Abstract: Many of the physiological effects of nitric oxide are mediated by activation of soluble guanylyl cyclase, resulting in cellular cGMP accumulation. In the 1990s, the benzylindazole derivative YC-1 was identified as a novel modulator of cGMP signalling that exerted complex actions in a NO-independent manner. A recent study describes a high-affinity YC-1 analogue that decreases blood pressure in hypertensive rats and increases bleeding time, which suggests that this drug might have therapeutic potential as a vasodilator with antiplatelet activity.
Publication Year: 2001
Publication Date: 2001-11-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 28
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