Publication Information

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'formation': [9, 202, 1398, 1846, 1881, 3359, 3383, 3567, 3613, 3676, 4808], 'of': [10, 16, 32, 43, 54, 64, 71, 82, 96, 108, 120, 128, 140, 149, 175, 184, 189, 203, 209, 225, 236, 247, 257, 264, 275, 289, 301, 313, 321, 333, 342, 368, 377, 382, 403, 466, 477, 509, 535, 610, 676, 710, 726, 816, 972, 989, 1066, 1075, 1082, 1092, 1102, 1220, 1232, 1242, 1334, 1341, 1347, 1356, 1358, 1388, 1399, 1408, 1412, 1505, 1520, 1537, 1627, 1638, 1644, 1667, 1673, 1703, 1706, 1715, 1772, 1778, 1792, 1804, 1816, 1831, 1835, 1844, 1865, 1879, 1895, 1920, 1948, 1958, 1971, 1973, 1980, 2004, 2031, 2052, 2060, 2077, 2083, 2085, 2090, 2097, 2099, 2104, 2109, 2122, 2149, 2167, 2190, 2204, 2212, 2231, 2251, 2262, 2354, 2379, 2471, 2486, 2743, 2750, 2758, 2768, 2791, 2800, 2805, 2834, 2853, 2859, 2866, 2874, 2884, 2903, 2908, 2925, 2929, 2940, 2942, 2952, 2960, 2962, 2976, 2998, 3005, 3013, 3021, 3033, 3042, 3054, 3071, 3075, 3089, 3096, 3110, 3125, 3151, 3158, 3165, 3170, 3178, 3180, 3188, 3223, 3234, 3239, 3244, 3252, 3259, 3266, 3272, 3280, 3309, 3358, 3360, 3367, 3382, 3384, 3391, 3493, 3506, 3530, 3561, 3568, 3603, 3614, 3625, 3627, 3653, 3660, 3675, 3677, 3703, 3715, 3719, 3724, 3751, 3762, 3786, 3796, 3825, 3863, 3889, 3908, 3913, 4062, 4066, 4078, 4166, 4186, 4194, 4204, 4220, 4233, 4263, 4267, 4287, 4300, 4310, 4320, 4326, 4334, 4338, 4351, 4363, 4370, 4379, 4390, 4424, 4470, 4474, 4486, 4503, 4513, 4519, 4545, 4580, 4589, 4626, 4651, 4654, 4663, 4670, 4675, 4682, 4701, 4721, 4767, 4800, 4809, 4823, 4830, 4866, 4868, 4877, 4888, 4897, 4908], 'carbamoyl': [11, 204, 391, 1400, 1413], '2': [14, 207, 2224, 3333, 3348], 'mol': [15, 208], 'ATP,': [17, 210, 1868, 1944, 1959, 3926, 3936, 3996, 3998], 'bicarbonate,': [18, 211, 1403, 3606], 'and': [19, 34, 56, 122, 162, 212, 227, 249, 315, 355, 408, 474, 506, 514, 525, 547, 624, 669, 717, 728, 898, 1190, 1227, 1331, 1349, 1405, 1438, 1500, 1617, 1636, 1653, 1708, 1750, 1754, 1807, 1813, 1849, 1874, 1945, 1951, 1976, 2015, 2042, 2094, 2113, 2137, 2157, 2268, 2291, 2295, 2335, 2367, 2441, 2476, 2512, 2620, 2659, 2698, 2727, 2779, 2856, 2955, 2980, 3100, 3192, 3202, 3289, 3305, 3467, 3488, 3605, 3655, 3726, 3733, 3753, 3789, 3900, 3918, 4070, 4249, 4276, 4302, 4308, 4348, 4392, 4434, 4456, 4497, 4499, 4515, 4536, 4572, 4593, 4686, 4693, 4704, 4778, 4790, 4857, 4863], 'glutamine.': [20, 213, 1779, 1817], 'CPS': [21, 65, 97, 129, 214, 258, 290, 322, 1148, 1170, 1225, 1387, 1707, 1981, 2091, 2105, 2232, 2240, 2475, 2751, 2806, 2909, 2930, 2943, 3022, 3034, 3090, 3166, 3224, 3326, 3341, 3531, 3564, 3704, 3720, 3763, 4063, 4167, 4234, 4431, 4676, 4789, 4833, 4898], 'was': [22, 47, 66, 75, 160, 166, 177, 215, 240, 259, 268, 353, 359, 370, 412, 1725, 1746, 1766, 1785, 1821, 1853, 1882, 1963, 1984, 2038, 2047, 2154, 2162, 2235, 2243, 2273, 2280, 2382, 2478, 2777, 2816, 2830, 2878, 2910, 2933, 2946, 2967, 3002, 3058, 3077, 3114, 3130, 3200, 3208, 3227, 3285, 3362, 3386, 3521, 4772, 4793, 4815], 'inactivated': [23, 216, 3286, 4910], 'by': [24, 68, 79, 93, 168, 217, 261, 272, 286, 361, 415, 1100, 1230, 1325, 1338, 1361, 1429, 1891, 1982, 1986, 2049, 2092, 2164, 2480, 2807, 2887, 2931, 2944, 3007, 3023, 3035, 3091, 3225, 3229, 3287, 3563, 3705, 3799, 3828, 4387, 4714, 4899], 'glutamine': [26, 83, 155, 219, 276, 348, 404, 712, 727, 810, 818, 974, 990, 1538, 1605, 1628, 1962, 2754, 2844, 3401, 3406, 3498, 3546, 3562, 3661, 3771, 3787, 4364, 4381, 4435, 4457, 4475, 4514, 4568, 4642], 'analog,': [27, 220], 'acivicin.': [28, 99, 221, 292, 3024, 3706, 3800, 4526], 'In': [29, 51, 222, 244, 1696, 2173, 2237, 2872, 3517, 3600, 3859], 'presence': [31, 224, 1340, 2108, 2951, 2975, 3095, 3187], 'ATP': [33, 55, 121, 226, 248, 314, 1348, 1848, 2112, 2860, 2954, 2979, 3076, 3099, 3191, 3368, 3392, 3604, 3654, 3725, 3732, 3752], 'bicarbonate': [35, 57, 123, 228, 250, 316, 1850, 2116, 2956, 3195, 3656, 3727, 3734, 3757], 'second-order': [37, 59, 230, 252, 2071, 2218, 2897, 2920, 2991, 3015, 3049, 3066, 3105, 3119, 3205, 3608, 3709, 3739], 'rate': [38, 60, 231, 253, 1333, 1355, 1843, 1878, 1970, 2044, 2063, 2072, 2082, 2096, 2159, 2188, 2207, 2219, 2789, 2849, 2898, 2921, 2939, 2959, 2992, 3016, 3028, 3050, 3067, 3084, 3106, 3120, 3150, 3177, 3206, 3357, 3381, 3609, 3624, 3659, 3669, 3674, 3710, 3740, 3785, 3795, 3892, 4077, 4207], 'constant': [39, 61, 232, 254, 2045, 2160, 2189, 2220, 2790, 2899, 2922, 2993, 3051, 3068, 3107, 3121, 3207, 3610, 3711, 3741], 'for': [40, 62, 154, 233, 255, 347, 1517, 1604, 1640, 1664, 1827, 2028, 2074, 2130, 2146, 2221, 2228, 2540, 2571, 2585, 2797, 2843, 2851, 2900, 2923, 3018, 3030, 3052, 3069, 3086, 3108, 3122, 3220, 3295, 3301, 3319, 3611, 3700, 3712, 3823, 3894, 4176, 4384, 4548, 4559, 4583, 4667, 4853, 4894], 'inactivation': [42, 63, 78, 235, 256, 271, 1099, 1335, 1357, 1705, 1972, 2076, 2084, 2121, 2230, 2799, 2828, 2852, 2902, 2924, 2941, 2961, 3032, 3053, 3070, 3088, 3109, 3222, 3551, 3714, 3824, 3862, 3891, 3912, 4896], 'glutamine-dependent': [45, 238, 1218, 1956, 1977, 2087, 2124, 2741, 2802, 2857, 2905, 2964, 3073, 3528, 3717, 4068], 'activities': [46, 90, 239, 283, 709, 1219, 1322, 1979, 2742, 3308, 3529, 3539, 3718, 4069], '4.0': [48, 241, 2968], '×': [49, 242, 2569, 2582, 2611, 2689, 2971, 3214, 3746, 3928, 3932, 3938, 3942, 3953, 3957, 3962, 3966, 3976, 3980, 3985, 3989, 4000, 4004], '104m−1s−1.': [50, 243], 'absence': [53, 246, 2997, 3602, 3723], 'reduced': [67, 260, 1829, 2535], 'a': [69, 133, 190, 262, 326, 383, 400, 475, 685, 809, 993, 1000, 1005, 1392, 1430, 1699, 1885, 2039, 2050, 2165, 2210, 2310, 2355, 2376, 2593, 2734, 2766, 2788, 2864, 2986, 3040, 3168, 3231, 3377, 3400, 3569, 3665, 3780, 3790, 4051, 4072, 4169, 4422, 4575, 4655, 4664, 4694, 4775, 4785, 4843], 'factor': [70, 263, 2537, 2603, 2607, 2627, 2631, 2685], '200.': [72, 265], 'The': [73, 88, 118, 157, 172, 266, 281, 311, 