Publication Information

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473, 639, 650, 704, 730, 998, 1002, 1010, 1075, 1080, 1086, 1115, 1119, 1245, 1255, 1259, 1262, 1314, 1319, 1368, 1372, 1378, 1384, 1400, 1419, 1424, 1427, 1432, 1439, 1489, 1521, 1527, 1543, 1546, 1551, 1554, 1609, 1612, 1631, 1669, 1691, 1695, 1700, 1733, 1746, 1753, 1876, 1883, 1947, 1977, 1984, 1991, 2001, 2005, 2009, 2014, 2021, 2028, 2039, 2049, 2058, 2067, 2102, 2107, 2124, 2129, 2156, 2160, 2166, 2171, 2175, 2179, 2192, 2223, 2366, 2382, 2385, 2392, 2395, 2472, 2483, 2486, 2492, 2495, 2534, 2622, 2631, 2798, 2806, 2811, 2816, 2819, 2839, 2848, 2861, 2867, 2879, 2883, 2887, 2897, 2900, 3014, 3019, 3023, 3031, 3034, 3039, 3044, 3062, 3067, 3071, 3080, 3088, 3106, 3114, 3132, 3136, 3148, 3159, 3164, 3180, 3194, 3211, 3215, 3221, 3280, 3285, 3303, 3310, 3314, 3345, 3349, 3361, 3370, 3415, 3428, 3439, 3461, 3472, 3481, 3651, 3673, 3679, 3917, 4007, 4010, 4015, 4086, 4205, 4208, 4211, 4215, 4226, 4234, 4400, 4411, 4465, 4491], 'mature': [26, 105, 255, 334, 1120, 1379, 1433, 1701, 1884, 1956, 2010, 2022, 3040, 3680], 'caspase-3': [27, 74, 164, 215, 256, 303, 393, 444, 541, 644, 826, 1003, 1049, 1247, 1373, 1380, 1429, 1528, 1555, 1616, 1670, 1697, 1747, 1756, 1759, 1885, 2023, 2095, 2181, 2275, 2369, 2478, 2496, 2535, 2627, 2820, 2903, 3092, 3312, 3352, 3497, 3676, 3681, 3920, 4012, 4111, 4212, 4302, 4405], 'are': [28, 257, 1062, 1134, 1230, 1980, 2510, 2875, 4002], 'proteolytically': [29, 258], 'generated': [30, 259], 'during': [31, 260, 1990], 'apoptosis.': [32, 261], 'Two': [33, 262], 'amino': [34, 263, 1232], 'acid': [35, 264, 1233], 'sequences,': [36, 265, 1234], 'ESMD↓S': [37, 101, 183, 192, 266, 330, 412, 421, 1235, 1865, 2002, 2052, 2884, 3020, 3107, 3286, 3346, 3462], '(amino': [38, 43, 267, 272, 1236, 1241, 1866, 1871], 'acids': [39, 44, 268, 273, 1237, 1242, 1867, 1872], '25–29)': [40, 269, 1238, 1868], 'IETD↓S': [42, 83, 112, 271, 312, 341, 1240, 1870, 2031, 2062, 2161, 2176, 2487, 2536, 2812, 3068, 3089], '172–176),': [45, 274, 1243], 'have': [49, 278, 645, 1251, 1391, 1395, 1475, 1623, 1680, 2617, 2714, 2728, 3153, 3206, 3225, 3422, 3690, 3997, 4406], 'been': [50, 279, 632, 646, 834, 1252, 1393, 2618, 2711, 2722, 3155, 3207, 3226, 3691, 4021, 4100, 4393, 4407], 'defined': [51, 280, 1253], 'cleavage': [54, 109, 148, 189, 283, 338, 377, 418, 1256, 1315, 1713, 1863, 1941, 1998, 2029, 2050, 2060, 2069, 2099, 2111, 2121, 2135, 2172, 2484, 3016, 3053, 3064], 'sites': [55, 284, 1257, 1390], 'for': [56, 285, 1258, 1438, 1524, 1542, 1608, 2082, 2091, 2170, 2381, 2532, 3086, 3104, 3130, 3147, 3193, 3209, 3427], 'production': [58, 209, 287, 438, 1260, 3473], 'p17': [61, 106, 290, 335, 1263, 1879, 2011, 2017, 3041, 3133, 3162, 3355], 'p12': [63, 87, 292, 316, 1265, 1877, 1957, 1978, 2015, 3333, 3357, 3476], 'subunits.': [64, 293], 'Using': [65, 294], 'a': [66, 90, 115, 201, 217, 295, 319, 344, 430, 446, 477, 1095, 1137, 1594, 1684, 1722, 1955, 1960, 1997, 2083, 2213, 2687, 3097, 3120, 3289, 3306, 3336, 3423, 3457, 3700, 4199, 4238], 'cell-free': [67, 296, 1595, 1685], 'assay': [68, 297, 1627, 1686, 1992], 'system,': [69, 298, 2362], 'we': [70, 206, 299, 435, 1474, 1622, 1679, 3152, 4182], 'demonstrate': [71, 207, 300, 436], 'that': [72, 118, 145, 179, 187, 198, 208, 301, 347, 374, 408, 416, 427, 437, 464, 1078, 1085, 1250, 1387, 1398, 1435, 1478, 1514, 1548, 1641, 1682, 1707, 1716, 1758, 1881, 1933, 1970, 1974, 2105, 2165, 2217, 2505, 2795, 2808, 2847, 2854, 2860, 2899, 3083, 3113, 3190, 3205, 3277, 3283, 3295, 3320, 3330, 3341, 3464, 3665, 3999, 4103, 4184, 4195, 4202, 4225], 'appears': [76, 222, 305, 451, 1050, 1644, 1936, 3143], 'to': [77, 223, 306, 452, 836, 1051, 1073, 1409, 1414, 1645, 1651, 1874, 1937, 1951, 2063, 2127, 2191, 2205, 2517, 2620, 2713, 2727, 2871, 3144, 3157, 3228, 3302, 3369, 3436, 3449, 3471, 3493, 3650, 3696, 3908, 3911, 4023, 4214], 'be': [78, 307, 1052, 1090, 1652, 1967, 2137, 2518, 2530, 2837, 3111, 3145, 3229, 3300, 3328, 3433, 3447, 3491, 3909], 'cleaved': [79, 98, 308, 327], 'first': [80, 309, 2098, 3063], 'at': [81, 99, 110, 149, 181, 190, 310, 328, 339, 378, 410, 419, 1864, 1946, 2000, 2030, 2051, 2061, 2070, 2101, 2123, 2174, 2485, 2797, 2810, 3018, 3066, 3344, 4185], 'site,': [84, 102, 313, 331, 2813, 3090, 3347], 'producing': [85, 314, 3348], 'subunit': [88, 317, 670, 693, 732, 1958, 1979, 1989, 3134, 4431, 4454, 4493], '20-kDa': [91, 320], '(p20)': [92, 321], 'peptide.': [93, 322], 'Subsequently,': [94, 323, 1996], 'p20': [96, 325, 1961, 2006, 2888, 3024, 3035, 3137, 3331, 3478], 'generating': [103, 332, 3131], 'subunit.': [107, 336, 2012, 3042], 'site': [113, 152, 193, 342, 381, 422, 1949, 