': [219], 'not': [221], 'smo-inhibitor,': [225], 'SANT-1.': [226], 'These': [227], 'data': [228], 'reveal': [229], 'apparent': [231], 'cascade': [233], 'operating': [234], 'through': [235]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2091419984', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-08-15T08:59:25.650604', 'created_date': '2016-06-24'}