350, 365, 529, 1062, 1098, 1320, 1410, 1545, 1601, 1818, 1842, 1877, 1916, 1969, 2025, 2058, 2081, 2143, 2225, 2341, 2469, 2745, 2794, 2847, 2895, 2919, 2938, 2958, 3142, 3156, 3176, 3218, 3311, 3380, 3623, 3651, 3707, 3749, 4284, 4323, 4468, 4527, 4861, 4875], 'enzyme': [74, 159, 267, 352, 1394, 1652, 1719, 1989, 2821, 2886, 3144, 3235, 3298, 3549, 4911], 'protected': [76, 269, 3547], 'against': [77, 270], 'inclusion': [81, 274], 'in': [84, 277, 471, 715, 1095, 1436, 1486, 1658, 1992, 2106, 2253, 2285, 2466, 2556, 2592, 2733, 2747, 2762, 2774, 2949, 2973, 2995, 3009, 3093, 3148, 3174, 3185, 3256, 3315, 3376, 3421, 3667, 3721, 3769, 3776, 3783, 3793, 3905, 4050, 4075, 4172, 4229, 4237, 4281, 4367, 4439, 4458, 4464, 4480, 4483, 4539, 4640, 4838, 4846, 4886, 4914], 'reaction': [86, 279, 3755], 'mixture.': [87, 280], 'ammonia-dependent': [89, 282, 1321, 3306, 3538], 'were': [91, 284, 1757, 1851, 2013, 2117, 2135, 2138, 2266, 2304, 2406, 2437, 2782, 2809, 2861, 3274, 3299, 3698, 3832], 'unaffected': [92, 285, 1324], 'incubation': [95, 288, 3253], 'with': [98, 104, 186, 291, 297, 379, 406, 673, 1004, 1080, 1088, 1329, 1512, 1609, 1862, 2001, 2233, 2248, 2298, 2350, 2393, 2439, 2443, 2490, 2516, 2787, 3236, 3364, 3388, 3415, 3536, 3543, 3664, 3756, 3896, 4476, 4490, 4525, 4564, 4574, 4631, 4774, 4904], 'These': [100, 293, 659, 2705, 3774, 4181], 'results': [101, 294, 3312, 4182, 4482], 'are': [102, 295, 1323, 1442, 1720, 2464, 2554, 3037, 3313, 3735, 4446, 4569], 'consistent': [103, 296, 4903], 'covalent': [106, 299, 994, 1327, 3797], 'labeling': [107, 300], 'glutamine-binding': [110, 303, 1494, 4188], 'site': [111, 304, 1241, 1495, 1603, 2837, 2842, 3418, 3819, 4189, 4638, 4805, 4849], 'located': [112, 305, 1237], 'within': [113, 136, 306, 329, 1071, 1238, 1496, 2839, 3758, 3816, 4200, 4331, 4450], 'small': [115, 142, 308, 335, 1498, 1522, 4231, 4561, 4802], 'amidotransferase': [116, 138, 309, 331, 839, 1073, 1671, 3772], 'subunit.': [117, 310], 'binding': [119, 312, 1515, 1602, 1666, 2841, 3750, 4643], 'to': [124, 180, 317, 373, 666, 991, 1085, 1527, 1539, 1550, 1669, 1768, 1787, 1965, 2055, 2170, 2282, 2345, 2375, 2400, 2410, 2538, 2547, 2752, 2784, 2818, 2832, 2881, 2892, 2912, 3060, 3210, 3276, 3412, 3489, 3496, 3510, 3524, 3744, 4225, 4260, 4291, 4316, 4365, 4374, 4393, 4460, 4635, 4684, 4712, 4796, 4817, 4850], 'large': [126, 319, 1507, 1552, 3760, 4202], 'subunit': [127, 143, 320, 336, 1499, 1508, 1523, 1553, 3761, 4203, 4232, 4803], 'must': [130, 323, 1655, 3764, 4209], 'also': [131, 324, 520, 2155, 2810, 3522, 4437], 'induce': [132, 325, 3766, 4071], 'conformational': [134, 327, 3767, 4215], 'change': [135, 328, 3666], 'domain': [139, 332, 1672, 4658], 'that': [144, 337, 411, 679, 812, 981, 1007, 1395, 1432, 1532, 2826, 3269, 3403, 3558, 3808, 4059, 4184, 4253, 4359, 4679, 4851, 4901], 'enhances': [145, 338], 'nucleophilic': [147, 340, 1234, 4385], 'character': [148, 341], 'thiol': [151, 173, 344, 366], 'group': [152, 174, 345, 367, 2348, 4286, 4325, 4337, 4473, 4512], 'required': [153, 346, 3275], 'hydrolysis.': [156, 349], 'acivicin-inhibited': [158, 351], 'crystallized,': [161, 354], 'three-dimensional': [164, 357], 'structure': [165, 358, 1714, 2470, 3778, 4625, 4646, 4907], 'determined': [167, 360, 1854, 1985, 2994, 3059, 3228, 3300], 'x-ray': [169, 362, 1712, 2372, 2401, 2434, 2460, 2543, 4717, 4906], 'diffraction': [170, 363], 'techniques.': [171, 364, 2483], 'Cys-269': [176, 369, 1519, 4061, 4391, 4771], 'covalently': [178, 371, 1086, 1717, 4258, 4633], 'attached': [179, 372, 4259, 4634], 'dihydroisoxazole': [182, 375, 1090, 4255, 4353, 4478], 'ring': [183, 376, 1002, 1091, 4256, 4479], 'acivicin': [185, 378, 467, 510, 519, 536, 611, 1101, 1362, 1639, 1668, 1704, 1983, 2068, 2093, 2147, 2199, 2214, 2234, 2252, 2477, 2759, 2808, 2869, 2888, 2932, 2945, 3008, 3036, 3045, 3092, 3159, 3198, 3226, 3267, 3273, 3520, 3713, 3861, 3895, 4288, 4481, 4537, 4566, 4632, 4878, 4900], 'displacement': [188, 381], 'chloride': [191, 384, 1006, 2649, 2717], 'ion.': [192, 385], 'CPScarbamoyl': [386], 'synthetaseIGPimidazole': [388], 'glycerol': [389, 395, 4628], 'imidazole': [394, 4627], 'Acivicin': [397, 807, 998, 1214, 1621, 1745, 2737, 3398, 3801, 4164, 4841], '(I)': [398], 'is': [399, 682, 808, 1008, 1336, 1391, 1415, 1433, 1547, 1606, 1622, 2176, 2181, 2186, 2193, 2200, 2615, 2622, 2693, 2700, 2760, 2985, 3172, 3254, 3399, 3514, 3619, 3630, 3634, 3728, 3742, 3811, 3903, 4235, 4246, 4257, 4279, 4289, 4329, 4436, 4521, 4836, 4902, 4912], 'heterocyclic': [401], 'analog': [402, 3402], '(II)': [405], 'anti-cancer': [407], 'anti-tumor': [409], 'activity': [410, 2035, 2089, 2103, 2133, 2153, 2271, 2776, 2804, 2907, 2928, 2966, 3057, 3113, 3129, 3164, 3184, 3247, 3921, 4082], 'initially': [413, 3812], 'discovered': [414], 'screening': [416], 'fermentation': [417], 'broths': [418], 'ofStreptomyces': [419], 'sviceus': [420], '(1Hanka': [421], 'L.J.': [422, 437], 'Dietz': [423], 'A.': [424, 771, 871, 905, 1557, 2504, 2521, 4086, 4117, 4149], 'Antimicrob.': [425], 'Agents': [426], 'Chemother.': [427, 443, 1163], '1973;': [428, 445, 458], '3:': [429], '425-431Crossref': [430], 'PubMed': [431, 489, 501, 603, 698, 746, 758, 782, 802, 855, 893, 913, 933, 952, 1057, 1117, 1143, 1185, 1208, 1257, 1281, 1299, 1317, 1382, 1458, 1479, 1567, 1578, 1598, 1691, 1740, 1911, 2428, 2454, 3436, 3462, 3485, 3586, 3646, 3691, 3854, 3882, 4022, 4041, 4096, 4107, 4122, 4161, 4414, 4616, 4741, 4758], 'Scopus': [432, 461, 490, 502, 604, 699, 747, 759, 783, 803, 833, 856, 894, 914, 934, 953, 1022, 1041, 1058, 1118, 1144, 1258, 1282, 1383, 1459, 1480, 1579, 1692, 1741, 1912, 2429, 2455, 2508, 3437, 3463, 3596, 3647, 3692, 3855, 3883, 4023, 4042, 4108, 4123, 4415, 4617, 4742, 4759], '(41)': [433, 1145, 1283, 1384, 3464, 3856], 'Google': [434, 448, 463, 492, 504, 563, 585, 606, 657, 701, 749, 761, 785, 805, 835, 858, 877, 896, 916, 936, 955, 969, 