Publication Information

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'https://openalex.org/W2050559178', 'https://openalex.org/W2028156322', 'https://openalex.org/W2002027447', 'https://openalex.org/W1998792901'], 'abstract_inverted_index': {'Nitric': [0, 248, 496, 2492], 'oxide': [1, 249, 497, 570, 608, 1014, 2493], 'synthases': [2, 250, 562, 2494], '(NOSs)': [3, 251, 563], 'are': [4, 252, 648, 2495, 2712, 2721, 2754, 2801, 3038, 3132, 3319, 3439, 3532, 3708, 3739, 3759, 3765, 3832, 4076, 4294, 4336], 'classified': [5, 253], 'functionally,': [6, 254], 'based': [7, 255, 1469, 1619, 2048, 3672], 'on': [8, 220, 256, 468, 1033, 1470, 1620, 2049, 2141, 2302, 2377, 3194, 3322, 3479, 3673, 4073, 4128, 4136, 4244, 4273], 'whether': [9, 257], 'calmodulin': [10, 94, 115, 141, 224, 258, 342, 363, 389, 472, 2468, 3246], 'binding': [11, 43, 95, 113, 127, 225, 259, 291, 343, 361, 375, 473, 695, 821, 841, 966, 1010, 1047, 1702, 1799, 1857, 1880, 1884, 1975, 2573, 2596, 2632, 2645, 2702, 2752, 2804, 2837, 2886, 2993, 3094, 3208, 3247, 3258, 3281, 3336, 3422, 3500, 3529, 3561, 3573, 3648, 3660, 3865, 3873, 3928, 3985, 4009, 4236, 4264, 4304], 'is': [12, 46, 69, 182, 191, 211, 260, 294, 317, 430, 439, 459, 498, 696, 731, 756, 827, 2813, 2820, 2969, 2987, 3146, 3171, 3413, 3465, 3550, 3563, 3796, 3823, 3842, 3948, 3955, 4166], 'Ca2+-dependent': [13, 261, 705, 798, 1001], '(cNOS)': [14, 262], 'or': [15, 51, 263, 299, 799, 1476, 1554, 1960, 2182, 2246, 2488, 3188, 3296, 4012, 4290, 4325], 'Ca2+-independent': [16, 264], '(iNOS).': [17, 265], 'This': [18, 121, 266, 369, 704, 1154, 2901, 3107, 3145, 3754], 'key': [19, 267], 'dichotomy': [20, 268], 'has': [21, 269, 802, 2507, 2644, 2871, 2979, 3178, 3350, 4173], 'not': [22, 47, 148, 270, 295, 396, 3469], 'been': [23, 271, 803, 2768, 3253, 3351], 'defined': [24, 272], 'at': [25, 273, 749, 1163, 1334, 1388, 1442, 1453, 1466, 1574, 1795, 1956, 2045, 2121, 2221, 2328, 3221, 3353, 3732, 4317], 'the': [26, 63, 66, 70, 84, 93, 101, 151, 187, 192, 209, 274, 311, 314, 318, 332, 341, 349, 399, 435, 440, 457, 579, 585, 617, 623, 725, 759, 811, 845, 965, 1008, 1020, 1110, 1113, 1117, 1124, 1143, 1187, 1198, 1471, 1477, 1527, 1543, 1566, 1685, 1871, 1888, 1965, 2022, 2030, 2054, 2104, 2255, 2329, 2421, 2510, 2601, 2641, 2680, 2683, 2718, 2805, 2809, 2816, 2824, 2829, 2883, 2889, 2892, 2905, 2919, 2960, 2991, 2996, 3076, 3092, 3099, 3110, 3150, 3155, 3162, 3186, 3197, 3201, 3238, 3245, 3256, 3312, 3323, 3328, 3334, 3339, 3343, 3420, 3443, 3458, 3473, 3487, 3491, 3495, 3498, 3506, 3523, 3526, 3539, 3547, 3567, 3571, 3585, 3646, 3658, 3700, 3704, 3712, 3715, 3721, 3724, 3728, 3743, 3751, 3768, 3772, 3777, 3780, 3783, 3793, 3813, 3816, 3835, 3840, 3845, 3848, 3854, 3863, 3879, 3883, 3902, 3910, 3916, 3919, 3923, 3926, 3931, 3934, 3946, 3987, 4001, 4019, 4042, 4046, 4089, 4105, 4110, 4231, 4234, 4332], 'molecular': [27, 80, 275, 328, 1149, 2317, 3250], 'level.': [28, 276], 'Here': [29, 277, 980], 'we': [30, 278, 962, 981, 3542], 'show': [31, 279, 3655], 'that': [32, 65, 83, 173, 208, 280, 313, 331, 421, 456, 647, 831, 964, 1862, 2725, 2971, 3068, 3174, 3215, 3299, 3429, 3639, 3758, 3825, 3871, 3882, 3901, 3949], 'cNOS': [33, 119, 281, 367, 1215, 1220, 3052, 3128, 3163, 4090], 'isoforms': [34, 282, 676, 1002, 1016, 2709, 3994], 'contain': [35, 283, 3045, 3220], 'a': [36, 88, 218, 238, 284, 336, 466, 486, 499, 641, 790, 797, 807, 817, 977, 983, 991, 1034, 1136, 1190, 1347, 1371, 1405, 1434, 1533, 1578, 1584, 1637, 1678, 1785, 1848, 1946, 2040, 2096, 2228, 2501, 2565, 2571, 2872, 2949, 2972, 3206, 3270, 3394, 3414, 3450, 3509, 3536, 3544, 3593, 3906, 4005, 4028, 4174, 4258], 'unique': [37, 239, 285, 487, 994], 'polypeptide': [38, 67, 286, 315, 922, 3953, 4002, 4032, 4086], 'insert': [39, 68, 85, 104, 188, 210, 287, 316, 333, 352, 436, 458, 2986, 3089, 3903, 3947, 4003, 4022, 4048, 4232, 4266], 'in': [40, 59, 197, 288, 307, 445, 506, 682, 701, 796, 1072, 1109, 1330, 1343, 1395, 1428, 1433, 1462, 1532, 1570, 1583, 1597, 1613, 1706, 1784, 1847, 1860, 1887, 1901, 1978, 2039, 2095, 2132, 2227, 2410, 2499, 2509, 2713, 2730, 2798, 2803, 2841, 2875, 2880, 2897, 2912, 2922, 2965, 2981, 2990, 3135, 3196, 3240, 3307, 3433, 3440, 3482, 3577, 3592, 3851, 3887, 3973, 3992, 4051, 4061, 4078, 4233, 4257], 'their': [41, 289, 652, 839, 2916, 3124, 3167], 'FMN': [42, 290, 1009, 1046, 1073, 2806, 2836, 2885, 2966, 2992, 3093, 3129, 3257, 3280, 3335, 3421, 3444, 3499, 3528, 3572, 3647, 3659, 3705, 3752, 3794, 4235, 4263], 'domains': [44, 58, 292, 306, 2630, 2753, 3259, 3661], 'which': [45, 222, 293, 470, 836, 988, 998, 1304, 1614, 2500, 2720, 3153, 3183, 3265, 3938, 3954], 'shared': [48, 296], 'with': [49, 76, 125, 150, 184, 217, 297, 324, 373, 398, 432, 465, 503, 844, 1044, 1361, 1370, 1675, 1712, 1727, 1810, 1959, 2245, 2288, 2313, 2413, 2888, 3104, 3419, 3442, 3486, 3517, 3668, 3798, 4142, 4178, 4320], 'iNOS': [50, 167, 298, 415, 763, 1615, 3080, 3118, 3316, 3663, 4149, 4171], 'other': [52, 300, 2393, 2762, 3967], 'related': [53, 301, 2756, 2763, 3064], 'flavoproteins.': [54, 302], 'Previously': [55, 303], 'identified': [56, 304, 681, 2840], 'autoinhibitory': [57, 71, 213, 230, 305, 319, 461, 478, 921, 4021], 'calmodulin-regulated': [60, 308], 'enzymes': [61, 309, 2498], 'raise': [62, 310], 'possibility': [64, 312], 'domain': [72, 320, 2563, 2643, 2887, 3282, 3574, 3795, 4010, 4237, 4265], 'of': [73, 105, 114, 118, 154, 186, 321, 353, 362, 366, 402, 434, 582, 588, 620, 626, 643, 654, 677, 707, 711, 716, 724, 728, 753, 762, 810, 910, 918, 967, 1003, 1007, 1012, 1041, 1049, 1065, 1107, 1349, 1364, 1380, 1400, 1407, 1426, 1473, 1479, 1530, 1536, 1545, 1548, 1552, 1557, 1568, 1580, 1595, 1632, 1640, 1644, 1649, 1652, 1681, 1730, 1782, 1813, 1870, 1873, 1876, 1890, 1894, 1912, 1915, 1919, 1949, 1964, 1968, 1972, 2019, 2025, 2029, 2051, 2053, 2106, 2109, 2135, 2146, 2185, 2257, 2260, 2268, 2292, 2320, 2341, 2503, 2512, 2686, 2707, 2811, 2828, 2834, 2869, 2882, 2894, 2907, 2948, 2952, 