Identification of Dicarboxylate Carrier Slc25a10 as Malate Transporter in de Novo Fatty Acid Synthesis

Name: Work Video:
Duration: 3 min 30 s
Shinji Mizuarai; Satomi Miki; Hiromitsu Araki; Kazuhiko Takahashi; Hidehito Kotani
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'identified.': [55, 276], 'In': [56, 277, 788, 1743, 3517, 3935, 4140, 4226, 4280], 'present': [58, 279, 1556], 'study,': [59, 280, 1557], 'we': [60, 112, 281, 333, 1558, 2035, 3110, 3231, 3436, 3509, 3539, 3555, 3912, 4066], 'clarified': [61, 282], 'role': [63, 195, 284, 416, 1618], 'of': [64, 76, 116, 138, 160, 177, 211, 285, 297, 337, 359, 381, 398, 432, 535, 544, 582, 620, 649, 772, 786, 793, 811, 820, 830, 871, 1014, 1075, 1083, 1146, 1261, 1270, 1321, 1366, 1386, 1399, 1416, 1421, 1492, 1504, 1544, 1563, 1604, 1637, 1673, 1697, 1776, 1819, 1832, 1837, 1862, 1906, 1919, 1983, 1993, 2046, 2062, 2100, 2161, 2170, 2202, 2222, 2243, 2300, 2306, 2393, 2409, 2430, 2465, 2471, 2495, 2533, 2576, 2587, 2639, 2650, 2690, 2703, 2713, 2839, 2873, 2896, 2909, 2934, 2971, 2995, 3034, 3068, 3091, 3116, 3158, 3225, 3328, 3365, 3385, 3398, 3441, 3481, 3493, 3501, 3544, 3560, 3571, 3601, 3612, 3615, 3626, 3672, 3699, 3710, 3727, 3760, 3773, 3785, 3799, 3833, 3886, 3892, 3927, 3941, 3966, 4034, 4054, 4060, 4070, 4082, 4100, 4115, 4148, 4160, 4169, 4200, 4264], 'Slc25a10': [65, 77, 90, 117, 142, 161, 178, 191, 212, 286, 298, 311, 338, 363, 382, 399, 412, 433, 913, 1076, 1147, 1583, 1605, 1614, 1638, 2003, 2144, 3329, 3442, 3475, 3482, 3494, 3530, 3561, 3572, 3616, 3702, 3732, 3768, 3774, 3786, 3800, 3826, 3921, 3967, 4035, 4083, 4090, 4101, 4111, 4156, 4245, 4273, 4283, 4292], 'and': [72, 83, 100, 132, 172, 207, 293, 304, 321, 353, 393, 428, 530, 667, 842, 880, 924, 926, 1021, 1329, 1372, 1390, 1404, 1427, 1513, 1570, 1592, 1651, 1680, 1684, 1699, 1704, 1755, 1779, 1787, 1802, 1858, 1879, 1909, 1925, 1952, 1975, 2131, 2233, 2247, 2257, 2267, 2295, 2406, 2421, 2444, 2456, 2468, 2482, 2507, 2567, 2572, 2630, 2635, 2652, 2705, 2808, 2821, 2885, 2912, 2930, 2954, 3002, 3026, 3042, 3070, 3095, 3118, 3128, 3132, 3135, 3243, 3312, 3340, 3377, 3394, 3456, 3464, 3497, 3514, 3524, 3542, 3549, 3581, 3583, 3596, 3603, 3633, 3679, 3722, 3778, 3790, 3871, 3970, 3990, 4010, 4172, 4182, 4188, 4195, 4210, 4224, 4277], 'examined': [73, 113, 294, 334, 1601, 3782], 'effect': [75, 115, 296, 336, 1603, 3500, 3784, 4059], 'suppression': [78, 118, 143, 159, 176, 299, 339, 364, 380, 397, 1415, 1495, 1606, 1636, 3546, 3570, 3625, 3769, 3787, 3922, 4081, 4102], 'on': [79, 123, 300, 344, 1577, 1607, 2999, 3152, 3258, 3353, 3503, 3788, 4064, 4124], 'lipogenic': [81, 128, 164, 302, 349, 385, 449, 917, 1019, 1367, 1581, 3106, 3518, 4130, 4202, 4228], 'pathway': [82, 303, 1398, 1549, 3107, 4131], 'lipid': [84, 181, 216, 305, 402, 437, 1646], 'accumulation.': [85, 306], 'We': [86, 134, 155, 307, 355, 376, 1305, 1599, 1611, 1631, 3351, 3468, 3781, 4164], 'have': [87, 308, 1158, 1407, 1707], 'reported': [88, 309], 'an': [89, 193, 310, 414, 642, 1086, 1805, 1928, 2022, 2906, 3104, 3343, 4051], 'increase': [91, 312, 3164, 3473], 'white': [93, 314, 453, 462, 498], 'obese': [97, 318, 1322, 1371, 1429, 1567, 1589, 1701, 3117, 3123, 3241, 3309, 3391, 3444], 'mouse': [98, 106, 319, 327, 1568, 1573, 1590, 1597, 2143, 3120, 3124, 3138, 3310, 3445, 3515, 3525], 'models': [99, 320, 1375, 1434, 1569, 1591, 3125, 3242, 3446], 'a': [101, 104, 322, 325, 555, 857, 1325, 1560, 1571, 1616, 1761, 1991, 2033, 2047, 2159, 2223, 2461, 2485, 2711, 2714, 2789, 2826, 3084, 3141, 3432, 3471, 3754], 'decrease': [102, 323, 3924], 'fasted': [105, 326, 1572, 1745, 1751, 3119, 3137, 3251, 3316, 3378, 3402], 'model': [107, 328, 1574, 3139, 3311, 3392], 'using': [108, 329, 1565, 1798, 1868, 1927, 2004, 2311, 2460, 2484, 2593, 2710, 2825, 3083], 'expression': [109, 171, 330, 392, 921, 929, 976, 1418, 1503, 1942, 3440, 3573, 3628, 3638, 3670, 3709, 4069, 4168, 4198, 4234, 4251, 4263, 4295, 4307], 'profiles.': [110, 331], 'Next,': [111, 332, 3435, 3554], 'small': [120, 341, 488, 524], 'interfering': [121, 342, 489, 525], 'RNA': [122, 343, 1493, 1793, 1820, 1874], 'cell': [129, 350, 2521, 2539, 2977, 3847, 3987, 4007, 4229], 'lines': [130, 351], 'HepG2': [131, 352, 1984, 2070, 2212, 3548, 3580, 3602, 3632, 3664, 3802, 3974], '3T3-L1.': [133, 354], 'observed': [135, 356, 3460, 3540, 3875, 4237], 'that': [136, 158, 190, 209, 357, 379, 411, 430, 1312, 1500, 1613, 1634, 3356, 3879, 3914, 4128], 'inhibition': [137, 210, 358, 431, 3502, 3891], 'significantly': [144, 365, 4297], 'reduced': [145, 366, 1507, 1645, 3593, 3916, 4061, 4145, 4232], 'from': [149, 370, 797, 1264, 1796, 1877, 2211, 2479, 2698, 2770, 3522, 3565, 3579, 3660, 3852, 3895, 4041, 4046], 'mitochondria': [151, 372, 1084, 2210, 2273, 2291, 2387, 2435, 2657, 3563, 3576, 3658, 3749, 3854, 3873, 3897], 'to': [152, 373, 547, 584, 609, 807, 813, 846, 883, 1161, 1575, 1760, 1850, 1914, 1946, 2262, 2569, 2632, 2788, 2811, 2845, 2914, 2949, 3147, 3163, 3594, 3731, 3840, 3898, 4146], 'cytosol.': [154, 375, 3856, 3900, 3973], 'also': [156, 377, 639, 978, 1306, 1632, 