1024, 1043, 1060, 1120, 1146, 1168, 1186, 1209, 1260, 1284, 1300, 1318, 1385, 1461, 1482, 1568, 1581, 1599, 1694, 1743, 1914, 2431, 2457, 2510, 3439, 3465, 3486, 3587, 3598, 3649, 3694, 3857, 3885, 4025, 4044, 4097, 4110, 4125, 4162, 4417, 4619, 4744, 4761], 'Scholar,': [435, 449, 493, 564, 586, 750, 762, 786, 917, 937, 956, 1025, 1044, 1261, 1285, 1301, 1462, 1569, 1582, 3588, 4098, 4111, 4126, 4133, 4143, 4745], '2Hanka': [436], 'Martin': [438], 'D.G.': [439, 451, 1046], 'Neil': [440, 481, 690, 738, 1156], 'G.L.': [441, 482, 691, 739, 863], 'Cancer': [442, 558, 579, 651, 872, 963, 1162], 'Rep.': [444, 581, 653, 965, 1164], '57:': [446], '141-148PubMed': [447], '3Martin': [450], 'Duchamp': [452], 'D.J.': [453], 'Chidester': [454], 'C.G.': [455], 'Tetrahedron': [456, 1017], 'Lett.': [457, 1018, 3592], '27:': [459], '2549-2552Crossref': [460], '(59)': [462], 'Scholar).': [464, 607, 658, 702, 806, 970, 1061, 1319, 1386, 1483, 1600, 1695, 1744, 1915, 2432, 2458, 3599, 3650, 3695, 3858, 3886, 4163, 4418, 4762], 'Administration': [465], 'stops': [468], 'tumor': [469, 512, 705], 'growth': [470], 'leukemia,': [472], 'melanoma,': [473], 'variety': [476], 'carcinomas': [478], '(4Earhart': [479, 688, 736], 'R.H.': [480, 566, 689, 737, 4151], 'Adv.': [483, 692, 740, 887], 'Enz.': [484, 693, 741, 888], 'Regul.': [485, 694, 742, 889], '1985;': [486, 695, 743, 890, 930, 949], '24:': [487, 696, 744, 891], '179-205Crossref': [488, 697, 745], '(48)': [491, 700, 748], '5Souba': [494, 751], 'W.W.': [495, 752, 796], 'Ann.': [496, 753, 797], 'Surg.': [497, 754, 798], '1993;': [498, 755, 799], '218:': [499, 756], '715-728Crossref': [500, 757], '(282)': [503, 760], 'Scholar),': [505, 836, 859, 878, 897, 1121, 1147, 1169, 1187, 3440, 3466], 'continued': [507], 'administration': [508], 'reduces': [511], 'size': [513], 'restores': [515], 'muscle': [516], 'mass.': [517], 'Unfortunately,': [518], 'causes': [521], 'many': [522, 815], 'undesirable': [523], 'gastrointestinal': [524], 'neurological': [526, 615, 660], 'side': [527, 661, 4382], 'effects.': [528], 'neurotoxic': [530], 'effects': [531, 616, 662], 'at': [532, 1422, 1492, 1839, 1898, 2017, 2245, 2306, 2384, 2889, 3196, 3263, 3369, 3393, 4342], 'low': [533], 'concentrations': [534, 609, 2250, 2890, 3199, 3366, 3390], 'include': [537, 2638, 2706], 'lethargy,': [538], 'depression,': [539], 'insomnia,': [540], 'headaches,': [541], 'confusion,': [542], 'mood': [543], 'swings,': [544], 'vivid': [545], 'dreams,': [546], '“large': [548], 'thoughts”': [549], '(6Weiss': [550], 'G.R.': [551], 'McGovren': [552, 573], 'J.P.': [553, 574], 'Schade': [554], 'D.': [555, 845, 943], 'Kufe': [556], 'D.W.': [557], 'Res.': [559, 873, 908], '1982;': [560, 640, 852], '42:': [561], '3892-3895PubMed': [562], '7Earhart': [565], 'Koeller': [567], 'J.M.': [568], 'Davis': [569, 575], 'T.E.': [570], 'Borden': [571], 'E.C.': [572], 'H.L.': [576], 'Tormey': [577], 'D.C.': [578], 'Treat.': [580, 652, 964], '1983;': [582, 654, 1179, 1293], '67:': [583, 655], '683-692PubMed': [584], '8Taylor': [587], 'S.': [588], 'Belt': [589], 'R.J.': [590], 'Joseph': [591], 'U.': [592], 'Haas': [593], 'C.D.': [594], 'Hoogstraten': [595], 'B.': [596, 841, 962], 'Invest.': [597], 'New': [598], 'Drugs.': [599], '1984;': [600, 830, 1019], '2:': [601], '311-314Crossref': [602], '(17)': [605], 'Higher': [608], 'produce': [612], 'more': [613], 'severe': [614], 'such': [617], 'as': [618, 1529, 1729, 2140, 2209, 2863, 3039, 3167, 3499, 4251, 4659, 4879], 'hallucinations,': [619], 'ataxia,': [620], 'paranoia,': [621], 'amnesia,': [622], 'hostility,': [623], 'transient': [625], 'unconsciousness': [626], '(9Murphy': [627], 'W.K.': [628], 'Burgess': [629], 'M.A.': [630, 764], 'Valdivierso': [631], 'M.': [632, 843], 'Bodey': [633], 'G.P.': [634], 'Proc.': [635, 4130], 'Am.': [636, 1035], 'Soc.': [637, 1037], 'Clin.': [638], 'Oncol.': [639], '1:': [641], '237Google': [642], 'Scholar,10Sridhar': [643], 'K.S.': [644], 'Ohnuma': [645], 'T.': [646, 901, 921], 'Chahinian': [647], 'A.P.': [648], 'Holland': [649], 'J.F.': [650], '701-703PubMed': [656], 'take': [663], '24–72': [664], 'h': [665, 2261, 3251], 'manifest': [667], 'themselves': [668], 'do': [670], 'not': [671, 2813, 3803, 3833, 4884], 'correlate': [672], 'peak': [674], 'levels': [675], 'acivicin,': [677, 1093, 1330, 2771, 3288, 3829], 'suggesting': [678, 3807], 'drug': [681], 'metabolized': [683], 'into': [684, 2020], 'neurotransmitter': [686], 'antagonist': [687, 811], 'Rapidly': [703], 'proliferating': [704], 'cells': [706, 722], 'have': [707, 3556, 4621, 4677], 'elevated': [708], 'amidotransferases': [713, 819, 975], 'involved': [714], 'purine': [716], 'pyrimidine': [718], 'biosynthesis.': [719], 'Consequently,': [720], 'these': [721, 1083, 1243, 1645, 2238, 2875, 2999, 3494, 3507, 4553, 4722, 4824, 4889], 'consume': [723], 'significant': [724], 'amounts': [725, 1815, 2003, 3238, 3265], 'deplete': [729], 'this': [730, 1697, 2174, 3010, 3518, 3628, 3809, 4590], 'amino': [731], 'acid': [732], 'blood': [735], '11Medina': [763], 'Sanchez-Jimenez': [765], 'F.': [766], 'Marquez': [767], 'J.': [768, 939, 941, 947, 1034, 1051, 1125, 1129, 1132, 1176, 1199, 1263, 1267, 1270, 1290, 1308, 1364, 1368, 1371, 1558, 1589, 3444, 3448, 3451, 3476, 3577, 3836, 3840, 3843, 4087, 4137, 4152], 'Rodriguez': [769], 'Quesada': [770], 'Nunez': [772], 'de': [773], 'Castro': [774], 'I.': [775, 1029, 1453, 2423, 2468], 'Mol.': [776], 'Cell': [777], 'Biochem.': [778, 828, 906, 928, 948], '1992;': [779, 3593], '113:': [780], '1-15Crossref': [781], '(175)': [784], '12Chen': [787], 'M.K.': [788], 'Espat': [789], 'N.J.': [790], 'Bland': [791], 'K.I.': [792], 'Copeland': [793], 'E.M.': [794], 'Souba': [795], '217:': [800], '655-667Crossref': [801], '(65)': [804], 'irreversibly': [813, 3404, 3525], 'inactivates': [814, 1216, 2739, 3405], 'including': [820], 'formylglycinamidine': [821], 'ribonucleotide': [822], '(13Elliot': [824], 