Publication Information

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'https://openalex.org/W4238456428', 'https://openalex.org/W3031328390', 'https://openalex.org/W2602725667', 'https://openalex.org/W2292402945', 'https://openalex.org/W2155030722', 'https://openalex.org/W2081165140', 'https://openalex.org/W1494554257'], 'abstract_inverted_index': {'The': [0, 44, 74, 112, 197, 241, 271, 309, 407, 741, 1311, 1410, 1843, 1904, 1958, 2050, 2103, 2439, 2542, 2578, 2714, 2758, 2786, 2866, 3093, 3428, 3999, 4098, 4196, 4533, 4594, 4649, 4741, 4794, 5130, 5233, 5269, 5405, 5449, 5477, 5557, 5784, 5831, 5923, 5976, 6313, 6346, 6417, 6453, 6590, 6634, 6662, 6742], 'unregulated': [1, 198], 'activities': [2, 21, 199, 218, 469, 1020, 1113, 1896, 3155, 3707, 3800, 4586], 'of': [3, 32, 56, 72, 76, 83, 97, 117, 126, 130, 138, 166, 200, 229, 253, 269, 273, 280, 294, 314, 323, 327, 335, 363, 398, 402, 405, 414, 485, 492, 623, 688, 698, 744, 851, 898, 905, 908, 924, 991, 1033, 1036, 1111, 1124, 1130, 1169, 1175, 1212, 1216, 1276, 1279, 1290, 1292, 1330, 1357, 1420, 1427, 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5324, 5357, 5361, 5368, 5408, 5413, 5420, 5424, 5457, 5461, 5473, 5479, 5489, 5530, 5533, 5559, 5561, 5565, 5569, 5577, 5583, 5607, 5687, 5696, 5742, 5748, 5761, 5781, 5791, 5803, 5807, 5811, 5819, 5828, 5833, 5849, 5916, 5925, 5935, 5978, 6013, 6019, 6039, 6062, 6141, 6145, 6167, 6170, 6182, 6231, 6316, 6326, 6332, 6348, 6352, 6361, 6425, 6447, 6456, 6477, 6486, 6501, 6509, 6542, 6546, 6553, 6593, 6598, 6605, 6609, 6642, 6646, 6658, 6664, 6674, 6715, 6718, 6744, 6746, 6750, 6754, 6762, 6768, 6792, 6872, 6881, 6927, 6933, 6946, 6966, 6975, 6982, 6991], 'matrix': [4, 201, 394, 408, 473, 612, 1177, 3094, 3159, 3298, 3865], 'metalloproteinases': [5, 33, 202, 230, 395, 399, 409, 493, 1725, 1860, 3095, 3179, 4414, 4550], '(MMPs)': [6, 203], 'are': [7, 22, 120, 204, 219, 317, 411, 474, 995, 1340, 1360, 1452, 1460, 1827, 3015, 3061, 3097, 3160, 3682, 4028, 4048, 4140, 4148, 4517, 5706, 5752, 6891, 6937], 'implicated': [8, 205], 'in': [9, 48, 123, 151, 194, 206, 245, 320, 348, 391, 423, 457, 470, 672, 894, 1025, 1038, 1348, 1454, 1462, 1471, 1673, 1703, 1746, 1879, 2151, 2170, 2316, 2365, 2403, 2494, 2508, 2568, 2630, 2828, 2900, 2957, 3009, 3054, 3076, 3109, 3143, 3156, 3358, 3581, 3712, 3725, 4036, 4142, 4150, 4159, 4362, 4392, 4435, 4569, 4842, 4861, 5007, 5056, 5094, 5185, 5199, 5259, 5321, 5519, 5591, 5648, 5700, 5745, 5767, 6024, 6043, 6190, 6239, 6277, 6369, 6383, 6443, 6506, 6704, 6776, 6833, 6885, 6930, 6952], 'disease': [10, 207, 638, 3324], 'processes': [11, 208, 429, 639, 3115, 3325], 'including': [12, 209, 430, 640, 3116, 3326], 'arthritis': [13, 210], 'and': [14, 18, 64, 101, 115, 191, 211, 215, 261, 298, 312, 388, 433, 459, 482, 625, 645, 648, 674, 693, 832, 910, 916, 1001, 1024, 1078, 1166, 1321, 1328, 1336, 1345, 1370, 1375, 1434, 1443, 1470, 1553, 1590, 1609, 1660, 1715, 1819, 1881, 1941, 1979, 1982, 2067, 2085, 2090, 2182, 2201, 2481, 2496, 2554, 2560, 2725, 2780, 2830, 3000, 3002, 3074, 3119, 3145, 3168, 3311, 3331, 3334, 3360, 3380, 3519, 3597, 3603, 3688, 3711, 3765, 3854, 4009, 4016, 4024, 4033, 4058, 4063, 4122, 4131, 4158, 4242, 4279, 4298, 4349, 4404, 4509, 4571, 4632, 4670, 4673, 4758, 4776, 4781, 4873, 4892, 5172, 5187, 5245, 5251, 5416, 5471, 5521, 5691, 5693, 5765, 5814, 5852, 5855, 5940, 5958, 5963, 6055, 6074, 6356, 6371, 6429, 6435, 6601, 6656, 6706, 6876, 6878, 6950, 6977], 'tumor': [15, 212, 642, 3328], 'cell': [16, 213, 643, 2198, 3329, 4889, 6071], 'invasion': [17, 214, 647, 3333], 'metastasis.': [19, 216], 'MMP': [20, 156, 217, 353, 633, 1022, 1747, 1831, 1899, 2063, 2583, 3319, 3709, 4436, 4521, 4589, 4754, 5274, 5936, 6458], 'controlled': [23, 220], 'by': [24, 221, 707, 1361, 1513, 1538, 1548, 2065, 2131, 2431, 2608, 2883, 3394, 4049, 4202, 4227, 4237, 4756, 4822, 5122, 5299, 5574, 5938, 6004, 6305, 6483, 6759], 'four': [25, 222, 486, 3172], 'homologous': [26, 223], 'endogenous': [27, 224, 487, 3173], 'protein': [28, 225, 1297, 1916, 1928, 2111, 2157, 3985, 4607, 4619, 4802, 4848, 5789, 5801, 5984, 6030], 'inhibitors,': [29, 226, 1832, 4522], 'tissue': [30, 227, 396, 403, 425, 490, 646, 1039, 3111, 3176, 3332, 3726], 'inhibitors': [31, 228, 397, 491, 1023, 1929, 2081, 3177, 3710, 4620, 4772, 5802, 5954], '(TIMPs),': [34, 231], 'yet': [35, 232, 2124, 4815, 5997], 'different': [36, 78, 110, 233, 275, 307, 745, 1859, 1939, 2093, 2279, 2312, 2424, 3432, 4549, 4630, 4784, 4970, 5003, 5115, 5812, 5966, 6153, 6186, 6298], 'TIMPs': [37, 188, 234, 385, 624, 683, 746, 852, 899, 992, 1029, 3310, 3370, 3433, 3539, 3586, 3679, 3716], 'show': [38, 235, 1579, 1845, 1863, 2761, 3047, 4268, 4535, 4553, 5452, 5738, 6637, 6923], 'little': [39, 236, 892, 1867, 2175, 3579, 4557, 4866, 6048], 'specificity': [40, 108, 125, 136, 237, 305, 322, 333, 893, 1748, 1818, 1855, 2039, 2579, 2781, 3075, 3580, 4437, 4508, 4545, 4730, 5270, 5472, 5766, 5912, 6454, 6657, 6951], 'for': [41, 80, 109, 155, 162, 178, 184, 189, 192, 238, 277, 306, 352, 359, 375, 381, 386, 389, 848, 1121, 1598, 1611, 1666, 1732, 1841, 1858, 1924, 1932, 1949, 2055, 2082, 2107, 2177, 2278, 2444, 2462, 2547, 2552, 2558, 2720, 2816, 3018, 3535, 3809, 4287, 4300, 4355, 4421, 4531, 4548, 4615, 4623, 4640, 4746, 4773, 4798, 4868, 4969, 5135, 5153, 5238, 5243, 5249, 5411, 5507, 5709, 5797, 5805, 5822, 5928, 5955, 5980, 6050, 6152, 6318, 6336, 6422, 6427, 6433, 6596, 6692, 6894, 6984, 6994], 'individual': [42, 239], 'MMPs.': [43, 111, 240, 308, 1957, 2488, 2785, 4648, 5179, 5476, 5830, 6345, 6363, 6661], 'large': [45, 92, 242, 289, 1617, 2775, 2911, 4306, 5466, 5602, 6651, 6787], 'interaction': [46, 243, 2410, 2464, 2734, 2845, 2903, 2919, 5101, 5155, 5425, 5536, 5594, 5610, 6284, 6338, 6610, 6721, 6779, 6795], 'interface': [47, 244], 'the': [49, 59, 69, 95, 107, 124, 134, 148, 163, 246, 256, 266, 292, 304, 321, 331, 345, 360, 471, 483, 621, 755, 849, 895, 903, 906, 989, 1031, 1108, 1127, 1172, 1213, 1273, 1288, 1293, 1316, 1322, 1325, 1331, 1342, 1349, 1365, 1417, 1428, 1432, 1436, 1440, 1455, 1463, 1467, 1472, 1480, 1519, 1532, 1596, 1604, 1662, 1706, 1721, 1724, 1729, 1733, 1739, 1813, 1854, 1870, 1882, 1886, 1935, 1944, 1973, 1977, 2044, 2060, 2079, 2137, 2148, 2164, 2167, 2186, 2268, 2276, 2290, 2294, 2301, 2305, 2354, 2404, 2409, 2435, 2445, 2453, 2459, 2463, 2469, 2474, 2500, 2504, 2548, 2569, 2600, 2609, 2612, 2631, 2667, 2678, 2730, 2767, 2778, 2796, 2812, 2840, 2843, 2871, 2879, 2884, 2901, 2914, 2917, 2958, 3003, 3044, 3049, 3052, 3055, 3058, 3067, 3071, 3088, 3091, 3157, 3169, 3307, 3442, 3536, 3582, 3590, 3593, 3676, 