Publication Information

{'id': 'https://openalex.org/W2090662277', 'doi': 'https://doi.org/10.1097/cad.0b013e3280115111', 'title': 'Ceramide induces early and late apoptosis in human papilloma virus+ cervical cancer cells by inhibiting reactive oxygen species decay, diminishing the intracellular concentration of glutathione and increasing nuclear factor-κB translocation', 'display_name': 'Ceramide induces early and late apoptosis in human papilloma virus+ cervical cancer cells by inhibiting reactive oxygen species decay, diminishing the intracellular concentration of glutathione and increasing nuclear factor-κB translocation', 'publication_year': 2006, 'publication_date': '2006-12-08', 'ids': {'openalex': 'https://openalex.org/W2090662277', 'doi': 'https://doi.org/10.1097/cad.0b013e3280115111', 'mag': '2090662277', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17159601'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/cad.0b013e3280115111', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S158028025', 'display_name': 'Anti-Cancer Drugs', 'issn_l': '0959-4973', 'issn': ['0959-4973', '1473-5741'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080965669', 'display_name': 'Gisela Gutiérrez', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210157394', 'display_name': 'Instituto Nacional de Cardiología', 'ror': 'https://ror.org/046e90j34', 'country_code': 'MX', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157394']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Gisela Gutiérrez', 'raw_affiliation_strings': ['Department of Cell Biology, National Institute of Cardiology Ignacio Chávez, Juan Badiano No. 1, Colonia Sección 16, Tlalpan, CP 14080, Mexico DF, Mexico.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, National Institute of Cardiology Ignacio Chávez, Juan Badiano No. 1, Colonia Sección 16, Tlalpan, CP 14080, Mexico DF, Mexico.', 'institution_ids': ['https://openalex.org/I4210157394']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047719071', 'display_name': 'Criselda Mendoza-Milla', 'orcid': 'https://orcid.org/0000-0003-0304-2313'}, 'institutions': [], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Criselda Mendoza', 'raw_affiliation_strings': ['Investigation Center of Infectious Diseases, INER, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Investigation Center of Infectious Diseases, INER, Mexico', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077159822', 'display_name': 'Luis F. Montaño', 'orcid': 'https://orcid.org/0000-0002-2019-3140'}, 'institutions': [{'id': 'https://openalex.org/I8961855', 'display_name': 'Universidad Nacional Autónoma de México', 'ror': 'https://ror.org/01tmp8f25', 'country_code': 'MX', 'type': 'education', 'lineage': ['https://openalex.org/I8961855']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Luis F. Montaño', 'raw_affiliation_strings': ['Laboratory of Immunology, Department of Biochemistry, School of Medicine, UNAM, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Immunology, Department of Biochemistry, School of Medicine, UNAM, Mexico', 'institution_ids': ['https://openalex.org/I8961855']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5007509247', 'display_name': 'Rebeca López‐Marure', 'orcid': 'https://orcid.org/0000-0003-1090-5084'}, 'institutions': [{'id': 'https://openalex.org/I4210157394', 'display_name': 'Instituto Nacional de Cardiología', 'ror': 'https://ror.org/046e90j34', 'country_code': 'MX', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157394']}], 'countries': ['MX'], 'is_corresponding': True, 'raw_author_name': 'Rebeca López-Marure', 'raw_affiliation_strings': ['Department of Cell Biology, National Institute of Cardiology, Ignacio Chávez'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, National Institute of Cardiology, Ignacio Chávez', 'institution_ids': ['https://openalex.org/I4210157394']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5007509247'], 'corresponding_institution_ids': ['https://openalex.org/I4210157394'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.805, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.627036, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '18', 