'W.L.': [825], 'Weber': [826, 885, 926], 'G.': [827, 886, 927, 1157, 1449, 2419], 'Pharmacol.': [829, 851, 929], '34:': [831, 931], '243-248Crossref': [832], '(18)': [834], '5-phosphoribosyl': [837], '1-pyrophosphate': [838], '(14Ardalan': [840], 'Arakawa': [842], 'Villacorte': [844], 'Jayaram': [846], 'H.': [847, 1198, 1307, 1586, 3475], 'Cooney': [848, 1152], 'D.A.': [849, 1153], 'Chem.': [850, 1036, 1134, 1178, 1201, 1272, 1292, 1310, 1373, 1560, 1591, 3453, 3478, 3579, 3845, 4089, 4154], '31:': [853], '1509-1513Crossref': [854], '(15)': [857], 'CTP': [860], '(15Neil': [862], 'Berger': [864], 'A.E.': [865], 'McPartland': [866], 'R.P.': [867], 'Grindey': [868], 'G.B.': [869], 'Bloch': [870], '1979;': [874, 1038], '39:': [875, 1055], '852-856PubMed': [876], 'GMP': [879, 1122, 1223, 1359, 1674, 3441, 3826, 3901, 3916], '(16Achleitner': [881], 'E.': [882, 3533, 4113], 'Lui': [883], 'M.S.': [884], '225-232Crossref': [892], '(10)': [895], 'CPS1': [899], '(17Mukherjee': [900], 'Roy': [902], 'K.': [903, 1127, 1265, 1366, 3446, 3838], 'Bhaduri': [904], 'Biophys.': [907], 'Commun.': [909], '1990;': [910], '170:': [911], '426-432Crossref': [912], '(12)': [915], '18Sebolt': [918], 'J.S.': [919], 'Aoki': [920], 'Eble': [922], 'J.N.': [923], 'Glover': [924], 'J.L.': [925, 4606], '97-100Crossref': [932], '(16)': [935], '19Pausch': [938], 'Rasenack': [940], 'Haussinger': [942], 'Gerok': [944], 'W.': [945, 1033, 2448], 'Eur.': [946], '150:': [950], '189-194Crossref': [951], '(23)': [954], '20Jayaram': [957], 'H.N.': [958, 1151], 'Kensler': [959], 'T.W.': [960, 1016], 'Ardalan': [961], '1981;': [966], '65:': [967], '491-494PubMed': [968], 'All': [971, 2433], 'possess': [976], 'an': [977, 983, 1623, 1788, 1824, 2835, 3146, 3500, 4213, 4660, 4818, 4880], 'essential': [978, 1068], 'cysteine': [979, 1069, 1235, 3419, 4639], 'residue': [980, 1070, 1236, 2838, 4777], 'initiates': [982], 'attack': [984, 4386], 'on': [985, 2390, 3160], 'amide': [987, 1535], 'carbonyl': [988, 1536, 4336, 4377, 4501, 4517], 'form': [992, 1540, 1830], 'γ-glutamyl': [995, 1542, 3570, 3616, 4811, 4858], 'thioester': [996, 1543, 3571, 3617, 3679, 4812, 4859], 'intermediate.': [997, 1544, 4696], 'contains': [999], '4,5-dihydroisoxazole': [1001], 'substituted': [1003], 'readily': [1009], 'displaced': [1010], '(21Vyas': [1011], 'D.M.': [1012], 'Chiang': [1013], 'Y.': [1014], 'Doyle': [1015], '25:': [1020], '487-490Crossref': [1021], '(88)': [1023], '22Kelly': [1026], 'R.C.': [1027], 'Schletter': [1028], 'Stein': [1030], 'S.J.': [1031], 'Wierenga': [1032], '101:': [1039], '1054-1056Crossref': [1040], '(51)': [1042], '23Martin': [1045], 'Mizsak': [1047], 'S.A.': [1048], 'Nielsen': [1049], 'J.W.': [1050], 'Antibiot.': [1052], '(Tokyo).': [1053], '1986;': [1054, 1592], '603-605Crossref': [1056], '(4)': [1059], 'activated': [1063], 'thiolate': [1064, 4262, 4389], 'anion': [1065], 'family': [1074], 'enzymes': [1076, 1084, 1244, 1756, 3495, 3509], 'has': [1077, 1211, 1524, 1676, 3409, 4356, 4709], 'been': [1078, 1212, 1525, 1677, 3410, 4357, 4710], 'shown': [1079, 1526, 2817, 3173, 3411, 3523], 'some': [1081], 'react': [1087, 3414], 'resulting': [1094, 2342], 'irreversible': [1096], 'inactivation.': [1097], 'IGP': [1103, 1221, 3422, 3864, 3898, 3914, 3947, 3971], '(24Chittur': [1105, 1245, 1679, 3424, 3870], 'S.V.': [1106, 1246, 1680, 3425, 3871, 4030, 4602], 'Klem': [1107, 1247, 1681, 3426, 3872, 4031], 'T.J.': [1108, 1248, 1682, 3427, 3873, 4032], 'Shafer': [1109, 1249, 1683, 3428, 3874, 4033], 'C.M.': [1110, 1250, 1684, 3429, 3875, 4034], 'Davisson': [1111, 1251, 1685, 3430, 3876, 4035, 4592, 4603], 'V.J.': [1112, 1252, 1686, 3431, 3877, 4036, 4604], 'Biochemistry.': [1113, 1253, 1454, 1475, 1574, 1687, 1736, 1907, 2424, 3432, 3642, 3687, 3878, 4018, 4037, 4103, 4118, 4410, 4737, 4754], '2001;': [1114, 1254, 1688, 3433, 3879, 4038, 4608], '40:': [1115, 1255, 1689, 3434, 3880, 4039], '876-887Crossref': [1116, 1256, 1690, 3435, 3881, 4040], '(82)': [1119, 1259, 1693, 3438, 3884, 4043], '(25Nakamura': [1124, 1363, 3443, 3835], 'Straub': [1126, 1264, 1365, 3445, 3837], 'Wu': [1128, 1266, 1367, 3447, 3839], 'Lou': [1130, 1268, 1369, 3449, 3841], 'L.': [1131, 1269, 1370, 3450, 3842], 'Biol.': [1133, 1177, 1200, 1271, 1291, 1309, 1372, 1559, 1590, 3452, 3477, 3578, 3844, 4088, 4153], '1995;': [1135, 1273, 1374, 3454, 3846], '270:': [1136, 1274, 1375, 3455, 3847], '23450-23455Abstract': [1137, 1275, 1376, 3456, 3848], 'Full': [1138, 1140, 1182, 1205, 1276, 1278, 1296, 1314, 1377, 1379, 1564, 1595, 3457, 3459, 3482, 3583, 3849, 3851, 4093, 4158, 4611, 4613], 'Text': [1139, 1141, 1183, 1206, 1277, 1279, 1297, 1315, 1378, 1380, 1565, 1596, 3458, 3460, 3483, 3584, 3850, 3852, 4094, 4159, 4612, 4614], 'PDF': [1142, 1184, 1207, 1280, 1298, 1316, 1381, 1566, 1597, 3461, 3484, 3585, 3853, 4095, 4160, 4615], 'II': [1149], '(26Jayaram': [1150], 'Ryan': [1154], 'J.A.': [1155, 1904, 3639, 3684, 4015], 'Dion': [1158], 'R.L.': [1159], 'Bono': [1160], 'V.H.': [1161], '1975;': [1165, 1575, 4104, 4140], '59:': [1166], '481-491PubMed': [1167], 'III': [1171], '(27Casey': [1172], 'C.A.': [1173, 1287], 'Anderson': [1174, 1288, 4114], 'P.M.': [1175, 1289, 1571, 4100, 4115], '258:': [1180, 1294], '8723-8732Abstract': [1181, 1295], 'anthranilate': [1188, 1228, 3468], 'synthetase,': [1189, 1222, 1224, 3899], 'glutamate': [1191, 1773, 1805, 1819, 1845, 4366, 4685, 4791], 'synthase': [1192, 4630], '(28Tso': [1193, 3470], 'J.Y.': [1194, 1303, 3471], 'Bower': [1195, 1304, 3472], 'S.G.': [1196, 1305, 1466, 3473, 4401, 4728], 'Zalkin': [1197, 1306, 3474], '1980;': [1202, 1311, 3479, 4131], '255:': [1203, 1312, 3480], '6734-6738Abstract': [1204, 1313, 3481], 'Scholar)': [1210, 2511, 2534, 3487, 4620], 'described.': [1213], 'stoichiometrically': [1215, 3413], 'III,': [1226], 'alkylation': [1231], 'active': [1240, 1426, 1642, 2836, 3417, 3818, 4637, 4804, 4848], '25Nakamura': [1262], '27Casey': [1286], '28Tso': [1302], 