2003, 2104, 2126, 2177, 2488, 3021, 3069, 3287, 3463], 'required': [114, 200, 343, 429, 1607, 2169, 3085, 3103, 3192], 'protease': [116, 129, 137, 144, 177, 345, 358, 366, 373, 406, 1434, 1666, 1737, 2167, 2807, 2850, 2863, 3081, 3198, 3281, 3340, 3420, 4201], 'activity': [117, 178, 346, 407, 2168, 2632, 3082, 3100, 3199, 3282, 3297, 3322], 'was': [119, 153, 194, 348, 382, 423, 1407, 1423, 1436, 1486, 1719, 1760, 1858, 3049, 3084, 3128, 3139, 3191, 3200, 3906, 4094], 'selectively': [120, 154, 174, 349, 383, 403], 'inhibited': [121, 155, 175, 350, 384, 404, 2141, 2805, 3279], 'by': [122, 156, 351, 385, 470, 1094, 1412, 1484, 1565, 1654, 1721, 1735, 1861, 2114, 2142, 2269, 2638, 3653, 3693, 4088, 4189, 4231], 'peptide,': [124, 158, 353, 387], 'Ac-IETD-CHO': [125, 354, 2196], '(acetyl-IETD-aldehyde),': [126, 355], 'other': [128, 357, 2521], 'inhibitors,': [130, 359, 1667], 'such': [131, 360, 2523, 3499], 'cowpox': [134, 363, 2214], 'viral': [135, 364, 2215], 'serine': [136, 365, 1323, 2692], 'inhibitor,': [138, 165, 171, 367, 394, 400, 2195, 2399, 2904], 'CrmA,': [139, 368, 2034, 2115, 3655, 3666], 'andN-α-tosyl-l-phenylalanine': [140, 369], 'chloromethyl': [141, 370, 674, 697, 4435, 4458], 'ketone.': [142, 371], 'catalyzed': [146, 375, 1653, 1720], 'ESMD/S': [151, 380, 2125], 'another': [157, 386], 'Ac-ESMD-CHO': [159, 388], '(acetyl-ESMD-aldehyde).': [160, 389], 'More': [161, 390], 'interestingly,': [162, 391], 'Ac-DEVD-CHO,': [166, 395, 1673], 'but': [167, 396, 2065], 'not': [168, 397, 1392, 1981, 2066, 2389, 2710, 3154, 3177, 3299], 'caspase-1': [170, 399, 2227, 2367, 2386, 2398, 2506], 'Ac-YVAD-CHO,': [172, 401], 'also': [173, 402, 1476, 2203, 2845, 4003], 'cleaves': [180, 409, 2809, 3284], 'site.': [184, 413, 2537, 3108], 'This': [185, 414, 1083, 2110, 2134, 2538, 2857, 3029, 3076], 'indicated': [186, 415], 'either': [195, 424, 3091], 'autocatalytic': [196, 425, 2138], 'or': [197, 426, 827, 2035, 2055, 2368, 2507, 3451], 'it': [199, 428, 1965, 2188, 2201, 2356, 2502, 2708, 2720, 2792, 2843, 3056, 3317, 3326, 3437, 3445, 3466, 3489, 4090, 4098, 4196], 'caspase-3-like': [202, 431, 828, 2508, 3098], 'activity.': [203, 432, 1725], 'In': [204, 433, 458, 635, 996, 1114, 1472, 1619, 3203, 4096, 4219, 4396], 'summary,': [205, 434], 'p17:p12': [212, 441], 'form': [213, 442, 1079, 1882, 2020, 3335], 'sequential': [218, 447, 1712, 1940, 2084], 'two-step': [219, 448, 2085, 2089], 'process': [220, 449, 1369, 1632, 1643, 1709, 1935, 2473, 2625, 4206], 'require': [224, 453, 1069, 1938], 'two': [225, 454, 1076, 1231, 1604, 1647, 1655, 1711, 1939], 'distinct': [226, 455], 'enzymatic': [227, 456], 'activities.': [228, 457, 2370], 'recent': [459, 1563, 4220], 'years,': [460, 4221], 'evidence': [461, 2081, 2380, 4222], 'has': [462, 631, 833, 1597, 2183, 2709, 2721, 3484, 4020, 4099, 4105, 4223, 4392], 'accumulated': [463, 4224], 'degradation': [466, 4227], 'certain': [468, 1016, 1665, 4229], 'proteins': [469, 1493, 4230], 'members': [471, 1061, 2221, 4232], 'caspase': [474, 538, 1059, 2224, 2527, 4235, 4299], 'family': [475, 539, 1060, 2225, 4236, 4300], 'general': [478, 2688, 4239], 'biochemical': [479, 1421, 1750, 4240], 'event': [480, 4241], 'taking': [481, 4242], 'place': [482, 4243], 'undergoing': [485, 4246], 'apoptosis': [486, 838, 1014, 1411, 1479, 1525, 2733, 3698, 3905, 4025, 4193, 4247], '(for': [487, 1098, 4248], 'reviews,': [488, 4249], 'see': [489, 1100, 3187, 4250], 'Refs.': [490, 4251], '1Martin': [491, 4252], 'S.J.': [492, 941, 4253], 'Green': [493, 948, 4254], 'D.R.': [494, 612, 850, 871, 949, 1210, 1838, 2287, 3719, 3741, 3973, 4255, 4373], 'Cell.': [495, 619, 857, 1217, 1579, 1845, 2242, 2294, 3726, 3980, 4256, 4380], '1995;': [496, 529, 593, 620, 858, 877, 897, 1191, 1218, 1300, 1359, 1819, 1846, 1919, 2295, 2748, 2762, 2786, 2939, 3267, 3407, 3535, 3727, 3747, 3813, 3835, 3849, 3873, 3891, 3954, 3981, 4043, 4057, 4081, 4145, 4257, 4290, 4354, 4381], '82:': [497, 4258], '349-352Abstract': [498, 4259], 'Full': [499, 554, 623, 723, 756, 758, 861, 880, 882, 956, 958, 986, 988, 1152, 1221, 1462, 1464, 1583, 1585, 1780, 1849, 2246, 2298, 2321, 2323, 2345, 2347, 2560, 2562, 2583, 2585, 2607, 2609, 2652, 2654, 2676, 2678, 2984, 2986, 3582, 3584, 3730, 3750, 3752, 3984, 4171, 4173, 4260, 4315, 4384, 4484], 'Text': [500, 555, 624, 724, 757, 759, 862, 881, 883, 957, 959, 987, 989, 1153, 1222, 1463, 1465, 1584, 1586, 1781, 1850, 2247, 2299, 2322, 2324, 2346, 2348, 2561, 2563, 2584, 2586, 2608, 2610, 2653, 2655, 2677, 2679, 2985, 2987, 3583, 3585, 3731, 3751, 3753, 3985, 4172, 4174, 4261, 4316, 4385, 4485], 'PDF': [501, 556, 625, 725, 760, 863, 884, 960, 990, 1154, 1223, 1466, 1587, 1782, 1851, 2248, 2300, 2325, 