Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2090145223', 'doi': 'https://doi.org/10.7326/0003-4819-153-11-201012070-00023', 'title': 'Standard-Dose Tegafur Combined With Uracil Is Not Safe Treatment After Severe Toxicity From 5-Fluorouracil or Capecitabine', 'display_name': 'Standard-Dose Tegafur Combined With Uracil Is Not Safe Treatment After Severe Toxicity From 5-Fluorouracil or Capecitabine', 'publication_year': 2010, 'publication_date': '2010-12-07', 'ids': {'openalex': 'https://openalex.org/W2090145223', 'doi': 'https://doi.org/10.7326/0003-4819-153-11-201012070-00023', 'mag': '2090145223', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21135311'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-153-11-201012070-00023', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5085647012', 'display_name': 'Maarten J. Deenen', 'orcid': 'https://orcid.org/0000-0002-4389-6420'}, 'institutions': [{'id': 'https://openalex.org/I4210111138', 'display_name': 'Oncode Institute', 'ror': 'https://ror.org/01n92vv28', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I4210111138']}, {'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}, {'id': 'https://openalex.org/I4210105568', 'display_name': 'OLVG', 'ror': 'https://ror.org/01d02sf11', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105568']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Maarten J. Deenen', 'raw_affiliation_strings': ['From The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands', 'Onze Lieve Vrouwe Gasthuis, 1091 AC, Amsterdam, The Netherlands', 'The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'From The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210111138', 'https://openalex.org/I2898336195']}, {'raw_affiliation_string': 'Onze Lieve Vrouwe Gasthuis, 1091 AC, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210105568']}, {'raw_affiliation_string': 'The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.', 'institution_ids': ['https://openalex.org/I4210111138', 'https://openalex.org/I2898336195']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076109573', 'display_name': 'Wim Terpstra', 'orcid': 'https://orcid.org/0000-0002-2779-1813'}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}, {'id': 'https://openalex.org/I4210111138', 'display_name': 'Oncode Institute', 'ror': 'https://ror.org/01n92vv28', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I4210111138']}, {'id': 'https://openalex.org/I4210105568', 'display_name': 'OLVG', 'ror': 'https://ror.org/01d02sf11', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105568']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Wim E. Terpstra', 'raw_affiliation_strings': ['From The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands', 'Onze Lieve Vrouwe Gasthuis, 1091 AC, Amsterdam, The Netherlands', 'The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.', 'institution_ids': ['https://openalex.org/I2898336195', 'https://openalex.org/I4210111138']}, {'raw_affiliation_string': 'From The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210111138', 'https://openalex.org/I2898336195']}, {'raw_affiliation_string': 'Onze Lieve Vrouwe Gasthuis, 1091 AC, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210105568']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017478217', 'display_name': 'Annemieke Cats', 'orcid': 'https://orcid.org/0000-0001-6509-9804'}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}, {'id': 'https://openalex.org/I4210111138', 'display_name': 'Oncode Institute', 'ror': 'https://ror.org/01n92vv28', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I4210111138']}, {'id': 'https://openalex.org/I4210105568', 'display_name': 'OLVG', 'ror': 'https://ror.org/01d02sf11', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105568']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Annemieke