3718, 3795, 3815, 3860, 3901, 3961, 3976, 3981, 4004, 4010, 4013, 4019, 4030, 4037, 4053, 4105, 4116, 4120, 4124, 4128, 4143, 4151, 4155, 4160, 4168, 4208, 4221, 4285, 4293, 4351, 4395, 4410, 4413, 4418, 4422, 4428, 4503, 4544, 4560, 4572, 4576, 4626, 4635, 4664, 4668, 4735, 4751, 4770, 4828, 4839, 4855, 4858, 4877, 4959, 4967, 4981, 4985, 4992, 4996, 5045, 5095, 5100, 5126, 5136, 5144, 5150, 5154, 5160, 5165, 5191, 5195, 5239, 5260, 5291, 5300, 5303, 5322, 5358, 5369, 5421, 5458, 5469, 5487, 5503, 5531, 5534, 5562, 5570, 5575, 5592, 5605, 5608, 5649, 5694, 5735, 5740, 5743, 5746, 5749, 5758, 5762, 5779, 5782, 5808, 5817, 5846, 5850, 5917, 5933, 5952, 6010, 6021, 6037, 6040, 6059, 6142, 6150, 6164, 6168, 6175, 6179, 6228, 6278, 6283, 6309, 6319, 6327, 6333, 6337, 6343, 6349, 6375, 6379, 6423, 6444, 6475, 6484, 6487, 6507, 6543, 6554, 6606, 6643, 6654, 6672, 6688, 6716, 6719, 6747, 6755, 6760, 6777, 6790, 6793, 6834, 6879, 6920, 6925, 6928, 6931, 6934, 6943, 6947, 6964, 6967, 6989], 'TIMP-1·MMP-3': [50, 247, 1312, 2302, 2679, 3059, 4000, 4993, 5370, 5750, 6176, 6555, 6935], 'complex': [51, 248, 1123, 1168, 1549, 2371, 2680, 2809, 3060, 3811, 3856, 4238, 5062, 5371, 5500, 5751, 6245, 6556, 6685, 6936], 'includes': [52, 249], 'a': [53, 91, 103, 142, 167, 250, 288, 300, 339, 364, 412, 694, 749, 921, 1122, 1167, 1208, 1280, 1414, 1522, 1583, 1669, 1743, 1810, 1821, 1850, 1890, 1921, 2034, 2110, 2126, 2156, 2171, 2178, 2311, 2509, 2565, 2763, 2774, 2897, 2905, 2909, 3098, 3381, 3436, 3608, 3810, 3855, 3896, 3968, 4102, 4211, 4272, 4358, 4432, 4500, 4511, 4540, 4580, 4612, 4725, 4801, 4817, 4847, 4862, 4869, 5002, 5200, 5256, 5454, 5465, 5588, 5596, 5600, 5794, 5907, 5983, 5999, 6029, 6044, 6051, 6185, 6384, 6440, 6639, 6650, 6773, 6781, 6785], 'contiguous': [54, 251], 'region': [55, 85, 252, 282, 845, 1722, 2307, 3532, 4411, 4998, 6181], 'TIMP-1': [57, 131, 152, 254, 328, 349, 919, 1011, 1125, 1527, 1552, 1714, 1817, 1880, 1984, 2153, 2718, 2893, 3606, 3698, 3813, 4216, 4241, 4403, 4507, 4570, 4675, 4844, 5409, 5584, 5857, 6026, 6594, 6769], 'around': [58, 255], 'disulfide': [60, 257, 709, 1366, 1608, 2437, 3396, 4054, 4297, 5128, 6311], 'bond': [61, 258, 1367, 1535, 4055, 4224], 'between': [62, 259, 620, 1319, 1333, 1368, 1551, 1587, 1869, 3306, 4007, 4021, 4056, 4240, 4276, 4559], 'Cys1': [63, 260, 1369, 1412, 1605, 4057, 4100, 4294], 'Cys70': [65, 262, 1607, 4296], 'that': [66, 87, 173, 263, 284, 370, 419, 843, 1272, 1315, 1526, 1543, 1580, 1602, 1647, 1711, 1726, 1741, 1826, 1846, 1864, 1915, 2030, 2078, 2112, 2158, 2173, 2315, 2362, 2449, 2599, 2662, 2762, 2889, 2907, 3012, 3048, 3105, 3530, 3960, 4003, 4215, 4232, 4269, 4291, 4336, 4400, 4415, 4430, 4516, 4536, 4554, 4606, 4721, 4769, 4803, 4849, 4864, 5006, 5053, 5140, 5290, 5353, 5453, 5580, 5598, 5703, 5739, 5788, 5903, 5951, 5985, 6031, 6046, 6189, 6236, 6323, 6474, 6538, 6638, 6765, 6783, 6888, 6924, 6997], 'inserts': [67, 264], 'into': [68, 265, 748, 2499, 3435, 5190, 6374], 'active': [70, 267, 626, 2180, 3312, 4871, 6053], 'site': [71, 268, 1509, 1731, 1888, 2046, 2181, 2406, 2769, 2846, 4198, 4420, 4578, 4737, 4872, 5097, 5460, 5537, 5919, 6054, 6280, 6645, 6722], 'MMP-3.': [73, 270], 'effects': [75, 272, 1594, 1618, 1654, 2051, 2295, 2414, 4283, 4307, 4343, 4742, 4986, 5105, 5924, 6169, 6288], 'fifteen': [77, 274, 1836, 4526], 'substitutions': [79, 177, 276, 374, 1581, 1610, 1646, 1840, 1968, 2054, 2094, 4270, 4299, 4335, 4530, 4659, 4745, 4785, 5841, 5927, 5967], 'threonine': [81, 278, 2555, 5246, 6430], '2': [82, 119, 129, 154, 279, 316, 326, 351, 1878, 2032, 2273, 2614, 2891, 4568, 4723, 4964, 5305, 5582, 5905, 6147, 6489, 6767], 'this': [84, 88, 281, 285, 844, 1514, 1544, 1847, 2789, 3531, 4203, 4233, 4537, 5480, 6665], 'reveal': [86, 283, 1271, 3959], 'residue': [89, 118, 153, 165, 286, 315, 350, 362, 1735, 1740, 1848, 1884, 2031, 2272, 2613, 2765, 2890, 2906, 4424, 4429, 4538, 4574, 4722, 4963, 5304, 5456, 5581, 5597, 5904, 6146, 6488, 6641, 6766, 6782], 'makes': [90, 287], 'contribution': [93, 290], 'to': [94, 144, 291, 341, 496, 912, 1014, 1018, 1027, 1364, 1416, 1606, 1657, 1675, 1678, 1728, 1942, 2162, 2183, 2288, 2423, 2576, 2593, 2617, 2784, 2805, 3082, 3087, 3182, 3599, 3701, 3705, 3714, 4052, 4104, 4295, 4346, 4364, 4367, 4417, 4633, 4853, 4874, 4979, 5114, 5267, 5284, 5308, 5475, 5496, 5773, 5778, 5815, 6035, 6056, 6162, 6297, 6451, 6468, 6492, 6660, 6681, 6958, 6963, 6988], 'stability': [96, 293, 3089, 5780, 6965], 'complexes': [98, 295, 1005, 2638, 3692, 5329, 6514], 'with': [99, 133, 176, 296, 330, 373, 616, 637, 853, 902, 993, 1006, 1126, 1171, 1207, 1283, 1518, 1705, 1720, 1839, 1897, 1952, 2072, 2193, 2275, 2411, 2465, 2468, 2584, 2619, 2811, 2955, 3302, 3323, 3540, 3589, 3680, 3693, 3814, 3859, 3895, 3971, 4207, 4394, 4409, 4529, 4587, 4643, 4763, 4884, 4966, 5102, 5156, 5159, 5275, 5310, 5502, 5646, 5825, 5945, 6066, 6149, 6285, 6339, 6342, 6459, 6494, 6687, 6831], 'MMPs': [100, 297, 759, 1931, 1940, 2280, 2412, 2425, 3446, 4622, 4631, 4971, 5103, 5116, 5804, 5813, 6154, 6286, 6299], 'has': [102, 299, 1742, 1849, 2033, 2174, 2310, 2659, 2908, 4431, 4539, 4724, 4865, 5001, 5350, 5599, 5906, 6047, 6184, 6535, 6784], 'dominant': [104, 301, 1744, 4433], 'influence': [105, 302, 1852, 2037, 2776, 2912, 4542, 4728, 5467, 5603, 5910, 6652, 6788], 'on': [106, 303, 900, 1425, 1595, 1619, 1655, 1853, 1893, 2038, 2088, 2298, 2353, 2415, 2675, 2777, 2808, 2876, 2913, 3587, 4113, 4284, 4308, 4344, 4543, 4583, 4729, 4779, 4989, 5044, 5106, 5366, 5468, 5499, 5567, 5604, 5911, 5961, 6172, 6227, 6289, 6551, 6653, 6684, 6752, 6789], 'size,': [113, 310], 'charge,': [114, 311], 'hydrophobicity': [116, 313], 'key': [121, 143, 318, 340, 1415, 4103], 'factors': [122, 319], 'TIMP.': [127, 324], 'Threonine': [128, 325], 'interacts': [132, 329], 'S1′': [135, 332, 2454, 2475, 2501, 5145, 5166, 5192, 6328, 6350, 6376], 'pocket': [137, 334, 2455, 2476, 2502, 2514, 2580, 5146, 5167, 5193, 5205, 5271, 6329, 6351, 6377, 6389, 6455], 'MMP-3,': [139, 336, 1599, 1661, 2086, 2497, 4288, 4350, 4777, 5188, 5959, 6372], 'which': [140, 337, 753, 1524, 1709, 2491, 3440, 4213, 4398, 5182, 6366], 'is': [141, 338, 614, 635, 705, 846, 891, 920, 1114, 1413, 1516, 1529, 1536, 1546, 1702, 1866, 1910, 1920, 2113, 2191, 2285, 2479, 2563, 2673, 2791, 3080, 3300, 3321, 3392, 3533, 3578, 3607, 3801, 4101, 4205, 4218, 4225, 4235, 4391, 4556, 4600, 4611, 4804, 4882, 4976, 5170, 5254, 5364, 5482, 5771, 5793, 5986, 6064, 6159, 6354, 6438, 6549, 6667, 6956], 'substrate': [145, 342, 1892, 2587, 4582, 5278, 6462], 'specificity,': [146, 343], 'but': [147, 344, 1542, 1861, 1972, 