'issue': '2', 'first_page': '149', 'last_page': '159'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Metabolism and Signaling', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Metabolism and Signaling', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11591', 'display_name': 'NF-κB Signaling Pathways', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2777851122', 'wikidata': 'https://www.wikidata.org/wiki/Q424213', 'display_name': 'Ceramide', 'level': 3, 'score': 0.8755478}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.61804837}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.60305965}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5558777}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.4884607}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4651813}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.45451212}, {'id': 'https://openalex.org/C538909803', 'wikidata': 'https://www.wikidata.org/wiki/Q116907', 'display_name': 'Glutathione', 'level': 3, 'score': 0.42042553}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.36665398}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.31327778}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.05681002}], 'mesh': [{'descriptor_ui': 'D002518', 'descriptor_name': 'Ceramides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002583', 'descriptor_name': 'Uterine Cervical Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D002583', 'descriptor_name': 'Uterine Cervical Neoplasms', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D061945', 'descriptor_name': 'Caspase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002518', 'descriptor_name': 'Ceramides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008564', 'descriptor_name': 'Membrane Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008564', 'descriptor_name': 'Membrane Potentials', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D051336', 'descriptor_name': 'Mitochondrial Membranes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051336', 'descriptor_name': 'Mitochondrial Membranes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009573', 'descriptor_name': 'Nitrites', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009573', 'descriptor_name': 'Nitrites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013450', 'descriptor_name': 'Sulfones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013450', 'descriptor_name': 'Sulfones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014178', 'descriptor_name': 'Translocation, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014178', 'descriptor_name': 'Translocation, Genetic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002583', 'descriptor_name': 'Uterine Cervical Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1097/cad.0b013e3280115111', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S158028025', 'display_name': 'Anti-Cancer Drugs', 'issn_l': '0959-4973', 'issn': ['0959-4973', '1473-5741'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17159601', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W133248599', 'https://openalex.org/W1602308243', 'https://openalex.org/W1950610522', 'https://openalex.org/W1965745450', 'https://openalex.org/W1983430147', 'https://openalex.org/W1984656331', 'https://openalex.org/W2005484362', 'https://openalex.org/W2009936156', 'https://openalex.org/W2011925577', 'https://openalex.org/W2012577664', 'https://openalex.org/W2030539713', 'https://openalex.org/W2036246693', 'https://openalex.org/W2038522823', 'https://openalex.org/W2041576624', 'https://openalex.org/W2046895342', 'https://openalex.org/W2048243484', 'https://openalex.org/W2061043761', 'https://openalex.org/W2061434349', 'https://openalex.org/W2066613757', 'https://openalex.org/W2069527610', 'https://openalex.org/W2070005836', 'https://openalex.org/W2077992887', 'https://openalex.org/W2078248452', 'https://openalex.org/W2078261279', 'https://openalex.org/W2081397031', 'https://openalex.org/W2083671881', 'https://openalex.org/W2085936016', 'https://openalex.org/W2088680792', 