Publication Information

{'id': 'https://openalex.org/W2090248115', 'doi': 'https://doi.org/10.1161/01.atv.0000075300.76279.bb', 'title': 'A Peculiar Result and a Fanciful Hypothesis Regarding <scp>l</scp> -Arginine', 'display_name': 'A Peculiar Result and a Fanciful Hypothesis Regarding <scp>l</scp> -Arginine', 'publication_year': 2003, 'publication_date': '2003-06-01', 'ids': {'openalex': 'https://openalex.org/W2090248115', 'doi': 'https://doi.org/10.1161/01.atv.0000075300.76279.bb', 'mag': '2090248115', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12807714'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.atv.0000075300.76279.bb', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.0000075300.76279.BB', 'source': {'id': 'https://openalex.org/S3485792', 'display_name': 'Arteriosclerosis Thrombosis and Vascular Biology', 'issn_l': '1079-5642', 'issn': ['1079-5642', '1524-4636'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.0000075300.76279.BB', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5039670487', 'display_name': 'John P. Cooke', 'orcid': 'https://orcid.org/0000-0003-0033-9138'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John P. Cooke', 'raw_affiliation_strings': ['Program in Vascular Medicine and Biology, Stanford University School of Medicine, Calif'], 'affiliations': [{'raw_affiliation_string': 'Program in Vascular Medicine and Biology, Stanford University School of Medicine, Calif', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111385893', 'display_name': 'Karsten Sydow', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Karsten Sydow', 'raw_affiliation_strings': ['Program in Vascular Medicine and Biology, Stanford University School of Medicine, Calif'], 'affiliations': [{'raw_affiliation_string': 'Program in Vascular Medicine and Biology, Stanford University School of Medicine, Calif', 'institution_ids': ['https://openalex.org/I97018004']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.399289, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 72, 'max': 74}, 'biblio': {'volume': '23', 'issue': '6', 'first_page': '1128', 'last_page': '1128'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10155', 'display_name': 'Nitric Oxide and Endothelin Effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10155', 'display_name': 'Nitric Oxide and Endothelin Effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System Studies', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12230', 'display_name': 'Cardiovascular Issues in Pregnancy', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/asymmetric-dimethylarginine', 'display_name': 'Asymmetric dimethylarginine', 'score': 0.49837184}, {'id': 'https://openalex.org/keywords/knockout-mouse', 'display_name': 'Knockout mouse', 'score': 0.485502}], 'concepts': [{'id': 'https://openalex.org/C2777468819', 'wikidata': 'https://www.wikidata.org/wiki/Q173670', 'display_name': 'Arginine', 'level': 3, 'score': 0.713895}, {'id': 'https://openalex.org/C164007495', 'wikidata': 'https://www.wikidata.org/wiki/Q24721374', 'display_name': 'Arginase', 'level': 4, 'score': 0.50638855}, {'id': 'https://openalex.org/C2779877776', 'wikidata': 'https://www.wikidata.org/wiki/Q752685', 'display_name': 'Asymmetric dimethylarginine', 'level': 4, 'score': 0.49837184}, {'id': 'https://openalex.org/C16613235', 'wikidata': 'https://www.wikidata.org/wiki/Q285982', 'display_name': 'Endogeny', 'level': 2, 'score': 0.49060526}, {'id': 'https://openalex.org/C182704531', 'wikidata': 'https://www.wikidata.org/wiki/Q1364740', 'display_name': 'Knockout mouse', 'level': 3, 'score': 