Title: Vitamin D3 metabolism in a pig strain with pseudo vitamin D-deficiency rickets, type I
Abstract: Abstract. Vitamin D metabolism was studied in the 'Hannover Pig', a strain which suffers from pseudo vitamin D-deficiency rickets, type I. Animals of this strain are known to be devoid of renal 25-hydroxyvitamin D 3 -1α-hydroxylase and -24-hydroxylase activities. Pigs with florid rickets and hypocalcaemia were treated with single im injections of 0.25 to 1.25 mg of vitamin D 3 , doses that have been shown in previous studies to be effective in producing transient healing of rachitic symptoms. The levels of vitamin D 3 and its most relevant physiological metabolites in plasma were estimated at intervals before and after this vitamin D 3 treatment. Vitamin D 3 rose from 14.8 ± 8.1 to 364 ± 190 nmol/l (mean ± sd ) 2 to 3 days post injectionem, 25-hydroxyvitamin D 3 from 131.0 ± 46.2 to 1068 ± 160 nmol/l within 7 days post injectionem. The 1α,25-dihydroxyvitamin D 3 concentration in plasma was elevated from 73.9 ± 25.0 to 281 ± 168 pmol/l 2 to 3 days post injectionem and declined continually from that time. 24R,25-dihydroxyvitamin D 3 and 25S,26-dihydroxyvitamin D 3 levels after treatment showed different responses in different animals being either elevated or unchanged. Clinical healing of the pigs with these doses of vitamin D 3 was attributed to the transient rise of 1α,25-dihydroxyvitamin D 3 in plasma. It was assumed that 1α,25-dihydroxyvitamin D 3 synthesis takes place under these circumstances in extrarenal tissues.
Publication Year: 1987
Publication Date: 1987-07-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 19
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