2349, 2564, 2587, 2611, 2656, 2680, 2988, 3586, 3732, 3754, 3986, 4175, 4262, 4317, 4386, 4486], 'PubMed': [502, 519, 532, 557, 596, 626, 726, 761, 793, 818, 864, 885, 900, 918, 935, 961, 991, 1043, 1109, 1155, 1194, 1224, 1303, 1362, 1467, 1588, 1783, 1822, 1852, 1922, 2249, 2301, 2326, 2350, 2463, 2565, 2588, 2612, 2657, 2681, 2701, 2765, 2942, 2961, 2989, 3007, 3270, 3410, 3538, 3557, 3587, 3619, 3644, 3733, 3755, 3772, 3795, 3816, 3852, 3894, 3957, 3987, 4060, 4148, 4176, 4263, 4280, 4293, 4318, 4357, 4387, 4487], 'Scopus': [503, 520, 533, 597, 627, 762, 794, 819, 865, 886, 901, 919, 936, 962, 992, 1044, 1110, 1195, 1225, 1304, 1363, 1468, 1589, 1823, 1853, 1923, 2250, 2302, 2327, 2351, 2464, 2566, 2589, 2613, 2658, 2682, 2702, 2766, 2943, 2962, 2990, 3008, 3271, 3411, 3539, 3558, 3588, 3620, 3645, 3734, 3756, 3773, 3796, 3817, 3853, 3895, 3958, 3988, 4061, 4149, 4177, 4264, 4281, 4294, 4358, 4388], '(1258)': [504, 4265], 'Google': [505, 522, 535, 558, 599, 629, 727, 764, 796, 821, 867, 888, 903, 921, 938, 964, 994, 1046, 1112, 1156, 1197, 1227, 1306, 1365, 1470, 1511, 1591, 1784, 1825, 1855, 1925, 2252, 2304, 2329, 2353, 2466, 2568, 2591, 2615, 2660, 2684, 2704, 2768, 2789, 2945, 2964, 2992, 3010, 3273, 3413, 3541, 3560, 3590, 3622, 3647, 3736, 3758, 3775, 3798, 3819, 3855, 3876, 3897, 3960, 3990, 4063, 4084, 4151, 4179, 4266, 4283, 4296, 4319, 4360, 4390, 4488], 'Scholar,': [506, 523, 559, 600, 765, 797, 889, 904, 922, 939, 965, 1157, 1198, 1785, 1826, 2253, 2661, 2751, 2769, 2946, 2965, 2993, 3542, 3591, 3623, 3737, 3776, 3799, 3820, 3838, 3856, 3877, 3961, 4046, 4064, 4152, 4267, 4284, 4320, 4361], '2Takahashi': [507, 4268], 'A.': [508, 563, 716, 811, 910, 1161, 1270, 1329, 1789, 1889, 2909, 2999, 3237, 3377, 3505, 3637, 3764, 3812, 3881, 3924, 4115, 4269, 4324, 4477], 'Earnshaw': [509, 2955, 3551, 4270], 'W.C.': [510, 2956, 3552, 4271], 'Curr.': [511, 4272], 'Opin.': [512, 4273], 'Genet.': [513, 4274], '&': [514, 4275], 'Dev.': [515, 4276], '1996;': [516, 753, 790, 815, 915, 932, 953, 983, 1040, 1106, 1459, 1508, 1580, 2318, 2557, 2580, 2673, 2981, 3004, 3579, 3616, 3641, 3769, 4168, 4277], '6:': [517, 4278], '50-55Crossref': [518, 4279], '(150)': [521, 4282], '3Whyte': [524, 4285], 'M.': [525, 571, 577, 602, 840, 869, 924, 1169, 1175, 1200, 1278, 1284, 1337, 1343, 1797, 1803, 1828, 1897, 1903, 2277, 2334, 2452, 2596, 2641, 2737, 2917, 2923, 3245, 3251, 3385, 3391, 3513, 3519, 3709, 3739, 3801, 3824, 3883, 3932, 3938, 3963, 4032, 4123, 4129, 4286, 4332, 4338, 4363], 'Evan': [526, 4287], 'G.': [527, 545, 783, 1143, 1771, 2261, 2436, 3609, 4288, 4306], 'Nature.': [528, 592, 896, 931, 1039, 1190, 1299, 1358, 1818, 1918, 2459, 2938, 2957, 3266, 3406, 3534, 3553, 3953, 4144, 4289, 4353], '376:': [530, 594, 1192, 1301, 1360, 1820, 1920, 2940, 3268, 3408, 3536, 3955, 4146, 4291, 4355], '17-18Crossref': [531, 4292], '(53)': [534, 4295], 'Scholar).': [536, 822, 995, 1047, 1113, 1228, 1366, 1471, 2354, 2790, 3274, 3898, 3991, 4180, 4297], 'One': [537, 4298], 'member,': [540, 4301], '(4Fernandes-Alnemri': [542, 1140, 1768, 4303], 'T.': [543, 743, 803, 1141, 1449, 1769, 2971, 3569, 3629, 4158, 4304, 4504], 'Litwack': [544, 782, 1142, 1770, 3608, 4305], 'Alnemri': [546, 780, 1144, 1772, 3606, 4307], 'E.S.': [547, 781, 1145, 1773, 3607, 4308], 'J.': [548, 717, 750, 789, 812, 874, 914, 950, 967, 980, 1146, 1456, 1499, 1574, 1774, 2312, 2315, 2339, 2420, 2428, 2554, 2574, 2577, 2601, 2646, 2667, 2670, 2978, 3003, 3576, 3615, 3638, 3744, 3768, 3805, 4165, 4309, 4478], 'Biol.': [549, 718, 751, 875, 951, 981, 1147, 1457, 1775, 2316, 2340, 2555, 2578, 2602, 2647, 2671, 2979, 3577, 3745, 4166, 4310, 4479], 'Chem.': [550, 719, 752, 876, 952, 982, 1148, 1458, 1776, 2317, 2341, 2556, 2579, 2603, 2648, 2672, 2980, 3578, 3746, 4167, 4311, 4480], '1994;': [551, 720, 1149, 1777, 2958, 3554, 3792, 4312, 4481], '269:': [552, 721, 1150, 1778, 4313, 4482], '30761-30764Abstract': [553, 1151, 1779, 4314], '5Nicholson': [560, 1158, 1786, 4321], 'D.W.': [561, 775, 801, 893, 979, 1103, 1159, 1268, 1327, 1787, 1887, 2907, 3235, 3375, 3503, 3601, 3627, 3922, 4113, 4322], 'Ali': [562, 1160, 1269, 1328, 1788, 1888, 2908, 3236, 3376, 3504, 3923, 4114, 4323], 'Thornberry': [564, 806, 974, 1162, 1271, 1330, 1790, 1890, 2910, 3238, 3378, 3506, 3632, 3925, 4116, 4325], 'N.A.': [565, 581, 807, 975, 1163, 1179, 1272, 1288, 1331, 1347, 1791, 1807, 1891, 1907, 2402, 2911, 2927, 3239, 3255, 3379, 3395, 3507, 3523, 3633, 3926, 3942, 4117, 4133, 4326, 4342], 'Vaillancourt': [566, 1164, 1273, 1332, 1792, 1892, 2912, 3240, 3380, 3508, 3927, 4118, 4327], 'J.P.': [567, 1165, 1274, 1333, 1793, 1893, 2444, 2913, 3241, 3381, 3509, 3928, 4119, 4328], 