2962, 2975, 2995, 3047, 3060, 3079, 3098, 3142, 3149, 3200, 3212, 3227, 3260, 3278, 3300, 3315, 3325, 3333, 3338, 3346, 3375, 3462, 3472, 3494, 3508, 3525, 3570, 3652, 3657, 3662, 3703, 3714, 3723, 3727, 3735, 3748, 3774, 3779, 3782, 3789, 3805, 3815, 3819, 3847, 3896, 3918, 3925, 3950, 3976, 3986, 4018, 4023, 4030, 4045, 4082, 4088, 4148, 4162, 4227, 4238, 4267, 4270, 4298, 4309, 4312, 4340, 4344], 'cNOSs.': [74, 322, 2983], 'Consistent': [75, 323], 'this': [77, 190, 325, 438, 824, 1202, 3055, 3736, 3897, 3982], 'possibility,': [78, 326], 'three-dimensional': [79, 327], 'modeling': [81, 329, 1006], 'suggested': [82, 330], 'originates': [86, 334], 'from': [87, 100, 158, 335, 348, 406, 848, 1025, 1224, 1298, 1307, 1565, 1605, 1609, 2150, 2189, 2388, 2420, 2430, 2445, 2451, 2466, 2470, 2475, 2483, 3000, 3490, 3645, 3962, 4004, 4054, 4104, 4230], 'site': [89, 153, 219, 337, 401, 467, 3423, 3562, 3588, 3718, 3929, 4007], 'immediately': [90, 338, 2821, 3564], 'adjacent': [91, 339, 3565, 3861], 'to': [92, 110, 128, 176, 200, 340, 358, 376, 424, 448, 805, 969, 995, 1062, 1135, 1158, 1168, 1172, 1180, 1185, 1189, 1481, 1654, 1677, 1832, 1881, 2361, 2368, 2517, 2678, 2697, 2717, 2757, 2815, 2918, 3050, 3057, 3204, 3236, 3244, 3269, 3505, 3534, 3553, 3566, 3741, 3792, 3800, 3812, 3858, 3862, 3930, 3966, 3989, 4036, 4056, 4170, 4302], 'sequence.': [96, 344], 'Synthetic': [97, 345, 2384], 'peptides': [98, 146, 346, 394, 2385, 4132, 4153], 'derived': [99, 347], '45-amino': [102, 350], 'acid': [103, 351, 813, 819, 986, 2373, 2427, 3101, 3120], 'endothelial': [106, 354, 580, 618, 687, 1219], 'NOS': [107, 198, 244, 355, 446, 492, 678, 729, 792, 1042, 1458, 1602, 1783, 2687, 2708, 2884, 2899, 3340, 3993, 4074, 4245, 4274, 4313], 'were': [108, 356, 1059, 1077, 1120, 1195, 1222, 1305, 1338, 1386, 1440, 1451, 1540, 1623, 1704, 1722, 1757, 1790, 1807, 1845, 1907, 1976, 2101, 2219, 2273, 2300, 2355, 2386, 2444, 2450, 2464, 2481, 2676, 3287, 3291, 4049, 4070, 4103, 4125, 4133, 4282], 'found': [109, 357, 2989], 'potently': [111, 165, 359, 413], 'inhibit': [112, 360], 'and': [116, 134, 226, 236, 246, 364, 382, 474, 484, 494, 508, 686, 719, 834, 997, 1022, 1068, 1138, 1151, 1174, 1177, 1184, 1217, 1229, 1236, 1328, 1353, 1368, 1416, 1421, 1431, 1449, 1526, 1636, 1646, 1744, 1779, 1798, 1822, 1826, 1843, 1892, 1934, 2021, 2092, 2111, 2279, 2282, 2309, 2339, 2359, 2392, 2404, 2407, 2440, 2472, 2564, 2603, 2638, 2650, 2688, 2700, 2710, 2750, 2761, 2770, 2819, 2955, 3063, 3117, 3138, 3217, 3263, 3272, 3289, 3317, 3372, 3437, 3557, 3665, 3720, 3750, 3776, 3915, 3921, 3933, 3970, 3978, 4066, 4095, 4108, 4115, 4144, 4156, 4172, 4218, 4225, 4240, 4247, 4276, 4288, 4331], 'activation': [117, 365, 974], 'isoforms.': [120, 368, 3341], 'inhibition': [122, 135, 370, 383, 2134, 4139, 4147, 4210], 'was': [123, 371, 1017, 1133, 1203, 1211, 1296, 1460, 1563, 1603, 1607, 1617, 1658, 1673, 1749, 1800, 1830, 1858, 1885, 1898, 1954, 2037, 2113, 2139, 2252, 2284, 2323, 2375, 2397, 2469, 2474, 2839, 2891, 2902, 4025, 4140, 4154, 4305], 'associated': [124, 183, 372, 431], 'peptide': [126, 374, 1531, 1877, 1891, 4068, 4271], 'NOS,': [129, 377, 568, 574, 606, 612, 1882, 2913, 2953], 'rather': [130, 378], 'than': [131, 379, 3298, 3834, 3889], 'free': [132, 380], 'calmodulin,': [133, 381, 591, 629, 1523, 2085], 'could': [136, 384, 3266, 3998], 'be': [137, 201, 385, 449, 806, 2556, 3267, 3477, 3591, 3859, 3875], 'reversed': [138, 386], 'by': [139, 387, 557, 651, 698, 816, 829, 913, 975, 1079, 1085, 1122, 1205, 1423, 1542, 1656, 1752, 1803, 1910, 2103, 2254, 2286, 2311, 2325, 2399, 2424, 2570, 2772, 2823, 2843, 2904, 2915, 2924, 3808, 3878, 3957, 4008, 4151], 'increasing': [140, 388], 'concentration.': [142, 390], 'In': [143, 391, 721, 1868], 'contrast,': [144, 392, 722], 'insert-derived': [145, 393], 'did': [147, 163, 395, 411], 'interfere': [149, 397], 'arginine': [152, 400], 'cNOS,': [155, 403, 572, 610], 'as': [156, 404, 990, 1083, 1209, 1238, 1483, 1625, 1659, 1987, 2357, 2727, 3449, 3905, 4041, 4059], 'assessed': [157, 405], '[3H]N': [159, 407, 1973, 4326], 'G-nitro-l-arginine': [160, 408, 1974, 4327], 'binding,': [161, 409], 'nor': [162, 410], 'they': [164, 412, 3803], 'effect': [166, 414, 1872, 1875, 4127, 4269], 'activity.': [168, 416, 2136, 4097], 'Limited': [169, 417, 2137], 'proteolysis': [170, 418, 2138, 2283], 'studies': [171, 419, 1869], 'showed': [172, 420], "calmodulin's": [174, 422], 'ability': [175, 423], 'gate': [177, 425], 'electron': [178, 426, 2598, 2728], 'flow': [179, 427], 'through': [180, 428, 3844, 4013], 'cNOSs': [181, 221, 235, 429, 469, 483, 970, 996, 2999, 3070, 3116, 4024, 4239], 'displacement': [185, 433, 917], 'polypeptide;': [189, 437], 'first': [193, 441, 680, 1908, 2677, 2810, 2878], 'specific': [194, 442, 1679], 'calmodulin-induced': [195, 443], 'change': [196, 444], 'conformation': [199, 447, 3537, 3595], 'identified.': [202, 450], 'Together,': [203, 451], 'our': [204, 452], 'findings': [205, 453, 830], 'strongly': [206, 454, 3899], 'suggest': [207, 455, 3638, 3900], 'an': [212, 460, 919, 1376, 2289, 2303, 2378, 2560, 3073, 3088, 3140, 3518, 3951], 'control': [214, 231, 462, 479, 978, 992, 3907, 3914], 'element,': [215, 463, 3908], 'docking': [216, 464], 'impedes': [223, 471], 'enzymatic': [227, 475], 'activation.': [228, 476], 'The': [229, 477, 672, 1129, 1593, 2628, 2704, 2748, 2877, 3127, 3210, 3225, 3383, 3392, 3559, 3787, 3867, 4098], 'element': [232, 480, 993], 'molecularly': [233, 481, 999], 'defines': [234, 482, 1000], 'offers': [237, 485], 'target': [240, 488], 'for': [241, 489, 713, 739, 746, 758, 853, 1148, 1234, 1340, 1446, 1577, 1724, 1792, 1938, 2118, 2224, 2575, 2634, 2647, 3232, 3255, 3538, 3945, 4242, 4314], 'developing': [242, 490], 'novel': [243, 491], 'activators': [245, 493], 'inhibitors.': [247, 495], 'ubiquitous': [500], 'cell-signaling': [501], 'molecule,': [502], 'protean': [504], 'roles': [505], 'physiology': [507], 'pathophysiology': [509], '(1Nathan': [510], 