Cats', 'raw_affiliation_strings': ['From The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands', 'Onze Lieve Vrouwe Gasthuis, 1091 AC, Amsterdam, The Netherlands', 'The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'From The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I2898336195', 'https://openalex.org/I4210111138']}, {'raw_affiliation_string': 'The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.', 'institution_ids': ['https://openalex.org/I4210111138', 'https://openalex.org/I2898336195']}, {'raw_affiliation_string': 'Onze Lieve Vrouwe Gasthuis, 1091 AC, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210105568']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048883988', 'display_name': 'Henk Boot', 'orcid': 'https://orcid.org/0000-0003-4986-761X'}, 'institutions': [{'id': 'https://openalex.org/I4210111138', 'display_name': 'Oncode Institute', 'ror': 'https://ror.org/01n92vv28', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I4210111138']}, {'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}, {'id': 'https://openalex.org/I4210105568', 'display_name': 'OLVG', 'ror': 'https://ror.org/01d02sf11', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105568']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Henk Boot', 'raw_affiliation_strings': ['From The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands', 'Onze Lieve Vrouwe Gasthuis, 1091 AC, Amsterdam, The Netherlands', 'The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.', 'institution_ids': ['https://openalex.org/I4210111138', 'https://openalex.org/I2898336195']}, {'raw_affiliation_string': 'From The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210111138', 'https://openalex.org/I2898336195']}, {'raw_affiliation_string': 'Onze Lieve Vrouwe Gasthuis, 1091 AC, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210105568']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000418012', 'display_name': 'Jan H.M. Schellens', 'orcid': 'https://orcid.org/0000-0001-6832-1976'}, 'institutions': [{'id': 'https://openalex.org/I4210111138', 'display_name': 'Oncode Institute', 'ror': 'https://ror.org/01n92vv28', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I4210111138']}, {'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}, {'id': 'https://openalex.org/I4210105568', 'display_name': 'OLVG', 'ror': 'https://ror.org/01d02sf11', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210105568']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jan H.M. Schellens', 'raw_affiliation_strings': ['From The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands', 'Onze Lieve Vrouwe Gasthuis, 1091 AC, Amsterdam, The Netherlands', 'The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.'], 'affiliations': [{'raw_affiliation_string': 'The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.', 'institution_ids': ['https://openalex.org/I4210111138', 'https://openalex.org/I2898336195']}, {'raw_affiliation_string': 'From The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210111138', 'https://openalex.org/I2898336195']}, {'raw_affiliation_string': 'Onze Lieve Vrouwe Gasthuis, 1091 AC, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210105568']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.626126, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 79, 'max': 81}, 'biblio': {'volume': '153', 'issue': '11', 'first_page': '767', 'last_page': '767'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10950', 'display_name': 'Acute Lymphoblastic Leukemia research', 'score': 0.9911, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10950', 'display_name': 'Acute Lymphoblastic Leukemia research', 'score': 0.9911, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 