Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2090575139', 'doi': 'https://doi.org/10.1126/science.1846707', 'title': 'Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G <sub>q</sub>', 'display_name': 'Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G <sub>q</sub>', 'publication_year': 1991, 'publication_date': '1991-02-15', 'ids': {'openalex': 'https://openalex.org/W2090575139', 'doi': 'https://doi.org/10.1126/science.1846707', 'mag': '2090575139', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1846707'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.1846707', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002671842', 'display_name': 'Alan V. Smrcka', 'orcid': 'https://orcid.org/0000-0003-3099-8812'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alan V. Smrcka', 'raw_affiliation_strings': ['Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75235.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75235.', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001113992', 'display_name': 'John R. Hepler', 'orcid': 'https://orcid.org/0000-0002-1090-2919'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John R. Hepler', 'raw_affiliation_strings': ['Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75235.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75235.', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061398820', 'display_name': 'Kendall O. Brown', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kendall O. Brown', 'raw_affiliation_strings': ['Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75235.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75235.', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5001377302', 'display_name': 'Paul C. Sternweis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul C. Sternweis', 'raw_affiliation_strings': ['Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75235.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75235.', 'institution_ids': ['https://openalex.org/I867280407']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 55.225, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 884, 'citation_normalized_percentile': {'value': 0.999962, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '251', 'issue': '4995', 'first_page': '804', 'last_page': '807'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10617', 'display_name': 'Mechanisms of Intracellular Membrane Trafficking', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Molecular Mechanisms of Ion Channels Regulation', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gq-alpha-subunit', 'display_name': 'Gq alpha subunit', 'score': 0.90576607}, {'id': 'https://openalex.org/keywords/second-messenger-system', 'display_name': 'Second messenger system', 'score': 0.7688962}, {'id': 'https://openalex.org/keywords/phosphoinositide-phospholipase-c', 'display_name': 'Phosphoinositide phospholipase C', 'score': 0.7138056}, {'id': 'https://openalex.org/keywords/inositol-trisphosphate', 'display_name': 'Inositol trisphosphate', 'score': 0.60428625}, {'id': 'https://openalex.org/keywords/phospholipase-c', 'display_name': 'Phospholipase C', 'score': 0.541305}, {'id': 'https://openalex.org/keywords/phosphatidylinositol-4,5-bisphosphate', 'display_name': 'Phosphatidylinositol 4,5-bisphosphate', 'score': 0.46471652}], 'concepts': [{'id': 'https://openalex.org/C66135807', 'wikidata': 'https://www.wikidata.org/wiki/Q24726231', 'display_name': 'Gq alpha subunit', 'level': 4, 'score': 0.90576607}, {'id': 'https://openalex.org/C2778597717', 'wikidata': 'https://www.wikidata.org/wiki/Q420248', 'display_name': 'Phospholipase C', 'level': 3, 'score': 0.8632007}, {'id': 'https://openalex.org/C163235415', 'wikidata': 'https://www.wikidata.org/wiki/Q899814', 'display_name': 'Second messenger system', 'level': 3, 'score': 0.7688962}, {'id': 'https://openalex.org/C80631254', 'wikidata': 'https://www.wikidata.org/wiki/Q407438', 'display_name': 'G protein', 'level': 3, 'score': 0.7607237}, {'id': 'https://openalex.org/C78297661', 'wikidata': 'https://www.wikidata.org/wiki/Q10760862', 'display_name': 'Phosphoinositide phospholipase C', 'level': 4, 'score': 0.7138056}, {'id': 'https://openalex.org/C36020004', 'wikidata': 'https://www.wikidata.org/wiki/Q106951674', 'display_name': 'Diacylglycerol kinase', 'level': 4, 'score': 0.6842677}, {'id': 'https://openalex.org/C49773422', 'wikidata': 'https://www.wikidata.org/wiki/Q4859345', 'display_name': 'Pertussis toxin', 'level': 4, 'score': 0.6652224}, {'id': 'https://openalex.org/C2780610907', 'wikidata': 'https://www.wikidata.org/wiki/Q2273248', 'display_name': 'Phosphatidylinositol', 'level': 3, 'score': 0.62104166}, {'id': 'https://openalex.org/C2777427919', 'wikidata': 'https://www.wikidata.org/wiki/Q407997', 'display_name': 'Inositol', 'level': 3, 'score': 0.61354274}, {'id': 'https://openalex.org/C2781387506', 'wikidata': 'https://www.wikidata.org/wiki/Q138145', 'display_name': 'Inositol trisphosphate', 'level': 4, 'score': 0.60428625}, {'id': 'https://openalex.org/C12927208', 'wikidata': 'https://www.wikidata.org/wiki/Q210430', 'display_name': 'Phospholipase', 'level': 3, 'score': 0.5116985}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4831914}, {'id': 'https://openalex.org/C83730767', 'wikidata': 'https://www.wikidata.org/wiki/Q24778884', 'display_name': 'G alpha subunit', 'level': 4, 'score': 