'C.': [511, 657, 777, 891, 2662, 2854, 4198], 'Xie': [512, 658, 766, 882, 4187], 'Q.W.': [513, 659, 767, 4188], 'Cell.': [514], '1994;': [515, 663, 953, 2586], '78:': [516], '915-918Abstract': [517], 'Full': [518, 666, 870, 872, 898, 900, 933, 956, 1322, 2589, 2740, 3607], 'Text': [519, 667, 871, 873, 899, 901, 934, 957, 1323, 2590, 2741, 3608], 'PDF': [520, 668, 874, 902, 935, 958, 1324, 2591, 2742, 3609], 'PubMed': [521, 535, 551, 669, 784, 875, 903, 936, 959, 1100, 1263, 1289, 1325, 1493, 1669, 1697, 2011, 2068, 2177, 2213, 2538, 2551, 2592, 2623, 2671, 2743, 2791, 2863, 2939, 3031, 3408, 3610, 3631, 3693, 4205], 'Scopus': [522, 536, 552, 785, 876, 904, 1101, 1264, 1290, 1698, 2012, 2069, 2178, 2214, 2539, 2624, 2672, 2744, 2792, 2864, 2940, 3032, 3409, 3611, 3632, 3694, 4206], '(2740)': [523], 'Google': [524, 538, 554, 670, 787, 878, 906, 937, 960, 1103, 1266, 1292, 1326, 1494, 1670, 1700, 2014, 2071, 2180, 2216, 2541, 2552, 2593, 2626, 2674, 2746, 2794, 2866, 2942, 3034, 3411, 3613, 3634, 3696, 4208], 'Scholar,': [525, 539, 879, 1267, 3614], '2Ignarro': [526], 'L.J.': [527, 1275, 2199, 2530], 'Annu.': [528], 'Rev.': [529], 'Pharmacol.': [530, 547], 'Toxicol.': [531], '1990;': [532, 3604], '30:': [533], '535-560Crossref': [534], '(1220)': [537], '3Moncada': [540], 'S.': [541, 1258, 2172, 2618, 2786, 3026, 3622, 3684], 'Palmer': [542], 'R.M.': [543], 'Higgs': [544], 'E.A.': [545, 2526, 2578], 'Biochem.': [546, 1282, 1692, 2004, 2063, 2206, 2735, 3602], '1989;': [548], '38:': [549], '1709-1715Crossref': [550], '(1099)': [553], 'Scholar).': [555, 671, 788, 907, 1104, 1293, 1495, 1671, 2072, 2217, 2553, 2594, 2627, 2747, 2795, 2943, 3382], 'Encoded': [556], 'distinct': [558], 'genes,': [559], 'mammalian': [560, 2982, 3051], 'NO': [561, 712, 737], '1The': [564, 602], 'abbreviations': [565, 603], 'used': [566, 604], 'are:': [567, 605], 'nitric': [569, 607, 1013], 'synthase;': [571, 609], 'calcium-dependent': [573, 611], 'iNOS,': [575, 613, 849, 3262, 3435, 4137], 'calcium-independent': [576, 614], 'NOS;': [577, 615], 'eNOS,': [578, 616, 1237, 1553, 4123, 4289], 'isoform': [581, 587, 619, 625, 727, 793], 'cNOS;': [583, 589, 621, 627], 'nNOS,': [584, 622, 835, 1549, 1916], 'neuronal': [586, 624, 683, 1214], 'CaM,': [590, 628, 747], 'SCR,': [592, 630], 'structurally': [593, 631, 1054], 'conserved': [594, 632, 1055, 1063, 2694, 2908], 'region;': [595, 633], 'CPR,': [596, 634, 2954, 3264], 'cytochrome': [597, 635], 'P450': [598, 636, 2690, 3348], 'reductase;': [599, 637], 'DTT,': [600, 638, 1520, 1740, 1766, 1933, 2239], 'dithiothreitol.': [601, 639], 'comprise': [640], 'family': [642], 'three': [644, 1424, 3189, 3241, 3852], 'calmodulin-dependent': [645, 2031], 'biopterohemoflavoproteins': [646], 'functionally': [649], 'distinguished': [650], 'modes': [653], 'regulation': [655, 708, 909], '(4Nathan': [656], 'J.': [660, 769, 778, 864, 881, 892, 927, 950, 1273, 1316, 1693, 1997, 2064, 2197, 2534, 2583, 4190, 4199], 'Biol.': [661, 865, 893, 928, 951, 1317, 2584], 'Chem.': [662, 866, 894, 929, 952, 1318, 2585], '269:': [664, 954, 2587], '13725-13728Abstract': [665], 'two': [673, 3187, 3223, 3430], 'constitutively': [674], 'expressed': [675], '(cNOSs),': [679], 'cells': [684, 688, 2154], '(nNOS)': [685, 1216], '(eNOS),': [689], 'remain': [690], 'dormant': [691], 'until': [692, 1456], 'calcium/calmodulin': [693], '(Ca2+/CaM)': [694], 'actuated': [697], 'transient': [699], 'elevations': [700], 'intracellular': [702, 754], 'Ca2+.': [703], 'mode': [706], 'provides': [709], 'pulses': [710], 'moment-to-moment': [714], 'modulation': [715], 'vascular': [717], 'tone': [718], 'neurosignaling.': [720], 'activity': [723, 855, 1459, 1616, 1680, 2112, 4075, 4150, 4246, 4275, 4280], 'immunostimulant-induced': [726], '(iNOS)': [730], 'Ca2+-independent,': [732], 'providing': [733], 'continuous': [734], 'high': [735, 744, 1080, 2400], 'output': [736], 'generation': [738], 'host': [740], 'defense.': [741], 'A': [742, 1571, 1598, 2984], 'remarkably': [743, 4175], 'affinity': [745], 'even': [748, 4182], 'basally': [750], 'low': [751], 'levels': [752], 'calcium,': [755], 'responsible': [757], 'Ca2+': [760, 852], 'independence': [761], '(5Cho': [764, 4185], 'H.J.': [765, 4186], 'Calaycay': [768, 4189], 'Mumford': [770, 4191], 'R.A.': [771, 4192], 'Swiderek': [772, 4193], 'K.M.': [773, 4194], 'Lee': [774, 4195], 'T.D.': [775, 2733, 4196], 'Nathan': [776, 890, 4197], 'Exp.': [779, 4200], 'Med.': [780, 4201], '1992;': [781, 1260, 1319, 2174, 4202], '176:': [782, 4203], '599-604Crossref': [783, 4204], '(559)': [786, 4207], 'Whether': [789], 'given': [791], 'binds': [794], 'CaM': [795, 820, 840, 1951, 2576, 3560, 3583, 3586, 3669, 3749, 3775, 3784, 3790, 3864, 3872, 3927, 3958, 3971, 3990, 3997, 4165, 4214], '-independent': [800], 'manner': [801], 'assumed': [804], 'property': [808], 'solely': [809], 'amino': [812, 985, 2426, 2977, 3042, 3100, 3119, 3980], 'sequence': [814, 847, 2351, 2574, 3846], 'specified': [815], '20–25-amino': [818], 'site.': [822, 3209, 3248, 3501, 3786, 3866], 'However,': [823], 'restrictive': [825], 'view': [826], 'challenged': [828], 'chimeric': [832], 'eNOS': [833, 2187, 3151, 3216, 3474, 3666, 4047, 4094, 4106], 'have': [837, 2631, 2767, 3139, 3252], 'had': [838], 'sequences': [842, 1043, 3081, 3085], 'replaced': [843, 1204], 'corresponding': [846, 1061, 2696, 2873, 2920, 2985, 3077, 3459, 4035], 'still': [850], 'require': [851], 'full': [854], '(6Venema': [856], 'R.C.': [857], 'Sayegh': [858], 'H.S.': [859], 'Kent': [860], 'J.D.': [861], 'Harrison': [862], 'D.G.': [863], '1996;': [867, 895, 1286, 1490, 1666, 2210, 2535, 2548], '271:': [868, 896], '6435-6440Abstract': [869], '(152)': [877], '7Ruan': [880], 'Q.': [883, 1271, 1999, 2195, 2543], 'Hutchinson': [884], 'N.': [885], 'Cho': [886], 'H.': [887], 'Wolfe': [888], 'G.C.': [889], '22679-22686Abstract': [897], '(90)': [905], 'Because': [908, 4164], 'enzyme': [911], 'systems': [912, 1233], 'Ca2+/CaM': [914, 968, 3105, 3913], 'typically': [915], 