3342, 3469, 3751, 3838, 4118, 4165, 4205, 4236], 'found': [157, 378, 1612, 1633], 'down-regulated': [162, 383, 1593, 1639, 3244], 'pathway,': [165, 386], 'indicated': [166, 208, 387, 429, 2425], 'decreases': [168, 389], 'ACC1': [170, 391, 4037, 4071, 4117, 4142, 4233, 4265, 4294], 'malonyl-CoA': [173, 394, 610, 2691, 2699, 2769, 2803, 4040], 'level.': [174, 395], 'Furthermore,': [175, 396], 'decreased': [179, 400, 3314, 3815, 3882, 3945, 4262], 'triglyceride': [180, 401, 1405, 2926], 'accumulation': [182, 217, 403, 438, 1647], 'adipose-differentiated': [184, 405, 3477], '3T3-L1': [185, 406, 2101, 2136, 2177, 2874, 3478, 3634, 3666, 4085, 4095, 4136, 4213, 4276], 'cells.': [186, 407, 3568, 3635, 3667, 3795, 4000, 4074, 4214], 'These': [187, 408], 'results': [188, 409, 1080], 'suggested': [189, 410], 'plays': [192, 413, 1615], 'important': [194, 415, 1163, 1379], 'required': [202, 423, 1626], 'might': [213, 434, 3923], 'effectively': [214, 435], 'reduce': [215, 436], 'tissues.': [220, 441], 'De': [442, 1213], 'novo': [443, 1401, 3505], 'occurs': [447], 'tissues': [450, 1020, 1368, 3336], '(WAT)': [456], '2The': [457], 'abbreviations': [458, 494], 'used': [459, 495, 1849, 1954, 1971, 2036, 2597], 'are:': [460, 496], 'WAT,': [461, 497], 'tissue;': [464, 500], 'ACC,': [465, 501, 3035], 'acetyl-CoA': [466, 502, 585, 606, 612, 1505], 'carboxylase;': [467, 503], 'DIO,': [468, 504, 3375, 3462], 'diet-induced': [469, 505], 'obesity;': [470, 506], 'FAS,': [471, 507], 'synthase;': [474, 510], 'Slc25a10,': [475, 511, 1015, 3354], '10;': [481, 517], 'SREBP,': [482, 518], 'sterol': [483, 519, 1271], 'regulatory': [484, 520, 1272], 'element-binding': [485, 521, 1273], 'protein;': [486, 522], 'siRNA,': [487, 523, 3575], 'RNA;': [490, 526], 'RT,': [491, 527], 'reverse': [492, 528, 2790], 'transcription.2The': [493], 'transcription.': [529], 'liver.': [532], 'A': [533, 1489, 2893], 'series': [534], 'reactions': [539, 660], 'begins': [540], 'with': [541, 790, 875, 919, 1308, 1515, 1773, 1804, 1894, 1999, 2021, 2056, 2074, 2086, 2140, 2158, 2165, 2181, 2193, 2215, 2274, 2446, 2509, 2527, 2564, 2625, 2806, 2819, 2882, 2905, 2923, 2942, 3022, 3040, 3053, 3167, 3268, 3337, 3372, 3381, 3820, 3950, 3978, 4108, 4153, 4242, 4257, 4268, 4289, 4300, 4312], 'export': [543], 'cytosol': [549, 815, 3885, 3905, 4062], '(1Kaplan': [558], 'R.S.': [559, 1475, 1528], 'Mayor': [560], 'J.A.': [561, 1212], 'Johnston': [562], 'N.': [563, 694, 720, 1117], 'Oliveira': [564], 'D.L.': [565], 'J.': [566, 710, 721, 903, 948, 1002, 1039, 1064, 1126, 1242, 1347, 1450, 1477, 1530, 1727, 2330, 2355, 2672, 2751, 3188, 3194, 3280], 'Biol.': [567, 1040, 1127, 1243, 1348, 1728, 2331, 2673, 2752], 'Chem.': [568, 1041, 1128, 1244, 1349, 1729, 2332, 2674, 2753], '1990;': [569], '265:': [570], '13379-13385Abstract': [571], 'Full': [572, 727, 729, 1045, 1047, 1132, 1134, 1248, 1250, 1353, 1355, 1733, 1735, 2336, 2338, 2678, 2680, 2757, 2759], 'Text': [573, 728, 730, 1046, 1048, 1133, 1135, 1249, 1251, 1354, 1356, 1734, 1736, 2337, 2339, 2679, 2681, 2758, 2760], 'PDF': [574, 731, 1049, 1136, 1252, 1357, 1737, 2340, 2682, 2761], 'PubMed': [575, 602, 632, 686, 732, 765, 907, 952, 970, 1006, 1050, 1069, 1137, 1196, 1221, 1253, 1300, 1358, 1461, 1484, 1537, 1738, 2125, 2341, 2360, 2381, 2683, 2762, 2862, 3217], 'Google': [576, 603, 635, 687, 733, 768, 910, 955, 973, 1009, 1053, 1072, 1140, 1199, 1224, 1256, 1303, 1361, 1464, 1487, 1540, 1741, 2128, 2344, 2363, 2384, 2686, 2765, 2865, 3220], 'Scholar)': [577], 'followed': [578, 2529, 3050], 'conversion': [581], 'ATP': [587], 'lyase': [589, 4209], '(2Wakil': [590, 674], 'S.J.': [591, 675, 1436], 'Stoops': [592, 676], 'J.K.': [593, 677], 'Joshi': [594, 678], 'V.C.': [595, 679], 'Annu.': [596, 680], 'Rev.': [597, 681], 'Biochem.': [598, 626, 682, 902, 947, 965, 1001, 1065, 2356], '1983;': [599, 683], '52:': [600, 684], '537-579Crossref': [601, 685], 'Scholar).': [604, 636, 769, 911, 974, 1010, 1073, 1257, 1304, 1362, 1488, 1541, 1742, 2129, 2385, 2503, 2687, 2766, 3221, 3285], 'The': [605, 770, 867, 1939, 2009, 2271, 2290, 2304, 2434, 2449, 2520, 2558, 2574, 2620, 2637, 2814, 3122, 3253, 3300, 3318, 3326, 3742, 3756, 3811, 4197, 4261], 'converted': [608, 2697], 'carboxylases': [613], '(ACC1': [614], 'ACC2),': [616], 'rate-limiting': [618], 'enzymes': [619], '(3Munday': [624], 'M.R.': [625, 2730], 'Soc.': [627], 'Trans.': [628], '2002;': [629, 724, 762], '30:': [630], '1059-1064Crossref': [631], 'Scopus': [633, 766, 908, 953, 971, 1007, 1051, 1070, 1138, 1197, 1222, 1254, 1301, 1359, 1462, 1485, 1538, 1739, 2126, 2342, 2361, 2382, 2684, 2763, 2863, 3218], '(206)': [634], 'Cytosol': [637, 3776], 'functions': [640, 4049], 'activator': [643], 'ACCs,': [645], 'accelerating': [646], 'rate': [648, 3587], 'synthesis.': [652, 823, 1610, 1630], 'Subsequently,': [653], 'acids': [655], 'are': [656, 781, 1958, 3404, 3729], 'synthesized': [657, 2016], 'sequential': [659], 'catalyzed': [661], 'synthetase': [665, 1506], '(FAS)': [666], 'other': [668, 3711, 4201, 4269], 'elongases': [671], 'desaturases': [673], 'Scholar,': [688, 734, 956, 1054, 