Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2090439227', 'doi': 'https://doi.org/10.4161/auto.7.11.17514', 'title': 'IFN-α/β and autophagy', 'display_name': 'IFN-α/β and autophagy', 'publication_year': 2011, 'publication_date': '2011-11-01', 'ids': {'openalex': 'https://openalex.org/W2090439227', 'doi': 'https://doi.org/10.4161/auto.7.11.17514', 'mag': '2090439227', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21997372', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3359484'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4161/auto.7.11.17514', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.4161/auto.7.11.17514?needAccess=true', 'source': {'id': 'https://openalex.org/S102544370', 'display_name': 'Autophagy', 'issn_l': '1554-8627', 'issn': ['1554-8627', '1554-8635'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.tandfonline.com/doi/pdf/10.4161/auto.7.11.17514?needAccess=true', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046764208', 'display_name': 'Jiaren Sun', 'orcid': 'https://orcid.org/0000-0001-5084-4437'}, 'institutions': [{'id': 'https://openalex.org/I55302922', 'display_name': 'The University of Texas Medical Branch at Galveston', 'ror': 'https://ror.org/016tfm930', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55302922']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jiaren Sun', 'raw_affiliation_strings': ['Department of Microbiology and Immunology; University of Texas Medical Branch at Galveston; Galveston, TX USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology; University of Texas Medical Branch at Galveston; Galveston, TX USA', 'institution_ids': ['https://openalex.org/I55302922']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047424576', 'display_name': 'Mayura Desai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I55302922', 'display_name': 'The University of Texas Medical Branch at Galveston', 'ror': 'https://ror.org/016tfm930', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55302922']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mayura M Desai', 'raw_affiliation_strings': ['University of Texas Medical Branch at Galveston'], 'affiliations': [{'raw_affiliation_string': 'University of Texas Medical Branch at Galveston', 'institution_ids': ['https://openalex.org/I55302922']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020114169', 'display_name': 'Lynn Soong', 'orcid': 'https://orcid.org/0000-0003-3370-3434'}, 'institutions': [{'id': 'https://openalex.org/I4210124771', 'display_name': 'Bipar', 'ror': 'https://ror.org/027364b18', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I17606148', 'https://openalex.org/I197681013', 'https://openalex.org/I4210088668', 'https://openalex.org/I4210099460', 'https://openalex.org/I4210124771', 'https://openalex.org/I4210138120']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Lynn Soong', 'raw_affiliation_strings': ['Microbiology And Immunology'], 'affiliations': [{'raw_affiliation_string': 'Microbiology And Immunology', 'institution_ids': ['https://openalex.org/I4210124771']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103344256', 'display_name': 'J H Ou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800817003', 'display_name': 'Southern California University for Professional Studies', 'ror': 'https://ror.org/058zz0t50', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I2800817003']}, {'id': 'https://openalex.org/I1174212', 'display_name': 'University of Southern California', 'ror': 'https://ror.org/03taz7m60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1174212']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J H James Ou', 'raw_affiliation_strings': ['University of Southern California'], 'affiliations': [{'raw_affiliation_string': 'University of Southern California', 'institution_ids': ['https://openalex.org/I2800817003', 'https://openalex.org/I1174212']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.026, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.711011, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '7', 'issue': '11', 'first_page': '1394', 'last_page': '1396'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11668', 'display_name': 'Innate Immunity to Viral Infection', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11668', 'display_name': 'Innate Immunity to Viral Infection', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11078', 'display_name': 'Molecular Mechanisms of Inflammasome Activation and Regulation', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10151', 'display_name': 'Hepatitis C Infection and Treatment', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/trif', 'display_name': 'TRIF', 'score': 0.7912216}, {'id': 'https://openalex.org/keywords/ns3', 'display_name': 'NS3', 'score': 0.5773969}, {'id': 'https://openalex.org/keywords/tlr3', 'display_name': 'TLR3', 'score': 0.49710348}, {'id': 'https://openalex.org/keywords/hepatitis-c-virus', 'display_name': 'Hepatitis C Virus', 'score': 0.461391}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8103008}, {'id': 'https://openalex.org/C43929388', 'wikidata': 'https://www.wikidata.org/wiki/Q4050587', 'display_name': 'TRIF', 'level': 5, 'score': 0.7912216}, {'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.7855296}, {'id': 'https://openalex.org/C183786373', 'wikidata': 'https://www.wikidata.org/wiki/Q5964993', 'display_name': 'Signal transducing adaptor protein', 'level': 3, 'score': 0.7153908}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.61593574}, {'id': 'https://openalex.org/C132379496', 'wikidata': 'https://www.wikidata.org/wiki/Q83141645', 'display_name': 'NS3', 'level': 4, 'score': 0.5773969}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5323985}, {'id': 