'involves': [916], 'intrinsic': [920], '(8Jarrett': [923], 'H.W.': [924], 'Madhavan': [925], 'R.': [926, 1315, 3364], '1991;': [930, 2065, 2668, 2737, 2860], '266:': [931], '362-371Abstract': [932], 'Scholar,9Brickey': [938], 'D.A.': [939], 'Bann': [940], 'J.G.': [941], 'Fong': [942], 'Y.L.': [943], 'Perrino': [944], 'L.': [945, 3618, 3680], 'Brennan': [946], 'R.G.': [947], 'Soderling': [948], 'T.R.': [949], '29047-29054Abstract': [955], 'Scholar),': [961, 2015, 2867, 3412, 4209], 'hypothesized': [963], 'may': [971, 3184], 'similarly': [972, 1899], 'trigger': [973], 'displacing': [976], 'element.': [979], 'identify': [982], 'multiple': [984], 'insertion': [987, 2974, 3102, 3108, 3239, 3488, 3540, 3841, 3884, 3920, 3932, 3988, 4107], 'serves': [989, 3448], 'NOS.': [1004, 1895, 2269], 'Molecular': [1005], 'module': [1011, 3130, 3385], 'synthase': [1015], 'done': [1018], 'using': [1019, 1142, 1197, 1684, 1708, 2016, 2335, 4027, 4284], 'Insight': [1021], 'Homology': [1023, 3427], 'programs': [1024], 'Biosym': [1026], '(BIOSYM/Molecular': [1027, 1146], 'Simulations,': [1028], 'San': [1029], 'Diego,': [1030], 'CA)': [1031, 2391], 'running': [1032], 'silicon': [1035], 'graphics': [1036], 'Indigo2': [1037], 'workstation.': [1038], 'After': [1039, 1105, 3276], 'alignment': [1040, 2881, 2947, 3056], 'homologous': [1045, 2716], 'proteins': [1048, 2520, 2724], 'known': [1050, 3061], 'structure': [1051, 1067, 1132, 1188, 3314, 3345, 3461, 3520, 3548], '(see': [1052], '"Results"),': [1053], 'region': [1056, 2994, 3078, 3203], '(SCR)': [1057], 'boxes': [1058, 1119], 'created': [1060], 'regions': [1064, 1069, 1076, 1115, 2695, 2797, 2838, 2896, 2963, 3046], 'secondary': [1066, 2909], 'involved': [1070, 2802, 2964], 'directly': [1071, 3643, 3860], 'binding.': [1074, 2967, 3959], 'These': [1075], 'characterized': [1078], 'positive': [1081, 3143], 'scores': [1082], 'evaluated': [1084, 2398, 4026], "Dayhoff's": [1086], 'mutation': [1087, 2925], 'matrix': [1088, 2926], '(10Dayhoff': [1089, 2928], 'M.O.': [1090, 2929], 'Hunt': [1091, 1093, 2930, 2932], 'W.C.': [1092, 1279, 2203, 2931], 'L.T.': [1094, 2933], 'Methods': [1095, 1488, 1664, 2546, 2934], 'Enzymol.': [1096, 1489, 1665, 2547, 2935], '1983;': [1097, 2936], '91:': [1098, 2937], '524-545Crossref': [1099, 2938], '(846)': [1102, 2941], 'assignment': [1106], 'coordinates': [1108], 'SCR': [1111, 1118], 'regions,': [1112], 'loop': [1114, 3516], 'between': [1116, 2600, 2682, 3115, 3161, 3711, 3912], 'modeled': [1121], 'searching': [1123], 'Brookhaven': [1125], 'protein': [1126, 2382], 'data': [1127], 'base.': [1128], 'crude': [1130], 'model': [1131, 3855, 3868, 3898], 'relaxed': [1134, 3268], 'sterically': [1137, 3271, 3876], 'energetically': [1139, 3273], 'reasonable': [1140, 1170, 3274], 'state': [1141], 'Discover': [1144], 'program': [1145], 'Simulations)': [1147], 'mechanics': [1150], 'dynamics': [1152], 'calculations.': [1153], 'includes': [1155], 'splice': [1156], 'repair': [1157, 1167], 'remove': [1159, 1181], 'unrealistic': [1160], 'structural': [1161, 1178, 2910, 3176, 3331], 'features': [1162], 'SCR-loop': [1164], 'junctions,': [1165], 'end': [1166, 3713, 3734], 'assign': [1169], 'structures': [1171, 3231], 'C-terminal': [1173, 2566, 2684], 'N-terminal': [1175, 2350, 2561, 3568, 3701], 'extensions,': [1176], 'optimization': [1179], 'steric': [1182, 3285, 3636, 3936], 'overlaps': [1183, 3286], 'reduce': [1186], 'energetic': [1191], 'minimum.': [1192], 'Energy': [1193], 'minimizations': [1194], 'begun': [1196], 'steepest': [1199], 'descent': [1200], 'method;': [1201], 'conjugate': [1206], 'gradient': [1207, 2305], 'method': [1208, 1687], 'convergence': [1210], 'approached.': [1212], 'Rat': [1213, 2434], 'bovine': [1218, 1969, 2083], '(eNOS)': [1221], 'purified': [1223, 2149, 2188, 4285], 'Escherichia': [1225], 'coli': [1226, 2191, 2456], 'harboring': [1227], 'pGroELS': [1228], 'pCW': [1230], 'vector': [1231], 'expression': [1232], 'nNOS': [1235, 2020, 2148, 2842, 3198, 3218, 3464, 4096, 4287], 'described': [1239, 1484, 1660, 1988], 'previously': [1240, 1485, 1989], '(11McMillan': [1241, 2155], 'K.': [1242, 1995, 2156, 2524, 2580], 'Bredt': [1243, 2157, 2652, 2844], 'D.S.': [1244, 2158, 2656, 2848], 'Hirsch': [1245, 2159], 'D.J.': [1246, 2160, 2612], 'Snyder': [1247, 2161, 2665, 2857], 'S.H.': [1248, 2162, 2666, 2858], 'Clark': [1249, 2163], 'J.E.': [1250, 2164], 'Masters': [1251, 1280, 2002, 2165, 2204, 2581, 3367], 'B.S.': [1252, 1281, 2003, 2166, 2205, 2522, 2582], 'Proc.': [1253, 2167, 2613, 2781, 3021], 'Natl.': [1254, 2168, 2614, 2782, 3022], 'Acad.': [1255, 2169, 2615, 2783, 3023], 'Sci.': [1256, 2170, 2616, 2736, 2784, 3024, 3603], 'U.': [1257, 2171, 2617, 2785, 3025], 'A.': [1259, 2060, 2173, 2619, 2787, 3027], '89:': [1261, 2175], '11141-11145Crossref': [1262, 2176], '(354)': [1265, 2179], '12Martasek': [1268], 'P.': [1269, 1993, 2193, 2532], 'Liu': [1270, 1272, 1998, 2194, 2196], 'Roman': [1274, 2198, 2529], 'Gross': [1276, 2000, 2200, 2544], 'S.S.': [1277, 1313, 1487, 1663, 2001, 2201, 2545], 'Sessa': [1278, 2202], 'Biophys.': [1283, 2005, 2207], 'Res.': [1284, 2006, 2208], 'Commun.': [1285, 2007, 2209], '219:': [1287, 2211], '359-365Crossref': [1288, 2212], '(142)': [1291, 2215], 'iNOS-rich': [1294, 1559, 1634], 'cytosol': [1295, 1635], 'prepared': [1297, 1624, 2356], 'rat': [1299, 1309, 1354, 1558, 1633], 'aortic': [1300], 'smooth': [1301], 'muscle': [1302], 'cells,': [1303], 'isolated': [1306], 'Fisher': [1308], 'thoracic': [1310], 'aortae': [1311], '(13Gross': [1312], 'Levi': [1314], '267:': [1320], '25722-25729Abstract': [1321], 'Scholar)': [1327, 2181, 2675, 3014], 'grown': [1329], '75-cm2': [1331], 'culture': [1332, 1344, 1398, 2438, 2442], 'flasks': [1333], 'passage': [1335], '10–15.': [1336], 'Cells': [1337], 'stimulated': [1339], '16': [1341], 'h': [1342], 'medium': [1345], 'containing': [1346, 1404, 1732, 1816, 2143], 'combination': [1348], 'lipopolysaccharide': [1350, 2454], '(30': [1351], 'μg/ml)': [1352], 