1200, 1225, 1465, 2345, 2364], '4Matsuzaka': [689], 'T.': [690, 696, 2370, 3196, 3210], 'Shimano': [691], 'H.': [692, 702, 716, 742, 1231, 1239, 1241, 1336, 1344, 1346, 1716, 1724, 1726, 2671, 3182, 3184], 'Yahagi': [693], 'Yoshikawa': [695], 'Amemiya-Kudo': [697], 'M.': [698, 738, 1115, 1123, 2665, 3190, 3192, 3198, 3208], 'Hasty': [699], 'A.H.': [700, 1097], 'Okazaki': [701], 'Tamura': [703], 'Y.': [704, 706, 748, 895, 940, 960, 964, 994, 1095, 2669, 3278], 'Iizuka': [705], 'Ohashi': [707], 'K.': [708, 889, 934, 962, 988, 1227, 1332, 1467, 1520, 1712], 'Osuga': [709], 'Takahashi': [711], 'A.': [712, 761, 958, 1103, 1189, 1204, 1235, 1237, 1293, 1340, 1342, 1720, 1722, 2121, 2858, 3180, 3212], 'Yato': [713], 'S.': [714, 718, 760, 1229, 1233, 1334, 1338, 1438, 1714, 1718, 2120, 2667, 2849, 2857, 3178], 'Sone': [715], 'Ishibashi': [717], 'Yamada': [719], 'Lipid.': [722], 'Res.': [723, 1217], '43:': [725], '911-920Abstract': [726], '5Ntambi': [735], 'J.M.': [736, 752], 'Miyazaki': [737], 'Stoehr': [739], 'J.P.': [740], 'Lan': [741], 'Kendziorski': [743], 'C.M.': [744], 'Yandell': [745], 'B.S.': [746], 'Song': [747], 'Cohen': [749], 'P.': [750, 1099, 1187, 1291], 'Friedman': [751], 'Attie': [753], 'A.D.': [754], 'Proc.': [755, 2115, 2852], 'Natl.': [756, 2116, 2853], 'Acad.': [757, 2117, 2854], 'Sci.': [758, 2118, 2855], 'U.': [759, 2119, 2856], '99:': [763], '11482-11496Crossref': [764], '(871)': [767], 'products': [771], 'synthesis,': [775, 1642, 3508], 'palmitate': [778, 2695], 'stearate,': [780], 'stored': [782], 'form': [785, 2633], 'triglyceride.': [787], 'contrast': [789], 'mechanism': [792, 806, 826, 3102], 'precursor': [799], 'citrate,': [800, 844, 2588, 3911], 'little': [801], 'known': [803, 3146, 3162], 'about': [804], 'regulate': [808], 'initial': [818, 3363], 'step': [819], 'However,': [824], 'involving': [827, 1770], 'supply': [829], 'cytosolic': [831, 840, 3917], 'transporter,': [836], 'which': [837, 1089, 2014, 3264, 3304, 3332, 3728, 4043, 4178], 'antiports': [838], 'remains': [845], 'be': [847], 'elucidated.Mitochondrial': [848], '(Slc2510)': [855], 'dicarboxylate,': [858], 'malate,': [861, 3331], 'composed': [870], 'six': [872, 3289], 'transmembrane': [873], 'regions': [874], 'three': [876, 1566, 1588], 'structurally': [877], 'cognate': [878], 'repeats': [879], 'localized': [882], 'membrane': [887, 3037, 3654, 3832], '(6Das': [888, 933, 987], 'Lewis': [890, 935, 989], 'R.Y.': [891, 936, 990], 'Combatsiaris': [892, 937, 991], 'T.P.': [893, 938, 992, 1105], 'Lin': [894, 939, 993], 'Shapiro': [896, 941, 995], 'L.': [897, 942, 996, 1028, 2319], 'Charron': [898, 943, 997], 'M.J.': [899, 944, 998, 1036, 1210, 2327], 'Scherer': [900, 945, 999, 1124], 'P.E.': [901, 946, 1000, 1125], '1999;': [904, 949, 1003], '344:': [905, 950, 1004], '313-320Crossref': [906, 951, 1005], '(25)': [909, 954, 1008], 'Mouse': [912, 3097], 'expressed': [915, 3075], 'tissues,': [918], 'predominant': [920], 'WAT': [923, 1320, 1564, 1797, 1878, 3092, 3115, 3373], 'secondary': [925, 3056], 'relatively': [927], 'low': [928, 4290], '7Unami': [957], 'Shinohara': [959, 2668], 'Kajimoto': [961], 'Baba': [963], 'Pharmacol.': [966], '2004;': [967, 1193, 1297, 3282], '67:': [968], '555-564Crossref': [969], '(36)': [972], 'Carrier': [975], 'induced': [979, 3306], 'when': [980, 3818, 3948, 4238, 4255, 4282, 4310], 'cells': [981, 1079, 1881, 1987, 2071, 2094, 2103, 2137, 2178, 2481, 2514, 2775, 2875, 2879, 2917, 2939, 2965, 3519, 3600, 3808, 3822, 3888, 3975, 4086, 4096, 4106, 4122, 4137, 4151, 4191, 4239, 4288], 'differentiate': [982], 'into': [983, 2107, 2841, 2876], 'adipocytes': [984, 2108], 'vitro': [986, 2019], 'Malate,': [1011, 2466], 'substrate': [1013, 3327], 'abundant': [1017], 'antiported': [1022], '(8Fiermonte': [1025, 2316], 'G.': [1026, 1479, 1532, 2317, 2368], 'Palmieri': [1027, 1033, 2318, 2324, 2373], 'Dolce': [1029, 2320], 'V.': [1030, 2321], 'Lasorsa': [1031, 2322], 'F.M.': [1032, 2323], 'F.': [1034, 2325, 2374], 'Runswick': [1035, 2326], 'Walker': [1037, 2328], 'J.E.': [1038, 2329], '1998;': [1042, 2333], '273:': [1043, 2334], '24754-24759Abstract': [1044, 2335], '(113)': [1052, 2343], '9Robinson': [1055], 'B.H.': [1056, 2347], 'Williams': [1057, 2348], 'G.R.': [1058, 2349], 'Halperin': [1059, 2350], 'M.L.': [1060, 2351], 'Leznoff': [1061, 2352], 'C.C.': [1062, 2353], 'Eur.': [1063, 2354], '1970;': [1066], '15:': [1067], '263-272Crossref': [1068], '(52)': [1071], 'Overexpression': [1074], 'cultured': [1078, 1880, 1889], 'hyperpolarization': [1082], 'via': [1085], 'unknown': [1087], 'mechanism,': [1088], 'produces': [1090, 4039], 'reactive': [1091], 'oxygen': [1092], 'species': [1093], '(10Lin': [1094], 'Berg': [1096], 'Iyengar': [1098], 'Lam': [1100], 'T.K.': [1101], 'Giacca': [1102], 'Combs': [1104], 'Rajala': [1106], 'M.W.': [1107], 'Du': [1108], 'X.': [1109, 1173, 1277], 'Rollman': [1110], 'B.': [1111, 1446], 'Li': [1112], 'W.': [1113], 'Hawkins': [1114], 'Barzilai': [1116], 'Rhodes': [1118], 'C.J.': [1119, 2748], 'Fantus': [1120], 'I.G.': [1121], 'Brownlee': [1122], '2005;': [1129], '280:': [1130], '4617-4626Abstract': [1131], '(410)': [1139], 