Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2091184112', 'doi': 'https://doi.org/10.1016/j.bbapap.2011.06.018', 'title': 'Pyridoxal phosphate: Biosynthesis and catabolism', 'display_name': 'Pyridoxal phosphate: Biosynthesis and catabolism', 'publication_year': 2011, 'publication_date': '2011-07-10', 'ids': {'openalex': 'https://openalex.org/W2091184112', 'doi': 'https://doi.org/10.1016/j.bbapap.2011.06.018', 'mag': '2091184112', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21767669'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbapap.2011.06.018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210222880', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics', 'issn_l': '1570-9639', 'issn': ['1570-9639', '1878-1454'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5052230062', 'display_name': 'Tathagata Mukherjee', 'orcid': 'https://orcid.org/0000-0002-6369-8923'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tathagata Mukherjee', 'raw_affiliation_strings': ['Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070467084', 'display_name': 'Jeremiah W. Hanes', 'orcid': 'https://orcid.org/0000-0002-2818-6885'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeremiah Hanes', 'raw_affiliation_strings': ['Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049818256', 'display_name': 'Ivo Tews', 'orcid': 'https://orcid.org/0000-0002-4704-1139'}, 'institutions': [{'id': 'https://openalex.org/I43439940', 'display_name': 'University of Southampton', 'ror': 'https://ror.org/01ryk1543', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I43439940']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ivo Tews', 'raw_affiliation_strings': ['University of Southampton, School of Biological Sciences Institute for Life Sciences (IfLS) B85, Highfield Campus Southampton SO17 1BJ, England, UK'], 'affiliations': [{'raw_affiliation_string': 'University of Southampton, School of Biological Sciences Institute for Life Sciences (IfLS) B85, Highfield Campus Southampton SO17 1BJ, England, UK', 'institution_ids': ['https://openalex.org/I43439940']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019164857', 'display_name': 'S.E. Ealick', 'orcid': 'https://orcid.org/0000-0001-8548-112X'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven E. Ealick', 'raw_affiliation_strings': ['Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064237607', 'display_name': 'Tadhg P. Begley', 'orcid': 'https://orcid.org/0000-0001-5134-2623'}, 'institutions': [{'id': 'https://openalex.org/I91045830', 'display_name': 'Texas A&M University', 'ror': 'https://ror.org/01f5ytq51', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I91045830']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Tadhg P. Begley', 'raw_affiliation_strings': ['Department of Chemistry, Texas A&M University, College Station, TX 77843, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Texas A&M University, College Station, TX 77843, USA', 'institution_ids': ['https://openalex.org/I91045830']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5064237607'], 'corresponding_institution_ids': ['https://openalex.org/I91045830'], 'apc_list': {'value': 3730, 'currency': 'USD', 'value_usd': 3730, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.249, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 97, 'citation_normalized_percentile': {'value': 0.994638, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '1814', 'issue': '11', 'first_page': '1585', 'last_page': '1596'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11162', 'display_name': 'Macromolecular Crystallography Techniques', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11162', 'display_name': 'Macromolecular Crystallography Techniques', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11882', 'display_name': 'Biosynthesis and Engineering of Terpenoids', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10252', 'display_name': 'Natural Products as Sources of New Drugs', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/catabolism', 'display_name': 'Catabolism', 'score': 0.86066794}, {'id': 'https://openalex.org/keywords/pyridoxal-phosphate', 'display_name': 'Pyridoxal phosphate', 'score': 0.6929736}, {'id': 'https://openalex.org/keywords/phytoalexin-biosynthesis', 'display_name': 'Phytoalexin Biosynthesis', 'score': 0.491483}], 'concepts': [{'id': 'https://openalex.org/C96942376', 'wikidata': 