'recombinant': [1355, 2147, 2186, 2435, 4286], 'interferon-γ': [1356], '(50': [1357], 'ng/ml),': [1358], 'washed': [1359, 1808], 'twice': [1360, 1809], '10': [1362, 1378, 1392, 1411, 1414, 1510, 1550, 1773, 1865, 1924, 2128, 2240, 2248], 'ml': [1363, 1379], 'ice-cold': [1365, 1401, 1814], 'phosphate-buffered': [1366, 1382], 'saline,': [1367], 'harvested': [1369], 'Teflon': [1372], 'cell': [1373, 2441], 'scraper': [1374], 'into': [1375, 2559], 'additional': [1377], 'iced': [1381], 'saline.': [1383], 'Cell': [1384], 'suspensions': [1385], 'centrifuged': [1387, 1441], '800': [1389], '×': [1390, 1444, 2294], 'gfor': [1391], 'min,': [1393, 2281], 'resuspended': [1394], '100': [1396, 1419, 1508, 1537, 1728, 1741, 1770, 1811, 1823, 1921, 2081, 2242], 'μl/75-cm2': [1397], 'flask': [1399], 'distilled': [1402], 'H2O': [1403], 'mixture': [1406, 1829], 'protease': [1408], 'inhibitors': [1409, 1878], '(pepstatin': [1410], 'μg/ml,': [1412, 1415], 'leupeptin': [1413], 'phenylmethylsulfonyl': [1417], 'fluoride': [1418], 'μm)': [1420, 1953], 'lysed': [1422], 'cycles': [1425], 'freezing': [1427], 'liquid': [1429, 1851, 2402], 'nitrogen': [1430], 'thawing': [1432], '37': [1435, 2046], '°C': [1436, 1455, 1468, 4319], 'water': [1437], 'bath.': [1438], 'Lysates': [1439], '100,000': [1443], 'g': [1445], '1': [1447, 1518, 1521, 1738, 1764, 1775, 1917, 1931, 2237, 2945], 'h,': [1448, 4249], 'supernatants': [1450], 'stored': [1452], '−70': [1454], 'use.': [1457], 'measured': [1461, 1573, 1600, 1618], '96-well': [1463, 1709, 1902, 1979, 2041], 'microtiter': [1464], 'plates': [1465, 1711, 1844, 1983], '25': [1467], 'kinetics': [1472], 'NADPH': [1474, 1497, 1561, 2701, 2751], 'consumption': [1475, 1498, 1562], 'oxidation': [1478, 1622, 1653], 'Fe2+-myoglobin': [1480, 1621, 1645], 'Fe3+-myoglobin,': [1482], '(14Gross': [1486, 1662], '268:': [1491, 1667, 2549], '159-168Crossref': [1492, 1668], 'For': [1496, 2349], 'measurements,': [1499], 'incubation': [1500, 1911, 4308], 'mixtures': [1501, 2074], 'contained': [1502, 1629, 1864, 2075, 2127, 4109], '50': [1503, 1733, 1760, 1817, 1926, 2076, 2183, 2232], 'mm': [1504, 1519, 1734, 1739, 1765, 1818, 1866, 1927, 1932, 2077, 2087, 2129, 2233, 2238, 2249], 'Tris-HCl': [1505], '(pH': [1506], '7.60),': [1507], 'μmCaCl2,': [1509, 2091], 'μm': [1511, 1514, 1522, 1742, 1771, 1824, 1922, 2243], 'tetrahydrobiopterin,': [1512, 2639], '500': [1513, 1516], 'NADPH,': [1515], 'μml-arginine,': [1517], 'pH': [1524, 1736, 1762, 1820, 1929, 2079, 2235], '7.6,': [1525, 1737, 1763, 1821, 1930, 2080, 2236], 'indicated': [1528, 1966, 2023, 4333], 'concentration': [1529, 1639, 1967], 'final': [1534, 1638], 'volume': [1535, 2230, 2291], 'μl.': [1538], 'Reactions': [1539, 2100], 'initiated': [1541, 2102, 2253], 'addition': [1544, 1963, 2105, 2256], '20': [1546, 2107, 2258, 2280], 'pmol': [1547, 1551, 1781, 1914, 2018, 2108, 2145, 2184, 2267, 4311], '15': [1555, 1630, 1793, 1939, 2225, 4315], 'μg': [1556, 1631], 'cytosol.': [1560], 'determined': [1564, 1859, 1886], 'rate': [1567, 1594, 1651, 2050], 'decrease': [1569], '340,': [1572], '15-s': [1575, 2122], 'intervals': [1576], 'period': [1579], '30': [1581], 'min': [1582, 1726, 1794, 1940, 2120, 2226, 4316], 'kinetic': [1585, 2042], 'microplate': [1586, 2043], 'spectrophotometer': [1587, 2044], '(Molecular': [1588], 'Devices;': [1589], 'Menlo': [1590], 'Park,': [1591], 'CA).': [1592], 'decline': [1596], '340': [1599], 'when': [1601], 'omitted': [1604], 'incubates': [1606, 2142], 'subtracted': [1608], 'all': [1610, 2411, 4131], 'values.': [1611], 'Samples': [1612, 1789, 2218, 2270], 'above,': [1626], 'but': [1627, 2365, 3044, 3086, 3468, 4124], 'additionally': [1628, 1863, 2126], '40': [1641, 2086, 2144], 'μmFe2+-myoglobin.': [1642], 'Preparation': [1643], 'spectrophotometric': [1647], 'measurement': [1648], 'its': [1650, 3974], 'Met-myoglobin': [1655], 'NO,': [1657], 'earlier': [1661], 'Calmodulin': [1672, 2595], 'labeled': [1674], '125I': [1676], '25–150': [1682], 'μCi/g,': [1683], 'Bolton-Hunter': [1686], '(15Bolton': [1688], 'A.E.': [1689], 'Hunter': [1690], 'W.M.': [1691], '1973;': [1694, 2788], '133:': [1695], '529-539Crossref': [1696], '(2392)': [1699], 'Scholar).125I-Calmodulin': [1701], 'assays': [1703], 'performed': [1705, 1977, 2140, 2324, 2376, 4283, 4306], 'triplicate': [1707, 4299, 4341], 'microfiltration': [1710, 1982], 'GFB': [1713], 'filter': [1714], 'bottoms': [1715], '(Millipore,': [1716, 1984], 'Bedford,': [1717, 1985], 'MA).': [1718, 2348], 'Before': [1719], 'use,': [1720], 'filters': [1721], 'preincubated': [1723, 2220], '1–2': [1725, 1780, 4310], 'μl': [1729, 1812], 'buffer': [1731, 1748, 1815], 'Tris-HCl,': [1735, 1819, 1928, 2078], 'CaCl2,': [1743, 1772, 1923, 2244], '0.5': [1745, 1767, 1935], 'mg/ml': [1746, 1768, 1936], 'β-lactoglobulin;': [1747], 'then': [1750, 2366], 'removed': [1751], 'vacuum': [1753, 1804], 'filtration.': [1754, 1805], 'Binding': [1755, 4301], 'reactions': [1756], 'comprised': [1758], 'of:': [1759], 'mmTris-HCl,': [1761], 'β-lactoglobulin,': [1769], 'μmtetrahydrobiopterin,': [1774, 1925], 'nm125I-CaM': [1776], '(2500–5000': [1777], 'cpm)': [1778], '100-μl': [1786, 2097, 2229], 'total': [1787, 2098], 'volume.': [1788, 2099], 'incubated': [1791], '23': [1796, 4318], '°C,': [1797, 2047], 'quickly': [1801], 'terminated': [1802, 2285], 'Filters': [1806], 'CaCl2': [1825], 'air-dried.': [1827], 'Scintillation': [1828], 'added': [1831, 1955], 'each': [1833, 2868, 2898, 3733], 'well': [1834], '(25': [1835, 2271], 'μl;': [1836], 'OptiPhase': [1837], 'SuperMix,': [1838], 'Wallac': [1839], 'Inc.,': [1840, 2346], 'Gaithersburg,': [1841], 'MD),': [1842], 'counted': [1846], 'Microbeta': [1849], 'Plus': [1850], 'scintillation': [1852], 'counter': [1853], '(Wallac': [1854], 'Inc.).': [1855], 'Nonspecific': [1856], 'samples': [1861], 'EGTA.': [1867, 2250], 'inhibitory': [1874, 3952, 3963, 4101], 'on125I-CaM': [1879], 'blank': [1883], 'presence': [1889, 3917], 'absence': [1893], 'Dissociation': [1896], 