Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2091240261', 'doi': 'https://doi.org/10.1016/s0140-6736(05)79761-0', 'title': 'Genetic selection and folate intake during pregnancy', 'display_name': 'Genetic selection and folate intake during pregnancy', 'publication_year': 1998, 'publication_date': '1998-10-01', 'ids': {'openalex': 'https://openalex.org/W2091240261', 'doi': 'https://doi.org/10.1016/s0140-6736(05)79761-0', 'mag': '2091240261', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9798595'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0140-6736(05)79761-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S49861241', 'display_name': 'The Lancet', 'issn_l': '0140-6736', 'issn': ['0140-6736', '1474-547X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068047664', 'display_name': 'E Muñoz-Morán', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I82767444', 'display_name': 'Universidad de Málaga', 'ror': 'https://ror.org/036b2ww28', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I82767444']}, {'id': 'https://openalex.org/I4210108548', 'display_name': 'Hospital Regional Universitario de Málaga', 'ror': 'https://ror.org/01mqsmm97', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108548']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'E Muñoz-Moran', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Facultad de Medicina, Universidad de Málaga, 29071-Málaga, Spain, and Laboratorio Endocrinologia Molecular, Hospital Regional Carlos Haya, Malaga'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Facultad de Medicina, Universidad de Málaga, 29071-Málaga, Spain, and Laboratorio Endocrinologia Molecular, Hospital Regional Carlos Haya, Malaga', 'institution_ids': ['https://openalex.org/I82767444', 'https://openalex.org/I4210108548']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031717026', 'display_name': 'JL Dieguez-Lucena', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210108548', 'display_name': 'Hospital Regional Universitario de Málaga', 'ror': 'https://ror.org/01mqsmm97', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108548']}, {'id': 'https://openalex.org/I82767444', 'display_name': 'Universidad de Málaga', 'ror': 'https://ror.org/036b2ww28', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I82767444']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'JL Dieguez-Lucena', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Facultad de Medicina, Universidad de Málaga, 29071-Málaga, Spain, and Laboratorio Endocrinologia Molecular, Hospital Regional Carlos Haya, Malaga'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Facultad de Medicina, Universidad de Málaga, 29071-Málaga, Spain, and Laboratorio Endocrinologia Molecular, Hospital Regional Carlos Haya, Malaga', 'institution_ids': ['https://openalex.org/I4210108548', 'https://openalex.org/I82767444']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080141363', 'display_name': 'N Fernández-Arcás', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210108548', 'display_name': 'Hospital Regional Universitario de Málaga', 'ror': 'https://ror.org/01mqsmm97', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108548']}, {'id': 'https://openalex.org/I82767444', 'display_name': 'Universidad de Málaga', 'ror': 'https://ror.org/036b2ww28', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I82767444']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'N Fernandez-Arcas', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Facultad de Medicina, Universidad de Málaga, 29071-Málaga, Spain, and Laboratorio Endocrinologia Molecular, Hospital Regional Carlos Haya, Malaga'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Facultad de Medicina, Universidad de Málaga, 29071-Málaga, Spain, and Laboratorio Endocrinologia Molecular, Hospital Regional Carlos Haya, Malaga', 'institution_ids': ['https://openalex.org/I4210108548', 'https://openalex.org/I82767444']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010614721', 'display_name': 'S Peran-Mesa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210108548', 'display_name': 'Hospital Regional Universitario de Málaga', 'ror': 'https://ror.org/01mqsmm97', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108548']}, {'id': 'https://openalex.org/I82767444', 'display_name': 'Universidad de Málaga', 'ror': 'https://ror.org/036b2ww28', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I82767444']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'S Peran-Mesa', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Facultad de Medicina, Universidad de Málaga, 29071-Málaga, Spain, and Laboratorio Endocrinologia Molecular, Hospital Regional Carlos Haya, Malaga'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Facultad de Medicina, Universidad de Málaga, 29071-Málaga, Spain, and Laboratorio Endocrinologia Molecular, Hospital Regional Carlos Haya, Malaga', 'institution_ids': ['https://openalex.org/I4210108548', 'https://openalex.org/I82767444']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101535861', 'display_name': 'Armando Reyes‐Engel', 'orcid': 'https://orcid.org/0000-0002-7294-8103'}, 'institutions': [{'id': 'https://openalex.org/I4210108548', 'display_name': 'Hospital Regional Universitario de Málaga', 'ror': 'https://ror.org/01mqsmm97', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210108548']}, {'id': 'https://openalex.org/I82767444', 'display_name': 'Universidad de Málaga', 'ror': 'https://ror.org/036b2ww28', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I82767444']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'A Reyes-Engel', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Facultad de Medicina, Universidad de Málaga, 29071-Málaga, Spain, and Laboratorio Endocrinologia Molecular, Hospital Regional Carlos Haya, Malaga'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Facultad de Medicina, Universidad de Málaga, 29071-Málaga, Spain, and Laboratorio Endocrinologia Molecular, Hospital Regional Carlos Haya, Malaga', 'institution_ids': ['https://openalex.org/I4210108548', 'https://openalex.org/I82767444']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 6830, 'currency': 'USD', 'value_usd': 6830, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 102, 'citation_normalized_percentile': {'value': 