Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2089739824', 'doi': 'https://doi.org/10.1111/j.1365-2559.1990.tb00679.x', 'title': 'Abundant expression of cytokeratin 7 in fibrolamellar carcinoma of the liver', 'display_name': 'Abundant expression of cytokeratin 7 in fibrolamellar carcinoma of the liver', 'publication_year': 1990, 'publication_date': '1990-08-01', 'ids': {'openalex': 'https://openalex.org/W2089739824', 'doi': 'https://doi.org/10.1111/j.1365-2559.1990.tb00679.x', 'mag': '2089739824', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1699871'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2559.1990.tb00679.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S14376486', 'display_name': 'Histopathology', 'issn_l': '0309-0167', 'issn': ['0309-0167', '1365-2559'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5037034114', 'display_name': 'Peter Van Eyken', 'orcid': 'https://orcid.org/0000-0002-2086-8582'}, 'institutions': [], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'P. VAN EYKEN', 'raw_affiliation_strings': ['Laboratory for Histo- and Cytochemistry, Pathology Department II, U.Z. St Rafaël, Catholic University of Leuven, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Histo- and Cytochemistry, Pathology Department II, U.Z. St Rafaël, Catholic University of Leuven, The Netherlands', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086102127', 'display_name': 'Raf Sciot', 'orcid': 'https://orcid.org/0000-0003-2244-5839'}, 'institutions': [], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'R. SCIOT', 'raw_affiliation_strings': ['Laboratory for Histo- and Cytochemistry, Pathology Department II, U.Z. St Rafaël, Catholic University of Leuven, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Histo- and Cytochemistry, Pathology Department II, U.Z. St Rafaël, Catholic University of Leuven, The Netherlands', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040654888', 'display_name': 'Penelope Brock', 'orcid': 'https://orcid.org/0000-0003-1239-6316'}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'P. BROCK', 'raw_affiliation_strings': ['Pediatrics Department, University Hospital, Catholic University of Leuven, Belgium, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Pediatrics Department, University Hospital, Catholic University of Leuven, Belgium, The Netherlands', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001862671', 'display_name': 'M Casteels-Van Daele', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'M. CASTEELS‐VAN DAELE', 'raw_affiliation_strings': ['Pediatrics Department, University Hospital, Catholic University of Leuven, Belgium, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Pediatrics Department, University Hospital, Catholic University of Leuven, Belgium, The Netherlands', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106182971', 'display_name': 'Frans C.�S. Ramaekers', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I145872427', 'display_name': 'Radboud University Nijmegen', 'ror': 'https://ror.org/016xsfp80', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I145872427']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'F.C.S. RAMAEKERS', 'raw_affiliation_strings': ['Department of Pathology, University Hospital, Nijmegen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, University Hospital, Nijmegen, The Netherlands', 'institution_ids': ['https://openalex.org/I145872427']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5018140442', 'display_name': 'Valeer Desmet', 'orcid': None}, 'institutions': [], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'V.J. DESMET', 'raw_affiliation_strings': ['Laboratory for Histo- and Cytochemistry, Pathology Department II, U.Z. St Rafaël, Catholic University of Leuven, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Histo- and Cytochemistry, Pathology Department II, U.Z. St Rafaël, Catholic University of Leuven, The Netherlands', 'institution_ids': []}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5037034114'], 'corresponding_institution_ids': [], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.597, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 65, 'citation_normalized_percentile': {'value': 0.91884, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '17', 'issue': '2', 'first_page': '101', 'last_page': '107'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11650', 'display_name': 'Biology and Pathology of Keratins and Related Disorders', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11650', 'display_name': 'Biology and Pathology of Keratins and Related Disorders', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'Regulation of RNA Processing and Function', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt Signaling in Development and Disease', 'score': 0.9806, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cancer', 'display_name': 'Cancer', 'score': 0.477835}], 'concepts': [{'id': 