2994, 3078, 4231, 4551, 4663, 5685, 5769, 5845, 6870, 6954], 'structural': [149, 346, 1109, 1814, 1905, 2291, 3068, 3796, 4504, 4595, 4982, 5759, 6165, 6944], 'requirements': [150, 347], 'binding': [157, 354, 1026, 1656, 1674, 1730, 2064, 2460, 2571, 2601, 2783, 2875, 3019, 3713, 4345, 4363, 4419, 4755, 5151, 5262, 5292, 5474, 5566, 5710, 5937, 6334, 6446, 6476, 6659, 6751, 6895], 'differ': [158, 355], 'greatly': [159, 356], 'from': [160, 357, 2314, 2434, 2801, 5005, 5125, 5492, 6188, 6308, 6677], 'those': [161, 358, 2485, 5176, 6360], 'corresponding': [164, 361], 'peptide': [168, 365, 1444, 1534, 1737, 1891, 4132, 4223, 4426, 4581], 'substrate.': [169, 366, 1903, 4593], 'These': [170, 367], 'results': [171, 368, 1520, 1844, 1913, 2760, 3046, 4209, 4534, 4604, 5451, 5737, 5786, 6636, 6922], 'demonstrate': [172, 369], 'TIMP': [174, 371, 1277, 1320, 1421, 1511, 1857, 1919, 2070, 2141, 2190, 2366, 2603, 3965, 4008, 4109, 4200, 4547, 4610, 4761, 4832, 4881, 5057, 5294, 5792, 5943, 6014, 6063, 6240, 6478, 6999], 'variants': [175, 372, 1825, 1965, 2071, 4515, 4656, 4762, 5838, 5944], 'Thr2': [179, 376, 1667, 1712, 2056, 2108, 2799, 2880, 3021, 4356, 4401, 4747, 4799, 5490, 5571, 5712, 5929, 5981, 6675, 6756, 6897], 'represent': [180, 377], 'suitable': [181, 378], 'starting': [182, 379], 'points': [183, 380], 'generating': [185, 382, 1824, 1925, 4514, 4616, 5798], 'more': [186, 383, 996, 1828, 1926, 2457, 2512, 3683, 4518, 4617, 5148, 5203, 5799, 6331, 6387], 'targeted': [187, 384, 1962, 4653, 5835], 'investigation': [190, 387], 'intervention': [193, 390], 'MMP-related': [195, 392], 'diseases.': [196, 393], 'N-terminal': [400, 686, 742, 1214, 1326, 1411, 2306, 3373, 3429, 3902, 4014, 4099, 4997, 6180], 'domain': [401, 687, 697, 704, 1129, 1174, 1215, 1275, 1351, 2169, 2716, 3374, 3384, 3391, 3817, 3862, 3903, 3963, 4039, 4860, 5407, 6042, 6592], 'inhibitor': [404, 923, 1901, 2118, 2589, 3610, 4591, 4809, 5280, 5991, 6464], 'metalloproteinases-1': [406, 915, 3602], '(MMPs)1': [410, 3096], 'family': [413, 1298, 3099, 3986], 'about': [415, 689, 699, 2059, 3101, 3376, 3386, 4750, 5932], 'twenty': [416, 3102], 'Zn2+-dependent': [417, 3103], 'endopeptidases': [418, 3104], 'have': [420, 684, 836, 1079, 1117, 1592, 1651, 1834, 2092, 3106, 3371, 3523, 3766, 3805, 4281, 4340, 4524, 4783, 5965], 'important': [421, 3017, 3063, 3081, 3107, 5708, 5754, 5772, 6893, 6939, 6957], 'roles': [422, 1937, 3108, 4628, 5810], 'connective': [424, 3110], 'turnover': [426, 3112], 'during': [427, 2370, 3113, 5061, 6244], 'physiological': [428, 3114], 'development,': [431, 3117], 'morphogenesis,': [432, 3118], 'wound': [434, 3120], 'healing': [435, 3121], '(1Woessner': [436, 650, 3122, 3336], 'Jr.,': [437, 651, 3123, 3337], 'J.F.': [438, 652, 3124, 3338], 'Ann.': [439, 653, 3125, 3339], 'N.': [440, 547, 654, 1146, 1390, 1762, 2332, 2694, 2974, 3126, 3233, 3340, 3834, 4078, 4451, 5023, 5385, 5665, 6206, 6570, 6850], 'Y.': [441, 655, 3127, 3341], 'Acad.': [442, 533, 656, 2645, 2937, 3128, 3219, 3342, 5336, 5628, 6521, 6813], 'Sci.': [443, 534, 657, 1071, 1101, 2234, 2260, 2646, 2938, 3129, 3220, 3343, 3758, 3788, 4925, 4951, 5337, 5629, 6107, 6133, 6522, 6814], '1994;': [444, 575, 658, 1072, 1234, 2235, 2534, 3130, 3261, 3344, 3759, 3922, 4926, 5225, 6108, 6409], '732:': [445, 659, 3131, 3345], '11-21Crossref': [446, 660, 3132, 3346], 'PubMed': [447, 518, 541, 563, 578, 606, 661, 736, 776, 801, 824, 864, 885, 936, 957, 983, 1056, 1075, 1161, 1201, 1237, 1265, 1306, 1405, 1503, 1568, 1637, 1696, 1777, 1803, 2003, 2024, 2219, 2238, 2347, 2396, 2537, 2653, 2709, 2753, 2861, 2928, 2945, 2989, 3038, 3133, 3204, 3227, 3249, 3264, 3292, 3347, 3423, 3463, 3488, 3511, 3551, 3572, 3623, 3644, 3670, 3743, 3762, 3849, 3889, 3925, 3953, 3994, 4093, 4191, 4257, 4326, 4385, 4466, 4492, 4694, 4715, 4910, 4929, 5038, 5087, 5228, 5344, 5400, 5444, 5552, 5619, 5636, 5680, 5729, 5876, 5897, 6092, 6111, 6221, 6270, 6412, 6529, 6585, 6629, 6737, 6804, 6821, 6865, 6914], 'Scopus': [448, 519, 542, 579, 607, 662, 737, 777, 802, 825, 865, 886, 937, 958, 984, 1057, 1162, 1202, 1238, 1266, 1307, 1406, 1504, 1569, 1638, 1697, 1778, 1804, 2004, 2025, 2220, 2348, 2397, 2538, 2654, 2710, 2754, 2862, 2929, 2946, 2990, 3039, 3134, 3205, 3228, 3265, 3293, 3348, 3424, 3464, 3489, 3512, 3552, 3573, 3624, 3645, 3671, 3744, 3850, 3890, 3926, 3954, 3995, 4094, 4192, 4258, 4327, 4386, 4467, 4493, 4695, 4716, 4911, 5039, 5088, 5229, 5345, 5401, 5445, 5553, 5620, 5637, 5681, 5730, 5877, 5898, 6093, 6222, 6271, 6413, 6530, 6586, 6630, 6738, 6805, 6822, 6866, 6915], '(436)': [449, 663, 3135, 3349], 'Google': [450, 521, 544, 564, 581, 609, 664, 739, 779, 804, 827, 867, 888, 939, 960, 986, 1059, 1076, 1105, 1164, 1204, 1240, 1268, 1309, 1408, 1506, 1571, 1640, 1699, 1780, 1806, 2006, 2027, 2222, 2239, 2264, 2350, 2399, 2540, 2656, 2712, 2756, 2864, 2931, 2948, 2992, 3041, 3136, 3207, 3230, 3250, 3267, 3295, 3350, 3426, 3466, 3491, 3514, 3554, 3575, 3626, 3647, 3673, 3746, 3763, 3792, 3852, 3892, 3928, 3956, 3997, 4096, 4194, 4260, 4329, 4388, 4469, 4495, 4697, 4718, 4913, 4930, 4955, 5041, 5090, 5231, 5347, 5403, 5447, 5555, 5622, 5639, 5683, 5732, 5879, 5900, 6095, 6112, 6137, 6224, 6273, 6415, 6532, 6588, 6632, 6740, 6807, 6824, 6868, 6917], 'Scholar,2Nagase': [451, 3137], 'H.': [452, 667, 811, 963, 1148, 1154, 1193, 1392, 1398, 1495, 1556, 1628, 1687, 1764, 1770, 1795, 1990, 2015, 2334, 2340, 2696, 2702, 2740, 2823, 2976, 2982, 3029, 3138, 3353, 3498, 3650, 3836, 3842, 3881, 4080, 4086, 4183, 4245, 4317, 4376, 4453, 4459, 4484, 4681, 4706, 5025, 5031, 5387, 5393, 5431, 5514, 5667, 5673, 5720, 5863, 5888, 6208, 6214, 6572, 6578, 6616, 6699, 6852, 6858, 6905], 'Hooper': [453, 668, 2824, 3139, 3354, 5515, 6700], 'N.M.': [454, 669, 2825, 3140, 3355, 5516, 6701], 'Zinc': [455, 670, 2826, 3141, 3356, 5517, 6702], 'Metalloproteinases': [456, 671, 2827, 3142, 3357, 5518, 6703], 'Health': [458, 673, 2829, 3144, 3359, 5520, 6705], 'Disease.': [460, 675, 2831, 3146, 3361, 5522, 6707], 'Taylor': [461, 676, 2832, 3147, 3362, 5523, 6708], '&': [462, 677, 2833, 3148, 3363, 5524, 6709], 'Francis': [463, 678, 2834, 3149, 3364, 5525, 6710], 'Ltd.,': [464, 679, 2835, 3150, 3365, 5526, 6711], 'London1996:': [465, 680, 2836, 3151, 3366, 5527, 6712], '153-204Google': [466, 681, 2837, 3152, 3367, 5528, 6713], 'Scholar).': [467, 610, 740, 828, 889, 987, 1106, 1205, 1310, 1409, 1572, 1641, 1700, 2351, 2400, 2541, 2657, 2713, 2757, 2865, 2949, 3042, 3153, 3296, 3368, 3427, 3515, 3576, 3674, 3793, 3893, 3998, 4097, 4195, 4261, 4330, 4389, 4496, 5042, 5091, 5232, 5348, 5404, 5448, 5556, 5640, 5733, 6138, 6225, 