0.9907, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9842, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tegafur', 'display_name': 'Tegafur', 'score': 0.4328351}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.80252653}, {'id': 'https://openalex.org/C2777909004', 'wikidata': 'https://www.wikidata.org/wiki/Q420207', 'display_name': 'Capecitabine', 'level': 4, 'score': 0.79004526}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5273783}, {'id': 'https://openalex.org/C2777299880', 'wikidata': 'https://www.wikidata.org/wiki/Q413370', 'display_name': 'Tegafur', 'level': 3, 'score': 0.4328351}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.24090484}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.19476476}], 'mesh': [{'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D003841', 'descriptor_name': 'Deoxycytidine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D054067', 'descriptor_name': 'Dihydropyrimidine Dehydrogenase Deficiency', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005472', 'descriptor_name': 'Fluorouracil', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D005472', 'descriptor_name': 'Fluorouracil', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D005641', 'descriptor_name': 'Tegafur', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069287', 'descriptor_name': 'Capecitabine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003841', 'descriptor_name': 'Deoxycytidine', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D003841', 'descriptor_name': 'Deoxycytidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042943', 'descriptor_name': 'Dihydrouracil Dehydrogenase (NADP)', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D042943', 'descriptor_name': 'Dihydrouracil Dehydrogenase (NADP)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005472', 'descriptor_name': 'Fluorouracil', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011355', 'descriptor_name': 'Prodrugs', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D011355', 'descriptor_name': 'Prodrugs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012004', 'descriptor_name': 'Rectal Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D012004', 'descriptor_name': 'Rectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005641', 'descriptor_name': 'Tegafur', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D005641', 'descriptor_name': 'Tegafur', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-153-11-201012070-00023', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21135311', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 4, 'referenced_works': ['https://openalex.org/W1989372206', 'https://openalex.org/W2066957784', 'https://openalex.org/W2077902459', 'https://openalex.org/W2093021939'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W4301748311', 'https://openalex.org/W3144346200', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W3030791662', 'https://openalex.org/W2748952813', 'https://openalex.org/W2415036230', 'https://openalex.org/W2404969713', 'https://openalex.org/W1995515455'], 'abstract_inverted_index': {'Letters7': [0], 'December': [1, 615, 626, 631], '2010Standard-Dose': [2], 'Tegafur': [3], 'Combined': [4], 'With': [5], 'Uracil': [6], 'Is': [7], 'Not': [8], 'Safe': [9], 'Treatment': [10], 'After': [11], 'Severe': [12], 'Toxicity': [13], 'From': [14, 504], '5-Fluorouracil': [15], 'or': [16, 575], 'CapecitabineMaarten': [17], 'J.': [18, 40], 'Deenen,': [19, 41], 'PharmD,': [20], 'Wim': [21, 71], 'E.': [22, 72], 'Terpstra,': [23, 73], 'MD,': [24, 28, 32, 38, 74, 106, 138, 172], 'PhD,': [25, 29, 33], 'Annemieke': [26, 104], 'Cats,': [27, 105], 'Henk': [30, 136], 'Boot,': [31, 137], 'and': [34, 61, 94, 126, 158, 168, 192, 203, 271, 286, 363, 468, 501, 523, 552], 'Jan': [35, 169], 'H.M.': [36, 170], 'Schellens,': [37, 