'Scholar);': [1141], 'however,': [1142], 'potential': [1144], 'involvement': [1145], 'examined.DNA': [1155], 'microarray': [1156, 1310, 1364, 1561, 1824, 1838, 3112], 'methods': [1157], 'utilized': [1160, 1822], 'identify': [1162, 1551], 'pathways': [1164, 1380], 'genes': [1166, 1382, 1546, 1859, 3227, 3233, 3290, 3319, 3371, 4203], 'involved': [1167, 1395, 3360], 'metabolic': [1170, 1392], 'syndrome': [1171], '(11Deng': [1172, 1276], 'Elam': [1174, 1278], 'M.B.': [1175, 1279], 'Wilcox': [1176, 1280], 'H.G.': [1177, 1281], 'Cagen': [1178, 1282], 'L.M.': [1179, 1283, 2726], 'Park': [1180, 1284], 'E.A.': [1181, 1285], 'Raghow': [1182, 1286], 'R.': [1183, 1287, 2372], 'Patel': [1184, 1288], 'D.': [1185, 1289], 'Kumar': [1186, 1290], 'Sheybani': [1188, 1292], 'Russell': [1190, 1294], 'J.C.': [1191, 1295], 'Endocrinology.': [1192, 1296, 3213], '145:': [1194, 1298], '5847-5861Crossref': [1195, 1299], '(41)': [1198, 1302], '12Lopez': [1201], 'I.P.': [1202], 'Marti': [1203], 'Milagro': [1205], 'F.I.': [1206], 'Zulet': [1207], 'M.A.': [1208], 'Moreno-Aliaga': [1209], 'Martinez': [1211], 'Miguel': [1214], 'C.': [1215, 2366], 'Obes.': [1216], '2003;': [1218, 1245, 1350, 1481, 1534, 1730, 2122, 2754, 3214], '11:': [1219], '188-194Crossref': [1220], '(131)': [1223], '13Takahashi': [1226], 'Mizuarai': [1228, 1333, 1713], 'Araki': [1230, 1335, 1715], 'Mashiko': [1232, 1337, 1717], 'Ishihara': [1234, 1339, 1719, 3179], 'Kanatani': [1236, 1341, 1721, 3211], 'Itadani': [1238, 1343, 1723], 'Kotani': [1240, 1345, 1725], '278:': [1246, 1351, 1731, 2755], '46654-46660Abstract': [1247, 1352, 1732], '(263)': [1255, 1360, 1740], 'For': [1258, 1835, 1888, 2044, 2097, 2585, 2648, 2688, 2932, 3031], 'example,': [1259], 'analysis': [1260, 1562, 1825, 1836, 3113, 3224, 3671], 'livers': [1263], 'hyperinsulinemic': [1265], 'rats': [1266], 'revealed': [1267], 'overexpression': [1269], 'protein-1C': [1274], '(SREBP-1C)': [1275], 'showed': [1307, 1499], 'study': [1311, 3746], 'monocyte': [1313], 'chemoattractant': [1314, 3413], 'protein-1': [1315], '(MCP-1)': [1316], 'overexpressed': [1318, 4285], 'mice,': [1323, 3466], 'indicating': [1324, 3609, 3878, 4127], 'relation': [1326], 'between': [1327, 3869], 'obesity': [1328], 'athero-sclerosis': [1330], '(13Takahashi': [1331, 1711], 'Further': [1363], 'studies': [1365], 'combining': [1369], 'several': [1370, 1432, 3335], 'lean': [1373, 1596], 'animal': [1374, 1433], 'may': [1376, 1550], 'reveal': [1377], 'more': [1378, 3236, 3246, 3382], 'development': [1385], 'increased': [1387, 1516, 3174, 3439, 4091, 4119, 4180, 4296], 'fat': [1388, 1425, 1508, 1517, 3175], 'mass': [1389, 1426], 'resultant': [1391], 'syndrome.The': [1393], 'proteins': [1394, 1423, 3714], 'de': [1400, 3504], 'attracted': [1408], 'attention': [1409], 'novel': [1411], 'anti-obesity': [1412, 1553], 'targets': [1413], 'because': [1414], 'function': [1420, 3492], 'these': [1422], 'reduces': [1424, 3617, 3968], 'improves': [1428], 'parameters': [1430], '(14Smith': [1435], 'Cases': [1437], 'Jensen': [1439], 'D.R.': [1440], 'Chen': [1441], 'H.C.': [1442], 'Sande': [1443], 'E.': [1444, 2663], 'Tow': [1445], 'Sanan': [1447], 'D.A.': [1448, 2728], 'Raber': [1449], 'Eckel': [1451], 'R.H.': [1452], 'Farese': [1453], 'Jr.,': [1454, 2719], 'R.V.': [1455], 'Nat.': [1456], 'Genet.': [1457], '2000;': [1458], '25:': [1459], '87-90Crossref': [1460], '(725)': [1463], '15Ashrafi': [1466], 'Chang': [1468, 1521], 'F.Y.': [1469, 1522], 'Watts': [1470, 1523], 'J.L.': [1471, 1524], 'Fraser': [1472, 1525], 'A.G.': [1473, 1526], 'Kamath': [1474, 1527], 'Ahringer': [1476, 1529], 'Ruvkun': [1478, 1531], 'Nature.': [1480, 1533], '421:': [1482, 1535], '268-272Crossref': [1483, 1536], '(823)': [1486, 1539], 'genome-wide': [1490], 'screening': [1491], 'interference': [1494], 'Caenorhabditis': [1497], 'elegans': [1498], 'inhibiting': [1501], 'levels': [1509, 3792, 3805, 3984, 4199], 'wild': [1511], 'type': [1512], 'mutants': [1514], 'content': [1518], '(15Ashrafi': [1519], 'Therefore,': [1542], 'identification': [1543], 'new': [1545, 1552, 3433], 'this': [1548, 3159, 3287], 'targets.In': [1554], 'performed': [1559, 1902, 3082, 3111, 3752], 'focus': [1576], 'changes': [1578, 1814, 3168], 'pathway.': [1582], 'was': [1584, 1758, 1794, 1821, 1843, 1875, 1897, 1901, 1912, 2012, 2015, 2054, 2084, 2163, 2191, 2416, 2454, 2458, 2477, 2525, 2562, 2578, 2623, 2641, 2708, 2786, 2817, 2823, 2833, 2903, 2957, 2979, 2997, 3038, 3140, 3313, 3531, 3588, 3592, 3639, 3655, 3703, 3736, 3750, 3764, 3814, 3837, 3850, 3874, 3881, 3933, 3944, 3958, 4002, 4103, 4132, 4144, 4216, 4235, 4252, 4266, 4284, 4308], 'up-regulated': [1585, 3234], 'all': [1587, 3389], 'model.': [1598, 3143], 'then': [1600, 2437], 'crucial': [1617], 'resulting': [1643], 'vitro.EXPERIMENTAL': [1649], 'PROCEDURESObese': [1650], 'Lean': [1652, 3096], 'Model': [1653], 'Mice—C57BL/6N': [1654], 'mice': [1655, 1702, 1749, 1847, 3130, 3379, 3393, 3403], '(6': [1656], 'weeks': [1657], 'old,': [1658], 'CLEA': [1659, 1687], 'Japan,': [1660], 'Tokyo,': [1661], 'Japan)': [1662, 1688], 