6274, 6416, 6533, 6589, 6633, 6741, 6825, 6918], 'Their': [468, 3154], 'extracellular': [472, 3158], 'stringently': [475, 3161], 'regulated': [476, 3162], 'through': [477, 1341, 1439, 2413, 3163, 4029, 4127, 5104, 6287], 'transcriptional': [478, 3164], 'control,': [479, 3165], 'zymogen': [480, 3166], 'activation,': [481, 3167], 'actions': [484, 897, 3170, 3584], 'inhibitory': [488, 756, 896, 1274, 1418, 1974, 3072, 3174, 3443, 3583, 3962, 4106, 4665, 5763, 5847, 6948], 'proteins,': [489, 3175], '(TIMPs)': [494, 3180], '1': [495, 1179, 1353, 1448, 3181, 3867, 4041, 4136], '4': [497, 3183], '(3Docherty': [498, 3184], 'A.J.P.': [499, 771, 794, 1228, 3185, 3458, 3481, 3916], 'Lyons': [500, 3186], 'A.': [501, 537, 763, 1068, 1140, 1191, 1384, 1493, 1756, 1793, 2231, 2326, 2649, 2688, 2941, 2968, 3187, 3223, 3450, 3755, 3828, 3879, 4072, 4181, 4445, 4482, 4922, 5017, 5340, 5379, 5632, 5659, 6104, 6200, 6525, 6564, 6817, 6844], 'Smith': [502, 725, 968, 2519, 3188, 3412, 3655, 5210, 6394], 'B.J.': [503, 726, 3189, 3413], 'Wright': [504, 3190], 'E.M.': [505, 3191], 'Stephens': [506, 3192], 'P.E.': [507, 3193], 'Harris': [508, 727, 3194, 3414], 'T.J.R.': [509, 728, 3195, 3415], 'Murphy': [510, 795, 970, 1092, 1225, 2251, 3196, 3482, 3657, 3779, 3913, 4942, 6124], 'G.': [511, 761, 796, 856, 928, 971, 1093, 1222, 1226, 2252, 3197, 3448, 3483, 3543, 3615, 3658, 3780, 3910, 3914, 4943, 6125], 'Reynolds': [512, 791, 3198, 3478], 'J.J.': [513, 792, 1189, 1491, 1791, 3199, 3479, 3877, 4179, 4480], 'Nature.': [514, 1157, 1401, 1773, 2343, 2705, 2985, 3200, 3845, 4089, 4462, 5034, 5396, 5676, 6217, 6581, 6861], '1985;': [515, 3201], '318:': [516, 3202], '66-69Crossref': [517, 3203], '(582)': [520, 3206], 'Scholar,': [522, 545, 565, 582, 665, 780, 805, 868, 940, 961, 1060, 1241, 1781, 2007, 2223, 2240, 2932, 3208, 3231, 3251, 3268, 3351, 3467, 3492, 3555, 3627, 3648, 3747, 3929, 4470, 4698, 4914, 4931, 5623, 5880, 6096, 6113, 6808], '4Boone': [523, 3209], 'T.C.': [524, 3210], 'Johnson': [525, 3211], 'M.J.': [526, 3212], 'DeClerck': [527, 3213], 'Y.A.': [528, 3214], 'Langley': [529, 3215], 'K.E.': [530, 3216], 'Proc.': [531, 2643, 2935, 3217, 5334, 5626, 6519, 6811], 'Natl.': [532, 2644, 2936, 3218, 5335, 5627, 6520, 6812], 'U.': [535, 2647, 2939, 3221, 5338, 5630, 6523, 6815], 'S.': [536, 716, 813, 1095, 1992, 2254, 2640, 2648, 2742, 2848, 2940, 3222, 3403, 3500, 3782, 4683, 4945, 5331, 5339, 5433, 5539, 5631, 5865, 6127, 6516, 6524, 6618, 6724, 6816], '1990;': [538, 733, 3224, 3420], '87:': [539, 3225], '2800-2804Crossref': [540, 3226], '(180)': [543, 3229], '5Pavloff': [546, 3232], 'Staskus': [548, 3234], 'P.W.': [549, 3235], 'Kishnani': [550, 3236], 'N.S.': [551, 3237], 'Hawkes': [552, 3238], 'S.P.': [553, 3239], 'J.': [554, 584, 595, 732, 879, 951, 972, 1069, 1197, 1232, 1247, 1254, 1302, 1499, 1564, 1631, 1690, 1799, 2018, 2232, 2378, 2385, 2850, 2855, 3032, 3240, 3270, 3281, 3419, 3566, 3638, 3659, 3756, 3885, 3920, 3935, 3942, 3990, 4187, 4253, 4320, 4379, 4488, 4709, 4923, 5069, 5076, 5541, 5546, 5723, 5891, 6105, 6252, 6259, 6726, 6731, 6908], 'Biol.': [555, 596, 880, 952, 973, 1255, 1632, 1691, 2019, 2386, 2533, 2857, 3033, 3241, 3282, 3567, 3639, 3660, 3943, 4321, 4380, 4710, 5077, 5224, 5548, 5724, 5892, 6260, 6408, 6733, 6909], 'Chem.': [556, 597, 881, 953, 974, 1256, 1633, 1692, 2020, 2387, 3034, 3242, 3283, 3568, 3640, 3661, 3944, 4322, 4381, 4711, 5078, 5725, 5893, 6261, 6910], '1992;': [557, 798, 1053, 2216, 3243, 3485, 3740, 4907, 6089], '267:': [558, 2926, 3244, 5617, 6802], '17321-17326Abstract': [559, 3245], 'Full': [560, 601, 603, 978, 980, 1260, 1262, 2391, 2393, 3246, 3287, 3289, 3665, 3667, 3948, 3950, 5082, 5084, 6265, 6267], 'Text': [561, 602, 604, 979, 981, 1261, 1263, 2392, 2394, 3247, 3288, 3290, 3666, 3668, 3949, 3951, 5083, 5085, 6266, 6268], 'PDF': [562, 605, 982, 1264, 2395, 3248, 3291, 3669, 3952, 5086, 6269], '6Silbiger': [566, 3252], 'S.M.': [567, 3253], 'Jacobsen': [568, 3254], 'V.L.': [569, 3255], 'Cupples': [570, 3256], 'R.L.': [571, 3257], 'Koski': [572, 3258], 'R.A.': [573, 786, 1220, 1253, 2384, 3259, 3473, 3908, 3941, 5075, 6258], 'Gene.': [574, 3260], '141:': [576, 3262], '293-297Crossref': [577, 3263], '(66)': [580, 3266], '7Greene': [583, 3269], 'Wang': [585, 3271], 'M.': [586, 720, 769, 782, 1138, 1382, 1754, 2324, 2686, 2966, 3272, 3407, 3456, 3469, 3826, 4070, 4443, 5015, 5377, 5657, 6198, 6562, 6842], 'Liu': [587, 873, 945, 3273, 3560, 3632], 'Y.E.': [588, 594, 872, 874, 944, 946, 3274, 3280, 3559, 3561, 3631, 3633], 'Raymond': [589, 3275], 'L.A.': [590, 3276], 'Rosen': [591, 3277], 'C.': [592, 1181, 1483, 1783, 2854, 3278, 3869, 4171, 4472, 5545, 6730], 'Shi': [593, 871, 943, 3279, 3558, 3630], '1996;': [598, 821, 975, 2000, 2650, 2750, 2942, 3284, 3508, 3662, 4691, 5341, 5441, 5633, 5873, 6526, 6626, 6818], '271:': [599, 976, 3285, 3663], '30375-30380Abstract': [600, 3286], '(475)': [608, 3294], 'Normal': [611, 3297], 'homeostasis': [613, 3299], 'associated': [615, 1285, 3301, 3973], 'an': [617, 629, 685, 1873, 1898, 2117, 2582, 3062, 3303, 3315, 3372, 4563, 4588, 4808, 5273, 5753, 5990, 6457, 6938], 'appropriate': [618, 3304], 'balance': [619, 3305], 'levels': [622, 3308], 'MMPs,': [627, 3313], 'whereas': [628, 918, 1010, 1600, 1644, 3314, 3605, 3697, 4289, 4333], 'imbalance': [630, 3316], 'involving': [631, 1476, 3317, 4164], 'excess': [632, 1953, 3318, 4644, 5826], 'activity': [634, 757, 1081, 1528, 1620, 1650, 1954, 2203, 3320, 3444, 3768, 4217, 4309, 4339, 4645, 4894, 5827, 6076], 'linked': [636, 1951, 3322, 4642, 5824], 'arthritis,': [641, 3327], 'metastasis,': [644, 3330], 'atherosclerosis': [649, 3335], '2Nagase': [666, 3352], 'Scholar).Mammalian': [682], '125': [690, 3377], 'amino': [691, 701, 1874, 3378, 3388, 4564], 'acids': [692, 3379], 'smaller': [695, 3382], 'C-terminal': [696, 834, 1350, 2168, 2715, 3383, 3521, 4038, 4859, 5406, 6041, 6591], '65': [700, 3387], 'acids;': [702, 3389], 'each': [703, 2671, 3390, 5362, 6547], 'stabilized': [706, 3393], 'three': [708, 1284, 3395, 3972], 'bonds': [710, 3397], '(8Williamson': [711, 3398], 'E.A.': [712, 3399], 'Marston': [713, 3400], 'F.A.O.': [714, 3401], 'Angal': [715, 3402], 'Koklitis': [717, 3404], 'P.': [718, 3405], 'Panico': [719, 3406], 'Morris': [721, 3408], 'H.R.': [722, 3409], 'Carne': [723, 3410], 'A.F.': [724, 3411], 'Freedman': [729, 789, 1229, 1248, 2379, 3416, 3476, 3917, 3936, 5070, 6253], 'R.B.': [730, 790, 1230, 1249, 2380, 3417, 3477, 3918, 3937, 5071, 6254], 'Biochem.': [731, 1563, 3418, 4252], '268:': [734, 3421], '267-274Crossref': [735, 3422], '(155)': [738, 3425], 'domains': [743, 835, 3430, 3522], 'fold': [747, 3434], 'correct': [750, 3437], 'native': [751, 2127, 3438, 4818, 6000], 'structure': [752, 1211, 1313, 1481, 1515, 2128, 2313, 2356, 2472, 2960, 3056, 3439, 3899, 4001, 4169, 4204, 4819, 5004, 5047, 5163, 5651, 5747, 6001, 6187, 6230, 6347, 6836, 6932], 'carries': [754, 3441], 'against': [758, 3445], '(9Murphy': [760, 3447], 'Houbrechts': [762, 3449], 'Cockett': [764, 787, 3451, 3474], 'M.I.': [765, 788, 3452, 3475], 'Williamson': [766, 785, 1252, 2383, 3453, 3472, 3940, 5074, 6257], 'R.O.