'Ding': [568, 1166, 1275, 1334, 1794, 1894, 2429, 2914, 3242, 3382, 3510, 3929, 4120, 4329], 'C.K.': [569, 1167, 1276, 1335, 1795, 1895, 2229, 2915, 3243, 3383, 3511, 3930, 4121, 4330], 'Gallant': [570, 1168, 1277, 1336, 1796, 1896, 2916, 3244, 3384, 3512, 3931, 4122, 4331], 'Gareau': [572, 1170, 1279, 1338, 1798, 1898, 2918, 3246, 3386, 3514, 3933, 4124, 4333], 'Y.': [573, 1171, 1280, 1339, 1799, 1899, 2919, 3247, 3387, 3515, 3934, 4125, 4334], 'Griffin': [574, 1172, 1281, 1340, 1800, 1900, 2920, 3248, 3388, 3516, 3935, 4126, 4335], 'P.R.': [575, 1173, 1282, 1341, 1801, 1901, 2237, 2921, 3249, 3389, 3517, 3936, 4127, 4336], 'Labelle': [576, 1174, 1283, 1342, 1802, 1902, 2922, 3250, 3390, 3518, 3937, 4128, 4337], 'Lazebnik': [578, 1176, 1285, 1344, 1804, 1904, 2924, 3252, 3392, 3520, 3939, 4130, 4339], 'Y.A.': [579, 1177, 1286, 1345, 1805, 1905, 2925, 2948, 3253, 3393, 3521, 3544, 3940, 4131, 4340], 'Munday': [580, 1178, 1287, 1346, 1806, 1906, 2926, 3254, 3394, 3522, 3941, 4132, 4341], 'Raju': [582, 1180, 1289, 1348, 1808, 1908, 2439, 2928, 3256, 3396, 3524, 3943, 4134, 4343], 'S.M.': [583, 1181, 1290, 1349, 1809, 1909, 2416, 2440, 2929, 3257, 3397, 3525, 3944, 4135, 4344], 'Smulson': [584, 1182, 1291, 1350, 1810, 1910, 2930, 3258, 3398, 3526, 3945, 4136, 4345], 'M.E.': [585, 1183, 1292, 1351, 1811, 1911, 2931, 3259, 3399, 3527, 3946, 4137, 4346], 'Yamin': [586, 976, 1184, 1293, 1352, 1812, 1912, 2445, 2932, 3260, 3400, 3528, 3947, 4138, 4347], 'T.-T.': [587, 1185, 1294, 1353, 1813, 1913, 2446, 2933, 3261, 3401, 3529, 3948, 4139, 4348], 'Yu': [588, 1186, 1295, 1354, 1814, 1914, 2934, 3262, 3402, 3530, 3949, 4140, 4349], 'V.L.': [589, 1187, 1296, 1355, 1815, 1915, 2935, 3263, 3403, 3531, 3950, 4141, 4350], 'Miller': [590, 711, 808, 972, 1188, 1297, 1356, 1816, 1916, 2413, 2936, 3264, 3404, 3532, 3634, 3951, 4142, 4351, 4472], 'D.K.': [591, 712, 809, 973, 1189, 1298, 1357, 1817, 1917, 2414, 2937, 3265, 3405, 3533, 3635, 3952, 4143, 4352, 4473], '37-43Crossref': [595, 1193, 1302, 1361, 1821, 1921, 2941, 3269, 3409, 3537, 3956, 4147, 4356], '(3777)': [598, 1196, 1305, 1364, 1824, 1924, 2944, 3272, 3412, 3540, 3959, 4150, 4359], '6Tewari': [601, 1199, 1827, 3962, 4362], 'Quan': [603, 841, 1201, 1829, 2278, 3710, 3964, 4364], 'L.T.': [604, 842, 1202, 1830, 2279, 3711, 3965, 4365], "O'Rourke": [605, 843, 1203, 1831, 2280, 2548, 3712, 3966, 4366], 'K.': [606, 844, 1024, 1204, 1832, 2281, 2547, 2549, 3713, 3967, 4367], 'Desnoyers': [607, 845, 1205, 1833, 2282, 2951, 3547, 3714, 3968, 4368], 'S.': [608, 771, 846, 930, 971, 1028, 1206, 1834, 2283, 2745, 2952, 3548, 3597, 3715, 3811, 3832, 3887, 3969, 4040, 4369], 'Zeng': [609, 847, 1207, 1835, 2284, 3716, 3970, 4370], 'Z.': [610, 739, 848, 1208, 1445, 1495, 1836, 2285, 2967, 3565, 3717, 3971, 4154, 4371, 4500], 'Beidler': [611, 849, 1209, 1837, 2286, 3718, 3972, 4372], 'Poirier': [613, 851, 1211, 1839, 2288, 2953, 3549, 3720, 3974, 4374], 'G.G.': [614, 852, 1212, 1840, 2289, 2954, 3550, 3721, 3975, 4375], 'Salvesen': [615, 853, 1213, 1841, 2238, 2290, 2335, 2550, 2597, 2642, 3722, 3976, 4376], 'G.S.': [616, 854, 1214, 1842, 2239, 2291, 2336, 2551, 2598, 2643, 3723, 3977, 4377], 'Dixit': [617, 855, 872, 1215, 1843, 2292, 2337, 2552, 2599, 2644, 3724, 3742, 3978, 4378], 'V.M.': [618, 856, 873, 1216, 1844, 2293, 2338, 2553, 2600, 2645, 3725, 3743, 3979, 4379], '81:': [621, 859, 1219, 1847, 2296, 3728, 3982, 4382], '801-809Abstract': [622, 860, 1220, 1848, 2297, 3729, 3983, 4383], '(2264)': [628, 866, 1226, 1854, 2303, 3735, 3989, 4389], 'Scholar),': [630, 728, 1512, 1856, 2274, 2305, 2330, 2467, 2705, 3011, 3414, 4085, 4391, 4489], 'studied': [633, 4394], 'extensively.': [634, 4395], 'particular,': [636, 4097, 4397], 'several': [637, 2220, 4027, 4398], 'cellular': [640, 1385, 4401], 'protein': [641, 666, 689, 735, 1249, 1557, 2216, 3174, 4402, 4427, 4450, 4496], 'targets': [642, 4403], 'identifed.': [647, 4408], 'These': [648, 4409], 'include': [649, 4410], 'DNA': [651, 2270, 4412], 'repair': [652, 4413], 'enzyme': [653, 1121, 4414], 'poly(ADP-ribose)': [654, 662, 685, 4415, 4423, 4446], 'polymerase': [655, 4416], '(PARP)': [656, 4417], '1The': [657, 680, 4418, 4441], 'abbreviations': [658, 681, 4419, 4442], 'used': [659, 682, 2800, 4420, 4443], 'are:': [660, 683, 4421, 4444], 'PARP,': [661, 684, 4422, 4445], 'polymerase;': [663, 686, 4424, 4447], 'DNA-PK,': [664, 687, 4425, 4448], 'DNA-dependent': [665, 688, 734, 4426, 4449, 4495], 'kinase;': [667, 690, 4428, 4451], 'DNA-PKcs,': [668, 691, 4429, 4452], 'catalytic': [669, 692, 731, 4430, 4453, 4492], 'DNA-PK;': [672, 695, 4433, 4456], 'TPCK,N-α-tosyl-l-phenylalanine': [673, 696, 4434, 4457], 'ketone;': [675, 698, 4436, 