0.485502}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37232912}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.36906147}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.33747578}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.33011198}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.22361192}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.19351074}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.13481548}], 'mesh': [{'descriptor_ui': 'D001120', 'descriptor_name': 'Arginine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D005998', 'descriptor_name': 'Glycine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D006710', 'descriptor_name': 'Homocysteine', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D006937', 'descriptor_name': 'Hypercholesterolemia', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D001120', 'descriptor_name': 'Arginine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001120', 'descriptor_name': 'Arginine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D005998', 'descriptor_name': 'Glycine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005998', 'descriptor_name': 'Glycine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006710', 'descriptor_name': 'Homocysteine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006937', 'descriptor_name': 'Hypercholesterolemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006937', 'descriptor_name': 'Hypercholesterolemia', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.atv.0000075300.76279.bb', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.0000075300.76279.BB', 'source': {'id': 'https://openalex.org/S3485792', 'display_name': 'Arteriosclerosis Thrombosis and Vascular Biology', 'issn_l': '1079-5642', 'issn': ['1079-5642', '1524-4636'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12807714', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.atv.0000075300.76279.bb', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.ATV.0000075300.76279.BB', 'source': {'id': 'https://openalex.org/S3485792', 'display_name': 'Arteriosclerosis Thrombosis and Vascular Biology', 'issn_l': '1079-5642', 'issn': ['1079-5642', '1524-4636'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1542321498', 'https://openalex.org/W1558405571', 'https://openalex.org/W1952735225', 'https://openalex.org/W1969703987', 'https://openalex.org/W1969714386', 'https://openalex.org/W1970161435', 'https://openalex.org/W1970798352', 'https://openalex.org/W1992830364', 'https://openalex.org/W199931476', 'https://openalex.org/W2008842767', 'https://openalex.org/W2010686273', 'https://openalex.org/W2039998354', 'https://openalex.org/W2044764484', 'https://openalex.org/W2054949240', 'https://openalex.org/W2056052261', 'https://openalex.org/W2083285004', 'https://openalex.org/W2086558138', 'https://openalex.org/W2105847016', 'https://openalex.org/W2107818859', 'https://openalex.org/W2120435538', 'https://openalex.org/W2120785970', 'https://openalex.org/W2136257776', 'https://openalex.org/W2138192222', 'https://openalex.org/W2156588431', 'https://openalex.org/W2167474616', 'https://openalex.org/W2170748270', 'https://openalex.org/W2172296189', 'https://openalex.org/W2419604885', 'https://openalex.org/W2518705557'], 'related_works': ['https://openalex.org/W3101553925', 'https://openalex.org/W2418564481', 'https://openalex.org/W2138140959', 'https://openalex.org/W2118602159', 'https://openalex.org/W2069851652', 'https://openalex.org/W2062447062', 'https://openalex.org/W2011992952', 'https://openalex.org/W1994681908', 'https://openalex.org/W1976754884', 'https://openalex.org/W1518247306'], 'abstract_inverted_index': {'HomeArteriosclerosis,': [0], 'Thrombosis,': [1, 96, 1118, 1755], 'and': [2, 10, 33, 42, 54, 69, 77, 97, 129, 183, 188, 260, 298, 397, 478, 511, 558, 619, 702, 771, 777, 946, 955, 983, 996, 1036, 1119, 1126, 1186, 1266, 1311, 1323, 1332, 1359, 1377, 1397, 1436, 1440, 1578, 1599, 1626, 1628, 1674, 1696, 1710, 1718, 1726, 1732, 