-A.': [767, 3454], 'Shea': [768, 3455], 'Docherty': [770, 793, 1227, 3457, 3480, 3915], 'Biochemistry.': [772, 797, 1233, 3459, 3484, 3921], '1991;': [773, 3460], '30:': [774, 3461], '8097-8102Crossref': [775, 3462], '(283)': [778, 3465], "10O'Shea": [781, 3468], 'Willenbrock': [783, 857, 929, 3470, 3544, 3616], 'F.': [784, 858, 930, 3471, 3545, 3617], '31:': [799, 3486], '10146-10152Crossref': [800, 3487], '(73)': [803, 3490], '11Huang': [806, 3493], 'W.': [807, 1156, 1183, 1400, 1485, 1622, 1681, 1772, 1785, 1986, 2009, 2342, 2704, 2736, 2984, 3023, 3494, 3844, 3871, 4088, 4173, 4311, 4370, 4461, 4474, 4677, 4700, 5033, 5395, 5427, 5675, 5714, 5859, 5882, 6216, 6580, 6612, 6860, 6899], 'Suzuki': [808, 1143, 1387, 1557, 1625, 1684, 1759, 1987, 2012, 2329, 2691, 2737, 2971, 3026, 3495, 3831, 4075, 4246, 4314, 4373, 4448, 4678, 4703, 5020, 5382, 5428, 5662, 5717, 5860, 5885, 6203, 6567, 6613, 6847, 6902], 'K.': [809, 818, 1044, 1046, 1050, 1064, 1089, 1136, 1144, 1150, 1195, 1380, 1388, 1394, 1497, 1558, 1562, 1626, 1630, 1685, 1689, 1752, 1760, 1766, 1797, 1988, 1997, 2013, 2017, 2207, 2209, 2213, 2227, 2248, 2322, 2330, 2336, 2684, 2692, 2698, 2738, 2747, 2964, 2972, 2978, 3027, 3031, 3496, 3505, 3731, 3733, 3737, 3751, 3776, 3824, 3832, 3838, 3883, 4068, 4076, 4082, 4185, 4247, 4251, 4315, 4319, 4374, 4378, 4441, 4449, 4455, 4486, 4679, 4688, 4704, 4708, 4898, 4900, 4904, 4918, 4939, 5013, 5021, 5027, 5375, 5383, 5389, 5429, 5438, 5655, 5663, 5669, 5718, 5722, 5861, 5870, 5886, 5890, 6080, 6082, 6086, 6100, 6121, 6196, 6204, 6210, 6560, 6568, 6574, 6614, 6623, 6840, 6848, 6854, 6903, 6907], 'Nagase': [810, 1147, 1391, 1627, 1686, 1763, 1989, 2014, 2333, 2695, 2739, 2975, 3028, 3497, 3835, 4079, 4316, 4375, 4452, 4680, 4705, 5024, 5386, 5430, 5666, 5719, 5862, 5887, 6207, 6571, 6615, 6851, 6904], 'Arumugam': [812, 1991, 2741, 3499, 4682, 5432, 5864, 6617], 'Van': [814, 1993, 2743, 3501, 4684, 5434, 5866, 6619], 'Doren': [815, 1994, 2744, 3502, 4685, 5435, 5867, 6620], 'S.R.': [816, 1995, 2745, 3503, 4686, 5436, 5868, 6621], 'Brew': [817, 1149, 1393, 1561, 1629, 1688, 1765, 1996, 2016, 2335, 2697, 2746, 2977, 3030, 3504, 3837, 4081, 4250, 4318, 4377, 4454, 4687, 4707, 5026, 5388, 5437, 5668, 5721, 5869, 5889, 6209, 6573, 6622, 6853, 6906], 'FEBS': [819, 1051, 1998, 2214, 2748, 3506, 3738, 4689, 4905, 5439, 5871, 6087, 6624], 'Lett.': [820, 1052, 1999, 2215, 2749, 3507, 3739, 4690, 4906, 5440, 5872, 6088, 6625], '384:': [822, 2001, 2751, 3509, 4692, 5442, 5874, 6627], '155-161Crossref': [823, 2002, 2752, 3510, 4693, 5443, 5875, 6628], '(97)': [826, 2005, 2755, 3513, 4696, 5446, 5878, 6631], 'Although': [829, 2136, 3516, 4827, 6009], 'correctly': [830, 3517], 'folded': [831, 3518], 'functional': [833, 3520], 'not': [837, 2143, 3524, 4834, 6016], 'been': [838, 1118, 2660, 3525, 3806, 5351, 6536], 'described,': [839, 3526], 'truncation': [840, 3527], 'experiments': [841, 3528], 'indicate': [842, 1710, 2029, 3529, 4399, 4720, 5902], 'responsible': [847, 3534], 'interactions': [850, 990, 1318, 1339, 1475, 2165, 2450, 3537, 3677, 4006, 4027, 4163, 4856, 5141, 6038, 6324], 'pro-MMPs': [854, 994, 3541, 3681], '(12Murphy': [855, 927, 3542, 3614], 'Methods': [859, 931, 3546, 3618], 'Enzymol.': [860, 932, 3547, 3619], '1995;': [861, 933, 2925, 3548, 3620, 5616, 6801], '248:': [862, 934, 3549, 3621], '496-510Crossref': [863, 935, 3550, 3622], '(243)': [866, 938, 3553, 3625], '13Bigg': [869, 941, 3556, 3628], 'H.F.': [870, 942, 3557, 3629], 'Steffensen': [875, 947, 3562, 3634], 'B.': [876, 948, 969, 1083, 1091, 1097, 2242, 2250, 2256, 2530, 3563, 3635, 3656, 3770, 3778, 3784, 4933, 4941, 4947, 5221, 6115, 6123, 6129, 6405], 'Overall': [877, 949, 3564, 3636], 'C.M.': [878, 950, 3565, 3637], '1997;': [882, 954, 1102, 1158, 1402, 1565, 1634, 1693, 1774, 2021, 2261, 2344, 2706, 2986, 3035, 3569, 3641, 3789, 3846, 4090, 4254, 4323, 4382, 4463, 4712, 4952, 5035, 5397, 5677, 5726, 5894, 6134, 6218, 6582, 6862, 6911], '272:': [883, 955, 1635, 1694, 2022, 3036, 3570, 3642, 4324, 4383, 4713, 5727, 5895, 6912], '15496-15500Crossref': [884, 956, 3571, 3643], '(143)': [887, 959, 3574, 3646], 'There': [890, 3577], 'metalloproteinases,': [901, 3588], 'exception': [904, 3591], 'ability': [907, 2610, 3594, 5301, 6485], 'TIMP-2': [909, 1000, 1170, 1718, 3596, 3687, 3858, 4407], 'TIMP-3': [911, 3598], 'inhibit': [913, 3600], 'membrane-type': [914, 1176, 3601, 3864], '-2,': [917, 3604], 'poor': [922, 3609], 'these': [925, 1112, 1270, 1908, 2723, 3013, 3612, 3799, 3958, 4598, 5414, 5704, 6599, 6889], 'enzymes': [926, 3613], '14Will': [962, 3649], 'Atkinson': [964, 3651], 'S.J.': [965, 3652], 'Butler': [966, 3653], 'G.S.': [967, 3654], '17119-17123Abstract': [977, 3664], '(506)': [985, 3672], 'However,': [988, 1107, 3675, 3794], 'specific.': [997, 3684], 'For': [998, 3685], 'example,': [999, 2559, 3686, 5250, 6434], 'TIMP-4': [1002, 3689], 'form': [1003, 2953, 3690, 5644, 6829], 'specific': [1004, 1927, 1956, 3691, 4618, 4647, 5800, 5829], 'pro-MMP-2': [1007, 3694], '(progelatinase': [1008, 3695], 'A),': [1009, 3696], 'can': [1012, 2159, 3699, 4850, 6032], 'bind': [1013, 3700], 'pro-MMP-9.': [1015, 3702], 'In': [1016, 2300, 3703, 4991, 6174], 'addition': [1017, 3704], 'their': [1019, 1894, 3085, 3706, 4584, 5776, 6961], 'as': [1021, 1820, 1830, 1900, 2116, 2129, 2197, 2420, 3708, 4510, 4520, 4590, 4807, 4820, 4888, 5111, 5989, 6002, 6070, 6294], 'pro-MMPs,': [1028, 3715], 'promote': [1030, 3717], 'growth': [1032, 2199, 3719, 4890, 6072], 'various': [1034, 3721], 'types': [1035, 3722], 'cells': [1037, 3724], 'culture': [1040, 3727], '(15Hayakawa': [1041, 2204, 3728, 4895, 6077], 'T.': [1042, 1062, 2205, 2225, 2516, 2921, 3729, 3749, 4896, 4916, 5207, 5612, 6078, 6098, 6391, 6797], 'Yamashita': [1043, 1063, 2206, 2226, 3730, 3750, 4897, 4917, 6079, 6099], 'Tanzawa': [1045, 2208, 3732, 4899, 6081], 'Uchijima': [1047, 2210, 3734, 4901, 6083], 'E.': [1048, 1066, 1087, 2211, 2229, 2246, 3735, 3753, 3774, 4902, 4920, 4937, 6084, 6102, 6119], 'Iwata': [1049, 2212, 3736, 4903, 6085], '298:': [1054, 2217, 3741, 4908, 6090], '29-31Crossref': [1055, 