'were': [1663, 1669, 1689, 1750, 1780, 1848, 1866, 1923, 1944, 1970, 1988, 2072, 2095, 2104, 2138, 2179, 2205, 2213, 2260, 2278, 2292, 2309, 2388, 2436, 2515, 2545, 2549, 2591, 2602, 2658, 2776, 2804, 2880, 2928, 2940, 2966, 3011, 3060, 3074, 3081, 3255, 3291, 3459, 3577, 3809, 3862, 3976, 3994, 4179, 4204, 4240], 'housed': [1664], 'individual': [1666], 'cages.': [1667], 'Mice': [1668], 'maintained': [1670], 'under': [1671], 'conditions': [1672], 'controlled': [1674], 'temperature': [1675, 3018], '(23': [1676], '±': [1677, 3078], '2': [1678, 2186, 2244, 2407, 2888, 2919], '°C)': [1679], 'light': [1681], '(07:00–19:00).': [1682], 'Water': [1683], 'food': [1685, 1756, 3165], '(CA-1,': [1686], 'available': [1690], 'ad': [1691], 'libitum': [1692], 'unless': [1693], 'noted': [1694], 'otherwise.': [1695], 'Models': [1696], 'DIO': [1698, 3127], 'd-Trp34NPY-treated': [1700, 3129], '(free-fed': [1703, 3131], 'pair-fed': [1705, 3133], 'models)': [1706], 'described': [1709, 1883, 2716], 'previously': [1710, 2715], 'model,': [1746], '17-week-old': [1747], 'male': [1748], '21': [1753], 'h,': [1754, 2080, 2187], 'intake': [1757], 'restricted': [1759], '3-h': [1762], 'period': [1763], 'daily': [1764], '7': [1766], 'days.': [1767], 'All': [1768], 'procedures': [1769], 'animals': [1771], 'complied': [1772], 'National': [1774], 'Institutes': [1775], 'Health': [1777], 'guidelines': [1778], 'approved': [1781], 'Banyu': [1784], 'Animal': [1785], 'Care': [1786], 'Usage': [1788], 'Committee.Microarray': [1789], 'Study': [1790], 'WAT—Total': [1792], 'extracted': [1795, 1876, 2478, 2818, 3232, 3292], 'TRIzol': [1799, 1895], 'reagents': [1800, 1967, 3065], '(Invitrogen)': [1801, 2006, 2058], 'repurified': [1803], 'RNeasy': [1806], 'purification': [1807, 1893], 'kit': [1808, 2024], '(Qiagen,': [1809], 'Hilden,': [1810], 'Germany).': [1811], 'To': [1812, 2767, 4056], 'determine': [1813, 3841], 'expression,': [1816, 3263, 4293], 'μg': [1818, 2994], '(MG-U74U74A': [1826], 'chip,': [1827], 'Affymetrix,': [1828], 'Santa': [1829], 'Clara,': [1830], 'CA)': [1831, 2152], '∼12,000': [1833, 3226], 'genes.': [1834], 'data,': [1839], 'GeneChip': [1840], 'software': [1841], '(Affymetrix)': [1842], 'utilized.': [1844], 'Appropriate': [1845], 'control': [1846, 3661, 3821, 3870, 3952, 3981, 3997, 4094, 4121, 4149, 4187, 4258, 4302, 4313], 'provide': [1851], 'baseline': [1852], 'values': [1853, 1861], 'experimental': [1856], 'groups,': [1857], 'displaying': [1860], 'p': [1863, 3688, 4019, 4023], '<': [1864, 3689, 4020, 4024], '0.05': [1865], 'identified': [1867], 'Mann-Whitney': [1870], 'test.Quantitative': [1871], 'Real-time': [1872], 'RT-PCR—Total': [1873], 'previous': [1886], 'paragraph.': [1887], 'cells,': [1890, 1985, 2102, 2475, 2693, 2771, 3803, 3937, 4303], 'first': [1892, 2105], 'reagent': [1896], 'omitted.': [1898], 'Reverse': [1899], 'transcription': [1900, 2020], '500': [1904], 'ng': [1905], 'total': [1907], 'RNA,': [1908], 'cDNA': [1910], 'obtained': [1911, 2451], 'applied': [1913, 2787], 'TaqMan': [1915, 1965, 1973], 'PCR': [1916], 'quantification': [1918, 2470, 2586, 2649, 2689, 2933], 'mRNA': [1920, 1941, 3545, 3637, 3669, 3708], 'expression.': [1921], 'Data': [1922, 1962, 3069, 3771], 'collected': [1924, 2967], 'analyzed': [1926], 'ABI': [1929], 'PRISM': [1930], '7700': [1931], 'sequence': [1932, 2011, 2160], 'detector': [1933], 'system': [1934], '(Applied': [1935, 1968], 'Biosystems,': [1936], 'Warrington,': [1937], 'UK).': [1938], 'relative': [1940], 'data': [1943, 3073], 'normalized': [1945], 'β-actin': [1947], 'transferrin': [1949], 'receptor.': [1950, 3156], 'Probes': [1951], 'primers': [1953, 1976], 'quantitative': [1956, 3642], 'RT-PCR': [1957, 3449, 3644], 'listed': [1959], 'Supplemental': [1961], '1.': [1963], 'Pre-Developed': [1964], 'assay': [1966, 2488], 'Biosystems)': [1969], 'probe': [1974], 'human': [1978, 2002, 3513], 'β-actin.siRNA': [1979], 'Transfection—For': [1980], 'siRNA': [1981, 2000, 2010, 2023, 2026, 2040, 2050, 2098, 2141, 2155, 3511, 3528, 3537, 3630, 3700, 3797, 4109, 4154, 4243, 4270], 'transfection': [1982, 1998, 2045, 2082, 2099, 2189], 'seeded': [1989], 'at': [1990, 2237, 2280, 2287, 2411, 2423, 2582, 2611, 2645, 2961, 2983, 2990, 3016], 'confluency': [1992], '10%': [1994, 2779, 2891], 'one': [1995], 'day': [1996], 'before': [1997, 2660], 'Oligofectamine': [2005, 2057], 'follows.': [2008, 2154], '5′-AGCCUCUCCACUCACCAGCTT-3′,': [2013], '(Silencedr': [2025], 'construction': [2027], 'kit,': [2028], 'Ambion,': [2029], 'Austin,': [2030], 'TX).': [2031], 'As': [2032], 'control,': [2034], 'scramble': [2037], 'II': [2038], 'duplex': [2039], '(Dharmacon,': [2041], 'Lafayette,': [2042], 'CO).': [2043], '6-well': [2048], 'plate,': [2049], 'solution': [2051, 2083, 2190, 2553, 2559, 2622, 2895], '(50': [2052, 2608], 'nm)': [2053, 2157], 'complexed': [2055], '100': [2060, 2168, 2227, 2397], 'μl': [2061, 2169], 'Opti-MEM': [2063], '(Invitrogen).': [2064], 'After': [2065, 2078, 2172, 2185, 2251, 2537, 2782, 2921, 2976, 3569, 3796, 3857], 'incubating': [2066, 2173, 2218], '20': [2068, 2175, 2230, 2400, 3025], 'min,': [2069, 