Merochlorins A–D, Cyclic Meroterpenoid Antibiotics Biosynthesized in Divergent Pathways with Vanadium-Dependent Chloroperoxidases

Name: Work Video:
Duration: 3 min 30 s
Leonard Kaysser; Peter Bernhardt; Sang‐Jip Nam; Sandra Loesgen; J. Graham Ruby; Peter Skewes-Cox; Paul R. Jensen; William Fenical; Bradley S. Moore
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'abstract_inverted_index': {'Meroterpenoids': [0], 'are': [1], 'mixed': [2], 'polyketide-terpenoid': [3], 'natural': [4], 'products': [5], 'with': [6], 'a': [7], 'broad': [8], 'range': [9], 'of': [10, 18, 78, 91, 101], 'biological': [11], 'activities.': [12], 'Herein,': [13], 'we': [14], 'present': [15], 'the': [16, 27, 52, 59, 87, 92, 98], 'structures': [17], 'four': [19], 'new': [20], 'meroterpenoid': [21], 'antibiotics,': [22], 'merochlorins': [23], 'A-D,': [24], 'produced': [25], 'by': [26, 86], 'marine': [28], 'bacterium': [29], 'Streptomyces': [30, 56], 'sp.': [31], 'strain': [32], 'CNH-189,': [33], 'which': [34], 'possess': [35], 'novel': [36], 'chemical': [37], 'skeletons': [38], 'unrelated': [39], 'to': [40, 117], 'known': [41], 'bacterial': [42, 71], 'agents.': [43], 'Draft': [44], 'genome': [45], 'sequencing,': [46], 'mutagenesis,': [47], 'and': [48], 'heterologous': [49], 'biosynthesis': [50, 100], 'in': [51, 97], 'genome-minimized': [53], 'model': [54], 'actinomycete': [55], 'coelicolor': [57], 'provided': [58], '57.6': [60], 'kb': [61], 'merochlorin': [62, 102, 115, 118], 'gene': [63, 94], 'cluster': [64], 'that': [65, 83, 105], 'contains': [66], 'two': [67, 79], 'genes': [68], 'encoding': [69], 'rare': [70], 'vanadium-dependent': [72], 'haloperoxidase': [73], '(VHPO)': [74], 'genes.': [75], 'Pathway': [76], 'expression': [77], 'different': [80], 'fosmid': [81], 'clones': [82], 'differ': [84], 'largely': [85], 'presence': [88], 'or': [89], 'absence': [90], 'VHPO': [93], 'mcl40': [95], 'resulted': [96], 'differential': [99], 'C,': [103], 'suggesting': [104], 'Mcl40': [106], 'catalyzes': [107], 'an': [108], 'unprecedented': [109], '15-membered': [110], 'chloronium-induced': [111], 'macrocyclization': [112], 'reaction': [113], 'converting': [114], 'D': [116], 'C.': [119]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2090466503', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 25}, {'year': 2017, 'cited_by_count': 25}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 15}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-07T02:20:37.579317', 'created_date': '2016-06-24'}
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