2218, 3742, 4909, 6091], '(645)': [1058, 2221, 3745, 4912, 6094], '16Hayakawa': [1061, 2224, 3748, 4915, 6097], 'Ohuchi': [1065, 2228, 3752, 4919, 6101], 'Shimagawa': [1067, 2230, 3754, 4921, 6103], 'Cell': [1070, 2233, 3757, 4924, 6106], '107:': [1073, 2236, 3760, 4927, 6109], '2373-2379Crossref': [1074, 2237, 3761, 4928, 6110], 'Scholar)': [1077, 2028, 2838, 3764, 4719, 5529, 5901, 6714], 'anti-angiogenic': [1080, 2202, 3767, 4893, 6075], '(17Anand-Apte': [1082, 3769], 'Pepper': [1084, 2243, 3771, 4934, 6116], 'M.S.': [1085, 2244, 3772, 4935, 6117], 'Voest': [1086, 2245, 3773, 4936, 6118], 'Montesano': [1088, 2247, 3775, 4938, 6120], 'Olsen': [1090, 2249, 3777, 4940, 6122], 'Apte': [1094, 2253, 3781, 4944, 6126], 'Zetter': [1096, 2255, 3783, 4946, 6128], 'Invest.': [1098, 2257, 3785, 4948, 6130], 'Opthalmol.': [1099, 2258, 3786, 4949, 6131], 'Visual': [1100, 2259, 3787, 4950, 6132], '38:': [1103, 2262, 3790, 4953, 6135], '817-823PubMed': [1104, 2263, 3791, 4954, 6136], 'basis': [1110, 1815, 1906, 2292, 3069, 3797, 4505, 4596, 4983, 5760, 6166, 6945], 'unknown.Crystallographic': [1115], 'structures': [1116, 1708, 3804, 4397], 'recently': [1119, 3807], 'reported': [1120, 3808], 'catalytic': [1128, 1173, 1429, 2505, 3816, 3861, 4117, 5196, 6380], 'stromelysin-1,': [1131, 3819], 'MMP-3ΔC': [1132, 3820], '(18Gomis-Rüth': [1133, 1377, 1749, 2319, 2681, 2961, 3821, 4065, 4438, 5010, 5372, 5652, 6193, 6557, 6837], 'F.-X.': [1134, 1378, 1750, 2320, 2682, 2962, 3822, 4066, 4439, 5011, 5373, 5653, 6194, 6558, 6838], 'Maskos': [1135, 1194, 1379, 1496, 1751, 1796, 2321, 2683, 2963, 3823, 3882, 4067, 4184, 4440, 4485, 5012, 5374, 5654, 6195, 6559, 6839], 'Betz': [1137, 1381, 1753, 2323, 2685, 2965, 3825, 4069, 4442, 5014, 5376, 5656, 6197, 6561, 6841], 'Bergner': [1139, 1383, 1755, 2325, 2687, 2967, 3827, 4071, 4444, 5016, 5378, 5658, 6199, 6563, 6843], 'Huber': [1141, 1184, 1385, 1486, 1757, 1786, 2327, 2689, 2969, 3829, 3872, 4073, 4174, 4446, 4475, 5018, 5380, 5660, 6201, 6565, 6845], 'R.': [1142, 1185, 1386, 1487, 1758, 1787, 2328, 2690, 2970, 3830, 3873, 4074, 4175, 4447, 4476, 5019, 5381, 5661, 6202, 6566, 6846], 'Yoshida': [1145, 1389, 1761, 2331, 2693, 2973, 3833, 4077, 4450, 5022, 5384, 5664, 6205, 6569, 6849], 'Bourenkov': [1151, 1395, 1767, 2337, 2699, 2979, 3839, 4083, 4456, 5028, 5390, 5670, 6211, 6575, 6855], 'G.P.': [1152, 1396, 1768, 2338, 2700, 2980, 3840, 4084, 4457, 5029, 5391, 5671, 6212, 6576, 6856], 'Bartunik': [1153, 1397, 1769, 2339, 2701, 2981, 3841, 4085, 4458, 5030, 5392, 5672, 6213, 6577, 6857], 'Bode': [1155, 1182, 1399, 1484, 1771, 1784, 2341, 2703, 2983, 3843, 3870, 4087, 4172, 4460, 4473, 5032, 5394, 5674, 6215, 6579, 6859], '389:': [1159, 1403, 1775, 2345, 2707, 2987, 3847, 4091, 4464, 5036, 5398, 5678, 6219, 6583, 6863], '77-81Crossref': [1160, 1404, 1776, 2346, 2708, 2988, 3848, 4092, 4465, 5037, 5399, 5679, 6220, 6584, 6864], '(508)': [1163, 1407, 1779, 2349, 2711, 2991, 3851, 4095, 4468, 5040, 5402, 5682, 6223, 6587, 6867], 'Scholar),': [1165, 1269, 2993, 3853, 3957, 5684, 6869], 'metalloproteinase': [1178, 1323, 1433, 2179, 3866, 4011, 4121, 4870, 6052], '(19Fernandez-Catalan': [1180, 1482, 3868, 4170], 'Turk': [1186, 1488, 1788, 3874, 4176, 4477], 'D.': [1187, 1489, 1789, 3875, 4177, 4478], 'Calvete': [1188, 1490, 1790, 3876, 4178, 4479], 'Lichte': [1190, 1492, 1792, 3878, 4180, 4481], 'Tschesche': [1192, 1494, 1794, 3880, 4182, 4483], 'EMBO': [1196, 1301, 1498, 1798, 3884, 3989, 4186, 4487], '1998;': [1198, 1257, 1500, 1800, 2388, 3886, 3945, 4188, 4489, 5079, 6262], '17:': [1199, 1501, 1801, 3887, 4189, 4490], '5238-5248Crossref': [1200, 1502, 1802, 3888, 4190, 4491], '(307)': [1203, 1505, 1805, 3891, 4193, 4494], 'Together': [1206, 3894], 'solution': [1209, 3897], 'NMR': [1210, 2355, 3898, 5046, 6229], 'TIMP-2,': [1217, 3905], 'N-TIMP-2': [1218, 3906], '(20Williamson': [1219, 3907], 'Martorell': [1221, 3909], 'Carr': [1223, 1250, 2381, 3911, 3938, 5072, 6255], 'M.D.': [1224, 1251, 2382, 3912, 3939, 5073, 6256], 'Feeney': [1231, 1246, 2377, 3919, 3934, 5068, 6251], '33:': [1235, 3923], '11745-11759Crossref': [1236, 3924], '(95)': [1239, 3927], '21Muskett': [1242, 3930], 'F.W.': [1243, 2374, 3931, 5065, 6248], 'Frenkiel': [1244, 2375, 3932, 5066, 6249], 'T.A.': [1245, 2376, 3933, 5067, 6250], '273:': [1258, 2389, 3946, 5080, 6263], '21736-21743Abstract': [1259, 2390, 3947, 5081, 6264], '(72)': [1267, 2398, 3955, 5089, 6272], 'consists': [1278, 3966], '5-stranded': [1281, 3969], 'β-barrel': [1282, 3970], 'α-helices,': [1286, 3974], 'resembling': [1287, 3975], 'folds': [1289, 3977], 'members': [1291, 3979], 'OB': [1294, 3982], '(oligonucleotide/oligosaccharide': [1295, 3983], 'binding)': [1296, 3984], '(22Murzin': [1299, 3987], 'A.G.': [1300, 3988], '1993;': [1303, 3991], '12:': [1304, 3992], '861-867Crossref': [1305, 3993], '(762)': [1308, 3996], 'reveals': [1314, 4002], 'principle': [1317, 4005], 'involve': [1324, 4012], 'pentapeptide': [1327, 4015], 'part': [1329, 1808, 4017, 4498], 'loop': [1332, 1344, 4020, 4032], 'β-strands': [1334, 4022], 'C': [1335, 4023], 'D;': [1337, 4025], 'other': [1338, 1477, 1645, 2041, 2194, 2470, 2487, 2951, 4026, 4165, 4334, 4732, 4885, 5161, 5178, 5642, 5914, 6067, 6344, 6362, 6827], 'A-B': [1343, 4031], 'some': [1346, 2069, 4034, 4760, 5942], 'residues': [1347, 1362, 1373, 1588, 2952, 3014, 4035, 4050, 4061, 4277, 5643, 5705, 6828, 6890], '(Fig.': [1352, 1447, 2134, 4040, 4135, 4825, 6007], 'A).': [1354, 4042], 'Three': [1355, 4043], 'quarters': [1356, 4044], 'all': [1358, 3006, 4046, 5697, 6882], 'contacts': [1359, 1451, 2724, 2954, 3008, 3053, 4047, 4139, 5415, 5645, 5699, 5744, 6600, 6830, 6884, 6929], 'adjacent': [1363, 4051], 'Cys70,': [1371, 4059], 'specifically': [1372, 1961, 4060, 4652, 5834], '1–5': [1374, 4062], '66–70': [1376, 4064], 'strategy': [1419, 3073, 4107, 5764, 6949], 'because': [1422, 4110], 'it': [1423, 2359, 2814, 3079, 4111, 5050, 5505, 5770, 6233, 6690, 6955], 'sits': [1424, 4112], 'top': [1426, 4114], 'Zn2+': [1430, 4118], 'coordinates': [1435, 4123], 'metal': [1437, 4125], 'ion': [1438, 4126], 'α-amino': [1441, 4129], 'group': [1442, 1446, 4130, 4134], 'carbonyl': [1445, 4133], 'B).': [1449, 4137], 'Similar': [1450, 4138], 'seen': [1453, 4141], 'TIMP-2·MT1-MMP': [1456, 4144], 'complex,': [1457, 4145], 'although': [1458, 4146], 'there': [1459, 1865, 2284, 4147, 4555, 4975, 6158], 'differences': [1461, 4149], 'relative': [1464, 1677, 4152, 4366], 'orientations': [1465, 4153], 'two': [1468, 4156], 'proteins': [1469, 4157], 'extensiveness': [1473, 4161], 'parts': [1478, 4166], 'Scholar).The': [1507], 