'https://openalex.org/C2776408679', 'wikidata': 'https://www.wikidata.org/wiki/Q708693', 'display_name': 'Hepatitis C virus', 'level': 3, 'score': 0.5031149}, {'id': 'https://openalex.org/C2778420691', 'wikidata': 'https://www.wikidata.org/wiki/Q14866230', 'display_name': 'TLR3', 'level': 5, 'score': 0.49710348}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.48791596}, {'id': 'https://openalex.org/C2776178377', 'wikidata': 'https://www.wikidata.org/wiki/Q188269', 'display_name': 'Interferon', 'level': 2, 'score': 0.46658498}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.38050535}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.37120542}, {'id': 'https://openalex.org/C2776709828', 'wikidata': 'https://www.wikidata.org/wiki/Q408004', 'display_name': 'Toll-like receptor', 'level': 4, 'score': 0.33408916}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.2833565}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.2616315}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.17465287}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14460865}], 'mesh': [{'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D054884', 'descriptor_name': 'Host-Pathogen Interactions', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016898', 'descriptor_name': 'Interferon-alpha', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016899', 'descriptor_name': 'Interferon-beta', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016679', 'descriptor_name': 'Genome, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016679', 'descriptor_name': 'Genome, Viral', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016174', 'descriptor_name': 'Hepacivirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D054884', 'descriptor_name': 'Host-Pathogen Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016898', 'descriptor_name': 'Interferon-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016899', 'descriptor_name': 'Interferon-beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014764', 'descriptor_name': 'Viral Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014764', 'descriptor_name': 'Viral Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4161/auto.7.11.17514', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.4161/auto.7.11.17514?needAccess=true', 'source': {'id': 'https://openalex.org/S102544370', 'display_name': 'Autophagy', 'issn_l': '1554-8627', 'issn': ['1554-8627', '1554-8635'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3359484', 'pdf_url': 'https://europepmc.org/articles/pmc3359484?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359484', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21997372', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4161/auto.7.11.17514', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.4161/auto.7.11.17514?needAccess=true', 'source': {'id': 'https://openalex.org/S102544370', 'display_name': 'Autophagy', 'issn_l': '1554-8627', 'issn': ['1554-8627', '1554-8635'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.84}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 1, 'referenced_works': ['https://openalex.org/W2068320176'], 'related_works': ['https://openalex.org/W4247309095', 'https://openalex.org/W320525602', 'https://openalex.org/W3010148791', 'https://openalex.org/W2387502182', 'https://openalex.org/W2380101588', 'https://openalex.org/W2332500211', 'https://openalex.org/W2153231506', 'https://openalex.org/W2109972346', 'https://openalex.org/W2066586142', 'https://openalex.org/W2049262799'], 'abstract_inverted_index': {'Hepatitis': [0], 'C': [1], 'virus': [2], '(HCV)': [3], 'infects': [4], 'approximately': [5], '130': [6], 'million': [7], 'people': [8], 'worldwide.': [9], 'The': [10], 'clinical': [11], 'sequelae': [12], 'of': [13, 23, 61], 'this': [14, 54], 'chronic': [15], 'disease': [16], 'include': [17], 'cirrhosis,': [18], 'functional': [19], 'failure': [20], 'and': [21, 36, 41, 47, 79, 103, 123, 132], 'carcinoma': [22], 'the': [24, 56, 62, 93, 97, 120, 137], 'liver.': [25], 'HCV': [26, 57, 118, 129], 'induces': [27], 'autophagy,': [28], 'a': [29, 113], 'fundamental': [30], 'cellular': [31, 72], 'process': [32], 'for': [33], 'maintaining': [34], 'homeostasis': [35], 'mediating': [37], 'innate': [38], 'immune': [39], 'response,': [40], 'also': [42], 'inhibits': [43], 'autophagic': [44], 'protein': [45, 77], 'degradation': [46], 'suppresses': [48], 'antiviral': [49, 124], 'immunity.': [50], 'In': [51], 'addition': [52], 'to': [53], 'ploy,': [55], 'serine': [58], 'protease': [59], 'composed': [60], 'viral': [63], 'non-structural': [64], 'proteins': [65, 91], '3/4A': [66], '(NS3/4A)': [67], 'can': [68], 'enzymatically': [69], 'digest': [70], 'two': [71, 90], 'proteins,': [73], 'mitochondria-associated': [74], 'anti-viral': [75], 'signaling': [76, 122], '(MAVS)': [78], 'Toll/interleukin-1': [80], 'receptor': [81], 'domain': [82], 'containing': [83], 'adaptor': [84, 94], 'inducing': [85], 'IFN-β': [86], '(TRIF).': [87], 'Since': [88], 'these': [89], 'are': [92], 'molecules': [95], 'in': [96, 136], 'retinoic': [98], 'acid-inducible': [99], 'gene': [100], 'I': [101], '(RIG-I)': [102], 'TLR3': [104], 'pathways,': [105], 'respectively,': [106], 'their': [107], 'cleavage': [108], 'has': [109], 'been': [110], 'suggested': [111], 'as': [112], 'pivotal': [114], 'mechanism': [115], 'by': [116], 'which': [117], 'blunts': [119], 'IFN-α/β': [121, 135], 'responses.': [125], 'Thus': [126], 'far,': [127], 'how': [128], 'perturbs': [130], 'autophagy': [131], 'copes': [133], 'with': [134], 'liver': [138], 'remains': [139], 'unclear.': [140]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2090439227', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-08-13T15:43:01.766621', 'created_date': '2016-06-24'}