1745, 1751, 1756, 1771, 1777, 1791], 'Vascular': [3, 52, 75, 98, 1120, 1752, 1757], 'BiologyVol.': [4], '23,': [5, 1803], 'No.': [6], '6A': [7], 'Peculiar': [8, 31], 'Result': [9, 32], 'a': [11, 34, 253, 278, 283, 458, 473, 923, 1223, 1314, 1390, 1498, 1639, 1642], 'Fanciful': [12, 35], 'Hypothesis': [13, 36], 'Regarding': [14, 37], 'l-Arginine': [15, 38], 'Free': [16], 'AccessLetterPDF/EPUBAboutView': [17], 'PDFView': [18], 'EPUBSections': [19], 'ToolsAdd': [20], 'to': [21, 197, 209, 228, 256, 316, 353, 468, 1133, 1208, 1403, 1427, 1460, 1514, 1522, 1537, 1655, 1684], 'favoritesDownload': [22], 'citationsTrack': [23], 'citationsPermissions': [24], 'ShareShare': [25], 'onFacebookTwitterLinked': [26], 'InMendeleyReddit': [27], 'Jump': [28], 'toFree': [29], 'AccessLetterPDF/EPUBA': [30], 'John': [39, 45], 'P.': [40, 46, 48], 'Cooke': [41, 49, 540, 633, 668, 799, 824, 1060], 'Karsten': [43, 70], 'Sydow': [44, 72, 966, 1637], 'CookeJohn': [47], 'Program': [50, 73, 1634], 'in': [51, 74, 122, 140, 150, 155, 211, 236, 328, 389, 420, 461, 495, 508, 559, 586, 616, 649, 673, 705, 738, 853, 916, 922, 991, 1040, 1143, 1200, 1218, 1225, 1251, 1313, 1361, 1545, 1584, 1716, 1778], 'Medicine': [53, 76], 'Biology,': [55, 78, 1758], 'Stanford': [56, 79], 'University': [57, 80], 'School': [58, 81], 'of': [59, 82, 107, 159, 167, 172, 178, 203, 221, 232, 251, 292, 337, 342, 351, 374, 379, 416, 440, 446, 483, 518, 566, 589, 609, 647, 736, 769, 784, 832, 900, 913, 919, 950, 953, 994, 1069, 1099, 1156, 1230, 1236, 1248, 1278, 1296, 1306, 1320, 1393, 1409, 1489, 1503, 1542, 1575, 1622, 1641, 1680, 1688, 1694, 1730, 1789], 'Medicine,': [60, 83], 'Calif': [61, 84], 'Search': [62, 85], 'for': [63, 86, 200, 280, 403, 488, 828, 988, 1152, 1198, 1260, 1302, 1781], 'more': [64, 87, 1425], 'papers': [65, 88], 'by': [66, 89, 286, 294, 308, 345, 436, 515, 582, 677, 1105, 1149, 1456, 1510, 1582, 1590, 1616, 1646], 'this': [67, 90, 108, 141, 263, 309, 579, 1414], 'author': [68, 91], 'SydowKarsten': [71], 'Originally': [92, 1811], 'published1': [93], 'Jun': [94], '2003https://doi.org/10.1161/01.ATV.0000075300.76279.BBArteriosclerosis,': [95], 'Biology.': [99], '2003;23:1128To': [100], 'the': [101, 103, 123, 132, 157, 170, 176, 201, 230, 241, 312, 335, 349, 356, 438, 444, 450, 481, 564, 650, 734, 1064, 1097, 1135, 1160, 1201, 1219, 1231, 1245, 1252, 1303, 1321, 1342, 1366, 1410, 1424, 1454, 1473, 1486, 1508, 1540, 1560, 1573, 1579, 1619, 1629, 1647, 1685, 1721], 'Editor:In': [102], 'January': [104], '2003': [105, 1814], 'issue': [106, 1415], 'Journal,': [109], 'Chen': [110, 233, 596], 'et': [111, 234, 1458, 1512], 'al1': [112], 'observed': [113, 149], 'that': [114, 135, 244, 275, 302, 321, 363, 431, 452, 492, 502, 512, 569, 1137, 1159, 1169, 1191, 1210, 1241, 1290, 1413, 1451, 1463, 1480, 1482, 1549, 1562, 1594], 'l-arginine': [115, 161, 195, 246, 276, 352, 364, 381, 400, 417, 519, 546, 570, 576, 613, 648, 698, 732, 772, 915, 995, 1024, 1138, 1170, 1192, 1211, 1242, 1291, 1353, 1394, 1432, 1464, 1543, 1563, 1601, 1682], 'supplementation': [116, 365, 401, 571, 1139, 1212, 1243, 1351, 1465, 1518, 1531, 1544, 1564, 1602], 'did': [117, 406, 1213], 'not': [118, 323, 360, 384, 407, 548, 1194, 1214, 1356, 1383, 1558, 1611], 'affect': [119, 408], 'lesion': [120, 189], 'formation': [121], 'hypercholesterolemic': [124, 153, 193, 555, 560, 651], 'apolipoprotein': [125, 1144], 'E': [126, 1145, 1676], 'knockout': [127, 618, 708, 1147, 1184, 1203, 1221, 1233], 'mice,': [128, 1189, 1222], 'it': [130, 456, 1421, 1444, 1609], 'negated': [131], 'protective': [133, 1246], 'effect': [134, 581, 1247, 1392], 'iNOS': [136, 1161, 1199, 1249], 'gene': [137, 775], 'deficiency': [138, 1250], 'has': [139, 457], 'model.': [142], 'Their': [143], 'findings': [144], 'are': [145, 986, 1587], 'discordant': [146], 