4459], 'CHO,': [676, 699, 4437, 4460], 'aldehyde;': [677, 700, 4438, 4461], 'STS,': [678, 701, 4439, 4462], 'staurosporine.': [679, 4440], 'staurosporine.1component': [702, 4463], 'U1': [705, 4466], 'small': [706, 4467], 'nuclear': [707, 4468], 'ribonucleoprotein': [708, 4469], '(8Casciola-Rosen': [709, 4470], 'L.': [710, 799, 906, 2995, 3625, 3760, 4471], 'Anhalt': [713, 4474], 'G.J.': [714, 4475], 'Rosen': [715, 810, 3636, 4476], '30757-30760Abstract': [722, 4483], 'kinase': [736, 4497], '(DNA-PKcs)': [737, 4498], '(9Han': [738, 1444, 3564, 4499], 'Malik': [740, 1446, 2968, 3566, 4155, 4501], 'N.': [741, 773, 1447, 2969, 3567, 3599, 4156, 4502], 'Carter': [742, 1448, 2970, 3568, 4157, 4503], 'Reeves': [744, 1450, 2972, 3570, 4159, 4505], 'W.H.': [745, 747, 1451, 1453, 2973, 2975, 3571, 3573, 4160, 4162, 4506, 4508], 'Wyche': [746, 1452, 1504, 2974, 3572, 4161, 4507], 'Hendrickson': [748, 1454, 1502, 2976, 3574, 4163], 'E.A.': [749, 1455, 1503, 2977, 3575, 4164], '271:': [754, 954, 984, 1460, 2319, 2558, 2581, 2674, 2982, 3580, 4169], '25035-25040Abstract': [755, 1461, 2983, 3581, 4170], '(126)': [763, 1469, 2991, 3589, 4178], '10Song': [766, 3592], 'Q.': [767, 3593], 'Lees-Miller': [768, 3594], 'S.P.': [769, 779, 3595, 3605], 'Kumar': [770, 3596], 'Zhang': [772, 3598], 'Chan': [774, 3600], 'Smith': [776, 3602], 'G.C.M.': [777, 3603], 'Jackson': [778, 3604], 'Khanna': [784, 3610], 'K.K.': [785, 3611], 'Lavin': [786, 3612], 'M.F.': [787, 3613], 'EMBO': [788, 913, 3002, 3614, 3767], '15:': [791, 916, 3005, 3617, 3770], '3238-3246Crossref': [792, 3618], '(330)': [795, 3621], '11Casciola-Rosen': [798, 3624], 'Nicholson': [800, 892, 978, 3626], 'Chong': [802, 3628], 'Rowan': [804, 3630], 'K.R.': [805, 3631], 'Exp.': [813, 3639, 3888], 'Med.': [814, 3640], '183:': [816, 3642], '1957-1964Crossref': [817, 3643], '(576)': [820, 3646], 'Interestingly,': [823], 'inhibition': [824, 3195], 'proteases': [829, 1386, 1547, 2509, 2693], 'various': [831, 3694], 'shown': [835, 1397, 2619, 2712], 'block': [837, 1675, 1739, 3697, 3904], '(6Tewari': [839, 2276, 3708], 'Scholar,12Tewari': [868], 'Reidler': [870, 3740], '270:': [878, 3748], '18738-18741Abstract': [879, 3749], '(112)': [887, 3757], '13Darmon': [890], 'A.J.': [891, 2755, 3842, 4050], 'Bleackley': [894], 'R.C.': [895], '377:': [898], '446-448Crossref': [899], '(642)': [902], '14Dubrez': [905, 2994], 'Savoy': [907, 2996, 3761], 'I.': [908, 969, 2997, 3762], 'Hamman': [909, 2998, 3763], 'Solary': [911, 3000, 3765], 'E.': [912, 2695, 3001, 3766], '5504-5512Crossref': [917, 3006, 3771], '(163)': [920, 3009, 3774], '15Enari': [923], 'Talanian': [925], 'R.V.': [926], 'Wong': [927], 'W.W.': [928], 'Nagata': [929], '380:': [933], '723-726Crossref': [934], '(965)': [937], '16Martin': [940], 'Finucane': [942], 'D.M.': [943], 'Amarante-Mendes': [944], 'G.P.': [945], "O'Brien": [946], 'G.A.': [947], '28753-28756Abstract': [955], '(319)': [963], '17Schlegel': [966], 'Peters': [968], 'Orrenius': [970, 2744, 3831, 3886, 4039], 'T-T.': [977], '1841-1844Abstract': [985], '(467)': [993], 'addition,': [997, 1473], 'functional': [999], 'inactivation': [1000], 'gene': [1004, 1748, 2387], 'knock-out': [1006], 'mice': [1007], 'results': [1008, 1639, 1705, 1728, 1931, 2163, 3993], 'profound': [1011], 'absence': [1012], 'tissues': [1017], 'lethality': [1019], 'shortly': [1020], 'after': [1021], 'birth': [1022], '(18Kuida': [1023], 'Zheng': [1025], 'T.S.': [1026], 'Na': [1027], 'Kuan': [1029], 'C-Y.': [1030], 'Yang': [1031, 1573], 'D.': [1032, 1497, 2757, 3844, 4052], 'Karasuyama': [1033], 'H.': [1034, 2773, 3860, 4068], 'Rakic': [1035], 'P.': [1036, 1501, 3885], 'Flavell': [1037], 'R.A.': [1038, 2231, 2454], '384:': [1041], '368-372Crossref': [1042], '(1700)': [1045], 'Therefore,': [1048, 1531, 2501, 4181], 'extremely': [1054, 3367], 'biologically': [1055], 'relevant': [1056], 'protease.All': [1058], 'initially': [1063, 1761], 'synthesized': [1064, 1762], 'precursors': [1067], 'proteolytic': [1070, 1096, 1613, 1634, 1648, 1692, 1724, 1862, 2092, 2475, 2623, 3099, 3486], 'processing': [1071, 1635, 2086, 2093, 2817], 'themselves': [1072], 'generate': [1074, 2128], 'active': [1081, 1560, 1755, 2131, 3125, 3311, 3338, 3351, 3363, 3417, 3441, 3918, 4016, 4216], 'protease.': [1082, 2133, 2841, 2869, 3443, 4218], 'suggests': [1084, 3077, 3294], 'machinery': [1088], 'may': [1089, 2136, 2836, 3334, 3421, 3490], 'regulated,': [1091], 'part,': [1093], 'cascade': [1097], 'review,': [1099], 'Ref.': [1101], '19Nicholson': [1102], 'Nat.': [1104], 'Biotechnol.': [1105], '14:': [1107], '297-301Crossref': [1108], '(239)': [1111], 'case': [1116], 'formed': [1123], 'subunits,': [1132], 'produced': [1135], 