'of125I-CaM': [1897], 'monitored': [1900, 2038, 2114], 'filtration': [1903], 'plates.': [1904], '125I-CaM·nNOS': [1905], 'complexes': [1906], 'produced': [1909], '2': [1913, 2293, 3309, 3454, 3654, 3807], 'nm': [1918, 2082], '125I-CaM,': [1920], 'β-lactoglobulin': [1937], '(23': [1941], '°C).': [1942], 'To': [1943], 'initate': [1944], 'dissociation,': [1945], '3000-fold': [1947], 'excess': [1948, 3141], 'unlabeled': [1950], '(3': [1952], 'time': [1957, 2340], '0,': [1958, 2276], 'without': [1961, 2247, 4126, 4213], 'simultaneous': [1962], 'eNOS607–634.': [1970, 4145], 'Assays': [1971], 'polyvinylidene': [1980, 2369], 'difluoride': [1981, 2370], 'MA)': [1986], '(16Nishimura': [1990], 'J.S.': [1991, 2528], 'Martasek': [1992, 2531], 'McMillan': [1994, 2523, 2579], 'Salerno': [1996], '1995;': [2008, 3028], '210:': [2009], '288-294Crossref': [2010], '(52)': [2013], '5': [2017], 'concentrations': [2024, 4081], 'NOS-derived': [2026], 'peptides.': [2027, 4334], 'Activity': [2028], 'phosphatase': [2032, 2035], 'calcineurin': [2033], '(protein': [2034], '2B)': [2036], 'hydrolysis': [2052], 'artificial': [2055], 'substrate': [2056, 2635], 'p-nitrophenyl': [2057, 2088], 'phosphate': [2058], '(17Takai': [2059], 'Mieskes': [2061], 'G.': [2062], '275:': [2066], '233-239Crossref': [2067], '(159)': [2070], 'Incubation': [2073], 'brain': [2084], 'phosphate,': [2089], '400': [2090], '0.1%': [2093], '2-mercaptoethanol': [2094], 'calcineurin,': [2110], 'continually': [2115], 'atA': [2116], '405': [2117], '60': [2119], 'intervals.': [2123], 'Assay': [2124], 'blanks': [2125], 'EGTA,': [2130], 'resulting': [2131, 2429], '>90%': [2133], 'stably': [2151], 'transfected': [2152], 'HEK-293': [2153], 'E.': [2190, 3626, 3688], '(12Martasek': [2192], 'room': [2222], 'temperature': [2223], 'containing:': [2231], 'Tris,': [2234], 'μmCaM,': [2241], 'Proteolysis': [2251], 'microunits': [2259], 'l-1-tosylamido-2-phenylethyl': [2261], 'chloromethyl': [2262, 2461], 'ketone-immobilized': [2263, 2462], 'trypsin': [2264, 2463], '(Sigma)': [2265], 'per': [2266], 'μl)': [2272], 'collected': [2274], 'after': [2275, 4183, 4307], '5,': [2277], '10,': [2278], 'boiling': [2287, 4184], 'equal': [2290], 'SDS': [2295], 'gel-loading': [2296], 'buffer.': [2297], 'Peptide': [2298], 'products': [2299, 2423], 'resolved': [2301], '8–16%': [2304], 'SDS-polyacrylamide': [2306, 2362], 'gel': [2307, 2363], 'electrophoresis': [2308], 'visualized': [2310], 'staining': [2312], 'Coomassie': [2314], 'Blue.': [2315], 'Accurate': [2316], 'mass': [2318, 2326, 2405, 3828], 'determination': [2319], 'tryptic': [2321, 2353], 'fragments': [2322, 4069, 4087, 4272], 'spectrometry': [2327], 'Rockefeller': [2330], 'University': [2331, 3374], 'Protein/DNA': [2332], 'Biotechnology': [2333], 'Center,': [2334], 'matrix-assisted': [2336], 'laser': [2337], 'desorption': [2338], 'flight': [2342], 'detection': [2343], '(Perseptive': [2344], 'Biosystems': [2345, 2380], 'Framingham,': [2347], 'analysis,': [2352], 'digests': [2354], 'above': [2358, 3699, 3771], 'subject': [2360], 'electrophoresis,': [2364], 'electrotransfered': [2367], 'membranes.': [2371], 'Amino': [2372], 'sequencing': [2374], 'Applied': [2379], '477A': [2381], 'sequencer.': [2383], 'obtained': [2387, 2465, 4141], 'SynPep': [2389], '(Dublin,': [2390], 'commercial': [2394], 'suppliers.': [2395], 'Purity': [2396], 'performance': [2401], 'chromatography': [2403], 'spectroscopy': [2406], 'exceeded': [2408], '80%': [2409], 'cases': [2412], 'typical': [2414], 'purity': [2415], '≈90%.': [2416], 'Predominant': [2417], 'impurities': [2418], 'differed': [2419], 'desired': [2422], 'one': [2425, 2833, 3425, 3890, 4160], 'residue,': [2428], 'incompletely': [2431], 'coupled': [2432], 'synthesis.': [2433], 'interferon-γ,': [2436], 'RPMI': [2437], 'medium,': [2439], 'reagents': [2443], 'Life': [2446], 'Technologies,': [2447], 'Inc.': [2448], 'Radioisotopes': [2449], 'Dupont': [2452], 'NEN,': [2453], '(E.': [2455], 'serotype': [2457], '0111:B4),': [2458], 'chemicals,': [2459], 'andl-1-tosylamido-2-phenylethyl': [2460], 'Sigma,': [2467], 'Calbiochem,': [2471], 'tetrahydrobiopterin': [2473], 'Schirks': [2476], 'Laboratories': [2477], '(Jona,': [2478], 'Switzerland).': [2479], 'Enzymes': [2480], 'purchased': [2482], 'Pharmacia': [2484], 'LKB': [2485], 'Biotechnology,': [2486], 'Promega,': [2487], 'New': [2489], 'England': [2490], 'Biolabs.': [2491], 'large': [2496], 'multidomain': [2497], 'series': [2502, 4029], 'gene': [2504], 'fusion': [2505], 'events': [2506], 'resulted': [2508], 'incorporation': [2511], 'modules': [2513, 2706, 3337], 'showing': [2514], 'significant': [2515, 4138], 'homology': [2516, 2681, 2917, 3049, 3159, 3388], 'smaller': [2518], 'ancestral': [2519], '(18Masters': [2521], 'Sheta': [2525], 'Nishimura': [2527], 'FASEB': [2533], '10:': [2536], '552-558Crossref': [2537], '(194)': [2540], 'Scholar,19Liu': [2542], '311-324Crossref': [2550], 'NOSs': [2554], 'can': [2555, 3476, 3885], 'coarsely': [2557], 'dissected': [2558], 'oxygenase': [2562, 2629], 'reductase': [2567, 2602, 2642, 2691, 2760], 'domain,': [2568], 'bridged': [2569], 'canonical': [2572], '(20Sheta': [2577], '15147-15153Abstract': [2588], 'initiates': [2597], 'transfer': [2599], 'catalytic': [2604], 'domains,': [2605], 'thereby': [2606], 'activating': [2607], 'catalysis': [2608], '(21Abu-Soud': [2609], 'H.M.': [2610], 'Stuehr': [2611], '1993;': [2620, 3628, 3690], '90:': [2621], '10769-10772Crossref': [2622], '(394)': [2625], 'sites': [2633, 2646, 3991, 4039], '(arginine),': [2636], 'heme,': [2637], 'whereas': [2640], 'FAD,': [2648, 2699], 'FMN,': [2649, 2698], 'NADPH.': [2651], 'et': [2653, 2845, 3675], 'al.': [2654, 2846, 3676], '(22Bredt': [2655, 2847], 'Hwang': [2657, 2849], 'P.M.': [2658, 2850], 'Glatt': [2659, 2851], 'C.E.': [2660, 2852], 'Lowenstein': [2661, 2853], 'Reed': [2663, 2855], 'R.R.': [2664, 2856], 'Nature.': [2667, 2859, 3404], '351:': [2669, 2861], '714-718Crossref': [2670, 2862], '(2165)': [2673, 2865], 'reveal': [2679], 