'with': [147, 393, 476, 505, 612, 742, 1227, 1352], 'those': [148], 'most': [151, 192, 554], 'other': [152, 1228, 1400], 'models': [154], 'which': [156], 'administration': [158, 382], 'supplemental': [160, 245, 303, 914], 'improves': [162, 572], 'vasodilation,': [163], 'increases': [164, 210, 585, 859, 893, 1466], 'endothelial': [165, 258, 499, 671, 778, 804, 829, 894, 989, 1398, 1438, 1552, 1689], 'synthesis': [166, 202, 435, 1300, 1484, 1496], 'NO,': [168, 1175], 'reduces': [169, 184, 480, 733], 'generation': [171, 899], 'superoxide': [173, 901], 'anion,': [174], 'suppresses': [175], 'activation': [177], 'oxidant': [179], 'sensitive': [180], 'transcriptional': [181], 'proteins,': [182], 'monocyte': [185], 'adhesion,': [186], 'infiltration,': [187], 'formation.2–7': [190], 'In': [191, 391, 411, 553, 1154, 1775], 'models,': [194, 557], 'appears': [196], 'be': [198, 207, 1345, 1355, 1357, 1363, 1434, 1446, 1520, 1534], 'rate-limiting': [199], 'NO.': [204], 'This': [205, 485], 'may': [206, 577, 1292, 1354, 1360, 1445], 'due': [208], 'plasma': [212, 249, 386, 425, 509, 550, 587, 1027, 1294], 'asymmetric': [213, 1070], 'dimethylarginine': [214, 833, 1106], '(ADMA,': [215], 'an': [216, 498, 506, 1337], 'endogenous': [217], 'NOS': [218, 594], 'inhibitor),': [219], 'expression': [220, 776, 852], 'tissue': [222, 591], 'arginase,': [223, 592], 'or': [224, 269, 561, 593], 'NO': [225, 434, 621, 779, 1065, 1495], 'synthase': [226, 622, 780, 898, 1066, 1103], 'uncoupling.8–10Attempting': [227], 'explain': [229, 1515], 'results': [231, 1312, 1326, 1574], 'al,': [235], 'his': [237, 318, 1281, 1585], 'editorial': [238, 1474, 1586], 'Loscalzo11': [239], 'proposes': [240], 'fanciful': [242], 'hypothesis': [243, 264, 1136, 1335, 1367], 'could': [247, 305, 1193], 'increase': [248, 306, 367, 385, 507, 549, 1173, 1293, 1569], 'levels': [250, 327, 388, 588, 1295], 'homocyst(e)ine,': [252], 'substance': [254], 'known': [255], 'induce': [257], 'dysfunction': [259, 501, 990], 'atherosclerosis.': [261], 'Unfortunately,': [262], 'lacks': [265], 'any': [266], 'mechanistic': [267], 'basis': [268], 'experimental': [270, 493, 1370, 1591], 'support.': [271], 'Loscalzo': [272, 300, 909, 1284, 1452, 1476, 1506, 1583], 'notes': [273], 'correctly': [274], 'is': [277, 371, 377, 466, 503, 513, 675, 1163, 1336, 1416, 1603, 1638], 'precursor': [279], 'guanidinoacetate': [281], '(GAA),': [282], 'reaction': [284], 'catalyzed': [285], 'l-arginine:glycine': [287], 'amidinotransferase': [288], '(AGAT).': [289], 'The': [290, 339, 1334], 'methylation': [291, 920, 1316, 1528], 'GAA': [293, 332, 346], 's-adenosylmethionine': [295], 'yields': [296], 'creatine': [297, 954, 1299, 1483, 1517], 's-adenosylhomocysteine.': [299], 'speculates': [301], 'arginine': [304, 1309, 1492, 1504], 'homocysteine': [307, 326, 368, 387, 432, 551, 947, 1029, 1467, 1570], 'pathway.': [310], 'However,': [311, 1554], 'article': [313, 358, 1455, 1509], 'he': [314], 'cites': [315, 1453, 1477, 1507], 'support': [317], 'speculation': [319], 'revealed': [320], 'GAA,': [322], 'l-arginine,': [324], 'increased': [325, 1032], 'Sprague-Dawley': [329], 'rats.12': [330], 'Notably,': [331, 427], 'markedly': [333], 'suppressed': [334], 'activity': [336, 344, 445, 781], 'AGAT.': [338], 'negative': [340], 'regulation': [341], 'AGAT': [343, 1524], 'would': [347, 366, 1140, 1344, 1433, 1519, 1532], 'inhibit': [348], 'conversion': [350], 'GAA.': [354], 'Thus,': [355, 1179, 1365, 1420], 'cited': [357], 'does': [359, 383, 547], 'provide': [361, 1461], 'evidence': [362, 378, 1462, 1780], 'levels.Not': [369], 'only': [370], 'there': [372, 376], 'absence': [373], 'evidence,': [375], 'absence.': [380], 'humans.': [390], 'patients': [392, 422], 'peripheral': [394], 'arterial': [395, 1719], 'disease': [396], 