'There': [1229], '(5Nicholson': [1267, 1326, 1886, 2906, 3234, 3374, 3502, 3921, 4112], 'Scholar)': [1307, 1592, 1926, 2592, 2616, 3561], '(see': [1308, 1927], 'Fig.': [1309, 1928], '1).': [1310, 1929], 'At': [1311], 'both': [1312, 2543, 2634, 2832, 4000], 'sites,': [1313], 'should': [1316, 1537, 1966, 3446, 3468], 'occur': [1317, 1952, 2064], 'between': [1318], 'aspartic': [1320], '(Asp)': [1321], '(Ser)': [1324], 'residues': [1325], 'However,': [1367, 1964, 2355, 3141], 'how': [1371], 'converted': [1376], 'into': [1377, 1431, 1558, 1663, 1699, 1732, 3038, 3460, 3678, 4014], 'remains': [1381, 1994, 2516], 'uncharacterized,': [1382], 'cleave': [1388], 'these': [1389], 'identified.We': [1394], 'recently': [1396], 'when': [1399], 'human': [1401], 'promyelocytic': [1402], 'leukemia': [1403], 'HL-60': [1404, 1481, 1515, 1535, 2376, 3115], 'cell': [1405, 1532, 3116], 'line': [1406], 'induced': [1408], 'undergo': [1410], 'exposure': [1413], 'staurosporine': [1415], '(STS),': [1416], 'one': [1417, 4187], 'early': [1420], 'events': [1422], 'conversion': [1425, 1552, 1693, 3032, 3671, 4008, 4209], 'responsible': [1437, 2531, 3129], 'subsequent': [1440], 'proteolysis': [1441], 'DNA-PKcs': [1443, 3563], 'demonstrated': [1477, 1681], 'triggered': [1483], 'STS': [1485], 'independent': [1487], 'synthesis': [1490], 'new': [1492], '(20Han': [1494], 'Chatterjee': [1496], 'Early': [1498], 'Pantazis': [1500], 'J.H.': [1505], 'Cancer': [1506], 'Res.': [1507, 3890], '56:': [1509], '1621-1628PubMed': [1510], 'indicating': [1513], 'constitutively': [1517], 'express': [1518], 'all': [1519], 'factors': [1522, 1606], 'necessary': [1523], 'including': [1526, 1668, 2226], 'proteases.': [1530, 1657], 'extracts': [1533], 'provide': [1538, 1729, 2079], 'ideal': [1540], 'system': [1541, 1596, 1628, 1687], 'identification': [1544], 'can': [1549, 1674, 1975, 2218, 4197], 'catalyze': [1550], 'protease.A': [1562], 'study': [1564, 1660, 2895, 3996], 'Liu': [1566], 'et': [1567, 2783, 3870, 4078], 'al.': [1568], '(21Liu': [1569], 'X.': [1570, 1578, 2308, 2314, 2570, 2576, 2663, 2669], 'Kim': [1571, 2309, 2571, 2664], 'C.N.': [1572, 2310, 2572, 2665], 'Jemmerson': [1575], 'R.': [1576], 'Wang': [1577, 2313, 2575, 2668], '86:': [1581], '147-157Abstract': [1582], '(4433)': [1590], 'using': [1593, 3496], 'identified': [1598], 'cytochrome': [1599, 1688], 'c': [1600, 1689], 'dATP': [1602], 'essential': [1605], 'induction': [1610], 'activation': [1614, 2476, 2624], 'vitro.': [1618], 'our': [1620, 1659, 1704, 1727, 2077, 2361, 2802], 'study,': [1621, 1678], 'modified': [1624], 'thisin': [1625], 'vitro': [1626], 'investigated': [1630], 'caspase-3.': [1637, 1702], 'Our': [1638, 1930], 'show': [1640], 'this': [1642, 1677, 1708, 1934, 1988, 2513, 2828, 2873, 2894, 3052, 3142, 3197, 3296, 3321, 3453, 3495, 3995, 4092], 'involve': [1646], 'steps': [1649, 1714, 1942], 'different': [1656, 2852, 3706], 'Lastly,': [1658], 'provides': [1661], 'insight': [1662, 1731], 'why': [1664], 'selective': [1671, 2397, 2902, 3050], 'inhibitor': [1672, 2497, 2689, 3212, 3372], 'apoptosis.DISCUSSIONIn': [1676], 'induces': [1690], 'Furthermore,': [1703], 'showed': [1706, 1757], 'involved': [1710, 2511], 'each': [1717], 'step': [1718, 2173, 3017, 3065], 'unique': [1723], 'Finally,': [1726], 'additional': [1730], 'mechanisms': [1734], 'inhibitors': [1738, 3689, 4001], 'apoptosis.Proteolytic': [1740], 'Processing': [1741], 'Caspase-3Molecular': [1743], 'cloning': [1744], 'analysis': [1751, 2374], 'purified,': [1754], 'subsequently': [1859], 'processed': [1860, 2043], '172–176)': [1873], 'produce': [1875], 'indicate': [1932], '(Fig.': [1943, 2024, 2197, 2209, 2479, 2498, 3026, 3358], '5).': [1944, 2025, 2826, 3359], 'Cleavage': [1945], 'IETD/S': [1948, 2103], 'appeared': [1950], 'first,': [1953], 'yielding': [1954, 2008], 'intermediate': [1962, 3036, 3339, 3419], 'product.': [1963], 'pointed': [1968], 'out': [1969], 'since': [1971, 2542, 3055], 'good': [1972], 'antibodies': [1973], 'recognize': [1976], 'available': [1982], 'now,': [1983], 'exact': [1985], 'status': [1986], 'period': [1993], 'speculative.': [1995], 'occurred': [1999], 'intermediate,': [2007], 'Together,': [2013], 'then': [2019, 2831, 3488], 'Thus,': [2026, 2076, 2791], 'blocking': [2027, 2048], 'with': [2032, 2053, 2512, 3172], 'Ac-IETD-CHO,': [2033], 'TPCK': [2036, 2208, 2833, 4019, 4104, 4191], 'completely': [2037], 'abrogated': [2038], 'appearance': [2040], 'any': [2042, 3485], 'products': [2044], 'whereas': [2047], 'Ac-EMSD-CHO': [2054], 'Ac-DEVD-CHO': [2056, 2143, 2905, 3048, 3184, 3216, 3278, 3373, 3429, 3658, 3669, 3903], 'allowed': [2057], 'primary': [2059], 'secondary': [2068], 'EMSD↓S': [2071], '(Figs.': [2072, 