2176, 2253], 'treated': [2073, 2180, 2941, 3977, 4107, 4152, 4241], 'lipid/siRNA': [2076, 2183], 'solution.': [2077, 2184], '6': [2079, 2132], 'replaced': [2085, 2192], 'growth': [2087], 'medium.': [2088], 'Two': [2089, 2130], 'days': [2090, 2133, 2198, 2870, 4114, 4159], 'after': [2091, 2134, 2199, 2452, 2505, 2871, 4097, 4112, 4157], 'transfection,': [2092], 'assayed.': [2096], 'differentiated': [2106, 3604, 4135], '(16Tang': [2109], 'Q.Q.': [2110], 'Otto': [2111], 'T.C.': [2112], 'Lane': [2113], 'M.D.': [2114], '100:': [2123], '850-855Crossref': [2124], '(398)': [2127], 'differentiation,': [2135, 2203, 4098], 'transfected': [2139], 'GeneSilencer': [2146, 2166], '(Gene': [2147], 'Therapy': [2148], 'Systems,': [2149], 'San': [2150], 'Diego,': [2151], '(20': [2156], '5′-CGUCAGGAUGCAGAACGACTT-3′': [2162], 'mixed': [2164], 'Opti-MEM.': [2171], 'medium': [2194], 'differentiation.': [2196, 4116], 'Ten': [2197], 'onset': [2201], 'they': [2204], 'assayed.Mitochondrial': [2206], 'Transport': [2207, 3485], 'Study—Freshly': [2208], 'isolated': [2209, 3564, 3578, 3622, 3659, 3748], 'loaded': [2214], 'ml': [2221, 2299, 2392, 2970], 'buffer': [2225, 2277, 2395, 2607, 2974], 'containing': [2226, 2396, 2560, 2773, 2802], 'mm': [2228, 2231, 2235, 2249, 2255, 2398, 2401, 2404, 2432, 2609, 2615, 2618], 'KCl,': [2229, 2399], 'Hepes,': [2232, 2402], '1': [2234, 2391, 2403, 3014], 'EGTA': [2236], 'pH': [2238, 2412, 2556, 2612], '7.0,': [2239], 'presence': [2242, 2702], 'mg/ml': [2245], 'rotenone': [2246, 2410], '0.75': [2248], 'malate.': [2250, 2599], '5': [2252, 2254, 2285, 2617], 'phenylsuccinate': [2256], '1,2,3-benzene': [2258], 'tricarboxylate': [2259], 'added': [2261, 2844, 2913], 'inhibit': [2263], 'oxoglutarate': [2265, 3675], 'carrier,': [2269, 3674, 3676, 3678, 3716, 3719, 3721], 'respectively.': [2270, 3467], 'malate-loaded': [2272], 'centrifuged': [2279], '20,000': [2281], '×': [2282, 2985], 'g': [2283, 2986], 'min': [2286, 2948, 2989], '4': [2288, 2991], '°C.': [2289], 'washed': [2293, 2442, 2881], 'once': [2294], 'resuspended': [2296], '2.0': [2298], 'buffer.': [2303], 'kinetics': [2305], '[14C]malate/malate': [2307], 'determined': [2310, 3256], 'inhibitor': [2313], 'stop': [2314], 'method': [2315, 2717], '17Robinson': [2346], '1971;': [2357], '20:': [2358], '65-71Crossref': [2359], '(72)': [2362], '18Indiveri': [2365], 'Prezioso': [2367], 'Dierks': [2369], 'Kramer': [2371], 'Biochim.': [2375], 'Biophys.': [2376], 'Acta.': [2377], '1993;': [2378], '1143:': [2379], '310-318Crossref': [2380], '(32)': [2383], 'Malate-loaded': [2386], 'incubated': [2389, 3039], 'reaction': [2394], 'EGTA,': [2405], 'mg': [2408], '7.0.': [2413], 'Exchange': [2414], 'adding': [2419], '[14C]malate': [2420], 'terminated,': [2422], 'times,': [2426], 'addition': [2429, 2532], '12.5': [2431], 'n-butylmalonate.': [2433], 'immediately': [2438], 'reisolated': [2439], 'centrifugation,': [2441, 2542, 2783], 'once,': [2443], 'acidified': [2445], '20%': [2447], 'HClO4.': [2448], 'supernatant': [2450, 2785], 'centrifugation': [2453, 2982], 'diluted,': [2455], 'radioactivity': [2457, 2822], 'measured': [2459, 2483, 2579, 2642, 2709, 2824, 2834, 2958, 3556, 3640, 3656, 3839, 3995, 4004, 4067, 4166], 'liquid': [2462, 2827], 'scintillation': [2463, 2828, 2846], 'counter.Quantification': [2464], 'Citrate,': [2467], 'Malonyl-CoA—For': [2469], 'whole': [2474, 3794, 3846, 3936, 3986, 4006], '109': [2480], 'standard': [2486], 'enzymatic': [2487], '(19Lowry': [2489], 'O.H.': [2490], 'Passonneau': [2491], 'J.V.': [2492], 'Flexible': [2493], 'System': [2494], 'Enzymatic': [2496], 'Analysis.': [2497], 'Academic': [2498], 'Press,': [2499], 'New': [2500], 'York1972:': [2501], '149-218Google': [2502], 'Briefly,': [2504], 'collection': [2506], 'washing': [2508, 2922], "Hanks'": [2510], 'balanced': [2511], 'salt': [2512], 'solution,': [2513], 'dissolved': [2516, 2550, 2603, 2777], '70%': [2518], 'EtOH.': [2519], 'lysate': [2522], 'EtOH': [2524], 'homogenized': [2526], 'sonication': [2528], 'formic': [2534], '(4%).': [2536], 'removing': [2538], 'debris': [2540, 2978], 'supernatants': [2544], 'evaporated.': [2546], 'Dried': [2547, 2600], 'samples': [2548, 2590, 2601, 3943], 'hydrazine': [2552], '(200': [2554], 'mm,': [2555], '9.3).': [2557], 'reacted': [2563, 2624, 2805], 'dehydrogenase': [2566], 'NAD': [2568], 'produce': [2570, 2812], 'oxaloacetate': [2571], 'NADH.': [2573], 'production': [2575], 'NADH': [2577, 2631], 'spectrometry': [2581, 2644, 2960], '340': [2583, 2646], 'nm.': [2584, 2647], 'dried': [2589], 'prepared': [2592], 'same': [2595], 'procedure': [2596], 'detection': [2606, 3033], 'Tris-HCl': [2610], '7.4,': [2613], 'MgSO4,': [2616], 'EDTA).': [2619], 'lyase,': [2627], 'dehydrogenase,': [2629], 'NAD+.': [2636], 'formation': [2638], 'NAD+': [2640], 'mitochondria,': [2655, 3834, 3859], 'fractionated': [2659], 'measurement': [2661], '(20Majima': [2662], 'Ishida': [2664], 'Miki': [2666], 'Terada': [2670], '2001;': [2675], '276:': [2676], '9792-9799Abstract': [2677], '(16)': [2685], 'radiolabeled': [2694, 2815], 'stoichiometrically': [2696], '[14C]acetyl-CoA,': [2704], 