171], 'PhDMaarten': [39], 'PharmDFrom': [42], 'The': [43, 50, 59, 62, 69, 76, 83, 92, 95, 102, 108, 115, 124, 127, 134, 140, 147, 156, 159, 166, 174, 181, 190, 193, 200, 215, 241, 347, 505, 512, 521, 524, 531], 'Netherlands': [44, 63, 77, 96, 109, 128, 141, 160, 175, 194, 506, 525], 'Cancer': [45, 64, 78, 97, 110, 129, 142, 161, 176, 195, 367, 401, 478, 507, 526], 'Institute,': [46, 65, 79, 98, 111, 130, 143, 162, 177, 196, 508, 527], '1066': [47, 66, 80, 99, 112, 131, 144, 163, 178, 197, 509, 528], 'CX,': [48, 67, 81, 100, 113, 132, 145, 164, 179, 198, 510, 529], 'Amsterdam,': [49, 58, 68, 82, 91, 101, 114, 123, 133, 146, 155, 165, 180, 189, 199, 511, 520, 530], 'Netherlands;': [51, 60, 84, 93, 116, 125, 148, 157, 182, 191, 513, 522], 'Onze': [52, 85, 117, 149, 183, 514], 'Lieve': [53, 86, 118, 150, 184, 515], 'Vrouwe': [54, 87, 119, 151, 185, 516], 'Gasthuis,': [55, 88, 120, 152, 186, 517], '1091': [56, 89, 121, 153, 187, 518], 'AC,': [57, 90, 122, 154, 188, 519], 'Netherlands.,': [70, 103, 135, 167], 'PhDFrom': [75, 107, 139, 173], 'Netherlands.Author,': [201], 'Article,': [202, 500], 'Disclosure': [204, 502], 'Informationhttps://doi.org/10.7326/0003-4819-153-11-201012070-00023': [205], 'SectionsAboutFull': [206], 'TextPDF': [207], 'ToolsAdd': [208], 'to': [209, 434, 546], 'favoritesDownload': [210], 'CitationsTrack': [211], 'CitationsPermissions': [212], 'ShareFacebookTwitterLinkedInRedditEmail': [213], 'Background:': [214], 'most': [216, 242], 'frequently': [217], 'prescribed': [218], 'anticancer': [219], 'drugs': [220], 'are': [221, 262], 'the': [222, 255, 284, 352, 398, 435, 438, 566, 598], 'fluoropyrimidines,': [223], 'which': [224, 277], 'include': [225], '5-fluorouracil': [226, 430, 443], '(5-FU).': [227], 'Most': [228, 294], 'patients': [229, 572, 604], 'tolerate': [230], 'fluoropyrimidines': [231, 285], 'well,': [232], 'but': [233], 'about': [234], '10%': [235], 'develop': [236], 'severe,': [237], 'potentially': [238], 'life-threatening': [239], 'complications.': [240], 'important': [243], 'cause': [244], 'of': [245, 251, 283, 354, 390, 423, 427, 437, 442, 463, 473, 487, 542, 555, 600, 612, 641], 'these': [246], 'complications': [247], 'is': [248, 303, 563, 581, 595], 'a': [249, 266, 424, 583, 610], 'deficiency': [250, 558], 'dihydropyrimidine': [252, 355, 392, 556, 588, 607], 'dehydrogenase': [253, 356, 393, 557, 608], '(DPD),': [254], 'primary': [256], 'enzyme': [257], 'that': [258, 268, 300], 'detoxifies': [259], 'fluoropyrimidines.': [260], 'Fluoropyrimidines': [261], 'often': [263], 'combined': [264], 'with': [265, 573, 605], 'compound': [267], 'inhibits': [269], 'DPD': [270, 275], 'creates': [272], 'an': [273, 428], 'artificial': [274], 'deficiency,': [276], 'reduces': [278], 'interpatient': [279], 'variability': [280], 'in': [281, 312, 351, 559, 571, 586, 592, 603], 'tolerance': [282], 'should': [287], 'allow': [288], 'uniform': [289], 'dosing': [290], 'for': [291, 305, 318, 597], 'all': [292], 'patients.': [293], 'clinicians': [295], 'who': [296], 'prescribe': [297], 'chemotherapy': [298], 'believe': [299], 'this': [301], 'practice': [302], 'safe': [304, 584, 596], 'DPD-deficient': [306], 'patients.Objective:': [307], 'To': [308], 'describe': [309], '4': [310], 'cases': [311], '...References1.': [313], 'NCI.': [314], 'Common': [315], 'Terminology': [316], 'Criteria': [317], 'Adverse': [319], 'Events': [320], 'Version': [321], '3.0.': [322], 'Accessed': [323, 327, 490], 'at': [324, 491], 'ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/ctcaev3.pdf': [325], 'on': [326, 493], 'July': [328, 495], '26,': [329], '2010': [330, 627, 632, 637], 'Google': [331, 497], 'Scholar2.': [332], 'Mattison': [333], 'LK,': [334], 'Fourie': [335], 'J,': [336], 'Hirao': [337], 'Y,': [338, 411], 'Koga': [339], 'T,': [340, 377, 409, 417], 