'half': [2685], 'NADPH-cytochrome': [2689, 3347], '(CPR),': [2692], 'noting': [2693], 'domains.': [2703], 'FMN-binding': [2705, 2723, 3384, 3837, 3849], 'CPR': [2711, 3318], 'turn': [2714], 'highly': [2715], 'flavodoxins,': [2719], 'small': [2722], 'function': [2726], 'carriers': [2729], 'bacteria': [2731], '(23Porter': [2732], 'Trends': [2734, 3601], '16:': [2738], '154-158Abstract': [2739], '(116)': [2745], 'FAD': [2749], 'closely': [2755, 3082], 'chloroplast': [2758], 'ferredoxin-NADP+': [2759], 'proteins.': [2764], 'Five': [2765], 'flavodoxins': [2766, 2800, 2890, 2923, 3062, 3233], 'crystallized': [2769], 'solved': [2771, 3228, 3330, 3545], 'x-ray': [2773, 3229], 'diffraction': [2774], '(24Watenpaugh': [2775], 'K.D.': [2776], 'Sieker': [2777], 'L.C.': [2778], 'Jensen': [2779], 'L.H.': [2780], '70:': [2789], '3857-3860Crossref': [2790], '(176)': [2793], 'Three': [2796], 'these': [2799, 2812, 2835, 2895, 3036, 3279, 4152], 'prosthetic': [2807], 'group;': [2808], 'close': [2814], 'N': [2817, 3168], 'terminus,': [2818], 'proceeded': [2822], 'initial': [2825, 3725], 'β': [2826, 3515], 'strand': [2827, 3702, 3726], 'structure.': [2830], 'Although': [2831, 3839], 'only': [2832, 3069], 'them': [2870], 'homolog': [2874, 3332], 'NOSs.': [2876], 'step': [2879], 'identification': [2893, 2906], 'isoform.': [2900], 'followed': [2903], 'elements': [2911, 2921], 'primarily': [2914], 'criteria': [2927], 'Fig.': [2944, 3308, 3453, 3483, 3578, 3653, 3806], 'shows': [2946, 3457], 'select': [2950], 'set': [2951], 'bacterial': [2956], 'flavodoxin': [2957, 3084, 3302], 'sequences,': [2958, 3121], 'illustrating': [2959], 'conservation': [2961, 3213], 'It': [2968, 3170, 3822, 3960], 'obvious': [2970], 'major': [2973], '≈45': [2976], 'acids': [2978], 'occurred': [2980], 'also': [2988, 3172, 3870], 'cloned': [2997], 'invertebrate': [2998], 'Rhodnius': [3001], 'prolixus': [3002], '(25.TM': [3003], 'accession': [3004, 3011], 'no.,': [3005, 3012], 'U59389,': [3006], 'Yuda,': [3007], 'M.': [3008, 3018, 3360], '(1996)': [3009], 'GenBankTM': [3010], 'U59389.Google': [3013], 'andDrosophila': [3015], 'melanogaster': [3016], '(26Regulski': [3017], 'Tully': [3019], 'T.': [3020, 3366, 3616, 3624, 3678, 3686], '92:': [3029], '9072-9076Crossref': [3030], '(215)': [3033], 'Scholar);': [3035, 3635], 'inserts': [3037], 'somewhat': [3039], 'larger': [3040, 3833], '(54–63': [3041], 'acids),': [3043], 'marked': [3048], 'inserts.': [3053], 'Expanding': [3054], 'include': [3058], 'dozens': [3059], 'FMN-containing': [3065], 'flavoproteins': [3066], 'reveals': [3067], 'exhibit': [3071], 'such': [3072, 4040], 'insertion.': [3074], 'Moreover,': [3075], 'resemble': [3083], 'lack': [3087, 3543, 3975], 'anywhere': [3090], 'within': [3091, 4159], 'domain.': [3095, 3649, 3706, 3753], 'Therefore,': [3096], 'occurrence': [3097], 'correlates': [3103], 'control.': [3106], 'represents': [3109], 'single': [3111], 'most': [3112, 4099], 'prominent': [3113], 'difference': [3114], 'considered': [3122], 'over': [3123], 'entire': [3125, 3527, 3836], 'length.': [3126], 'insertions': [3131, 3219, 4091], 'notably': [3133], 'rich': [3134], 'charged': [3136, 3191], 'residues': [3137, 3192, 3432, 3710, 3731, 3757], 'charge.': [3144], 'especially': [3147], 'true': [3148], 'isoform,': [3152], 'contains': [3154], 'motif': [3156, 3397, 4044, 4112], 'RRKRK.': [3157], 'Considerable': [3158], 'exists': [3160], 'insertions,': [3164], 'particularly': [3165], 'toward': [3166], 'termini.': [3169], 'apparent': [3173], 'some': [3175], 'reorganization': [3177], 'taken': [3179], 'place': [3180], 'during': [3181], 'evolution,': [3182], 'allow': [3185], 'positively': [3190], '(depending': [3193], 'species)': [3195], 'equivalent': [3199], 'RRKRK': [3202, 4043, 4111], 'recognize': [3205], 'similar': [3207, 3467], 'pattern': [3211], 'suggests': [3214], 'least': [3222], 'motifs.': [3224], 'availability': [3226], 'crystal': [3230, 3303, 3344], 'allows': [3234], 'us': [3235], 'position': [3237, 3556, 3770, 3788], 'dimensions': [3242, 3853], 'relative': [3243, 3555, 3791], 'Homology-based': [3249], 'models': [3251, 3656], 'constructed': [3254], 'cNOSs,': [3261], 'state.': [3275], 'relaxation': [3277], 'models,': [3283], 'no': [3284], 'present,': [3288], 'energies': [3290], 'approximately': [3292], '−300': [3293], 'kcal,': [3294], 'comparable': [3295], 'lower': [3297, 3820], 'reference': [3301], 'structures.': [3304], 'As': [3305], 'shown': [3306, 3481, 3549, 4060], '(upper': [3310, 3455], 'left),': [3311, 3485], 'backbone': [3313, 3324, 3460, 3475], 'virtually': [3320], 'superimposable': [3321], 'Desulfovibrio': [3326], 'vulgarisflavodoxin,': [3327], 'closest': [3329], '2Recently,': [3342], 'oxidoreductase': [3349], 'reported': [3352], '3.0': [3354], 'Å': [3355], 'resolution': [3356], '(27Kim': [3357], 'J.-J.': [3358], 'Wang': [3359], 'Roberts': [3361], 'D.L.': [3362], 'Paschke': [3363], 'Shea': [3365], 'B.S.S.': [3368], 'Stevenson': [3369], 'K.J.': [3370], 'Flavins': [3371], 'Flavoproteins.': [3373], 'Calgary': [3376], 'Press,': [3377], 'Calgary,': [3378], 'Alberta,': [3379], 'Canada1996:': [3380], '455-462Google': [3381], 'bears': [3386], 'striking': [3387], 'toD.': [3389], 'vulgaris': [3390], 'flavodoxin.': [3391], 'structure,': [3393], 'Rossmann': [3395], 'fold': [3396], '(28Rossmann': [3398], 'M.G.': [3399], 'Moras': [3400], 'D.': [3401], 'Olsen': [3402], 'K.W.': [3403], '1974;': [3405], '250:': [3406], '194-199Crossref': [3407], '(1163)': [3410], 'five': [3415], 'stranded': [3416], 'parallel': [3417], 'β-sheet': [3418, 3773], 'along': [3424], 'edge.': [3426], 'predicts': [3428, 3856, 3869], 'aromatic': [3431], 'murine': [3434], 'Phe587': [3436], 'Tyr625,': [3438], 'contact': [3441], 'ring': [3445], 'system;': [3446], 'Tyr625': [3447], 'shielding': [3451], 'residue.': [3452], 'right)': [3456], 'eNOS;': [3463], 'extremely': [3466], 'shown.': [3470], 'Most': [3471], 'superimposed': [3478], 'homologs': [3480], '2(upper': [3484], 'projecting': [3489], 'upper': [3492, 