Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2089368195', 'doi': 'https://doi.org/10.2332/allergolint.13-rai-0678', 'title': 'Serum Periostin: A Novel Biomarker for Asthma Management', 'display_name': 'Serum Periostin: A Novel Biomarker for Asthma Management', 'publication_year': 2014, 'publication_date': '2014-01-01', 'ids': {'openalex': 'https://openalex.org/W2089368195', 'doi': 'https://doi.org/10.2332/allergolint.13-rai-0678', 'mag': '2089368195', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24759559'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2332/allergolint.13-rai-0678', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116585092', 'display_name': 'Allergology International', 'issn_l': '1323-8930', 'issn': ['1323-8930', '1440-1592'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.2332/allergolint.13-rai-0678', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020149922', 'display_name': 'Hisako Matsumoto', 'orcid': 'https://orcid.org/0000-0002-8754-6318'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Hisako Matsumoto', 'raw_affiliation_strings': ['Department of Respiratory Medicine Kyoto University Kyoto Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Respiratory Medicine Kyoto University Kyoto Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5020149922'], 'corresponding_institution_ids': ['https://openalex.org/I22299242'], 'apc_list': {'value': 2280, 'currency': 'USD', 'value_usd': 2280, 'provenance': 'doaj'}, 'apc_paid': {'value': 2280, 'currency': 'USD', 'value_usd': 2280, 'provenance': 'doaj'}, 'fwci': 1.871, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 97, 'citation_normalized_percentile': {'value': 0.999191, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '63', 'issue': '2', 'first_page': '153', 'last_page': '160'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12418', 'display_name': 'Respiratory and Cough-Related Research', 'score': 0.9864, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12528', 'display_name': 'IL-33, ST2, and ILC Pathways', 'score': 0.9817, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/periostin', 'display_name': 'Periostin', 'score': 0.9900853}], 'concepts': [{'id': 'https://openalex.org/C2777699602', 'wikidata': 'https://www.wikidata.org/wiki/Q18035545', 'display_name': 'Periostin', 'level': 3, 'score': 0.9900853}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.79570365}, {'id': 'https://openalex.org/C2776042228', 'wikidata': 'https://www.wikidata.org/wiki/Q35869', 'display_name': 'Asthma', 'level': 2, 'score': 0.7898545}, {'id': 'https://openalex.org/C2779758542', 'wikidata': 'https://www.wikidata.org/wiki/Q2106364', 'display_name': 'Eosinophilic', 'level': 2, 'score': 0.73743284}, {'id': 'https://openalex.org/C2781197716', 'wikidata': 'https://www.wikidata.org/wiki/Q864574', 'display_name': 'Biomarker', 'level': 2, 'score': 0.7256253}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.63303214}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.46851516}, {'id': 'https://openalex.org/C2781142857', 'wikidata': 'https://www.wikidata.org/wiki/Q5420174', 'display_name': 'Exhaled nitric oxide', 'level': 4, 'score': 0.44991183}, {'id': 'https://openalex.org/C2776252253', 'wikidata': 'https://www.wikidata.org/wiki/Q7663815', 'display_name': 'Systemic inflammation', 'level': 3, 'score': 0.32248265}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.23909178}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.057614416}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D015815', 'descriptor_name': 'Cell Adhesion Molecules', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D056151', 'descriptor_name': 'Airway Remodeling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018927', 'descriptor_name': 'Anti-Asthmatic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018927', 'descriptor_name': 'Anti-Asthmatic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D015815', 'descriptor_name': 'Cell Adhesion Molecules', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019468', 'descriptor_name': 'Disease Management', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004804', 'descriptor_name': 'Eosinophils', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004804', 'descriptor_name': 'Eosinophils', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D004804', 'descriptor_name': 'Eosinophils', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2332/allergolint.13-rai-0678', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116585092', 'display_name': 'Allergology International', 'issn_l': '1323-8930', 