'reactive': [1508, 2045, 2405, 2768, 4197, 4736, 5096, 5459, 5918, 6279, 6644], 'revealed': [1512, 4201], 'consistent': [1517, 4206], 'study': [1523, 1811, 4212, 4501], 'showed': [1525, 4214], 'lost': [1530, 4219], 'when': [1531, 4220], 'Val69-Cys70': [1533, 4222], 'cleaved': [1537, 4226], 'human': [1539, 4228], 'neutrophil': [1540, 4229], 'elastase,': [1541, 4230], 'cleavage': [1545, 4234], 'prevented': [1547, 4236], 'formation': [1550, 2372, 2632, 2676, 2810, 4239, 5063, 5323, 5367, 5501, 6246, 6508, 6552, 6686], 'MMP-3': [1554, 1679, 2309, 2318, 2443, 2466, 2956, 4243, 4368, 5000, 5009, 5134, 5157, 5647, 6183, 6192, 6317, 6340, 6832], '(23Nagase': [1555, 4244], 'Cawston': [1559, 4248], 'T.E.': [1560, 4249], '325:': [1566, 4255], '163-167Crossref': [1567, 4256], '(39)': [1570, 4259], 'Previous': [1573, 4262], 'mutational': [1574, 4263], 'studies': [1575, 1933, 4264, 4624, 5806], 'N-TIMP-1': [1577, 1649, 1837, 2066, 3010, 4266, 4338, 4527, 4757, 5701, 5939, 6886], 'also': [1578, 1862, 2068, 2368, 2427, 2564, 4267, 4552, 4759, 5059, 5118, 5255, 5941, 6242, 6301, 6439], 'at': [1582, 1876, 1885, 1969, 2095, 2119, 2282, 4271, 4566, 4575, 4660, 4786, 4810, 4973, 5842, 5968, 5992, 6156], 'number': [1584, 4273], 'sites': [1586, 1971, 4275, 4662, 5844], '18': [1589, 4278], '45': [1591, 4280], 'small': [1593, 4282], 'affinity': [1597, 1964, 2089, 2176, 2277, 2441, 2635, 4286, 4655, 4780, 4867, 4968, 5132, 5326, 5837, 5962, 6049, 6151, 6315, 6511], 'mutations': [1601, 2297, 2402, 4290, 4988, 5093, 6171, 6276, 6996], 'disrupt': [1603, 4292], 'Thr2,': [1612, 2772, 4301, 5463, 6648], 'Met66,': [1613, 4302], 'or': [1614, 1902, 2100, 2588, 2620, 4303, 4592, 4791, 5279, 5311, 5973, 6463, 6495], 'Val69': [1615, 1980, 4304, 4671, 5853], 'had': [1616, 4305], '(24Huang': [1621, 1680, 3022, 4310, 4369, 5713, 6898], 'Meng': [1623, 1682, 2010, 3024, 4312, 4371, 4701, 5715, 5883, 6900], 'Q.': [1624, 1683, 2011, 3025, 4313, 4372, 4702, 5716, 5884, 6901], '22086-22091Crossref': [1636, 1695, 2023, 3037, 4325, 4384, 4714, 5728, 5896, 6913], '(90)': [1639, 1698, 2026, 3040, 4328, 4387, 4717, 5731, 5899, 6916], 'Most': [1642, 4331], 'significantly,': [1643, 4332], 'perturb': [1648, 4337], 'approximately': [1652, 2663, 4341, 5354, 6539], 'equal': [1653, 4342], 'MMP-1,': [1658, 2083, 4347, 4774, 5956], 'MMP-2,': [1659, 2084, 4348, 4775, 5957], 'substitution': [1663, 2104, 2150, 2885, 4352, 4795, 4841, 5576, 5977, 6023, 6761], 'Ala': [1665, 4354], 'produces': [1668, 2109, 4357, 4800, 5982], '17-fold': [1670, 4359], 'greater': [1671, 2036, 4360, 4727, 5909], 'loss': [1672, 2867, 4361, 5558, 6743], 'MMP-1': [1676, 2478, 2551, 4365, 5169, 5242, 6353, 6426], 'This': [1701, 4390], 'accord': [1704, 4393], 'crystallographic': [1707, 4396], 'Ser2': [1716, 4405], 'interact': [1719, 2618, 4408, 5309, 6493], 'correspond': [1727, 4416], 'P1′': [1734, 1887, 4423, 4577], 'substrates,': [1738, 4427], 'role': [1745, 4434], '19Fernandez-Catalan': [1782, 4471], 'Scholar).As': [1807], 'step': [1822, 3064, 4512, 5755, 6940], 'toward': [1823, 2503, 3065, 4513, 5194, 5756, 6378, 6941], 'selective': [1829, 4519], 'we': [1833, 4523], 'characterized': [1835, 4525], 'mutants': [1838, 1981, 2604, 4528, 4672, 5295, 5854, 6479], 'Thr2.': [1842, 4532], 'major': [1851, 4541], 'correlation': [1868, 4558], 'effect': [1871, 2790, 4561, 5481, 6666], 'acid': [1875, 4565], 'position': [1877, 2096, 4567, 4787, 5969], 'same': [1883, 4573], 'respective': [1895, 4585], 'observations': [1909, 4599], 'discussed.DISCUSSIONThe': [1911], 'present': [1912, 2759, 3045, 4603, 5450, 5736, 5785, 6635, 6921], 'suggest': [1914, 4605, 5787], 'engineering': [1917, 4608, 5790], 'viable': [1922, 4613, 5795], 'approach': [1923, 4614, 5796], 'biological': [1936, 4627, 5809], 'facilitate': [1943, 4634, 5816], 'development': [1945, 1959, 4636, 4650, 5818, 5832], 'therapeutic': [1947, 4638, 5820], 'agents': [1948, 4639, 5821], 'diseases': [1950, 4641, 5823], 'high': [1963, 2634, 4654, 5325, 5836, 6510], 'will': [1966, 2154, 2590, 2605, 4657, 4845, 5281, 5296, 5839, 6027, 6465, 6480], 'require': [1967, 4658, 5840], 'multiple': [1970, 2595, 4661, 5286, 5843, 6470], 'properties': [1975, 2266, 4666, 4957, 5848, 6140], 'Met66': [1978, 2999, 4669, 5690, 5851, 6875], 'full-length': [1983, 2152, 4674, 4843, 5856, 6025], '(11Huang': [1985, 2735, 4676, 5426, 5858, 6611], '24Huang': [2008, 4699, 5881], 'much': [2035, 4726, 5908], 'than': [2040, 2467, 2484, 2727, 2818, 3020, 4731, 5158, 5175, 5418, 5509, 5711, 5913, 6341, 6359, 6603, 6694, 6896], 'components': [2042, 4733, 5915], '(see': [2047, 4738, 5920], 'Fig.': [2048, 4739, 5921], '3).': [2049, 4740, 5922], 'systematic': [2053, 4744, 5926], 'provide': [2057, 4748, 5930], 'information': [2058, 2287, 4749, 4978, 5931, 6161], 'determinants': [2061, 4752, 5934], 'enhanced': [2073, 4764, 5946], 'specificity.': [2074, 4765, 5947, 7000], 'Table': [2075, 4766, 5948], 'II': [2076, 4767, 5949], 'shows': [2077, 4768, 5950], 'best': [2080, 4771, 5953], 'based': [2087, 4778, 5960], 'selectivity,': [2091, 4782, 5964], '2:': [2097, 4788, 5970], 'valine,': [2098, 4789, 5971], 'leucine,': [2099, 2557, 4790, 5248, 5972, 6432], 'serine,': [2101, 4792, 5974], 'respectively.': [2102, 4793, 5975], 'Gly': [2106, 4797, 5979], 'essentially': [2114, 4805, 5987], 'inactive': [2115, 4806, 5988], 'concentrations': [2120, 4811, 5993], 'below': [2121, 4812, 5994], '100': [2122, 4813, 5995], 'nm': [2123, 4814, 5996], 'retains': [2125, 4816, 5998], 'indicated': [2130, 4821, 6003], 'CD': [2132, 4823, 6005], 'spectroscopy': [2133, 4824, 6006], '2).': [2135, 4826, 6008], 'isolated': [2138, 4829, 6011], 'C-domain': [2139, 3007, 4830, 5698, 6012, 6883], 'may': [2142, 2367, 2426, 2545, 4833, 5058, 5117, 5236, 6015, 6241, 6300, 6420], 'be': [2144, 2160, 2428, 2591, 2606, 2895, 4835, 4851, 5119, 5282, 5297, 5586, 6017, 6033, 6302, 6466, 6481, 6771], 'capable': [2145, 4836, 6018], 'folding,': [2147, 4838, 6020], 'Gly2': [2149, 2446, 4840, 5137, 6022, 6320], 'generate': [2155, 4846, 6028], 'used': [2161, 4852, 6034], 'investigate': [2163, 4854, 6036], 'molecule': [2172, 4863, 6045], 'determine': [2184, 4875, 6057], 'whether': [2185, 4876, 6058], 'protease-inhibitory': [2187, 4878, 6060], 'action': [2188, 4879, 6061], 'connected': [2192, 4883, 6065], 'functions': [2195, 4886, 6068], 'such': [2196, 4887, 6069], 'stimulation': [2200, 4891, 6073], '17Anand-Apte': [2241, 4932, 6114], 'Scholar).Some': [2265, 4956], 'side': [2269, 2615, 2881, 4960, 5306, 5572, 6143, 6490, 6757], 'chain': [2270, 2616, 2882, 4961, 5307, 5573, 6144, 6491, 6758], 'correlate': [2274, 4965, 6148], 'but,': [2281, 4972, 6155], 