'purified': [2706, 2809], 'FAS': [2707, 2810], 'modification': [2712], '(21Harwood': [2718], 'H.J.': [2720], 'Petras': [2721], 'S.F.': [2722], 'Shelly': [2723], 'L.D.': [2724], 'Zaccaro': [2725], 'Perry': [2727], 'Makowski': [2729], 'Hargrove': [2731], 'D.M.': [2732], 'Martin': [2733, 2745], 'K.A.': [2734], 'Tracey': [2735], 'W.R.': [2736], 'Chapman': [2737], 'J.G.': [2738], 'Magee': [2739], 'W.P.': [2740], 'Dalvie': [2741], 'D.K.': [2742], 'Soliman': [2743], 'V.F.': [2744], 'W.H.': [2746], 'Mularski': [2747], 'Eisenbeis': [2749], 'S.A.': [2750], '37099-37111Abstract': [2756], '(216)': [2764], 'extract': [2768, 2950], 'pellets': [2772], '108': [2774], 'trichloroacetic': [2780], 'acid.': [2781], 'phase': [2791], 'chromatography': [2792], 'column': [2793], '(Sep-Pak': [2794], 'Vac': [2795], 'C18': [2796], 'cartridge,': [2797], 'Waters,': [2798], 'Milford': [2799], 'MA).': [2800], 'Extracts': [2801], '[14C]acetyl-CoA': [2807], 'palmitoyl-CoA.': [2813], 'palmitoyl-CoA': [2816], 'hexane,': [2820], 'counter.Lipid': [2829], 'Biosynthesis': [2830], 'Assay—Lipid': [2831], 'biosynthesis': [2832], '6-h': [2837], 'incorporation': [2838], '[14C]acetate': [2840], 'extractable': [2842], 'lipids': [2843], 'fluids': [2847], '(22Keay': [2848], 'Grossberg': [2850], 'S.E.': [2851], '1980;': [2859], '77:': [2860], '4099-40103Crossref': [2861], '(96)': [2864], 'Scholar).Oil': [2866], 'Red': [2867, 2898, 2936, 2952], 'O': [2868, 2899], 'Staining—Ten': [2869], 'differentiation': [2872, 4125, 4161, 4176], 'adipocytes,': [2877], 'phosphate-buffered': [2883], 'saline': [2884, 3021], 'fixed': [2886, 2916], 'h': [2889, 3015], 'formaldehyde.': [2892], '0.35%': [2894], 'Oil': [2897, 2935, 2951], 'isopropyl': [2901, 2944], 'alcohol': [2902, 2945], 'diluted': [2904], 'equal': [2907], 'volume': [2908, 3270], 'water,': [2910], 'filtered,': [2911], 'h.': [2920], 'PBS,': [2924], 'stained': [2925, 2938], 'droplets': [2927], 'visualized': [2929, 3061], 'photographed.': [2931], 'O,': [2937, 2953], '100%': [2943], 'colorimetric': [2955], 'intensity': [2956], '510': [2962], 'nm.Western': [2963], 'Blot—3T3-L1': [2964], '0.5': [2969], 'cold': [2972], 'M-PER': [2973], '(Pierce).': [2975], 'removed': [2980], '14,000': [2984], '15': [2988], '°C,': [2992], '30': [2993], 'protein': [2996], 'separated': [2998], '8%': [3000], 'SDS-PAGE': [3001], 'electroblotted': [3003], 'onto': [3004], 'polyvinylidene': [3005], 'difluoride': [3006], 'membranes': [3007], '(Amersham': [3008, 3066], 'Biosciences).': [3009], 'Membranes': [3010], 'blocked': [3012], 'room': [3017], 'Tris-buffered': [3020], '0.1%': [3023], 'Tween': [3024], '5%': [3027], 'nonfat': [3028], 'dry': [3029], 'milk.': [3030], 'anti-ACC': [3041], 'anti-Ser79-phosphorylated': [3043], 'ACC': [3044], 'antibody': [3045], '(Cell': [3046], 'Signaling,': [3047], 'Beverly,': [3048], 'MA)': [3049], 'incubation': [3052], 'horseradish': [3054], 'peroxidase-conjugated': [3055], 'antibodies.': [3057], 'Immunoreactive': [3058], 'bands': [3059], 'ECL': [3063], 'Plus': [3064], 'Biosciences).Evaluation': [3067], 'Statistical': [3071], 'Analysis—All': [3072], 'mean': [3077], 'S.D.': [3079], 'Statistics': [3080], 'two-tailed': [3085], 'unpaired': [3086], "Student's": [3087], 't': [3088], 'test.RESULTSMicroarray': [3089], 'Analysis': [3090], 'Obese': [3094], 'Models—To': [3098], 'understand': [3099], 'molecular': [3101], 'underlying': [3103], 'accelerated': [3105], 'obesity,': [3109], 'models.': [3121], 'included': [3126, 3320], 'models),': [3134], 'caloric-restricted': [3142], 'd-Trp34NPY': [3144], 'represent': [3148], 'appetite': [3149], 'stimulant': [3150], 'acting': [3151], 'NPY': [3154], 'Y5': [3155], 'Administration': [3157], 'neuropeptide': [3160], 'intake,': [3166], 'body': [3170], 'weight': [3171, 3176], 'accompanied': [3172], '(23Mashiko': [3177], 'Iwaasa': [3181], 'Sano': [3183], 'Oda': [3185], 'Z.': [3186], 'Ito': [3187], 'Yumoto': [3189], 'Okawa': [3191], 'Suzuki': [3193], 'Fukuroda': [3195], 'Jitsuoka': [3197], 'Morin': [3199], 'N.R.': [3200], 'MacNeil': [3201], 'D.J.': [3202], 'Van': [3203], 'der': [3204], 'Ploeg': [3205], 'L.H': [3206], 'Ihara': [3207], 'Fukami': [3209], '144:': [3215], '1793-1801Crossref': [3216], '(55)': [3219], 'Through': [3222], 'oligonucleotide': [3229], 'microarray,': [3230], 'than': [3237, 3247, 3383, 3396], '1.8-fold': [3238], '3.0-fold': [3248], 'mice.': [3252, 3317], 'thresholds': [3254], 'based': [3257], 'change': [3260, 3387, 3400, 3957], 'leptin': [3262, 3297], 'positively': [3266], 'correlated': [3267], '(24Guo': [3271], 'K.Y': [3272], 'Halo': [3273], 'P': [3274], 'Leibel': [3275], 'R.L': [3276], 'Zhang': [3277], 'Am.': [3279], 'Physiol.': [3281], '28:': [3283], 'R112-R119Google': [3284], 'With': [3286], 'threshold,': [3288], 'including': [3293], 'reference': [3295], 'gene,': [3296], '(TABLE': [3298], 'ONE).': [3299], 'list': [3301], 'includes': [3302], 'MCP-1,': [3303], 'dicarboxylate': [3323], 'Slc25a10.': [3325, 3516], 'increases': [3333, 3458], 'enhanced': [3338], 'lipogenesis': [3339, 3496], 'antiporter': [3344], 'focused': [3352], 'hypothesizing': [3355], 