'modification': [1328, 2833, 3020, 3798, 4165], 'facilitated': [1337], 'co-substrates.': [1342], 'For': [1343, 1954, 2119, 2275, 4419], 'example,': [1344], 'addition': [1346, 1864, 2757], 'xanthosine': [1350, 4008, 4055], 'monophosphate': [1351], 'greatly': [1352, 2947], 'accelerates': [1353], 'heterodimeric': [1393], 'glutamine,': [1404], 'two': [1406, 1514, 4491, 4690], 'molecules': [1407, 3271], 'ATP.': [1409, 1518], 'synthesis': [1411], 'accomplished': [1416], 'via': [1417, 4294], 'four': [1418, 4462], 'separate': [1419], 'reactions': [1420], 'occurring': [1421], 'three': [1423, 4487, 4825], 'physically': [1424], 'distinct': [1425], 'sites': [1427, 1516, 1643], 'connected': [1428], 'tunnel': [1431, 1490, 4666], '∼100': [1434], 'Å': [1435, 2366, 2381, 4333, 4344, 4452, 4582], 'length': [1437], 'through': [1439, 1502, 4212, 4689], 'which': [1440, 3633], 'intermediates': [1441, 4724], 'translocated': [1443], '(29Thoden': [1444, 2414], 'J.B.': [1445, 1464, 2415, 4399, 4726, 4747], 'Holden': [1446, 1473, 2416, 4408, 4735, 4752], 'H.M.': [1447, 1474, 2417, 4409, 4736, 4753], 'Wesenberg': [1448, 2418], 'Raushel': [1450, 1471, 1734, 1905, 2420, 3640, 3685, 4016, 4406, 4733, 4750], 'F.M.': [1451, 1472, 1735, 1906, 2421, 3641, 3686, 4017, 4407, 4734, 4751], 'Rayment': [1452, 2422], '1997;': [1455, 2425, 2451], '36:': [1456, 2426], '6305-6316Crossref': [1457, 2427], '(307)': [1460, 2430], '30Thoden': [1463], 'Miran': [1465, 4400, 4727], 'Phillips': [1467, 4402, 4729], 'J.C.': [1468, 4403, 4730], 'Howard': [1469, 4404, 4731], 'A.J.': [1470, 4405, 4732], '1998;': [1476, 1908, 3643, 3688, 4019, 4411, 4738], '37:': [1477, 1909, 3644, 3689, 4020, 4412, 4739], '8825-8831Crossref': [1478, 4413, 4740], '(89)': [1481, 4416, 4743], 'As': [1484, 3542, 4239, 4441], 'indicated': [1485, 3268], 'Fig.': [1487, 2763, 4282, 4839], '1,': [1488], 'begins': [1491], 'runs': [1501], 'interior': [1504, 4653], 'where': [1509, 2613, 2691], 'it': [1510, 4708], 'connects': [1511], 'function': [1528, 2211, 2865, 3041, 3169], 'nucleophile': [1531], 'attacks': [1533], 'ammonia': [1546, 3501, 3513, 4687], 'subsequently': [1548], 'channeled': [1549], '(31Pinkus': [1554, 4083], 'L.M.': [1555, 4084], 'Meister': [1556, 4085, 4116, 4136, 4148], '1972;': [1561, 4090], '247:': [1562, 4091], '6119-6127Abstract': [1563, 4092], '32Anderson': [1570, 4099], 'Carlson': [1572, 4101], 'J.D.': [1573, 4102], '14:': [1576, 4105], '3688-3694Crossref': [1577, 4106], '(37)': [1580, 4109], '33Rubino': [1583], 'S.D.': [1584], 'Nyunoya': [1585], 'Lusty': [1587], 'C.J.': [1588, 3590], '261:': [1593], '11320-11327Abstract': [1594], 'largely': [1607], 'hydrophilic': [1608], 'numerous': [1610], 'electrostatic': [1611], 'interactions': [1612, 1649, 4449, 4489], 'between': [1613, 1650, 2474, 4273, 4430, 4453, 4509, 4533, 4787], 'bound': [1615, 3815, 4199, 4227, 4305], 'substrate': [1616, 4702], 'protein': [1619, 2279, 2635, 3777, 4278, 4293, 4455, 4535, 4547], 'matrix.': [1620], 'extraordinarily': [1624], 'potent': [1625], 'inactivator': [1626], 'amidotransferases.': [1629, 3407], 'To': [1630, 4763, 4780], 'further': [1631], 'understand': [1632], 'high': [1634, 1710, 4715], 'affinity': [1635, 4544], 'selectivity': [1637], 'enzymes,': [1646], 'molecular': [1648, 4665], 'inhibitor': [1654, 3810, 4228, 4275, 4881], 'be': [1656, 2913, 3061, 4210, 4241, 4443], 'delineated': [1657], 'greater': [1659], 'detail.': [1660], 'A': [1661, 1762, 2180, 2202, 3242, 3887, 4217, 4265, 4304, 4821, 4892], 'theoretical': [1662], 'model': [1663, 2514, 4829], 'published': [1678, 2412], 'paper,': [1698], 'detailed': [1700], 'kinetic': [1701, 3291, 3910], 'analysis': [1702], 'resolution': [1711, 2378, 2574, 2588, 4716], 'crystal': [1713, 4624], 'modified': [1718, 3297, 3508], 'presented.': [1721], 'isolated': [1726], 'fromE.': [1727], 'described': [1730, 2141], 'previously': [1731, 2411], '(34Mareya': [1732], 'S.M.': [1733], '1994;': [1737], '33:': [1738], '2945-2950Crossref': [1739], '(45)': [1742], 'purchased': [1747], 'Sigma,': [1749], 'all': [1751, 2541, 4065, 4584, 4867], 'other': [1752, 3544], 'reagents': [1753, 4058], 'coupling': [1755], 'obtained': [1758, 2048, 2163], 'commercial': [1760], 'sources.': [1761], 'continuous': [1763], 'spectrophotometric': [1764], 'assay': [1765, 1789, 1858, 1890, 1917, 1967, 2023], 'used': [1767], 'monitor': [1769], 'production': [1771], 'following': [1774, 1892], 'enzymatic': [1776], 'hydrolysis': [1777, 2858, 3560, 3626, 3662, 3788, 4362, 4681], '(6–14': [1783], 'nmol)': [1784], 'added': [1786, 1964, 2953], 'solution': [1790, 1859, 1918, 2312], 'composed': [1791], '0.1': [1793, 1921, 1934, 1993, 3213], 'mHepes': [1794], '(pH': [1795, 1924, 1997, 2257, 2289, 2339], '7.6,': [1796, 1925, 1998, 3371, 3395], '25': [1797, 1926, 1999, 2246, 2336, 3372, 3396], '°C),': [1798, 1927], '100': [1799, 2292, 2323, 2612, 2690], 'mm': [1800, 1809, 1867, 1872, 1932, 1937, 1940, 1943, 1961, 2111, 2115, 2287, 2293, 2324, 2327, 2330, 2333, 2337, 2770, 2978, 2982, 3098, 3190, 3194], 'KCl,': [1801, 2325], '10': [1802, 1869, 1871, 1942, 1960, 2110, 2286, 2916, 2977, 3097, 3189], 'units': [1803], 'dehydrogenase,': [1806], '1.0': [1808, 1928], '3-acetylpyrimidine': [1810, 1832], 'adenine': [1811, 1833], 'nucleoside': [1812, 1834], 'varying': [1814, 2002], 'concentration': [1820, 2069, 2215, 2767, 2870, 3233], 'calculated': [1822, 2624, 2702], 'using': [1823, 1855, 1884, 2309], 'extinction': [1825], 'coefficient': [1826], '8.3': [1836], 'mm−1': [1837], 'cm−1': [1838], '363': [1840], 'nm.': [1841], 'when': [1847, 2197], 'present': [1852, 4834], 'same': [1857], 'but': [1860, 3535], 'supplemented': [1861], '5.0': [1866, 2769], 'mmMgCl2,': [1870], 'ornithine,': [1873, 1938, 2331], '40': [1875, 2114, 2981, 3101, 3193], 'mmbicarbonate.': [1876, 3102], 'ADP': [1880, 2643, 2711, 3361, 3385], 'assayed': [1883], 'pyruvate': [1886, 1949], 'kinase/lactate': [1887], 