'https://openalex.org/C2779012181', 'wikidata': 'https://www.wikidata.org/wiki/Q2750567', 'display_name': 'Cytokeratin', 'level': 3, 'score': 0.9558649}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.7253612}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.71342635}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.58760154}, {'id': 'https://openalex.org/C2777546739', 'wikidata': 'https://www.wikidata.org/wiki/Q33525', 'display_name': 'Carcinoma', 'level': 2, 'score': 0.57765985}, {'id': 'https://openalex.org/C85265743', 'wikidata': 'https://www.wikidata.org/wiki/Q885458', 'display_name': 'Blot', 'level': 3, 'score': 0.55389506}, {'id': 'https://openalex.org/C2778019345', 'wikidata': 'https://www.wikidata.org/wiki/Q1148337', 'display_name': 'Hepatocellular carcinoma', 'level': 2, 'score': 0.52344626}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45854664}, {'id': 'https://openalex.org/C2780849966', 'wikidata': 'https://www.wikidata.org/wiki/Q170758', 'display_name': 'Lymph node', 'level': 2, 'score': 0.45163095}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.29157364}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.27117008}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.12568697}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.049662054}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007633', 'descriptor_name': 'Keratins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015151', 'descriptor_name': 'Immunoblotting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007633', 'descriptor_name': 'Keratins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008207', 'descriptor_name': 'Lymphatic Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008207', 'descriptor_name': 'Lymphatic Metastasis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2559.1990.tb00679.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S14376486', 'display_name': 'Histopathology', 'issn_l': '0309-0167', 'issn': ['0309-0167', '1365-2559'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1699871', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1469270584', 'https://openalex.org/W1606423922', 'https://openalex.org/W1966002282', 'https://openalex.org/W1966891406', 'https://openalex.org/W1967233045', 'https://openalex.org/W1989363801', 'https://openalex.org/W2016693266', 'https://openalex.org/W2019465933', 'https://openalex.org/W2026816339', 'https://openalex.org/W2041986497', 'https://openalex.org/W2065889720', 'https://openalex.org/W2083883007', 'https://openalex.org/W2093376079', 'https://openalex.org/W2100837269', 'https://openalex.org/W2101108802', 'https://openalex.org/W2108283430', 'https://openalex.org/W2117750071', 'https://openalex.org/W2122153903', 'https://openalex.org/W2140905177', 'https://openalex.org/W2206959264', 'https://openalex.org/W2316200332', 'https://openalex.org/W2394641631', 'https://openalex.org/W2397433777', 'https://openalex.org/W2400076052', 'https://openalex.org/W2409188192', 'https://openalex.org/W2410112374', 'https://openalex.org/W34840195', 'https://openalex.org/W43325146', 'https://openalex.org/W69126464'], 'related_works': ['https://openalex.org/W628600844', 'https://openalex.org/W3173939782', 'https://openalex.org/W2809701302', 'https://openalex.org/W2417822880', 'https://openalex.org/W2416964324', 'https://openalex.org/W2415669453', 'https://openalex.org/W2410885201', 'https://openalex.org/W2385390897', 'https://openalex.org/W2053036460', 'https://openalex.org/W1570838273'], 'abstract_inverted_index': {'Two': [0], 'cases': [1], 'of': [2, 5, 30, 35, 54, 66, 70, 97, 100], 'fibrolamellar': [3, 71], 'carcinoma': [4], 'the': [6, 36, 62, 67, 76, 95], 'liver,': [7], 'one': [8], 'with': [9], 'lymph': [10], 'node': [11], 'metastasis': [12, 37], 'are': [13], 'reported.': [14], 'Using': [15], 'immunohistochemistry': [16], 'as': [17, 19], 'well': [18], 'one‐': [20], 'and': [21, 25, 34, 45, 73], 'two‐dimensional': [22], 'gel': [23], 'electrophoresis': [24], 'Western': [26], 'blotting,': [27], 'tumour': [28], 'cells': [29, 55], 'both': [31], 'primary': [32], 'lesions': [33], 'were': [38], 'found': [39], 'to': [40, 78, 84], 'express': [41], 'cytokeratin': [42, 49, 58, 68, 98], 'polypeptides': [43], '8': [44], '18': [46], 'and,': [47], 'surprisingly,': [48], '7.': [50], 'A': [51], 'small': [52], 'number': [53], 'also': [56, 75], 'expressed': [57], '19.': [59], 'This': [60], 'is': [61, 74], 'first': [63, 77], 'detailed': [64], 'analysis': [65], 'expression': [69, 99], 'carcinoma,': [72], 'present': [79], 'biochemical': [80], 'evidence': [81], 'that,': [82], 'contrary': [83], 'what': [85], 'has': [86], 'been': [87], 'suggested,': [88], 'hepatocellular': [89], 'carcinomas': [90], 'do': [91], 'not': [92], 'always': [93], 'preserve': [94], 'pattern': [96], 'normal': [101], 'hepatocytes.': [102]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2089739824', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-08-27T21:36:09.855438', 'created_date': '2016-06-24'}