'https://www.wikidata.org/wiki/Q21130714', 'display_name': 'Catabolism', 'level': 3, 'score': 0.86066794}, {'id': 'https://openalex.org/C197957613', 'wikidata': 'https://www.wikidata.org/wiki/Q407280', 'display_name': 'Cofactor', 'level': 3, 'score': 0.7919041}, {'id': 'https://openalex.org/C2780859938', 'wikidata': 'https://www.wikidata.org/wiki/Q3065731', 'display_name': 'Pyridoxal', 'level': 3, 'score': 0.74719894}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.69775534}, {'id': 'https://openalex.org/C2776834122', 'wikidata': 'https://www.wikidata.org/wiki/Q418957', 'display_name': 'Pyridoxal phosphate', 'level': 4, 'score': 0.6929736}, {'id': 'https://openalex.org/C553450214', 'wikidata': 'https://www.wikidata.org/wiki/Q851162', 'display_name': 'Biosynthesis', 'level': 3, 'score': 0.68490463}, {'id': 'https://openalex.org/C2777516457', 'wikidata': 'https://www.wikidata.org/wiki/Q2413613', 'display_name': 'Singlet oxygen', 'level': 3, 'score': 0.63098073}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.5982993}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5030114}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34117103}, {'id': 'https://openalex.org/C540031477', 'wikidata': 'https://www.wikidata.org/wiki/Q629', 'display_name': 'Oxygen', 'level': 2, 'score': 0.23073894}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D011732', 'descriptor_name': 'Pyridoxal Phosphate', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D011732', 'descriptor_name': 'Pyridoxal Phosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011732', 'descriptor_name': 'Pyridoxal Phosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014166', 'descriptor_name': 'Transferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014166', 'descriptor_name': 'Transferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014166', 'descriptor_name': 'Transferases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D025101', 'descriptor_name': 'Vitamin B 6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025101', 'descriptor_name': 'Vitamin B 6', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbapap.2011.06.018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210222880', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics', 'issn_l': '1570-9639', 'issn': ['1570-9639', '1878-1454'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21767669', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 119, 'referenced_works': ['https://openalex.org/W1483535685', 'https://openalex.org/W1489250509', 'https://openalex.org/W1491040572', 'https://openalex.org/W1493392084', 'https://openalex.org/W1499557141', 'https://openalex.org/W1508068038', 'https://openalex.org/W1514776781', 'https://openalex.org/W1517356485', 'https://openalex.org/W1535327305', 'https://openalex.org/W1536210106', 'https://openalex.org/W1539208787', 'https://openalex.org/W1543819219', 'https://openalex.org/W1566191044', 'https://openalex.org/W1569051084', 'https://openalex.org/W1570931863', 'https://openalex.org/W1590944458', 'https://openalex.org/W1599386520', 'https://openalex.org/W160040764', 'https://openalex.org/W1651928788', 'https://openalex.org/W1930334853', 'https://openalex.org/W1964422753', 'https://openalex.org/W1964867612', 'https://openalex.org/W1967527121', 'https://openalex.org/W1972612851', 'https://openalex.org/W1972653523', 'https://openalex.org/W1974502173', 'https://openalex.org/W1983526625', 'https://openalex.org/W1988059453', 'https://openalex.org/W1991320235', 'https://openalex.org/W1994083229', 'https://openalex.org/W1996713033', 'https://openalex.org/W1996878825', 'https://openalex.org/W1997485933', 'https://openalex.org/W1997495186', 'https://openalex.org/W1998449887', 'https://openalex.org/W1999890324', 'https://openalex.org/W2002653507', 'https://openalex.org/W2004588991', 'https://openalex.org/W2005186890', 'https://openalex.org/W2006227140', 'https://openalex.org/W2006693717', 'https://openalex.org/W2010591434', 'https://openalex.org/W2011235268', 'https://openalex.org/W2013053079', 'https://openalex.org/W2015257221', 'https://openalex.org/W2016372379', 'https://openalex.org/W2021198676', 'https://openalex.org/W2021762013', 'https://openalex.org/W2023557139', 'https://openalex.org/W2025356194', 'https://openalex.org/W2029339566', 'https://openalex.org/W2031866837', 'https://openalex.org/W2033280480', 'https://openalex.org/W2033743259', 'https://openalex.org/W2037525379', 