Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2090095827', 'doi': 'https://doi.org/10.7326/0003-4819-90-1-19', 'title': 'Oral Angiotensin-Converting Enzyme Inhibitor in Long-Term Treatment of Hypertensive Patients', 'display_name': 'Oral Angiotensin-Converting Enzyme Inhibitor in Long-Term Treatment of Hypertensive Patients', 'publication_year': 1979, 'publication_date': '1979-01-01', 'ids': {'openalex': 'https://openalex.org/W2090095827', 'doi': 'https://doi.org/10.7326/0003-4819-90-1-19', 'mag': '2090095827', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/217289'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-90-1-19', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5105933648', 'display_name': 'Hans R. Brunner', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'HANS R. BRUNNER', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5105933648'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 29.458, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 357, 'citation_normalized_percentile': {'value': 0.984083, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '90', 'issue': '1', 'first_page': '19', 'last_page': '19'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11561', 'display_name': 'Protein Hydrolysis and Bioactive Peptides', 'score': 0.9832, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11561', 'display_name': 'Protein Hydrolysis and Bioactive Peptides', 'score': 0.9832, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System Studies', 'score': 0.9811, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10144', 'display_name': 'Blood Pressure and Hypertension Studies', 'score': 0.9646, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/captopril', 'display_name': 'Captopril', 'score': 0.873786}, {'id': 'https://openalex.org/keywords/plasma-renin-activity', 'display_name': 'Plasma renin activity', 'score': 0.7257464}, {'id': 'https://openalex.org/keywords/renovascular-hypertension', 'display_name': 'Renovascular Hypertension', 'score': 0.66179115}, {'id': 'https://openalex.org/keywords/essential-hypertension', 'display_name': 'Essential hypertension', 'score': 0.5260917}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.91369796}, {'id': 'https://openalex.org/C2779479957', 'wikidata': 'https://www.wikidata.org/wiki/Q421119', 'display_name': 'Captopril', 'level': 3, 'score': 0.873786}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.7325897}, {'id': 'https://openalex.org/C138976137', 'wikidata': 'https://www.wikidata.org/wiki/Q7201790', 'display_name': 'Plasma renin activity', 'level': 4, 'score': 0.7257464}, {'id': 'https://openalex.org/C2781243531', 'wikidata': 'https://www.wikidata.org/wiki/Q3296793', 'display_name': 'Renovascular hypertension', 'level': 3, 'score': 0.66179115}, {'id': 'https://openalex.org/C2778525890', 'wikidata': 'https://www.wikidata.org/wiki/Q184564', 'display_name': 'Aldosterone', 'level': 2, 'score': 0.6585153}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6471391}, {'id': 'https://openalex.org/C27016395', 'wikidata': 'https://www.wikidata.org/wiki/Q128861', 'display_name': 'Angiotensin-converting enzyme', 'level': 3, 'score': 0.6201646}, {'id': 'https://openalex.org/C73787029', 'wikidata': 'https://www.wikidata.org/wiki/Q7104929', 'display_name': 'Orthostatic vital signs', 'level': 3, 'score': 0.58858204}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.585833}, {'id': 'https://openalex.org/C198710026', 'wikidata': 'https://www.wikidata.org/wiki/Q898218', 'display_name': 'Renin–angiotensin system', 'level': 3, 'score': 0.55647606}, {'id': 'https://openalex.org/C2777097880', 'wikidata': 'https://www.wikidata.org/wiki/Q988405', 'display_name': 'Essential hypertension', 'level': 3, 'score': 0.5260917}, {'id': 'https://openalex.org/C2777056448', 'wikidata': 'https://www.wikidata.org/wiki/Q285166', 'display_name': 'Oral administration', 'level': 2, 'score': 0.42136976}, {'id': 'https://openalex.org/C2776980637', 'wikidata': 'https://www.wikidata.org/wiki/Q427492', 'display_name': 'Enzyme inhibitor', 'level': 3, 'score': 0.41049686}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.15132788}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000806', 'descriptor_name': 'Angiotensin-Converting Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011392', 'descriptor_name': 'Proline', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001794', 'descriptor_name': 'Blood Pressure', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006978', 'descriptor_name': 'Hypertension, Renovascular', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D006978', 'descriptor_name': 'Hypertension, Renovascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011392', 'descriptor_name': 'Proline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011392', 