Title: Consumption of barley β-glucan ameliorates fatty liver and insulin resistance in mice fed a high-fat diet
Abstract: Molecular Nutrition & Food ResearchVolume 54, Issue 7 p. 1004-1013 Research Article Consumption of barley β-glucan ameliorates fatty liver and insulin resistance in mice fed a high-fat diet Joo Sun Choi, Joo Sun Choi Division of Metabolic Diseases, Center for Biomedical Science, National Institute of Health, Tongillo, Eunpyung-gu, Seoul, Korea These authors have contributed equally to this work.Search for more papers by this authorHyunsook Kim, Hyunsook Kim Division of Metabolic Diseases, Center for Biomedical Science, National Institute of Health, Tongillo, Eunpyung-gu, Seoul, Korea These authors have contributed equally to this work.Search for more papers by this authorMyeong Ho Jung, Myeong Ho Jung Division of Metabolic Diseases, Center for Biomedical Science, National Institute of Health, Tongillo, Eunpyung-gu, Seoul, KoreaSearch for more papers by this authorShinhee Hong, Shinhee Hong Division of Metabolic Diseases, Center for Biomedical Science, National Institute of Health, Tongillo, Eunpyung-gu, Seoul, KoreaSearch for more papers by this authorJihyun Song, Corresponding Author Jihyun Song [email protected] Division of Metabolic Diseases, Center for Biomedical Science, National Institute of Health, Tongillo, Eunpyung-gu, Seoul, KoreaDivision of Metabolic Diseases, Center for Biomedical Science, National Institute of Health 194, Tongillo, Eunpyung-gu, Seoul, 122-701 Korea Fax:+82-2-354-1057Search for more papers by this author Joo Sun Choi, Joo Sun Choi Division of Metabolic Diseases, Center for Biomedical Science, National Institute of Health, Tongillo, Eunpyung-gu, Seoul, Korea These authors have contributed equally to this work.Search for more papers by this authorHyunsook Kim, Hyunsook Kim Division of Metabolic Diseases, Center for Biomedical Science, National Institute of Health, Tongillo, Eunpyung-gu, Seoul, Korea These authors have contributed equally to this work.Search for more papers by this authorMyeong Ho Jung, Myeong Ho Jung Division of Metabolic Diseases, Center for Biomedical Science, National Institute of Health, Tongillo, Eunpyung-gu, Seoul, KoreaSearch for more papers by this authorShinhee Hong, Shinhee Hong Division of Metabolic Diseases, Center for Biomedical Science, National Institute of Health, Tongillo, Eunpyung-gu, Seoul, KoreaSearch for more papers by this authorJihyun Song, Corresponding Author Jihyun Song [email protected] Division of Metabolic Diseases, Center for Biomedical Science, National Institute of Health, Tongillo, Eunpyung-gu, Seoul, KoreaDivision of Metabolic Diseases, Center for Biomedical Science, National Institute of Health 194, Tongillo, Eunpyung-gu, Seoul, 122-701 Korea Fax:+82-2-354-1057Search for more papers by this author First published: 05 July 2010 https://doi.org/10.1002/mnfr.200900127Citations: 86 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Consumption of a diet high in barley β-glucan (BG) has been shown to prevent insulin resistance. To investigate the mechanism for the effects of barley BG, three groups of male 7-wk-old C57BL/6J mice were fed high-fat diets containing 0, 2, or 4% of barley BG for 12 wk. The 2% BG and 4% BG groups had significantly lower body weights compared with the 0% BG group. The 4% BG group demonstrated improved glucose tolerance and lower levels of insulin-resistance index and glucose-dependent insulinotropic polypeptide. Consumption of the BG diet decreased hepatic lipid content. Mice on the BG diet also demonstrated decreased fatty acid synthase and increased cholesterol 7α-hydroxylase gene expression levels. The BG diet promoted hepatic insulin signaling by decreasing serine phosphorylation of insulin receptor substrate 1 and activating Akt, and it decreased mRNA levels of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase. In summary, consumption of BG reduced weight gain, decreased hepatic lipid accumulation, and improved insulin sensitivity in mice fed a high-fat diet. Insulin signaling enhanced due to the expression changes of glucose and lipid metabolism genes by BG consumption. Consumption of barley BG could be an effective strategy for preventing obesity, insulin resistance, and the metabolic syndrome. 5 References 1Bonora, E., Kiechl, S., Willeit, J., Oberhollenzer, F. et al., Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. Diabetes 1998, 47, 1643–1649. 2Hauner, H., Insulin resistance and the metabolic syndrome – a challenge of the new millennium. Eur. J. Clin. Nutr. 2003, 56, S25–S29. 3Roth, J. 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Publication Year: 2010
Publication Date: 2010-01-28
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 108
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