0.47246432}, {'id': 'https://openalex.org/C2777853560', 'wikidata': 'https://www.wikidata.org/wiki/Q3083814', 'display_name': 'Phosphatidylinositol 4,5-bisphosphate', 'level': 4, 'score': 0.46471652}, {'id': 'https://openalex.org/C53009064', 'wikidata': 'https://www.wikidata.org/wiki/Q167', 'display_name': 'Pi', 'level': 2, 'score': 0.43237817}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.43055812}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4171238}, {'id': 'https://openalex.org/C139407321', 'wikidata': 'https://www.wikidata.org/wiki/Q408561', 'display_name': 'Heterotrimeric G protein', 'level': 4, 'score': 0.41248393}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.35508144}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.3059571}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.28303188}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.23292965}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D017607', 'descriptor_name': 'Aluminum Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019204', 'descriptor_name': 'GTP-Binding Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D010727', 'descriptor_name': 'Phosphoric Diester Hydrolases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000535', 'descriptor_name': 'Aluminum', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000535', 'descriptor_name': 'Aluminum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002417', 'descriptor_name': 'Cattle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005459', 'descriptor_name': 'Fluorides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005459', 'descriptor_name': 'Fluorides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019204', 'descriptor_name': 'GTP-Binding Proteins', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D019204', 'descriptor_name': 'GTP-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006153', 'descriptor_name': 'Guanosine Diphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043265', 'descriptor_name': 'Phosphatidylinositol Diacylglycerol-Lyase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054801', 'descriptor_name': 'Phosphoinositide Phospholipase C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010727', 'descriptor_name': 'Phosphoric Diester Hydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.1846707', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1846707', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W127340152', 'https://openalex.org/W1496902535', 'https://openalex.org/W1504737180', 'https://openalex.org/W1522007155', 'https://openalex.org/W1549940137', 'https://openalex.org/W1570939625', 'https://openalex.org/W1572781346', 'https://openalex.org/W1606421683', 'https://openalex.org/W1650467796', 'https://openalex.org/W1983596426', 'https://openalex.org/W1985799046', 'https://openalex.org/W2009716889', 'https://openalex.org/W2010491659', 'https://openalex.org/W2011758204', 'https://openalex.org/W2035905569', 'https://openalex.org/W2037434894', 'https://openalex.org/W2058012300', 'https://openalex.org/W2062748780', 'https://openalex.org/W2070111612', 'https://openalex.org/W2070288681', 'https://openalex.org/W2072705431', 'https://openalex.org/W2080875376', 'https://openalex.org/W2082497364', 'https://openalex.org/W2138476193', 'https://openalex.org/W2162213293', 'https://openalex.org/W2208774673', 'https://openalex.org/W2242690994', 'https://openalex.org/W2282580666'], 'related_works': ['https://openalex.org/W429778924', 'https://openalex.org/W2764749351', 'https://openalex.org/W2730317602', 'https://openalex.org/W2387957150', 'https://openalex.org/W2185380343', 'https://openalex.org/W2102112060', 'https://openalex.org/W2090575139', 'https://openalex.org/W2050923205', 'https://openalex.org/W165163710', 'https://openalex.org/W149292485'], 'abstract_inverted_index': {'The': [0, 47], 'hydrolysis': [1], 'of': [2, 29, 50, 73, 88], 'phosphatidylinositol': [3], '4,5-bisphosphate': [4], '(PIP': [5], '2': [6], ')': [7, 19, 60], 'by': [8, 26], 'phospholipase': [9, 75], 'C': [10, 76], 'yields': [11], 'the': [12, 36, 71, 82, 86], 'second': [13], 'messengers': [14], 'inositol': [15], '1,4,5-trisphosphate': [16], '(InsP': [17], '3': [18], 'and': [20, 65, 85], '1,2-diacylglycerol.': [21], 'This': [22], 'activity': [23, 72, 84], 'is': [24, 66], 'regulated': [25], 'a': [27, 51, 101], 'variety': [28], 'hormones': [30], 'through': [31], 'G': [32, 38, 56, 98, 102], 'protein': [33, 39, 57, 103], 'pathways.': [34], 'However,': [35], 'specific': [37], 'or': [40], 'proteins': [41], 'involved': [42], 'has': [43, 61], 'not': [44], 'been': [45, 63], 'identified.': [46], 'α': [48], 'subunit': [49], 'newly': [52], 'discovered': [53], 'pertussis': [54], 'toxin-insensitive': [55], '(G': [58], 'q': [59, 99], 'recently': [62], 'isolated': [64], 'now': [67], 'shown': [68], 'to': [69], 'stimulate': [70], 'polyphosphoinositide-specific': [74], '(PI-PLC)': [77], 'from': [78], 'bovine': [79], 'brain.': [80], 'Both': [81], 'maximal': [83], 'affinity': [87], 'PI-PLC': [89], 'for': [90], 'calcium': [91], 'ion': [92], 'were': [93], 'affected.': [94], 'These': [95], 'results': [96], 'identify': [97], 'as': [100], 'that': [104], 'regulates': [105], 'PI-PLC.': [106]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2090575139', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-09-13T04:15:46.068900', 'created_date': '2016-06-24'}