2822, 3682], '3': [2073, 2198, 2480, 2499, 3027, 3683], '4).': [2075, 2210, 3686], 'data': [2078], 'strong': [2080], 'mechanism.Figure': [2087], '5A': [2088], 'mechanism': [2090, 4087, 4188], '(cpp32).': [2096], 'occurs': [2100, 2122], 'generates': [2106], 'p20/p12': [2108, 3418, 3482], 'intermediate.': [2109], 'inhibitable': [2113, 2637], 'TPCK,': [2116, 2796, 3656, 3667], 'Ac-IETD-CHO.': [2118], 'second': [2120, 3015], 'fully': [2130, 3350, 3362, 3440], 'p17/p12': [2132, 3442], 'AC-EMSD-CHO.View': [2145], 'Large': [2146], 'Image': [2147], 'Figure': [2148], 'ViewerDownload': [2149], 'Hi-res': [2150], 'image': [2151], 'Download': [2152], '(PPT)The': [2153], 'Nature': [2154, 2877], 'Protease': [2157, 2880], 'That': [2158, 2881], 'Cleaves': [2159, 2882], 'SiteOur': [2162], 'suggest': [2164, 2859, 4183], 'some': [2184, 2725], 'novel': [2185, 4200], 'properties.': [2186], 'First,': [2187, 2371, 3151], 'sensitive': [2190, 2204, 3368, 3435], 'sequence-specific': [2193], 'peptide': [2194, 3025, 3037, 3217, 3371, 3430], 'B),': [2199], 'CrmA': [2206, 2211, 2363, 2639, 2835, 3901], 'inhibit': [2219, 4024, 4198], '(28Ray': [2228], 'Black': [2230], 'Kronheim': [2232], 'S.R.': [2233], 'Greenstreet': [2234], 'T.A.': [2235], 'Sleath': [2236], 'Pickup': [2240], 'D.J.': [2241], '1992;': [2243, 2460], '69:': [2244], '597-604Abstract': [2245], '(889)': [2251], '29Turner': [2254], 'P.C.': [2255], 'Musy': [2256], 'P.Y.': [2257], 'Moyer': [2258], 'R.W.': [2259], 'McDadden': [2260], 'Viroreceptors,': [2262], 'Virokines': [2263], 'Related': [2265], 'Immune': [2266], 'Modulators': [2267], 'Encoded': [2268], 'Viruses.': [2271], '1994:': [2272], '67-88Google': [2273], 'caspase-6': [2306, 2525, 2545], '(34Liu': [2307], 'Pohl': [2311, 2573, 2666], '13371-13376Abstract': [2320, 2582, 2675], '(87)': [2328, 2590, 2683], 'caspase-8': [2332, 2594], '(32Muzio': [2333, 2595, 2640], '1997;': [2342, 2604, 2649], '272:': [2343, 2605, 2650], '2952-2956Abstract': [2344, 2606, 2651], '(312)': [2352, 2614, 2659], 'unlikely': [2358, 2504, 3146], 'that,': [2359, 3078], 'inhibiting': [2365, 2815, 2838], 'Northern': [2372], 'blot': [2373], 'found': [2378, 4022], 'no': [2379, 2469, 3058, 4106], 'expression': [2383], '(data': [2388, 3176], 'shown).': [2390, 3178], 'Second,': [2391, 3179], 'presence': [2393, 2493, 3160, 3304], 'highly': [2396, 2901], 'Ac-YVAD-CHO': [2400], '(22Thornberry': [2401], 'Bull': [2403], 'H.G.': [2404], 'Calaycay': [2405], 'J.R.': [2406, 2418], 'Chapman': [2407], 'K.T.': [2408], 'Howard': [2409], 'A.D.': [2410], 'Kostura': [2411], 'M.J.': [2412, 2458], 'Molineaux': [2415], 'Weidner': [2417], 'Aunins': [2419], 'Elliston': [2421], 'K.O.': [2422], 'Ayala': [2423], 'J.M.': [2424], 'Casano': [2425], 'F.J.': [2426], 'Chin': [2427], 'G.J.-F.': [2430], 'Egger': [2431], 'L.A.': [2432], 'Gaffney': [2433], 'E.P.': [2434], 'Limjuco': [2435], 'Palyha': [2437], 'O.C.': [2438], 'Rolando': [2441], 'A.M.': [2442], 'Salley': [2443], 'Lee': [2447, 2772, 3781, 3859, 4067], 'T.D.': [2448], 'Shively': [2449], 'J.E.': [2450, 2743, 3830, 4038], 'MacCross': [2451], 'Mumford': [2453], 'Schmidt': [2455], 'J.A.': [2456], 'Tocci': [2457], '356:': [2461], '768-774Crossref': [2462], '(2185)': [2465], 'had': [2468, 3057], 'effect': [2470, 2717, 2731, 3046, 3060, 3915, 4093, 4109], 'on': [2471, 2718, 2732, 3061, 3218, 3916, 4110], 'D).': [2481], 'Third,': [2482], 'proceeded': [2489], 'normally': [2490], 'C).': [2500, 3028, 3075], 'event.': [2514], 'It': [2515, 3109], 'seen': [2519], 'if': [2520], 'caspases,': [2522, 2719], '8,': [2528], 'might': [2529], 'cleaving': [2533, 3087, 3105], 'potentially': [2540], 'likely': [2541, 3319], 'activated': [2544], '(33Orth': [2546], '20977-20980Abstract': [2559], '(187)': [2567], 'Scholar,34Liu': [2569], 'initiate': [2621], 'vitro,': [2629], 'caspases': [2635], '34Liu': [2662], 'Scholar).TPCK': [2685], 'chymotrypsin-like': [2691], '(30Shaw': [2694], 'Physiol.': [2696], 'Rev.': [2697], '1970;': [2698], '50:': [2699], '244-296Crossref': [2700], '(143)': [2703], 'while': [2707], 'inhibitory': [2716, 2730, 3045, 3914, 4108], 'observed,': [2723], 'studies,': [2726], '(25Chow': [2734, 4029], 'S.C.': [2735, 3822, 4030], 'Weis': [2736, 3823, 4031], 'Kass': [2738, 3825, 4033], 'G.E.N.': [2739, 3826, 4034], 'Holmstrom': [2740, 3827, 4035], 'T.H.': [2741, 3828, 4036], 'Eriksson': [2742, 3829, 4037], 'FEBS': [2746, 2760, 3833, 3847, 4041, 4055], 'Lett.': [2747, 2761, 3834, 3848, 4042, 4056], '264:': [2749, 3836, 4044], '134-138Google': [2750, 3837, 4045], '26Fearnhead': [2752, 3839, 4047], 'H.O.': [2753, 3840, 4048], 'Rivett': [2754, 3841, 4049], 'Dinsdale': [2756, 3843, 4051], 'Cohen': [2758, 3845, 4053], 'G.M.': [2759, 3846, 