'hyperhomocyst(e)inemia,': [398], 'oral': [399], '(24g/d': [402], '8': [404], 'weeks)': [405], 'homocyst(e)ine': [409], 'levels.13': [410], 'another': [412, 1287], 'study,': [413, 1592], 'intravenous': [414, 516], 'infusion': [415, 517, 1025], '(3': [418], 'g)': [419], 'diabetic': [421, 1043], 'actually': [423], 'reduced': [424, 1267], 'homocyst(e)ine.14': [426], 'we': [428, 1166, 1180, 1239, 1263, 1328, 1547, 1595], 'have': [429, 1372], 'shown': [430], 'inhibits': [433, 703], 'increasing': [437], 'elaboration': [439], 'ADMA.15': [441, 484], 'Homocysteine': [442, 471, 1062], 'impairs': [443, 1063, 1551], 'DDAH': [447, 465], '(dimethylarginine': [448], 'dimethylaminohydrolase),': [449], 'enzyme': [451], 'degrades': [453], 'ADMA.': [454], 'Because': [455], 'critical': [459], 'sulfhydryl': [460], 'its': [462], 'active': [463], 'site,': [464], 'vulnerable': [467], 'oxidative': [469, 984, 1038], 'attack16': [470], 'forms': [472], 'mixed': [474], 'disulfide': [475], 'DDAH,': [477], 'thereby': [479, 1526], 'degradation': [482], 'mechanism': [486, 827], 'accounts': [487, 1301], 'our': [489, 1177, 1324, 1576], 'recent': [490, 1157], 'observation': [491], 'hyperhomocysteinemia': [494, 1550], 'humans': [496], 'induces': [497], 'vasodilator': [500], 'associated': [504], 'ADMA,': [510, 590], 'reversed': [514], '(Stuhlinger': [520], 'MC,': [521, 1013, 1018, 1051], 'Oka': [522], 'RK,': [523], 'Graf': [524], 'EE,': [525], 'Schmolzer': [526], 'I,': [527, 1667], 'Upson': [528], 'BM,': [529], 'Kapoor': [530], 'O,': [531, 539, 1009, 1016], 'Szuba': [532], 'A,': [533, 728, 760, 815, 1663, 1665, 1669], 'Malinow': [534], 'MR,': [535], 'Wascher': [536], 'TC,': [537], 'Pachinger': [538], 'JP,': [541, 634], 'unpublished': [542], 'observations,': [543], '2003).To': [544], 'conclude,': [545], 'levels.': [552, 1468], 'animal': [556], 'hyperhomocysteinemic': [562], 'humans,': [563], 'majority': [565], 'investigators': [567], 'report': [568], 'vascular': [573], 'function.': [574, 1553], 'Supplemental': [575], 'exert': [578], 'beneficial': [580, 1391, 1435, 1604], 'opposing': [583], 'pathological': [584], 'uncoupling.1': [595], 'J,': [597, 605, 1078, 1080, 1084, 1089, 1768], 'Kuhlencordt': [598], 'P,': [599, 638, 640, 661, 885, 1091], 'Urano': [600], 'F,': [601, 751], 'Ichinose': [602], 'H,': [603, 665], 'Astern': [604], 'Huang': [606, 1127], 'PL.': [607], 'Effects': [608], 'chronic': [610], 'treatment': [611], 'on': [614, 773, 1395], 'atherosclerosis': [615, 704, 737, 1142, 1396], 'apoE': [617, 1183, 1220, 1232], 'apoE/inducible': [620], 'double-knockout': [623, 1188, 1254], 'mice.': [624, 709, 1204, 1255], 'Arterioscler': [625, 806, 926], 'Thromb': [626, 807, 927, 1115], 'Vasc': [627, 808, 928, 1116], 'Biol.': [628, 809, 929, 1110], '2003;': [629, 795, 930, 1001], '23:': [630, 931], '97–103.LinkGoogle': [631], 'Scholar2': [632], 'Singer': [635], 'AH,': [636], 'Tsao': [637, 660, 816, 1052], 'Zera': [639], 'Rowan': [641], 'RA,': [642], 'Billingham': [643], 'ME.': [644], 'Anti-atherogenic': [645], 'effects': [646, 768, 912, 949, 993, 1541, 1556], 'rabbit.': [652], 'J': [653, 958, 1770], 'Clin': [654], 'Invest.': [655], '1992;': [656], '90:': [657], '1168–1172.CrossrefMedlineGoogle': [658], 'Scholar3': [659], 'McEvoy': [662], 'LM,': [663, 935], 'Drexler': [664], 'Butcher': [666], 'EC,': [667], 'JP.': [669, 800, 825, 1061], 'Enhanced': [670], 'adhesiveness': [672], 'hypercholesterolemia': [674], 'attenuated': [676], 'l-arginine.': [678], 'Circulation.': [679, 710, 744, 835, 1072], '1994;': [680], '89:': [681], '2176–2182.CrossrefMedlineGoogle': [682], 'Scholar4': [683], 'Aji': [684], 'W,': [685, 762], 'Ravalli': [686], 'S,': [687, 756, 819, 1086, 1661], 'Szabolcs': [688], 'M,': [689, 724, 821, 883, 1007, 1057, 1082, 1766], 'Jiang': [690], 'XC,': [691], 'Sciacca': [692], 'RR,': [693], 