'dehydrogenase': [1888], 'coupled': [1889], 'loss': [1894, 2773, 4485], 'NADH': [1896], 'spectrophotometrically': [1897], '340': [1899], 'nm': [1900], '(35Miles': [1901, 3636, 3681], 'B.W.': [1902, 2500, 3637, 3682, 4013], 'Banzon': [1903, 3638, 3683, 4014], '16773-16779Crossref': [1910, 3645, 3690, 4021], '(34)': [1913, 3648, 3693, 4024], 'consisted': [1919], 'm': [1922, 1994, 2315], 'Hepes': [1923, 1995, 2255, 2288, 2338], 'mmphosphoenol': [1929], 'pyruvate,': [1930], '0.3': [1931], 'NADH,': [1933], 'mKCl,': [1935], '20': [1936, 1939, 2299], 'MgCl2,': [1941], '33': [1946], 'μg': [1947], 'kinase': [1950], 'lactate': [1952], 'dehydrogenase.': [1953], 'utilization': [1957], 'solutions.': [1968], 'glutaminase': [1975, 2855, 2927, 3056, 3112], 'ATPase': [1978, 2088, 2102, 2125, 2152, 2803, 2906, 2965, 3128, 3154, 3163, 3183, 3307, 4081, 4179], 'incubating': [1987, 3230], '(20': [1990, 2241], 'μm)': [1991, 2242], 'buffer': [1996, 2256], '°C)': [2000], 'inhibitor.': [2006, 4322, 4550], 'At': [2007, 2765], 'various': [2008, 2249, 3197], 'time': [2009, 2026, 2128, 2144, 2795, 3171], 'intervals,': [2010], 'aliquots': [2012, 2265], 'removed': [2014], 'diluted': [2016], 'least': [2018, 2487], '100-fold': [2019], 'appropriate': [2022], 'solution.': [2024], 'course': [2027, 2145], 'fraction': [2030, 2132], 'initial': [2033, 2067, 2868, 3044], 'catalytic': [2034, 2270, 2775], 'remaining': [2036, 2134, 2272, 3248], '(f)': [2037], 'pseudo-first-order': [2040, 2062, 2136, 2206], 'decay,': [2041], 'k': [2046, 2161, 2185], 'fit': [2051, 2166], 'data': [2054, 2169, 2373, 2402, 2435, 2461, 2544, 2559, 2781, 3261], 'Equation': [2056, 2171, 2785], '1.': [2057], 'plots': [2059, 2876], 'constants': [2064, 2073, 2208, 2850, 3017, 3029, 3085, 3292, 3893], 'versus': [2065], 'yielded': [2070, 2216], 'CPS.': [2078, 2744, 3281, 3310, 4205], 'f=e−ktEquation': [2079], '1': [2080, 2786], 'activation': [2098, 2148, 3124, 3179], 'bicarbonate-dependent': [2101, 2151, 3127, 3153, 3162, 3182, 4080, 4178], 'investigated.': [2118], 'activity,': [2126], 'courses': [2129, 2796], 'analyzed': [2139], 'previously.': [2142], 'pseudo-first-order,': [2156], '2.': [2172, 2764], 'equationv': [2175], 'observed': [2178, 2196, 2617, 2695, 3699, 3834, 4429, 4463, 4852], 'velocity,': [2179], 'amplitude': [2183, 2619, 2697], 'factor,': [2184], 'activation,': [2191], 'andvo': [2192], 'velocity': [2195], 'no': [2198, 2879, 3003], 'added.': [2201], 'plot': [2203, 3243], 'activation.': [2222], 'v=A(1−e−kt)+voEquation': [2223], 'partition': [2226], 'ratio': [2227], 'determined.': [2236, 2274], 'experiments': [2239], 'incubated': [2244, 2296], '°C': [2247, 2308], '0.1m': [2254], '7.6).': [2258], 'After': [2259], '6': [2260, 2936, 3250], 'incubation,': [2263], 'removed,': [2267], 'crystallization': [2276], 'trials,': [2277], 'concentrated': [2281], '4': [2283, 2307, 2645, 2657, 2660, 2713, 2725, 2728], 'mg/ml': [2284], '7.0)': [2290], 'KCl': [2294], 'overnight': [2297], 'mmacivicin.': [2300], 'Large': [2301, 3134, 4918], 'single': [2302], 'crystals': [2303, 2343, 2405], 'grown': [2305], 'precipitant': [2311], 'containing': [2313], '0.65': [2314], 'tetraethylammonium': [2316, 2646, 2714], 'chloride,': [2317], '8%': [2318], '(w/v)': [2319], 'poly(ethylene': [2320], 'glycol)': [2321], '8000,': [2322], '0.5': [2326, 2329], 'MnCl2,': [2328], '1.25': [2332], 'ADP,': [2334], '7.4).': [2340], 'belonged': [2344], 'space': [2347], 'P212121': [2349], 'unit': [2351], 'cell': [2352], 'dimensions': [2353], '=': [2356, 2360, 2364, 2564, 2577, 2608, 2686], '152.4': [2357], 'Å,': [2358, 2362], 'b': [2359], '164.4': [2361], 'andc': [2363], '333.2': [2365], 'one': [2368, 3278], 'α/β-heterotetramer/asymmetric': [2369], 'unit.': [2370], 'An': [2371], 'set': [2374], 'nominal': [2377], '2.1': [2380, 2548], 'collected': [2383, 3262], 'Stanford': [2386], 'Synchrotron': [2387], 'Radiation': [2388], 'Laboratory': [2389], 'beam-line': [2391], '7-1': [2392], 'MAR300': [2395], 'image': [2396, 3139, 4923], 'plate': [2397], 'system.': [2398], 'Prior': [2399], 'collection,': [2403], 'flash': [2407], 'frozen': [2408], 'according': [2409], 'procedures': [2413], 'frames': [2436], 'processed': [2438], 'DENZO': [2440], 'scaled': [2442], 'SCALEPACK': [2444], '(36Otwinowski': [2445], 'Z.': [2446], 'Minor': [2447], 'Methods': [2449, 4138], 'Enzymol.': [2450, 4139], '276:': [2452], '307-326Crossref': [2453], '(38617)': [2456], 'Relevant': [2459], 'collection': [2462, 2560], 'statistics': [2463, 2553], 'given': [2465, 4236, 4837], 'Table': [2467, 2596], 'complex': [2473, 4786], 'solved': [2479], 'difference': [2481], 'Fourier': [2482], 'Alternate': [2484], 'cycles': [2485], 'squares': [2488, 2551], 'refinement': [2489, 2552, 2599], 'program': [2492, 2518], 'TNT': [2493], '(37Tronrud': [2494], 'D.E.': [2495], 'Ten': [2496], 'Eyck': [2497], 'L.F.': [2498, 4147], 'Matthews': [2499], 'Acta': [2501], 'Crystallogr.': [2502], 'Sect.': [2503], '1987;': [2505], '43:': [2506], '489-501Crossref': [2507], '(874)': [2509], 'manual': [2513], 'building': [2515], 'TURBO': [2519], '(38Roussel': [2520], 'Cambillau': [2522], 'C.': [2523], 'Silicon': [2524, 2529], 'Graphics': [2525], 'Geometry': [2526], 'Partners': [2527], 'Directory.': [2528], 'Graphics,': [2530], 'Mountain': [2531], 'View,': [2532], 'CA1991Google': [2533], 'theR': [2536], '18.6%': [2539], 'measured': [2542], '30': [2546], 'Å.': [2549], 'Least': [2550], 'presented': [2555, 2761, 3255, 3314, 3904, 4280, 4438, 4913], 'TableII.Table': [2557], 'IX-ray': [2558], 'statisticsResolutionIndependent': [2561], 'reflectionsCompletenessRedundancyAverageI/average': [2562], 'ς(I)Rsym1-aRsym': [2563], '(Σ‖I': [2565, 2578], '−': [2566, 2579], '-I‖/Σ': [2567, 2580], 'I)': [2568, 2581], '100.