'Desmond': [341], 'RA,': [342], 'King': [343], 'JR,': [344], 'et': [345, 386, 420], 'al.': [346, 387, 421], 'uracil': [348], 'breath': [349], 'test': [350], 'assessment': [353], 'activity:': [357], 'pharmacokinetic': [358], 'relationship': [359], 'between': [360], 'expired': [361], '13CO2': [362], 'plasma': [364], '[2-13C]dihydrouracil.': [365], 'Clin': [366], 'Res.': [368], '2006;12:549-55.': [369], '[PMID:': [370, 404, 451, 481], '16428499]': [371], 'CrossrefMedlineGoogle': [372, 406, 453, 483], 'Scholar3.': [373], 'Ogura': [374], 'K,': [375, 385, 419], 'Nishiyama': [376], 'Takubo': [378], 'H,': [379, 383, 413], 'Kato': [380, 416], 'A,': [381], 'Okuda': [382], 'Arakawa': [384], 'Suicidal': [388], 'inactivation': [389], 'human': [391], 'by': [394, 444, 638], '(E)-5-(2-bromovinyl)uracil': [395], 'derived': [396], 'from': [397], 'antiviral,': [399], 'sorivudine.': [400], 'Lett.': [402], '1998;122:107-13.': [403], '9464498]': [405], 'Scholar4.': [407], 'Shirasaka': [408], 'Shimamato': [410], 'Ohshimo': [412], 'Yamaguchi': [414], 'M,': [415], 'Yonekura': [418], 'Development': [422], 'novel': [425], 'form': [426], 'oral': [429, 471], 'derivative': [431], '(S-1)': [432], 'directed': [433], 'potentiation': [436], 'tumor': [439], 'selective': [440], 'cytotoxicity': [441], 'two': [445], 'biochemical': [446], 'modulators.': [447], 'Anticancer': [448], 'Drugs.': [449], '1996;7:548-57.': [450], '8862723]': [452], 'Scholar5.': [454], 'Kim': [455], 'WY,': [456], 'Nakata': [457], 'B,': [458], 'Hirakawa': [459], 'K.': [460], 'Alternative': [461], 'pharmacokinetics': [462], 'S-1': [464, 474], 'components,': [465], '5-fluorouracil,': [466], 'dihydrofluorouracil': [467], 'alpha-fluoro-beta-alanine': [469], 'after': [470], 'administration': [472], 'following': [475], 'total': [476], 'gastrectomy.': [477], 'Sci.': [479], '2007;98:1604-8.': [480], '17683513]': [482], 'Scholar6.': [484], 'UFT': [485], 'Summary': [486], 'Product': [488], 'Characteristics.': [489], 'www.medicines.org.uk/EMC/medicine/4399/SPC/Uftoral+Hard+Capsules': [492], '26': [494], '2010.': [496], 'Scholar': [498], 'Author,': [499], 'InformationAffiliations:': [503], 'Netherlands.Disclosures:': [532], 'None': [533], 'disclosed.': [534], 'PreviousarticleNextarticle': [535], 'Advertisement': [536], 'FiguresReferencesRelatedDetails': [537], 'Metrics': [538], 'Cited': [539], 'byUpfront': [540], 'Genotyping': [541], 'DPYD': [543], '*': [544], '2A': [545], 'Individualize': [547], 'Fluoropyrimidine': [548], 'Therapy:': [549], 'A': [550], 'Safety': [551], 'Cost': [553], 'AnalysisDilemma': [554], 'colorectal': [560, 601], 'cancer': [561, 602], 'patients:': [562], 'Uftoral': [564], '®': [565], 'right': [567], 'answer?Capecitabine': [568], 'maintenance': [569], 'therapy': [570], 'recurrent': [574], 'metastatic': [576], 'breast': [577], 'cancerStandard-dose': [578], 'tegafur-uracil': [579], '(UFT)': [580, 591], 'not': [582], 'alternative': [585], 'partial': [587, 606], 'dehydrogenase-deficient': [589], 'patientsTegafur-uracil': [590], 'lower': [593], 'doses': [594], 'treatment': [599], 'deficiency:': [609], 'proof': [611], 'principle': [613], '7': [614, 625, 630], '2010Volume': [616], '153,': [617], 'Issue': [618, 628], '11Page:': [619], '767-768KeywordsCancer': [620], 'treatmentChemotherapyDiarrheaDrugsEnzymesHalf': [621], 'lifeNeutropeniaPhenotypesRectal': [622], 'cancerToxicity': [623], 'ePublished:': [624], 'Published:': [629], 'Copyright': [633], '&': [634], 'PermissionsCopyright': [635], '©': [636], 'American': [639], 'College': [640], 'Physicians.': [642], 'All': [643], 'Rights': [644], 'Reserved.PDF': [645], 'downloadLoading': [646], '...': [647]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2090145223', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-13T11:38:11.708353', 'created_date': '2016-06-24'}