'Michler': [694], 'RE,': [695], 'Cannon': [696], 'PJ.': [697], 'prevents': [699], 'xanthoma': [700], 'development': [701], 'LDL': [706], 'receptor': [707], '1997;': [711, 745], '95:': [712], '430–437.CrossrefMedlineGoogle': [713], 'Scholar5': [714], 'Boger': [715], 'RH,': [716], 'Bode-Boger': [717], 'SM,': [718, 973], 'Brandes': [719], 'RP,': [720], 'Phivthong-ngam': [721], 'L,': [722, 877], 'Bohme': [723], 'Nafe': [725], 'R,': [726], 'Mugge': [727], 'Frolich': [729], 'JC.': [730], 'Dietary': [731], 'progression': [735], 'cholesterol-fed': [739], 'rabbits:': [740], 'comparison': [741], 'lovastatin.': [743], '96:': [746], '1282–1290.CrossrefMedlineGoogle': [747], 'Scholar6': [748], 'De': [749, 1014, 1019], 'Nigris': [750], 'Lerman': [752, 759], 'LO,': [753], 'Williams': [754, 1122], 'Ignarro': [755, 763, 847], 'Sica': [757], 'G,': [758, 843, 1011, 1021], 'Palinski': [761], 'LJ,': [764], 'Napoli': [765], 'C.': [766, 1023], 'Beneficial': [767], 'antioxidants': [770], 'oxidation-sensitive': [774], 'at': [782], 'sites': [783], 'disturbed': [785], 'shear': [786], 'stress.': [787, 1529], 'Proc': [788, 862], 'Natl': [789, 863], 'Acad': [790, 864], 'Sci': [791, 865], 'U': [792, 866, 1673], 'S': [793, 867], 'A.': [794, 868], '100:': [796], '1420–1425.CrossrefMedlineGoogle': [797], 'Scholar7': [798], 'Does': [801], 'ADMA': [802, 982], 'cause': [803], 'dysfunction?': [805], '2000;': [810], '20:': [811], '2032–2037.CrossrefMedlineGoogle': [812], 'Scholar8': [813], 'Ito': [814], 'PS,': [817, 1053], 'Adimoolam': [818], 'Kimoto': [820, 1056], 'Ogawa': [822], 'T,': [823], 'Novel': [826], 'dysfunction:': [830], 'dysregulation': [831], 'dimethylaminohydrolase.': [834, 1107], '1999;': [836], '99:': [837], '3092–3095.CrossrefMedlineGoogle': [838], 'Scholar9': [839], 'Wei': [840], 'LH,': [841], 'Wu': [842, 882], 'Morris': [844], 'SM': [845], 'Jr,': [846, 875], 'LJ.': [848], 'Elevated': [849], 'arginase': [850], 'I': [851], 'rat': [854], 'aortic': [855], 'smooth': [856], 'muscle': [857], 'cells': [858], 'cell': [860, 895], 'proliferation.': [861], '2001;': [869, 962, 1073, 1111], '98:': [870], '9260–9264.CrossrefMedlineGoogle': [871], 'Scholar10': [872], 'Pritchard': [873], 'KA': [874], 'Groszek': [876], 'Smalley': [878], 'DM,': [879], 'Sessa': [880], 'WC,': [881], 'Villalon': [884], 'Wolin': [886], 'MS,': [887], 'Stemerman': [888], 'MB.': [889], 'Native': [890], 'low-density': [891], 'lipoprotein': [892], 'nitric': [896, 1033, 1101, 1690], 'oxide': [897, 1034, 1102, 1691], 'anion.': [902], 'Circ': [903], 'Res.': [904, 1000], '1995;': [905], '77:': [906], '510–518.CrossrefMedlineGoogle': [907], 'Scholar11': [908], 'J.': [910], 'Adverse': [911], 'atherosclerosis:': [917], 'consequences': [918], 'stress': [921, 985, 1715], 'complex': [924], 'catabolism.': [925], '3–5.LinkGoogle': [932], 'Scholar12': [933], 'Stead': [934, 1457, 1511], 'Au': [936], 'KP,': [937], 'Jacobs': [938], 'RL,': [939], 'Brosnan': [940, 942], 'ME,': [941], 'JT.': [943], 'Methylation': [944], 'demand': [945], 'metabolism:': [948], 'dietary': [951], 'provision': [952], 'guanidinoacetate.': [956], 'Am': [957], 'Physiol': [959], 'Endocrinol': [960], 'Metab.': [961], '281:': [963], 'E1095–E1100.CrossrefMedlineGoogle': [964], 'Scholar13': [965], 'K,': [967], 'Schwedhelm': [968], 'E,': [969], 'Arakawa': [970], 'N,': [971, 1707, 1742], 'Bode-Böger': [972], 'Tsikas': [974], 'D,': [975], 'Hornig': [976], 'B,': [977], 'Frölich': [978], 'JC,': [979], 'Böger': [980], 'RH.': [981], 'responsible': [987], 'hyperhomocyst(e)inemia:': [992], 'B': [997], 'vitamins.': [998], 'Cardiovasc': [999], '57:': [1002], '244–252.CrossrefMedlineGoogle': [1003], 'Scholar14': [1004], 'Cassone': [1005], 'Faldetta': [1006], 'Laurenti': [1008], 'Desideri': [1010], 'Bravi': [1012], 'Luca': [1015], 'Marinucci': [1017], 'Mattia': [1020], 