Abstract: The extracellular concentration of dopamine in the ventral striatum was measured daily by means of brain microdialysis. Chronic cocaine (10 mg/kg twice daily) altered the dopamine output compared to that in vehicle-injected rats, inducing a pronounced increase in the first 3 days followed by a clear-cut decrease. This reduction in the output of dopamine during chronic cocaine as well as during withdrawal may be neurochemical substrate for the additive properties of concaine.
Publication Year: 1992
Publication Date: 1992-03-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 99
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