'https://openalex.org/W2091572614', 'https://openalex.org/W2100250344', 'https://openalex.org/W2101981789', 'https://openalex.org/W2117021561', 'https://openalex.org/W2124760141', 'https://openalex.org/W2129087217', 'https://openalex.org/W2137750062', 'https://openalex.org/W2140634444', 'https://openalex.org/W2147921405', 'https://openalex.org/W2153377330', 'https://openalex.org/W2161990266', 'https://openalex.org/W2164754954', 'https://openalex.org/W2165053304', 'https://openalex.org/W2166766769', 'https://openalex.org/W2181148302', 'https://openalex.org/W2188526507', 'https://openalex.org/W2470499316'], 'related_works': ['https://openalex.org/W3080308451', 'https://openalex.org/W2765590223', 'https://openalex.org/W2377341619', 'https://openalex.org/W2347577273', 'https://openalex.org/W216760267', 'https://openalex.org/W2163338807', 'https://openalex.org/W2061260890', 'https://openalex.org/W2059246206', 'https://openalex.org/W2052122421', 'https://openalex.org/W1993194916'], 'abstract_inverted_index': {'Ceramide': [0], 'is': [1], 'regarded': [2], 'as': [3], 'an': [4, 92, 151, 167, 202], 'important': [5], 'cellular': [6], 'signal': [7], 'for': [8], 'the': [9, 21, 48, 64, 88, 184, 219], 'induction': [10], 'of': [11, 23, 32, 50, 56, 67, 95, 122, 137, 186, 189, 205], 'cell': [12, 40, 74, 130], 'death.': [13], 'We': [14], 'have': [15], 'previously': [16], 'shown': [17], 'that': [18, 213], 'ceramide': [19, 38], 'induces': [20, 39], 'death': [22, 41, 131], 'cervical': [24, 69, 226], 'tumor': [25], 'cells': [26], 'without': [27], 'biochemical': [28], 'and': [29, 129, 144, 157, 173, 192], 'morphological': [30], 'markers': [31], 'apoptosis.': [33], 'The': [34], 'mechanisms': [35], 'by': [36, 82, 87, 102, 108, 115, 126, 132, 199], 'which': [37, 147], 'are': [42], 'not': [43, 182, 197], 'understood,': [44], 'therefore': [45], 'we': [46], 'evaluated': [47], 'effect': [49, 195], 'C6-ceramide,': [51], 'a': [52, 133, 161, 174], 'synthetic': [53], 'cell-permeable': [54], 'analog': [55], 'endogenous': [57], 'ceramides,': [58], 'in': [59, 63, 153, 163, 169, 176, 218], 'signaling': [60], 'pathways': [61], 'involved': [62], 'oxidative': [65, 214], 'stress': [66, 215], 'three': [68], 'human': [70, 223], 'papilloma': [71, 224], 'virus': [72, 225], 'cancer': [73, 227], 'lines.': [75], 'Reactive': [76], 'oxygen': [77, 155], 'species': [78, 156], 'production': [79], 'was': [80, 148, 196], 'determined': [81], 'fluorescent': [83], '2,7-dichlorofluorescein,': [84], 'nitrite': [85], 'concentration': [86, 107], 'Griess': [89], 'reaction': [90], '(as': [91], 'indirect': [93], 'measure': [94], 'nitric': [96, 158], 'oxide': [97, 159], 'production),': [98], 'mitochondrial': [99, 164], 'membrane': [100, 165], 'potential': [101], 'staining': [103], 'with': [104, 150], 'Rh123,': [105], 'reduced-glutathione': [106], 'high-pressure': [109], 'liquid': [110], 'chromatography,': [111], 'nuclear': [112, 123, 170, 190, 206], 'factor-kappaB': [113, 124, 171, 191, 207], 'translocation': [114], 'electrophoretic': [116], 'mobility': [117], 'shift': [118], 'assay,': [119], 'inhibitory': [120, 187, 203], 'protein': [121, 188, 204], 'expression': [125, 185], 'Western': [127], 'blot': [128], 'poly-caspases': [134], 'fluorochrome-labeled': [135], 'inhibitors': [136], 'caspases': [138], 'apoptosis': [139], 'assay.': [140], 'C6-ceramide': [141, 180], 'induced': [142], 'early': [143], 'late': [145], 'apoptosis,': [146], 'associated': [149], 'increase': [152, 168], 'reactive': [154], 'production,': [160], 'loss': [162], 'potential,': [166], 'translocation,': [172], 'decrease': [175], 'reduced': [177], 'glutathione': [178], 'concentration.': [179], 'did': [181], 'modify': [183], 'its': [193], 'antiproliferative': [194], 'abrogated': [198], 'Bay': [200], '11-7082,': [201], 'kinase': [208], 'inhibitor.': [209], 'Our': [210], 'results': [211], 'suggest': [212], 'might': [216], 'participate': [217], 'ceramide-induced': [220], 'damage': [221], 'to': [222], 'cells.': [228]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2090662277', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-09T20:50:21.548029', 'created_date': '2016-06-24'}