'Ferri': [1022], 'decreases': [1026], 'total': [1028, 1307, 1490], 'concentrations': [1030], 'through': [1031], 'production': [1035], 'decreased': [1037], 'status': [1039], 'type': [1041], 'II': [1042], 'patients.': [1044], 'Diabetologia.': [1045], '2002;': [1046], '45:': [1047], '1120–1127.CrossrefMedlineGoogle': [1048], 'Scholar15': [1049], 'Stuhlinger': [1050], 'Her': [1054], 'J-H,': [1055], 'Balint': [1058], 'RF,': [1059], 'pathway:': [1067], 'role': [1068], 'dimethylarginine.': [1071], '104:': [1074], '2569–2575.CrossrefMedlineGoogle': [1075], 'Scholar16': [1076], 'Murray-Rust': [1077], 'Leiper': [1079], 'McAlister': [1081], 'Phelan': [1083], 'Tilley': [1085], 'Santa': [1087], 'Maria': [1088], 'Vallance': [1090], 'McDonald': [1092], 'N.': [1093], 'Structural': [1094], 'insights': [1095], 'into': [1096], 'hydrolysis': [1098], 'cellular': [1100, 1724], 'inhibitors': [1104], 'Nat': [1108], 'Struct': [1109], '8:': [1112], '679–683.CrossrefMedlineGoogle': [1113], 'ScholaratvbahaArterioscler': [1114], 'BioArteriosclerosis,': [1117], 'BiologyATVB1079-56421524-4636Lippincott': [1121], '&': [1123], 'WilkinsChen': [1124], 'Jiqiu': [1125], 'Paul01062003In': [1128], 'Response:Our': [1129], 'original': [1130], 'intent': [1131], 'was': [1132, 1614], 'test': [1134, 1539], 'reduce': [1141, 1215], '(apoE)': [1146], 'mice': [1148, 1185], 'providing': [1150], 'substrate': [1151, 1197, 1686], 'eNOS.1': [1153], 'light': [1155], 'data': [1158], 'isoform': [1162], 'potentially': [1164], 'proatherogenic,2,3': [1165], 'were': [1167, 1206], 'concerned': [1168], 'might': [1171, 1610], 'also': [1172], 'iNOS-derived': [1174], 'confounding': [1176], 'results.': [1178], 'studied': [1181], 'both': [1182], 'apoE/iNOS': [1187, 1253], 'reasoning': [1190], 'serve': [1195], 'as': [1196, 1270, 1272, 1276, 1349], 'double': [1202], 'We': [1205], 'surprised': [1207], 'find': [1209], 'atherosclerotic': [1216], 'burden': [1217], 'result': [1224], 'agreement': [1226], 'reports': [1229], 'mouse': [1234], 'model': [1235], 'atherogenesis.4': [1237], 'Furthermore,': [1238], 'found': [1240], 'eliminated': [1244], 'To': [1256], 'examine': [1257], 'potential': [1258, 1288], 'mechanisms': [1259], 'these': [1261, 1555], 'effects,': [1262], 'measured': [1264], 'oxidized': [1265], 'biopterin': [1268], 'levels,': [1269], 'well': [1271], 'MDA-TBA': [1273], 'reactive': [1274], 'material': [1275], 'markers': [1277], 'lipid': [1279], 'oxidation.In': [1280], 'accompanying': [1282], 'editorial,5': [1283], 'pointed': [1285], 'out': [1286], 'mechanism:': [1289], 'homocysteine,': [1297], 'because': [1298], 'major': [1304, 1487], 'fraction': [1305, 1488, 1501], 'body': [1308, 1491], 'utilization': [1310], 'significant': [1315], 'demand.': [1317], 'Loscalzo’s': [1318], 'analysis': [1319], 'literature': [1322, 1411], 'unexpected': [1325], 'was,': [1327], 'believe,': [1329], 'extremely': [1330], 'logical': [1331], 'cogent.': [1333], 'intriguing': [1338], 'one.': [1339], 'If': [1340], 'true,': [1341], 'implications': [1343], 'very': [1346], 'broad': [1347], 'indeed,': [1348], 'indiscriminate': [1350], 'helpful': [1358], 'fact': [1362], 'contraindicated.': [1364], 'certainly': [1368], 'merits': [1369], 'testing.We': [1371], 'three': [1373], 'comments': [1374], 'regarding': [1375], 'Cooke’s': [1376], 'Sydow’s': [1378], 'letter.': [1379], 'First,': [1380], 'they': [1381], 'do': [1382, 1557], 'acknowledge': [1384], 'that,': [1385], 'while': [1386, 1494], 'some': [1387], 'studies': [1388, 1401, 1725], 'suggest': [1389], 'function,': [1399], 'fail': [1402], 'show': [1404, 1481], 'such': [1405], 'effects.4,6–10': [1406], 'A': [1407, 1744], 'review': [1408], 'suggests': [1412], 'far': [1417], 'from': [1418, 1618], 'clear.': [1419], 'becomes': [1422], 'all': [1423], 'important': [1426], 'establish': [1428], 