'steps': [3364], 'synthesis.TABLE': [3368], 'ONECommon': [3369], 'signature': [3370], 'd-Trp34NPY-treated,': [3376], 'Genes': [3380], '1.8': [3384], '-fold': [3386, 3399], 'less': [3395], '-3.0': [3397], 'listed.': [3405], 'FF,': [3406], 'free-fed.': [3407], 'PF,': [3408], 'pair-fed.Probe': [3409], 'IDSymbolGene': [3410], 'name-Fold': [3411], 'changeDIOd-Trp34NPY-FFd-Trp34NPY-PFFasting102736_atMCP-1Monocyte': [3412], 'protein-17.26.34.9–3.092607_atMestMesoderm': [3414], 'specific': [3415], 'transcript3.74.22.1–3.099168_atPigsPhosphatidylinositol': [3416], 'glycan,': [3417], 'class': [3418], 'S2.94.41.8–3.798443_atLepLeptin2.33.01.8–3.699112_atSlc25a10Solute': [3419], '(dicarboxylate': [3423], 'transporter),': [3424], '102.03.01.9–5.0100342_i_atTubalTubulin,': [3426], 'α': [3427], '11.83.42.0–6.2': [3428], 'Open': [3429], 'table': [3430], 'tab': [3434], 'confirmed': [3437, 3470, 3704, 4267], 'real-time': [3448, 3643], '(Fig.': [3450, 3479, 3552, 3607, 3733, 3823, 3876, 3953, 3963, 4138, 4162, 4192, 4221, 4246, 4259], '1,': [3451], 'A–C).': [3452], 'Approximately': [3453], '2.0-,': [3454], '2.5-,': [3455], '2.0-fold': [3457], 'd-Trp34NPY-FF,': [3463], 'd-Try34NPY-PF': [3465], '40-fold': [3472], '1D).Suppression': [3480], 'Reduces': [3483, 3775], 'Malate': [3484, 3777, 3983], 'Activity': [3486], 'Isolated': [3488], 'Mitochondria—To': [3489], 'analyze': [3490], 'examine': [3498, 4057], 'designed': [3510], '(HepG2': [3520], 'derived': [3521, 3851, 4045], 'adipocyte': [3526], '3T3-L1),': [3527], 'transiently': [3532], 'transfected.': [3533], 'By': [3534], 'selecting': [3535], 'optimal': [3536], 'sequences,': [3538], '75': [3541], '90%': [3543], '3T3-L1,': [3550, 3582, 3605], 'respectively': [3551, 3606], '2A).': [3553], 'malate-transporting': [3558], 'activity': [3559, 3620, 3649], 'siRNA-treated': [3567, 3599, 3872, 3887, 3942, 3999, 4190], 'measured.': [3589, 3810, 3863, 3934], 'Malate-transporting': [3590], 'ability': [3591, 3759], '60': [3595], '45%': [3597], '2B),': [3608], 'functional': [3610], 'repression': [3611], 'Slc25a10.FIGURE': [3613], '2Suppression': [3614], 'mitochondria.': [3623], 'A,': [3624], 'Slc25a10-mRNA': [3627], 'Relative': [3636], 'analysis.': [3645], 'B,': [3646], 'Slc25a10-siRNA-treated': [3663], 'C,': [3668], 'malate/Asp': [3677, 3717], 'H+': [3680, 3723], 'RT-PCR.': [3683], 'SCR,': [3684, 4015], 'scrambled': [3685, 4016], 'control.': [3686, 3755, 4017], '**,': [3687, 4022], '0.01.View': [3690, 4025], 'Large': [3691, 4026], 'Image': [3692, 4027], 'Figure': [3693, 4028], 'ViewerDownload': [3694, 4029], 'Hi-res': [3695, 4030], 'image': [3696, 4031], 'Download': [3697, 4032], '(PPT)Specificity': [3698], 'quantifying': [3706], '(oxoglutarate': [3715], 'shuttle': [3718], 'carrier),': [3724], 'sequences': [3726, 4271], 'similar': [3730], '2C).': [3734], 'Expression': [3735, 4215], 'affected': [3738, 3766, 4218], 'Slc25a10-siRNA': [3740, 3979, 4220], 'treatment.': [3741], 'citrate/citrate': [3757], '(Supplemental': [3770], '2).Suppression': [3772], 'Citrate': [3779, 4001, 4048], 'Levels—': [3780], 'treatment': [3798], 'level': [3813, 3849], '38%': [3817], 'compared': [3819, 3949, 4256, 4311], '3A).': [3824], 'Since': [3825, 3901], 'whether': [3842], 'difference': [3844, 3865], 'isolating': [3858], 'concentrations': [3861], 'No': [3864], 'concentration': [3868, 3932, 3940, 3962], '3B),': [3877], 'speculated': [3913], 'caused': [3919], 'citrate/malate': [3925], 'carrier.': [3929], 'Thus,': [3930], '31%': [3947], '3C),': [3954], 'although': [3955], 'no': [3956], 'detected': [3959], '3D).FIGURE': [3964], '3Suppression': [3965], 'RNA.': [3982], 'fractions': [3988, 3992, 4008, 4013], '(A)': [3989], '(B)': [3993], 'simultaneously': [4003], '(C)': [4009], '(D).': [4014], '*,': [4018], '0.05;': [4021], '(PPT)Suppression': [4033], 'Decreases': [4036], 'Expression—ACC1': [4038], 'acetyl-CoA,': [4042], 'citrate.': [4047], 'allosteric': [4052], 'regulator': [4053], 'ACC1.': [4055], 'ACC1,': [4065], 'Slc25a10-suppressed': [4073], 'Fig.': [4075], '4A': [4076], 'shows': [4077], 'time': [4079], 'course': [4080], 'siRNA.': [4088], '30-fold': [4092], '∼90%': [4099], 'achieved': [4104], 'depending': [4123], 'time,': [4126], 'activated': [4133], '4B).': [4139, 4163], 'contrast,': [4141], 'induction': [4143], '50%': [4147], 'lipoprotein': [4170], 'lipase': [4171], 'markers,': [4177], '∼100-': [4181], '25-fold,': [4183], 'respectively,': [4184], 'both': [4185, 4274], '4,': [4193, 4222], 'C': [4194], 'D).': [4196], 'quantified': [4206], '(ATP': [4207], 'Fas)': [4211], 'E': [4223], 'F).': [4225], 'another': [4227], 'line,': [4230], 'HepG2,': [4231], '4G),': [4247], 'whereas': [4248, 4304], 'changed': [4254], '4H).': [4260], 'HepG2.': [4279], 'addition,': [4281], 'HEK293': [4287], 'endogenous': [4291], 'comparison': [4299], 'vector-transfected': [4301], 'unchanged': [4309], '(data': [4314], 'show': [4316]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2090053417', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-13T13:27:35.799806', 'created_date': '2016-06-24'}
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