3580], 'edge': [3493, 3569], 'sheet': [3496], 'opposite': [3497], 'Structurally,': [3502], 'it': [3503, 3640, 3857], 'corresponds': [3504], 'replacement': [3507], 'tight': [3510], '5–10': [3511], 'residue': [3512], 'α': [3513], '→': [3514], '≈50-residue': [3519], 'about': [3521, 3767, 3802], 'one-third': [3522], 'size': [3524], 'module.': [3530, 3838], 'We': [3531], 'unable': [3533], 'propose': [3535], 'because': [3541], 'homolog;': [3546], 'merely': [3551], 'intended': [3552], 'convey': [3554], 'size.': [3558], '(painted': [3575], 'white': [3576], '2,': [3579], 'left).': [3581], 'With': [3582], 'bound,': [3584], 'recognition': [3587, 3717, 3785, 4038], 'would': [3589, 3874, 3939], 'predictably': [3590], 'helical': [3594], "(29O'Neil": [3596], 'K.T.': [3597], 'De': [3598], 'Grado': [3599], 'W.F.': [3600], '15:': [3605], '59-64Abstract': [3606], '(712)': [3612], '30Vorherr': [3615], 'Knopfel': [3617, 3679], 'Hofmann': [3619, 3681], 'F.': [3620, 3682], 'Mollner': [3621, 3683], 'Pfeuffer': [3623, 3685], 'Carafoli': [3625, 3687], 'Biochemistry.': [3627, 3689], '32:': [3629, 3691], '6081-6088Crossref': [3630, 3692], '(139)': [3633, 3695], 'constraints': [3637], 'extends': [3641], 'almost': [3642], 'away': [3644], 'Thelower': [3650], 'panels': [3651], '(left)': [3664], '(right)': [3667], '(yellow': [3670], 'ribbon;': [3671], 'Vorherr': [3674], '(30Vorherr': [3677], 'Scholar))': [3697], 'positioned': [3698], 'There': [3707], '7–8': [3709], 'CAM': [3716], 'proper': [3719], 'start': [3722], 'β-sheet;': [3729], '2–3': [3730, 3756], 'short': [3737], 'linker': [3738], 'needed': [3740], 'clear': [3742], 'van': [3744], 'der': [3745], 'Waals': [3746], 'surfaces': [3747], 'leaves': [3755], 'conformationally': [3760], 'unrestricted,': [3761], 'and,': [3762], 'hence,': [3763], 'there': [3764], 'uncertainties': [3766], 'exact': [3769], 'orientation': [3778], 'axis': [3781, 3804, 3814], 'unspecified': [3797], 'respect': [3799], 'rotations': [3801], 'available': [3809], 'information': [3810], '(corresponding': [3811], 'CaM-binding': [3817], 'helix': [3818], 'panels).': [3821], 'notable': [3824], 'calmodulins': [3826], '(molecular': [3827], '≈': [3829], '17': [3830], 'kDa)': [3831], 'midway': [3843], 'module,': [3850], 'hindered': [3877], 'insertion,': [3880], 'suggesting': [3881], 'exist': [3886], 'more': [3888], 'physiologically': [3891], 'relevant': [3892], 'conformation.': [3893], 'Two': [3894], 'aspects': [3895], 'functions': [3904], '1)': [3909], 'correlation': [3911], '2)': [3922], 'proximity': [3924], 'probable': [3935], 'interactions': [3937], 'ensue.': [3940], 'An': [3941], 'attractive': [3942], 'potential': [3943], 'role': [3944], 'displaced': [3956], 'differs': [3961], 'polypeptides': [3964, 4102, 4120, 4228], 'common': [3965], 'CaM-dependent': [3968], 'enzymes,': [3969], 'itself,': [3972], 'acidic': [3977], 'hydrophobic': [3979], 'acids;': [3981], 'makes': [3983], 'direct': [3984], 'unlikely.': [3995], 'Nonetheless,': [3996], 'conceivably': [3999], 'displace': [4000], 'neighboring': [4006], 'overlap': [4011], 'allosteric': [4014], 'effects.': [4015], 'Functional': [4016], 'significance': [4017], 'putative': [4020], 'synthetic': [4031], 'fragments.': [4033], 'Polypeptides': [4034], 'promising': [4037], 'synthesized': [4050], 'lengths': [4052], 'ranging': [4053], '6': [4055], '33': [4057], 'residues,': [4058], 'Table': [4062, 4261], 'I.': [4063], 'Both': [4064], 'eNOS-': [4065], 'nNOS-derived': [4067, 4119], 'evaluated;': [4071], 'effects': [4072, 4243], 'summarized': [4077], 'TableII.': [4079], 'At': [4080], '50–100': [4083], 'μm,': [4084], 'several': [4085], 'profoundly': [4092], 'inhibited': [4093, 4122], 'effective': [4100], '(Table': [4113], 'II': [4114], 'Fig.3': [4116], 'A).': [4117], 'Human': [4118], 'weakly': [4121], 'nNOS.': [4129], 'While': [4130], 'less': [4134], 'potent': [4135], 'eNOS601–633': [4143], 'Notably,': [4146], 'rapid': [4155], 'apparently': [4157], 'complete': [4158], 'minute': [4161], 'addition.': [4163], 'very': [4167], 'tightly': [4168], 'bound': [4169], 'slow': [4176], 'off-rate,': [4177], 'little': [4179], 'dissociation': [4180], 'occurring': [4181], 'probably': [4211], 'occurs': [4212], 'displacement.Table': [4215], 'IPeptide': [4216], 'derivation': [4217, 4226], 'compositionDesignationDerivation1-ah,': [4219], 'human;': [4220, 4250], 'b,': [4221, 4251], 'bovine,': [4222, 4252], 'r,': [4223, 4253], 'rat.SequenceeNOS628–633bWRRKRKeNOS626–636bSSWRRKRKESSnNOS835–845hQEERKSYKVRFeNOS604–615hRPEQHKSYKIRFeNOS601–633bSSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKeNOS607–634bQHKSYKIRFNSVSCSDPLVSSWRRKRKEnNOS851–864rSDSRKSSGDGPDLRnNOS835–864hQEERKSYKVRFNSVSSYSDSQKSSGDGPDLSequence': [4224], 'excerpted': [4229], 'tested': [4241], 'binding.1-a': [4248], 'rat.': [4254], 'Open': [4255], 'table': [4256], 'new': [4259], 'tab': [4260], 'IIThe': [4262], 'cNOSs:': [4268], 'ligand': [4277], 'bindingPeptideNOS': [4278], 'activity2-aNOS': [4279], 'measurements': [4281], 'native': [4291], 'iNOS.': [4292], 'Values': [4293, 4335], 'means': [4295, 4337], '±': [4296, 4338, 4347, 4349, 4351, 4353, 4355, 4358, 4360, 4362, 4364, 4366, 4369, 4371, 4373, 4375], 'S.E.': [4297, 4339], 'determinations.Ligand': [4300], 'nNOS2-bRadioligand': [4303], 'either': [4321], '125I-calmodulin': [4322], '(1': [4323], 'nm)': [4324], '(NNA)': [4328], '(200': [4329], 'pm)': [4330], 'determinations.nNOSeNOSiNOS[3H]-NNA125I-CaMμg/ml': [4342], '(μm)%': [4343], 'controleNOS628–633100': [4345], '(107.0)11.0': [4346], '3.324.0': [4348], '2.891.1': [4350], '5.791.7': [4352], '5.16.7': [4354], '3.6eNOS626–636100': [4356], '(71.2)19.1': [4357], '0.927.7': [4359], '2.092.1': [4361], '1.3120.7': [4363], '12.70.0': [4365], '0.5nNOS835–845100': [4367], '(68.1)102.0': [4368], '2.193.6': [4370], '2.3101.1': [4372], '3.7118.9': [4374], '4.': [4376]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2091040535', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-16T10:13:52.194742', 'created_date': '2016-06-24'}