Å%%30.0–2.10429,95788.94.437.94.42.18–2.101-bStatistics': [2570], 'highest': [2573, 2587], 'bin.34,86172.72.55.917.91-a': [2575], 'Rsym': [2576], '100.1-b': [2583], 'Statistics': [2584], 'bin.': [2589], 'Open': [2590, 2731, 3374, 4048], 'table': [2591, 2732, 3375, 4049], 'new': [2594, 2735, 3378, 4052], 'tab': [2595, 2736, 3379, 4053], 'IIRelevant': [2597], 'least-squares': [2598], 'statisticsResolution': [2600], 'limits': [2601], '(Å)30.0–2.10R': [2602], '(overall)': [2604], '%/no.': [2605, 2629, 2633], 'reflections2-aR': [2606], '(Σ‖Fo': [2609, 2687], '−Fc‖/Σ‖Fo‖)': [2610, 2688], 'Fo': [2614, 2692], 'structure-factor': [2618, 2625, 2696, 2703], 'Fc': [2621, 2699], 'amplitude.18.6/429957R': [2626], '(working)': [2628], 'reflections18.7/386960R': [2630], '(free)': [2632], 'reflections21.1/42997No.': [2634], 'atoms44346No.': [2636], 'hetero-atoms45502-bThese': [2637], '4176': [2639, 2707], 'water': [2640, 2708, 4306], 'molecules,': [2641, 2644, 2709, 2712], '8': [2642, 2710], 'ions,': [2647, 2650, 2653, 2656, 2715, 2718, 2721, 2724], '22': [2648, 2716], '12': [2651, 2719], 'manganese': [2652, 2720], '32': [2654, 2722], 'potassium': [2655, 2723], 'phosphates,': [2658, 2726], 'ornithine': [2661, 2729], 'molecules.Weighted': [2662], 'root': [2663, 4576], 'mean': [2664, 4577], 'square': [2665, 4578], 'deviations': [2666], 'ideality': [2668], 'Bond': [2669, 2672], 'lengths': [2670], '(Å)0.010': [2671, 2680], 'angles': [2673, 2682], '(deg)2.12': [2674], 'Trigonal': [2675], 'planes': [2676, 2679], '(Å)0.006': [2677], 'General': [2678], 'Torsional': [2681], '(deg)17.72-a': [2683], 'R': [2684], 'amplitude.2-b': [2704], 'molecules.': [2730], 'rapidly': [2738], 'diminution': [2746], 'ability': [2749, 3492, 3505], 'hydrolyze': [2753], 'after': [2755, 3249], 'first-order,': [2778], 'fitted': [2783], '0.8': [2792], 'min−1.': [2793, 2918, 3080, 3622, 3730, 3748], 'first-order': [2811, 2848, 3027, 3083], '(data': [2812], 'shown).': [2814], 'Glutamine': [2815], 'protect': [2819], 'inactivation,': [2823], 'thus': [2824], 'demonstrating': [2825], 'event': [2829], 'due': [2831], '(Fig.': [2845, 3552, 3820], '2).': [2846, 3553], 'plotted': [2862, 3038], '(Fig.3A).': [2871], 'both': [2873, 4373, 4854], 'there': [2877, 4445], 'evidence': [2880], 'indicate': [2882, 4183], 'saturation': [2883, 3006, 3805, 3830, 3868], 'up': [2891], '45': [2893], 'mm.': [2894], 'apparent': [2896, 3204, 3708, 3738], 'found': [2911], '204': [2914], '±': [2915, 2935, 2969, 3212, 3328, 3330, 3332, 3335, 3337, 3339, 3343, 3345, 3347, 3351, 3353, 3355], 'm−1': [2917, 3079, 3132, 3621, 3930, 3934, 3940, 3944, 3955, 3959, 3964, 3968, 3978, 3982, 3987, 3991, 4002, 4006], '168': [2934, 3062], 'm−1min−1.': [2937, 3063, 3116], 'enhanced': [2948], '(Fig.3B).': [2957, 3217], '0.4': [2970], '104m−1min−1': [2972], 'HCO3−.': [2983], 'This': [2984, 4206, 4645], '∼200-fold': [2987], 'enhancement': [2988, 4208], 'over': [2989], 'substrates.': [3000], 'There': [3001], 'indication': [3004], 'plot.Figure': [3011], '3Determination': [3012], 'A,': [3025], 'concentration.': [3046], '●,': [3047, 3103], '○,': [3064, 3117], 'turnover': [3074], '200': [3078], 'B,': [3081], '40,000': [3115], '16,000': [3131], 'min−1.View': [3133], 'Image': [3135, 4919], 'Figure': [3136, 4920], 'ViewerDownload': [3137, 4921], 'Hi-res': [3138, 4922], 'Download': [3140, 4924], '(PPT)': [3141, 4925], 'acivicin-treated': [3143, 3320], 'had': [3145], 'increase': [3147, 3657, 3782, 3792, 4074, 4171], 'activity.': [3155, 4180], 'effect': [3157], 'Fig.4.': [3175], 'determined,': [3201], 'equal': [3209], '1.6': [3211], '104m−1': [3215, 3747], 'min−1': [3216], 'efficiency': [3219], 'fixed': [3232], 'stoichiometric': [3237], 'inactivator.': [3241], 'fractional': [3246], 'Fig.5.': [3257], 'Extrapolation': [3258], 'substoichiometric': [3264], '∼1.7': [3270], 'inactivate': [3277, 3526, 4064], 'molecule': [3279, 4307], '(Km': [3293], 'andkcat)': [3294], 'bicarbonate-,': [3303], 'glutamine-,': [3304], 'TableIII.Table': [3316], 'IIIKinetic': [3317], 'parameters': [3318, 3911], 'CPSNH3−-dependent': [3321], 'ATPaseGlutamine-dependent': [3322], 'ATPaseHCO3−-dependent': [3323], 'ATPaseWild': [3324], 'type': [3325], 'Km(μm)60': [3327], '11201': [3329], '2424': [3331], 'kcat(min−1)174': [3334], '6336': [3336], '513': [3338], '1Acivicin-treated': [3340], 'Km(μm)77': [3342], '516': [3344], '211': [3346], 'kcat': [3349], '(min−1)146': [3350], '218': [3352], '118': [3354], '1The': [3356], 'monitored': [3363, 3387], 'variable': [3365, 3389], 'pH': [3370, 3394], '°C.': [3373, 3397], 'It': [3408, 4355], 'residues': [3420], 'destroy': [3490], 'utilize': [3497, 3511], 'source.': [3502], 'However,': [3503], 'free': [3512], 'relatively': [3515], 'unchanged.': [3516], 'study,': [3519], 'left': [3540], 'unaffected.': [3541], 'amidotransferases,': [3545], 'Previous': [3554, 4672], 'studies': [3555, 4674], 'demonstrated': [3557], 'involves': [3565], 'intermediate': [3572, 3618, 3629, 3680, 4198], '(39Chaparian': [3573], 'M.G.': [3574], 'Evans': [3575], 'D.R.': [3576], '1991;': [3580], '266:': [3581], '3387-3395Abstract': [3582], '40Lusty': [3589], 'FEBS': [3591], '314:': [3594], '134-138Crossref': [3595], '(31)': [3597], '3,400': [3620], '0.17': [3631], 'min−1,': [3632], 'rate-determining': [3635], 'additions': [3652], '700-fold': [3663, 3781], 'determining': [3670], 'step': [3671], 'toward': [3672], 'Pseudo-first-order': [3696], 'kinetics': [3697, 3831, 3869], 'inhibition': [3702], '∼200m−1': [3729], 'When': [3731], 'added,': [3736], 'increased': [3743], '∼4.0': [3745], 'subsequent': [3754], 'therefore': [3765], 'changes': [3768], 'site.': [3773, 4644], 'alterations': [3775], 'promote': [3779], '200-fold': [3791], 'did': [3802, 3866], 'exhibit': [3804, 3867], 'kinetics,': [3806], 'rather': [3813], 'loosely': [3814], '3).': [3821], 'Similarly,': [3822], 'contrast,': [3860], 'comparison': [3888, 4420], 'CPS,': [3897, 4368], 'TableIV.Table': [3906], 'IVComparison': [3907], 'synthase,': [3915, 3917], 'CPSSubstratesAcivicin': [3919], 'inactivationGlutaminase': [3920], '(kcat/Km)S.': [3922], 'cerevisiaeCPS4-aMiles': [3923], 'et': [3924, 3949, 3973, 3994, 4011, 4028], 'al.