0.9601, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '352', 'issue': '9134', 'first_page': '1120', 'last_page': '1121'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10499', 'display_name': 'Role of Homocysteine in Health and Disease', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10499', 'display_name': 'Role of Homocysteine in Health and Disease', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11629', 'display_name': 'Developmental Origins of Adult Health and Disease', 'score': 0.9522, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11658', 'display_name': 'Esophageal Intervention Techniques', 'score': 0.9338, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thermolabile', 'display_name': 'Thermolabile', 'score': 0.8803849}, {'id': 'https://openalex.org/keywords/hypertension-risk', 'display_name': 'Hypertension Risk', 'score': 0.528808}], 'concepts': [{'id': 'https://openalex.org/C43563269', 'wikidata': 'https://www.wikidata.org/wiki/Q424709', 'display_name': 'Methylenetetrahydrofolate reductase', 'level': 4, 'score': 0.95154685}, {'id': 'https://openalex.org/C2779155592', 'wikidata': 'https://www.wikidata.org/wiki/Q2403956', 'display_name': 'Thermolabile', 'level': 3, 'score': 0.8803849}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.64234614}, {'id': 'https://openalex.org/C2777090595', 'wikidata': 'https://www.wikidata.org/wiki/Q192466', 'display_name': 'Homocysteine', 'level': 2, 'score': 0.58217233}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.5211335}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.45663598}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.44580072}, {'id': 'https://openalex.org/C134651460', 'wikidata': 'https://www.wikidata.org/wiki/Q3100717', 'display_name': 'Reductase', 'level': 3, 'score': 0.44480264}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.43681115}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.420968}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4063583}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3743774}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.25487992}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.1931395}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.109235495}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.08060843}], 'mesh': [{'descriptor_ui': 'D005492', 'descriptor_name': 'Folic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D006397', 'descriptor_name': 'Hematinics', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000587', 'descriptor_name': 'Oxidoreductases Acting on CH-NH Group Donors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002675', 'descriptor_name': 'Child, Preschool', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005492', 'descriptor_name': 'Folic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005787', 'descriptor_name': 'Gene Frequency', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006397', 'descriptor_name': 'Hematinics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006720', 'descriptor_name': 'Homozygote', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007223', 'descriptor_name': 'Infant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042965', 'descriptor_name': 'Methylenetetrahydrofolate Reductase (NADPH2)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000587', 'descriptor_name': 'Oxidoreductases Acting on CH-NH Group Donors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011247', 'descriptor_name': 'Pregnancy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013030', 'descriptor_name': 'Spain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0140-6736(05)79761-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S49861241', 'display_name': 'The Lancet', 'issn_l': '0140-6736', 'issn': ['0140-6736', '1474-547X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9798595', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.84, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 5, 'referenced_works': ['https://openalex.org/W107696508', 'https://openalex.org/W2008031088', 'https://openalex.org/W2048371995', 'https://openalex.org/W2165715420', 'https://openalex.org/W2325417132'], 'related_works': ['https://openalex.org/W52585057', 'https://openalex.org/W3158161280', 'https://openalex.org/W2626895270', 'https://openalex.org/W2416191197', 'https://openalex.org/W2231114048', 'https://openalex.org/W2088764004', 'https://openalex.org/W2075119373', 'https://openalex.org/W2073868696', 'https://openalex.org/W2016296136', 'https://openalex.org/W1507974144'], 'abstract_inverted_index': {'The': [0, 83], 'Ala225Val': [1], 'mutation': [2, 49], '(677C→T)': [3], 'for': [4, 44], 'the': [5, 68, 86, 103], 'methylenetetrahydrofolate': [6, 51], 'reductase': [7], '(MTHFR)': [8], 'gene': [9], 'has': [10], 'been': [11], 'associated': [12], 'with': [13, 17, 73], 'a': [14, 18, 47], 'thermolabile': [15], 'enzyme': [16], 'decreased': [19], 'activity': [20], 'that': [21], 'can': [22], 'provide': [23], 'an': [24], 'increase': [25], 'in': [26, 50, 93, 97, 102], 'plasma': [27], 'homocysteine': [28], 'concentrations.': [29], '1': [30], 'Frosst': [31], 'P': [32, 36], 'Blom': [33], 'HJ': [34], 'Goyette': [35], 'et': [37], 'al.': [38], 'A': [39], 'candidate': [40], 'genetic': [41], 'risk': [42], 'factor': [43], 'cardiovascular': [45, 74], 'disease:': [46], 'common': [48], 'reductase.': [52], 'Nat': [53], 'Genet.': [54], '1995;': [55], '10:': [56], '111-113': [57], 'Crossref': [58], 'PubMed': [59], 'Scopus': [60], '(5059)': [61], 'Google': [62], 'Scholar': [63], 'Several': [64], 'reports': [65], 'have': [66], 'studied': [67], 'relation': [69], 'of': [70, 85], 'this': [71], 'polymorphism': [72], 'diseases': [75], 'as': [76, 78], 'well': [77], 'schizophrenia,': [79], 'depression,': [80], 'and': [81], 'cancer.': [82], 'frequency': [84], 'homozygous': [87], 'VV': [88], 'genotype,': [89], 'however,': [90], 'varies': [91], 'geographically': [92], 'Europe': [94], 'from': [95], '6–10%': [96], 'northern': [98], 'countries': [99], 'to': [100], '13–18%': [101], 'Mediterranean': [104], 'population.': [105]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2091240261', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-09-09T21:33:14.173614', 'created_date': '2016-06-24'}