'under': [1429, 1441, 1566], 'what': [1430, 1442], 'conditions': [1431, 1443], 'restore': [1437], 'function': [1439], 'harmful.Second,': [1447], 'their': [1448], 'letter': [1449], 'misstates': [1450], 'al11': [1459, 1513], 'Rather,': [1469], 'if': [1470, 1600], 'one': [1471, 1535], 'reads': [1472], 'carefully,': [1475], 'numerous': [1478], 'references12–14': [1479], 'represents': [1485, 1497], 'utilization,': [1493], 'much': [1499], 'lower': [1500], '(1.2%)': [1502], 'flux.': [1505], 'why': [1516], 'expected': [1521], 'suppress': [1523], 'expression,': [1525], 'decreasing': [1527], 'Creatine': [1530], 'therefore': [1533], 'means': [1536], 'experimentally': [1538], 'vivo.Third,': [1546], 'agree': [1548], 'negate': [1559], 'possibility': [1561], 'may,': [1565], 'certain': [1567], 'conditions,': [1568], 'levels.We': [1571], 'believe': [1572], 'study': [1577], 'issues': [1580], 'raised': [1581], 'best': [1588], 'resolved': [1589], 'so': [1593], 'can': [1596], 'determine': [1597], 'when': [1598, 1608], 'and,': [1605], 'equally': [1606], 'importantly,': [1607], 'be.This': [1612], 'communication': [1613], 'supported': [1615], 'grants': [1617], 'National': [1620], 'Institutes': [1621], 'Health': [1623], '(RO1': [1624], 'HL63685': [1625], 'PO1AI50153),': [1627], 'Tobacco': [1630], 'Related': [1631], 'Disease': [1632], 'Research': [1633, 1649], '(7RT-0128).': [1635], 'Dr': [1636], 'recipient': [1640], 'research': [1643], 'grant': [1644], 'provided': [1645], 'German': [1648], 'Council': [1650], '(Sy': [1651], '41/1-1).': [1652], 'Previous': [1653], 'Back': [1654], 'top': [1656], 'Next': [1657], 'FiguresReferencesRelatedDetailsCited': [1658], 'By': [1659], 'Karbach': [1660], 'Simon': [1662], 'Slenzka': [1664], 'Jaenecke': [1666], 'Habermeier': [1668], 'Martiné': [1670], 'U,': [1671], 'Förstermann': [1672], 'Closs': [1675], '(2011)': [1677], 'Relative': [1678], 'contribution': [1679], 'different': [1681], 'sources': [1683], 'supply': [1687], 'synthase,': [1692], 'Journal': [1693, 1729, 1788], 'Molecular': [1695], 'Cellular': [1697], 'Cardiology,': [1698], '10.1016/j.yjmcc.2011.07.024,': [1699], '51:5,': [1700], '(855-861),': [1701], 'Online': [1702, 1737, 1761, 1797], 'publication': [1703, 1738, 1762, 1798], 'date:': [1704, 1739, 1763, 1799], '1-Nov-2011.': [1705], 'MADAMANCHI': [1706], 'HAKIM': [1708], 'Z': [1709], 'RUNGE': [1711], 'M': [1712, 1747], '(2005)': [1713], 'Oxidative': [1714, 1749], 'atherogenesis': [1717], 'thrombosis:': [1720], 'disconnect': [1722], 'between': [1723], 'clinical': [1727], 'outcomes,': [1728], 'Thrombosis': [1731], 'Haemostasis,': [1733], '10.1111/j.1538-7836.2004.01085.x,': [1734], '3:2,': [1735], '(254-267),': [1736], '1-Feb-2005.': [1740], 'Madamanchi': [1741], 'Vendrov': [1743], 'Runge': [1746], '(2004)': [1748, 1774], 'Stress': [1750], 'Disease,': [1753], 'Arteriosclerosis,': [1754], '25:1,': [1759], '(29-38),': [1760], '1-Jan-2005.': [1764], 'Parnell': [1765], 'Chin-Dusting': [1767], 'Starr': [1769], 'Kaye': [1772], 'D': [1773], 'vivo': [1776], 'vitro': [1779], 'ACh-stimulated': [1782], 'l': [1783], '-arginine': [1784], 'uptake': [1785], ',': [1786], 'American': [1787], 'Physiology-Heart': [1790], 'Circulatory': [1792], 'Physiology,': [1793], '10.1152/ajpheart.01094.2003,': [1794], '287:1,': [1795], '(H395-H400),': [1796], '1-Jul-2004.': [1800], 'June': [1801], '2003Vol': [1802], 'Issue': [1804], '6': [1805], 'Advertisement': [1806, 1817], 'Article': [1807], 'InformationMetrics': [1808], 'https://doi.org/10.1161/01.ATV.0000075300.76279.BBPMID:': [1809], '12807714': [1810], 'publishedJune': [1812], '1,': [1813], 'PDF': [1815], 'download': [1816]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2090248115', 'counts_by_year': [], 'updated_date': '2024-12-10T22:24:33.562450', 'created_date': '2016-06-24'}