(35).−': [3925], 'HCO3−2.0': [3927], '102': [3929, 3954, 3958, 3981], 'min−11.0': [3931, 3979], '103': [3933], 'min−1+': [3935, 3960, 3983], 'HCO3−4.0': [3937], '104': [3939, 3986], 'min−12.0': [3941], '106': [3943, 3967, 4001, 4005], 'min−1E.': [3945], 'synthetase4-bChittur': [3948, 3972, 3993], 'al.(24).−': [3950, 3974, 3995], 'PRFAR4-cPRFAR,N′-(5′-phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide': [3951], 'ribonucleotide.1.6': [3952], 'min−19.0': [3956], 'PRFAR6.0': [3961], '105': [3963, 3990], 'min−12.3': [3965], 'min−1S.': [3969], 'cerevisiae': [3970], 'PRFAR9.0': [3975], '101': [3977], 'PRFAR1.7': [3984], 'min−11.9': [3988], 'min−1GMP': [3992], 'XMPUndetectable+': [3997], 'XMP1.1': [3999], 'min−11.3': [4003], 'min−14-dXMP,': [4007], 'monophosphate.4-a': [4009], 'Miles': [4010], 'al.(35Miles': [4012], 'Scholar).4-b': [4026], 'Chittur': [4027, 4601], 'al.(24Chittur': [4029], 'Scholar).4-c': [4045], 'PRFAR,N′-(5′-phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide': [4046], 'ribonucleotide.': [4047], '4-dXMP,': [4054], 'monophosphate.': [4056], 'Chemical': [4057], 'modify': [4060], 'modest': [4073], '41Khedouri': [4112], '1966;': [4119], '5:': [4120], '3552-3557Crossref': [4121], '(56)': [4124], '42Kaseman': [4127], 'D.S.': [4128], 'Fed.': [4129], '392032Google': [4132], '43Wellner': [4134], 'V.P.': [4135], '250:': [4141], '3261-3266Google': [4142], '44Trotta': [4144], 'P.P.': [4145], 'Estis': [4146], 'Haschemeyer': [4150], '1974;': [4155], '249:': [4156], '482-489Abstract': [4157], 'produces': [4168], '3-fold': [4170], 'value': [4174], 'ofkcat/Km': [4175], 'occupancy': [4185], 'can': [4190, 4240, 4442], 'enhance': [4191], 'reactivity': [4193], 'carboxy': [4196], 'promoted': [4211], 'induced': [4214], 'change.': [4216], 'stereo': [4218], 'view': [4219], 'electron': [4222, 4244], 'density': [4223, 4245], 'corresponding': [4224], 'Fig.6A.': [4238], 'seen,': [4242, 4444], 'well': [4247], 'ordered': [4248], 'indicates,': [4250], 'expected,': [4252], 'Cys-269.': [4264], 'cartoon': [4266, 4423], 'hydrogen': [4269, 4314, 4426, 4507, 4530], 'bonding': [4270, 4427, 4531], 'pattern': [4271, 4428], 'formed': [4272], '6B.': [4283], 'α-carboxylate': [4285, 4862], 'anchored': [4290], 'backbone': [4296, 4492], 'NH': [4297, 4494], 'peptidic': [4298, 4493], 'groups': [4299, 4495, 4865], 'Gly-313': [4301], 'Phe-314.': [4303], 'Nε2': [4309], 'Gln-273': [4311], 'provide': [4312], 'additional': [4313], 'bonds': [4315], 'carboxylate': [4318], 'moiety': [4319], 'α-amino': [4324, 4511, 4864], 'ligand': [4328], 'positioned': [4330], '2.6': [4332], 'Gly-241.': [4339], 'Ser-47': [4340, 4371], 'lies': [4341], '∼3.9': [4343], 'oxygen': [4347, 4502, 4518], 'nitrogen': [4349], 'atoms': [4350], 'ring.': [4354], 'postulated': [4358], 'during': [4360, 4806], 'Oγ': [4369], 'serves': [4372], 'position': [4375], 'carbon': [4378], 'chain': [4383], 'stabilize': [4394], 'developing': [4396], 'oxyanion': [4397], '(30Thoden': [4398, 4725], 'purposes,': [4421], '(C269S': [4432], 'mutant)': [4433], 'Fig.6C.': [4440], 'eight': [4447], 'direct': [4448], '3.2': [4451], 'contrast': [4459], 'acivicin-bound': [4466], 'enzyme.': [4467], 'replacement': [4469], 'carboxamide': [4472], 'key': [4488], '(Gly-241': [4496], 'Leu-270)': [4498], 'Asn-311.': [4504], 'Additionally,': [4505], 'bond': [4508], 'Gly-243': [4520], 'lost': [4522], 'upon': [4523], 'complexation': [4524], 'less': [4528], 'extensive': [4529], 'network': [4532], 'may,': [4538], 'part,': [4540], 'explain': [4541], 'lower': [4543], 'Other': [4551], 'than': [4552], 'changes,': [4554], 'however,': [4555], 'polypeptide': [4557], 'chains': [4558], 'subunits': [4562], 'complexed': [4563], 'either': [4565], 'or': [4567], 'remarkably': [4570], 'similar': [4571, 4844], 'superimpose': [4573], 'deviation': [4579], '0.23': [4581], 'atoms.': [4585], '2Since': [4586], 'submission': [4588], 'manuscript,': [4591], 'co-workers': [4594], '(46Chaudhuri': [4595], 'B.N.': [4596], 'Lange': [4597], 'S.C.': [4598], 'Myers': [4599], 'R.S.': [4600], 'Smith': [4605], 'Structure.': [4607], '9:': [4609], '987-997Abstract': [4610], '(99)': [4618], 'reported': [4622], 'nicely': [4647], 'illustrates': [4648], 'use': [4650, 4700], 'TIM': [4656], 'barrel': [4657], 'integral': [4661], 'part': [4662], 'delivery': [4669], 'ammonia.': [4671], 'biochemical': [4673], 'suggested': [4678], 'γ-glutamine': [4683], 'proceeds': [4688], 'tetrahedral': [4691, 4783, 4856], 'adducts': [4692], 'glutamyl-thioester': [4695], 'By': [4697], 'judicious': [4699], 'analogs': [4703], 'site-directed': [4705], 'mutant': [4706], 'proteins,': [4707], 'possible': [4711], 'define,': [4713], 'analyses,': [4718], 'structures': [4720, 4826], 'proposed': [4723], '45Thoden': [4746], 'Huang': [4748], 'X.': [4749], '1999;': [4755], '38:': [4756], '16158-16166Crossref': [4757], '(61)': [4760], 'examine': [4764], 'geometry': [4766, 4799], 'Michaelis': [4769], 'complex,': [4770], 'replaced': [4773], 'serine': [4776], 'crystallized.': [4779], 'mimic': [4781], 'intermediate,': [4784, 4813], 'native': [4788], 'γ-semialdehyde': [4792], 'prepared.': [4794], 'Finally,': [4795], 'address': [4797], 'His-353': [4814], 'changed': [4816], 'asparagine': [4819], 'residue.': [4820], 'superposition': [4822], 'onto': [4827], 'acivicin-inactivated': [4832], 'here': [4835], '7.': [4840], 'adopts': [4842], 'conformation': [4845], 'intermediates.': [4860], 'ligands': [4870], 'occupy': [4871], 'nearly': [4872], 'identical': [4873], 'positions.': [4874], 'potency': [4876], 'is,': [4882], 'indeed,': [4883], 'surprising': [4885], 'light': [4887], 'structural': [4890], 'similarities.': [4891], 'mechanism': [4893], 'Scheme': [4915], 'FS1.Figure': [4916], 'FS1View': [4917]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2090740468', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-12T09:09:08.164783', 'created_date': '2016-06-24'}