'descriptor_name': 'Proline', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D011392', 'descriptor_name': 'Proline', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012083', 'descriptor_name': 'Renin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012083', 'descriptor_name': 'Renin', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.7326/0003-4819-90-1-19', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119722071', 'display_name': 'Annals of Internal Medicine', 'issn_l': '0003-4819', 'issn': ['0003-4819', '1539-3704'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316812', 'host_organization_name': 'American College of Physicians', 'host_organization_lineage': ['https://openalex.org/P4310316812'], 'host_organization_lineage_names': ['American College of Physicians'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/217289', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.82, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1901240262', 'https://openalex.org/W1966182689', 'https://openalex.org/W1987000855', 'https://openalex.org/W1996094088', 'https://openalex.org/W1997237739', 'https://openalex.org/W2000314850', 'https://openalex.org/W2008518019', 'https://openalex.org/W2046902532', 'https://openalex.org/W2073336434', 'https://openalex.org/W2076789308', 'https://openalex.org/W2092054151', 'https://openalex.org/W2092885332', 'https://openalex.org/W2107645164', 'https://openalex.org/W2142851189', 'https://openalex.org/W2151402663', 'https://openalex.org/W2166029232', 'https://openalex.org/W2315504621', 'https://openalex.org/W2316814104', 'https://openalex.org/W2330797711', 'https://openalex.org/W2335787154', 'https://openalex.org/W2339423792', 'https://openalex.org/W2342067247'], 'related_works': ['https://openalex.org/W2464922375', 'https://openalex.org/W2460498021', 'https://openalex.org/W2427221735', 'https://openalex.org/W2417418707', 'https://openalex.org/W2090095827', 'https://openalex.org/W2077998387', 'https://openalex.org/W2047608102', 'https://openalex.org/W2020390064', 'https://openalex.org/W2016647631', 'https://openalex.org/W1996437577'], 'abstract_inverted_index': {'The': [0], 'antihypertensive': [1, 101, 160], 'effect': [2, 102, 161], 'of': [3, 19, 67, 87, 99, 116, 123, 144, 152, 170, 189], 'the': [4, 65, 73, 85, 97, 100, 133, 159, 171, 187], 'orally': [5, 176], 'active': [6, 177], 'angiotensinconverting': [7], 'enzyme': [8, 173], 'inhibitor': [9], 'Captopril': [10, 88], '(SQ': [11], '14225)': [12], 'was': [13, 149, 162], 'assessed': [14], 'in': [15, 55], '22': [16], 'hypertensive': [17], 'patients': [18], 'whom': [20], '17': [21], 'were': [22], 'followed': [23], 'for': [24], 'periods': [25], 'ranging': [26], 'from': [27, 89, 158], '1': [28], 'to': [29, 91, 125, 140, 186], '7': [30], 'months.': [31], 'Of': [32], 'these,': [33], 'eight': [34, 38], 'had': [35, 39, 44], 'essential': [36], 'hypertension,': [37, 41], 'renovascular': [40], 'and': [42, 114, 155, 183], 'six': [43], 'hypertension': [45], 'associated': [46], 'with': [47, 60, 72, 118, 174], 'chronic': [48, 168], 'renal': [49], 'failure.': [50], 'Blood': [51], 'pressure': [52, 69, 110, 135], 'decreased': [53], 'markedly': [54], 'all': [56], 'patients,': [57], 'including': [58], 'those': [59], 'low': [61], 'renin': [62, 76], 'levels.': [63], 'Nevertheless,': [64], 'magnitude': [66], 'blood': [68, 109, 134], 'reduction': [70], 'correlated': [71], 'base-line': [74], 'plasma': [75], 'activity': [77], '(r': [78], '=': [79], '0.58,': [80], 'P': [81], '<': [82], '0.01).': [83], 'Increasing': [84], 'dose': [86, 122], '25': [90], '200': [92, 126], 'mg': [93, 127], 'did': [94, 104], 'not': [95], 'enhance': [96], 'amplitude': [98], 'but': [103], 'increase': [105], 'its': [106], 'duration.': [107], "Patients'": [108], 'remained': [111], 'well': [112], 'controlled': [113], 'free': [115], 'side-effects': [117], 'a': [119, 180], 'maximal': [120], 'daily': [121], 'up': [124], 'by': [128], 'mouth': [129], 'twice': [130], 'daily.': [131], 'Despite': [132], 'reduction,': [136], 'sodium': [137], 'excretion': [138], 'tended': [139], 'increase,': [141], 'probably': [142], 'because': [143], 'reduced': [145], 'aldosterone': [146], 'secretion.': [147], 'There': [148], 'no': [150, 156], 'evidence': [151], 'orthostatic': [153], 'hypotension,': [154], 'escape': [157], 'observed.': [163], 'These': [164], 'results': [165], 'indicate': [166], 'that': [167], 'inhibition': [169], 'angiotensin-converting': [172], 'an': [175], 'compound': [178], 'offers': [179], 'new,': [181], 'efficient,': [182], 'well-tolerated': [184], 'approach': [185], 'treatment': [188], 'hypertension.': [190]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2090095827', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-15T15:52:02.605883', 'created_date': '2016-06-24'}