'present,': [2283, 4974, 6157], 'insufficient': [2286, 4977, 6160], 'explain': [2289, 4980, 6163], 'activity.': [2299, 4990, 6173], 'crystal': [2303, 2959, 4994, 5650, 6177, 6835], 'structure,': [2304, 4995, 6178], 'free': [2317, 2731, 2872, 5008, 5422, 5563, 6191, 6607, 6748], 'Based': [2352, 5043, 6226], 'N-TIMP-2,': [2358, 5049, 6232], 'appears': [2360, 5051, 6234], 'possible': [2361, 5052, 6235], 'conformational': [2363, 5054, 6237], 'changes': [2364, 5055, 6238], 'occur': [2369, 5060, 6243], '(21Muskett': [2373, 5064, 6247], 'Consequently,': [2401, 5092, 6275], 'could': [2407, 2894, 5098, 5585, 6281, 6770], 'affect': [2408, 5099, 6282, 6998], 'local': [2416, 5107, 6290], 'dynamics': [2417, 5108, 6291], '(as': [2418, 5109, 6292], 'well': [2419, 5110, 6293], 'structure).': [2421, 5112, 6295], 'Binding': [2422, 5113, 6296], 'affected': [2429, 2607, 5120, 5298, 6303, 6482], 'differentially': [2430, 5121, 6304], 'regions': [2432, 5123, 6306], 'distant': [2433, 5124, 6307], 'Cys1-Cys70': [2436, 5127, 6310], 'bond.': [2438, 5129, 6312], 'higher': [2440, 5131, 6314], 'mutant': [2447, 5138, 6321], 'suggests': [2448, 5139, 6322], 'outside': [2451, 5142, 6325], 'contribute': [2456, 5147, 6330], 'energy': [2461, 2732, 2873, 5152, 5423, 5564, 6335, 6608, 6749], 'MMPs.The': [2471, 5162], 'narrower': [2480, 5171, 6355], 'less': [2482, 2510, 2726, 2817, 3016, 5173, 5201, 5417, 5508, 5707, 6357, 6385, 6602, 6693, 6892], 'deep': [2483, 2511, 5174, 5202, 6358, 6386], 'Arginine': [2489, 5180, 6364], '195,': [2490, 5181, 6365], 'replaces': [2492, 5183, 6367], 'leucine': [2493, 5184, 6368], 'MMP-2': [2495, 5186, 6370], 'projects': [2498, 5189, 6373], 'Zn2+,': [2506, 5197, 6381], 'resulting': [2507, 5198, 6382], 'cationic': [2513, 5204, 6388], '(31Stams': [2515, 5206, 6390], 'Spurlino': [2517, 5208, 6392], 'J.C.': [2518, 5209, 6393], 'D.L.': [2520, 5211, 6395], 'Wahl': [2521, 5212, 6396], 'R.C.': [2522, 5213, 6397], 'Ho': [2523, 5214, 6398], 'T.F.': [2524, 5215, 6399], 'Qoronfleh': [2525, 5216, 6400], 'M.W.': [2526, 5217, 6401], 'Banks': [2527, 5218, 6402], 'T.M.': [2528, 5219, 6403], 'Rubin': [2529, 5220, 6404], 'Nat.': [2531, 5222, 6406], 'Struct.': [2532, 5223, 6407], '1:': [2535, 5226, 6410], '119-123Crossref': [2536, 5227, 6411], '(201)': [2539, 5230, 6414], 'reduced': [2543, 5234, 6418], 'depth': [2544, 5235, 6419], 'account': [2546, 5237, 6421], 'preference': [2549, 5240, 6424], 'valine': [2553, 5244, 6428], 'over': [2556, 5247, 6431], 'charge': [2561, 5252, 6436], 'repulsion': [2562, 5253, 6437], 'likely': [2566, 5257, 6441], 'factor': [2567, 5258, 6442], 'unfavorable': [2570, 5261, 6445], 'positively': [2573, 5264, 6448], 'charged': [2574, 5265, 6449], 'substituents': [2575, 5266, 6450], 'MMP-1.': [2577, 5268, 6452], 'no': [2585, 5276, 6460], 'bound': [2586, 5277, 6461], 'expected': [2592, 5283, 6467], 'contain': [2594, 5285, 6469], 'solvent': [2596, 2622, 5287, 5313, 6471, 6497], 'molecules': [2597, 5288, 6472], 'so': [2598, 5289, 6473], 'displace': [2621, 5312, 6496], 'molecules.Large': [2623, 5314], 'areas': [2624, 5315, 6500], 'molecular': [2626, 5317, 6502], 'surface': [2627, 2669, 5318, 5360, 6503, 6545], 'become': [2628, 5319, 6504], 'buried': [2629, 2674, 2807, 5320, 5365, 5498, 6505, 6550, 6683], 'heterologous': [2636, 5327, 6512], 'protein-protein': [2637, 2918, 5328, 5609, 6513, 6794], '(32Jones': [2639, 5330, 6515], 'Thornton': [2641, 5332, 6517], 'J.M.': [2642, 5333, 6518], '93:': [2651, 2943, 5342, 5634, 6527, 6819], '13-20Crossref': [2652, 5343, 6528], '(2254)': [2655, 5346, 6531], 'It': [2658, 5349, 6534], 'estimated': [2661, 5352, 6537], '1300': [2664, 5355, 6540], 'Å2': [2665, 5356, 6541], 'accessible': [2668, 5359, 6544], 'component': [2672, 5363, 6548], 'accounts': [2719, 2815, 5410, 5506, 6595, 6691], 'few': [2721, 5412, 6597], '10%': [2728, 5419, 6604], 'single': [2764, 5455, 6640], 'N-TIMP-1,': [2771, 5462, 6647], 'exerts': [2773, 5464, 6649], 'strength': [2779, 2915, 5470, 5606, 6655, 6791], 'magnitude': [2787, 5478, 6663], 'surprising': [2792, 5483, 6668], 'because,': [2793, 5484, 6669], 'even': [2794, 5485, 6670], 'if': [2795, 5486, 6671], 'environment': [2797, 5488, 6673], 'changed': [2800, 5491, 6676], 'being': [2802, 5493, 6678], 'totally': [2803, 5494, 6679], 'exposed': [2804, 5495, 6680], '100%': [2806, 5497, 6682], 'protease,': [2813, 5504, 6689], '8%': [2819, 5510, 6695], '(102/1300': [2820, 5511, 6696], 'Å': [2821, 5512, 6697], '(2Nagase': [2822, 5513, 6698], 'area': [2841, 5532, 6717], 'protein−protein': [2844, 5535, 6720], '(33Miller': [2847, 5538, 6723], 'Janin': [2849, 5540, 6725], 'Lesk': [2851, 5542, 6727], 'A.M.': [2852, 5543, 6728], 'Chothia': [2853, 5544, 6729], 'Mol.': [2856, 5547, 6732], '1987;': [2858, 5549, 6734], '196:': [2859, 5550, 6735], '641-656Crossref': [2860, 5551, 6736], '(826)': [2863, 5554, 6739], '33–55%': [2869, 5560, 6745], 'removal': [2877, 3004, 5568, 5695, 6753, 6880], 'glycine': [2887, 5578, 6763], 'indicates': [2888, 3011, 5579, 5702, 6764, 6887], 'designated': [2896, 5587, 6772], '"hot': [2898, 5589, 6774], 'spot"': [2899, 5590, 6775], 'TIMP/MMP': [2902, 5593, 6778], 'interface,': [2904, 5595, 6780], 'uniquely': [2910, 5601, 6786], '(34Clackson': [2920, 5611, 6796], 'Wells': [2922, 5613, 6798], 'J.A.': [2923, 2934, 5614, 5625, 6799, 6810], 'Science.': [2924, 5615, 6800], '383-386Crossref': [2927, 5618, 6803], '(1772)': [2930, 5621, 6806], '35Wells': [2933, 5624, 6809], '1-6Crossref': [2944, 5635, 6820], '(359)': [2947, 5638, 6823], 'Many': [2950, 5641, 6826], 'mutagenesis': [2995, 5686, 6871], 'others,': [2997, 5688, 6873], 'particularly': [2998, 5689, 6874], 'Val69,': [3001, 5692, 6877], 'Thus,': [3043, 5734, 6919], 'nature': [3050, 5741, 6926], 'understanding': [3066, 5757, 6942], 'TIMP,': [3077, 5768, 6953], 'experimentally': [3083, 5774, 6959], 'evaluate': [3084, 5775, 6960], 'contributions': [3086, 5777, 6962], 'complex.': [3092, 5783, 6968], 'Mammalian': [3369], 'unknown.': [3802], 'Crystallographic': [3803], 'As': [4497], 'discussed.': [4601], 'DISCUSSIONThe': [4602], 'Some': [6139], 'molecules.': [6498], 'Large': [6499], 'We': [6969], 'thank': [6970], 'Dr.': [6971], 'Per': [6972], 'Nissen,': [6973], 'Dept.': [6974], 'Biology': [6976], 'Nature': [6978], 'Conservation,': [6979], 'Agricultural': [6980], 'University': [6981], 'Norway,': [6983], 'drawing': [6985], 'our': [6986], 'attention': [6987], 'usefulness': [6990], 'log−log': [6992], 'plots': [6993], 'identifying': [6995]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2089481053', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-12T12:22:04.977439', 'created_date': '2016-06-24'}