'https://openalex.org/W2038227178', 'https://openalex.org/W2038944166', 'https://openalex.org/W2040885190', 'https://openalex.org/W2043194010', 'https://openalex.org/W2043371406', 'https://openalex.org/W2053636413', 'https://openalex.org/W2053828364', 'https://openalex.org/W2053987999', 'https://openalex.org/W2055344488', 'https://openalex.org/W2056003961', 'https://openalex.org/W2059487306', 'https://openalex.org/W2060572124', 'https://openalex.org/W2061393819', 'https://openalex.org/W2061591743', 'https://openalex.org/W2063462243', 'https://openalex.org/W2063528461', 'https://openalex.org/W2065658773', 'https://openalex.org/W2071553325', 'https://openalex.org/W2073879684', 'https://openalex.org/W2076736589', 'https://openalex.org/W2077182195', 'https://openalex.org/W2080416920', 'https://openalex.org/W2081252762', 'https://openalex.org/W2081546475', 'https://openalex.org/W2083013894', 'https://openalex.org/W2085525114', 'https://openalex.org/W2089480036', 'https://openalex.org/W2093168138', 'https://openalex.org/W2094161656', 'https://openalex.org/W2095452332', 'https://openalex.org/W2101889307', 'https://openalex.org/W2108320871', 'https://openalex.org/W2110094991', 'https://openalex.org/W2118294872', 'https://openalex.org/W2119550888', 'https://openalex.org/W2127897889', 'https://openalex.org/W2129890743', 'https://openalex.org/W2132976660', 'https://openalex.org/W2137387674', 'https://openalex.org/W2137758628', 'https://openalex.org/W2146660498', 'https://openalex.org/W2147651357', 'https://openalex.org/W2150941176', 'https://openalex.org/W2151953515', 'https://openalex.org/W2151956762', 'https://openalex.org/W2153167305', 'https://openalex.org/W2158649512', 'https://openalex.org/W2163027365', 'https://openalex.org/W2168341971', 'https://openalex.org/W2168357217', 'https://openalex.org/W2171161326', 'https://openalex.org/W2206566392', 'https://openalex.org/W2328564170', 'https://openalex.org/W2398409855', 'https://openalex.org/W2414810693', 'https://openalex.org/W2952755535', 'https://openalex.org/W2971283165', 'https://openalex.org/W3026590205', 'https://openalex.org/W328595349', 'https://openalex.org/W4246090862', 'https://openalex.org/W4251966730', 'https://openalex.org/W4254807231', 'https://openalex.org/W4318471123', 'https://openalex.org/W71327590'], 'related_works': ['https://openalex.org/W3023811396', 'https://openalex.org/W2414394704', 'https://openalex.org/W2413750031', 'https://openalex.org/W2313555002', 'https://openalex.org/W2091184112', 'https://openalex.org/W2067421265', 'https://openalex.org/W2054896917', 'https://openalex.org/W2032199426', 'https://openalex.org/W2030985217', 'https://openalex.org/W1514293504'], 'abstract_inverted_index': {'Vitamin': [0], 'B6': [1, 78, 97], 'is': [2, 17, 42, 56, 103], 'an': [3], 'essential': [4], 'cofactor': [5], 'that': [6], 'participates': [7], 'in': [8, 73], 'a': [9, 62, 88, 106], 'large': [10], 'number': [11], 'of': [12, 44, 91, 95, 105], 'biochemical': [13], 'reactions.': [14], 'Pyridoxal': [15, 110], 'phosphate': [16], 'biosynthesized': [18], 'de': [19], 'novo': [20], 'by': [21], 'two': [22], 'different': [23], 'pathways': [24], '(the': [25], 'DXP': [26], 'dependent': [27], 'pathway': [28, 50], 'and': [29, 33, 66, 99], 'the': [30, 39, 45, 92], 'R5P': [31], 'pathway)': [32], 'can': [34], 'also': [35, 57], 'be': [36], 'salvaged': [37], 'from': [38], 'environment.': [40], 'It': [41, 55], 'one': [43], 'few': [46], 'cofactors': [47], 'whose': [48], 'catabolic': [49], 'has': [51, 67], 'been': [52], 'comprehensively': [53], 'characterized.': [54], 'known': [58], 'to': [59], 'function': [60], 'as': [61], 'singlet': [63], 'oxygen': [64], 'scavenger': [65], 'protective': [68], 'effects': [69], 'against': [70], 'oxidative': [71], 'stress': [72], 'fungi.': [74], 'Enzymes': [75], 'utilizing': [76], 'vitamin': [77, 96], 'are': [79], 'important': [80], 'targets': [81], 'for': [82], 'therapeutic': [83], 'agents.': [84], 'This': [85, 101], 'review': [86], 'provides': [87], 'concise': [89], 'overview': [90], 'mechanistic': [93], 'enzymology': [94], 'biosynthesis': [98], 'catabolism.': [100], 'article': [102], 'part': [104], 'Special': [107], 'Issue': [108], 'entitled:': [109], 'Phosphate': [111], 'Enzymology.': [112]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2091184112', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-09-17T16:09:18.973957', 'created_date': '2016-06-24'}