4054], '357:': [2763, 3850, 4058], '242-246Crossref': [2764, 3851, 4059], '(51)': [2767, 3854, 4062], '27Kim': [2770, 3857, 4065], 'H': [2771, 3858, 4066], 'S': [2774, 3861, 4069], 'Chang': [2775, 3862, 4070], 'K.T': [2776, 3863, 4071], 'Ko': [2777, 3864, 4072], 'T.H': [2778, 3865, 4073], 'Baek': [2779, 3866, 4074], 'K.J.': [2780, 3867, 4075], 'Kwon': [2781, 3868, 4076], 'N.S': [2782, 3869, 4077], 'al.J.': [2784, 3871, 4079], 'Immunol.': [2785, 3872, 4080], ':': [2787, 3874, 4082], '4741-4748PubMed': [2788, 3875, 4083], 'possible': [2794, 2846, 3448], 'concentrations': [2799], 'assay,': [2803], 'directly': [2804], 'thus': [2814, 3432], '4': [2823], 'A': [2824], 'If': [2827, 3480], 'true,': [2830], 'same': [2840], 'Alternatively,': [2842], 'TPCK-sensitive': [2849, 2862], 'CrmA.': [2856], 'would': [2858], 'acts': [2864], 'upstream': [2865], 'CrmA-sensitive': [2868], 'Experiments': [2870], 'test': [2872], 'possibility': [2874], 'underway.The': [2876], 'Site': [2885], 'Intermediate': [2889], 'PeptideOne': [2890], 'surprising': [2891], 'finding': [2892], 'observation': [2898], '7Lazebnik': [2947, 3543], 'Kaufmann': [2949, 3545], 'S.H.': [2950, 3546], '371:': [2959, 3555], '346-347Crossref': [2960, 3556], '(2339)': [2963, 3559], '9Han': [2966, 4153], 'blocked': [3012, 3670], 'only': [3013, 3475], 'prevented': [3030], 'Apparently,': [3043], 'upon': [3051], 'step,': [3054], 'observable': [3059], '(Fig.3': [3074], 'unlike': [3079], 'itself': [3093], 'or,': [3094], 'more': [3095], 'likely,': [3096], 'specifically': [3102], 'could': [3110, 3298, 3327], 'argued': [3112], 'S-100': [3117, 3166], 'extract': [3118, 3167], 'contained': [3119], 'trace': [3121, 3307], 'amount': [3122, 3308], 'endogenous,': [3124], 'once': [3135], 'product': [3138], 'available.': [3140], 'following': [3149], 'reasons.': [3150], 'able': [3156, 3492], 'detect': [3158], 'untreated': [3165], 'even': [3168], 'Western': [3170], 'blots': [3171], 'overloaded': [3173], 'samples': [3175], 'effective': [3181], 'concentration': [3182], '(50–100': [3185], 'nm;': [3186], 'Fig.3': [3188], 'C)': [3189], 'relatively': [3201], 'high.': [3202], 'assays': [3204], 'described': [3208], 'assessing': [3210], 'potency': [3213], 'purified': [3219], 'K': [3222], 'i': [3223], 'values': [3224], 'estimated': [3227], 'less': [3230, 3434], 'than': [3231, 3438], '1': [3232], 'nm': [3233, 3293], 'fact': [3276], 'range': [3290], '50–100': [3292], 'attributed': [3301], 'extract.': [3315], 'Rather,': [3316], 'simply': [3324], 'caspase-3-like.Aternatively,': [3325], 'speculated': [3329], 'partially': [3337, 3416], 'undergoes': [3342], 'autocatalysis': [3343], 'consisting': [3353], 'Unlike': [3360], 'much': [3424], 'lower': [3425], 'affinity': [3426], 'Experimentally,': [3444], 'prove': [3450], 'disapprove': [3452], 'hypothesis.': [3454], 'Introduction': [3455], 'point': [3458], 'mutation': [3459], 'makes': [3465], 'uncleavable': [3467], 'give': [3469], 'rise': [3470], 'peptides.': [3479], 'complex': [3483], 'activity,': [3487], 'quantify': [3494], 'substrates': [3498], 'PARP': [3501], 'Scholar).New': [3648], 'Aspects': [3649], 'Mechanisms': [3652], 'Inhibit': [3659], 'ApoptosisIt': [3660], 'worthy': [3662], 'note': [3664], 'C': [3684], 'All': [3687], 'three': [3688], 'shown,': [3692], 'investigators,': [3695], 'variety': [3701], 'under': [3704], 'many': [3705], 'treatments': [3707], '12Tewari': [3738], 'Scholar,14Dubrez': [3759], '23Gagliardini': [3777], 'V.': [3778], 'Fernandez': [3779], 'P-A.': [3780], 'R.K.K.': [3782], 'Drexler': [3783], 'H.C.A.': [3784], 'Rotello': [3785], 'R.J.': [3786], 'Fishman': [3787], 'M.C.': [3788], 'Yuan': [3789], 'J': [3790], 'Science.': [3791], '263:': [3793], '826-828Crossref': [3794], '(604)': [3797], '24Miura': [3800], 'Friedlander': [3802], 'R.M.': [3803], 'Yuang': [3804], 'Proc.': [3806], 'Natl.': [3807], 'Acad.': [3808], 'Sci.': [3809], 'U.': [3810], '92:': [3814], '8318-8322Crossref': [3815], '(231)': [3818], '25Chow': [3821], '31Zhivotovsky': [3878], 'B.': [3879], 'Gahm': [3880], 'Ankarcrona': [3882], 'Nicotera': [3884], 'Cell': [3889], '221:': [3892], '404-412Crossref': [3893], '(86)': [3896], 'reason': [3900], 'thought': [3907], 'due': [3910], 'their': [3912], 'direct': [3913, 4107], 'revealed': [3998], 'capable': [4004], 'preventing': [4006], 'protease.Finally,': [4017], 'although': [4018], 'studies': [4028], 'mediates': [4091], 'unclear.': [4095], 'well': [4101], 'characterized': [4102], 'least': [4186], 'prevents': [4192], 'participates': [4203], 'Hendrickso': [4509]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2090414390', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': 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