'issn': ['1323-8930', '1440-1592'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/2c4a2c5baf34436f89b1e8f78d303d63', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24759559', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2332/allergolint.13-rai-0678', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S116585092', 'display_name': 'Allergology International', 'issn_l': '1323-8930', 'issn': ['1323-8930', '1440-1592'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.69}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W1480416172', 'https://openalex.org/W1805755361', 'https://openalex.org/W1970245716', 'https://openalex.org/W1972268671', 'https://openalex.org/W1972979290', 'https://openalex.org/W1978995149', 'https://openalex.org/W1981782394', 'https://openalex.org/W1984066690', 'https://openalex.org/W1984384057', 'https://openalex.org/W1989882955', 'https://openalex.org/W1995024650', 'https://openalex.org/W1999039702', 'https://openalex.org/W2005282716', 'https://openalex.org/W2011487006', 'https://openalex.org/W2013105339', 'https://openalex.org/W2014769346', 'https://openalex.org/W2018892195', 'https://openalex.org/W2021701428', 'https://openalex.org/W2026981830', 'https://openalex.org/W2032080656', 'https://openalex.org/W2032110591', 'https://openalex.org/W2033038444', 'https://openalex.org/W2046313062', 'https://openalex.org/W2047882259', 'https://openalex.org/W2063801679', 'https://openalex.org/W2066251250', 'https://openalex.org/W2076393307', 'https://openalex.org/W2080317016', 'https://openalex.org/W2082881223', 'https://openalex.org/W2083318788', 'https://openalex.org/W2089046927', 'https://openalex.org/W2092387947', 'https://openalex.org/W2095754126', 'https://openalex.org/W2099429774', 'https://openalex.org/W2106715003', 'https://openalex.org/W2108919922', 'https://openalex.org/W2112904080', 'https://openalex.org/W2117441064', 'https://openalex.org/W2118746967', 'https://openalex.org/W2121627842', 'https://openalex.org/W2121954044', 'https://openalex.org/W2124566107', 'https://openalex.org/W2127482775', 'https://openalex.org/W2132380956', 'https://openalex.org/W2138538481', 'https://openalex.org/W2148637982', 'https://openalex.org/W2149317841', 'https://openalex.org/W2149686080', 'https://openalex.org/W2150035260', 'https://openalex.org/W2164092307', 'https://openalex.org/W2164111564', 'https://openalex.org/W2166142092', 'https://openalex.org/W2167829087', 'https://openalex.org/W2168421693', 'https://openalex.org/W2182306628', 'https://openalex.org/W2316052637', 'https://openalex.org/W2440788877', 'https://openalex.org/W2496928257', 'https://openalex.org/W3093672339'], 'related_works': ['https://openalex.org/W4281491362', 'https://openalex.org/W2990092627', 'https://openalex.org/W2954737486', 'https://openalex.org/W2593423078', 'https://openalex.org/W2373590828', 'https://openalex.org/W2338386049', 'https://openalex.org/W2256456193', 'https://openalex.org/W2159168168', 'https://openalex.org/W2138787051', 'https://openalex.org/W2005818888'], 'abstract_inverted_index': {'Chronic': [0], 'airway': [1, 33], 'inflammation': [2, 24, 50, 103], 'and': [3, 25, 51, 99], 'remodeling': [4, 52], 'are': [5, 18, 36, 40, 139], 'fundamental': [6], 'features': [7], 'of': [8, 32, 53, 76, 95, 131], 'asthma.': [9], 'Even': [10], 'with': [11, 89, 106], 'adequate': [12], 'inhaled': [13], 'corticosteroid': [14], '(ICS)': [15], 'treatment,': [16], 'there': [17], 'still': [19], 'patients': [20, 65, 105], 'who': [21, 66], 'exhibit': [22], 'Th2/eosinophilic': [23, 49, 125], 'develop': [26], 'airflow': [27], 'limitation,': [28], 'a': [29, 85, 93, 117], 'functional': [30], 'consequence': [31], 'remodeling.': [34], 'There': [35], 'few': [37], 'biomarkers': [38, 60, 138], 'that': [39, 46], 'applicable': [41], 'in': [42, 84, 104], 'the': [43, 54, 74, 128], 'clinical': [44], 'setting': [45], 'reflect': [47], 'refractory': [48, 100, 124], 'asthmatic': [55], 'airways.': [56], 'Therefore,': [57], 'establishing': [58], 'such': [59], 'is': [61], 'essential': [62], 'for': [63, 120], 'managing': [64], 'suffer': [67], 'from': [68], 'these': [69], 'conditions.': [70], 'This': [71], 'review': [72], 'addresses': [73], 'importance': [75], 'serum': [77, 113, 132], 'periostin': [78, 90, 114, 133], 'measurements': [79], 'by': [80], 'describing': [81], 'observations': [82], 'made': [83], 'KiHAC': [86], 'multicenter': [87], 'cohort': [88], 'used': [91], 'as': [92, 134], 'marker': [94], 'pulmonary': [96], 'function': [97], 'decline': [98], 'Th2/': [101], 'eosinophilic': [102], 'asthma': [107], 'receiving': [108], 'long-term': [109], 'ICS': [110], 'treatment.': [111], 'Furthermore,': [112], 'could': [115], 'be': [116], 'companion': [118], 'diagnostic': [119], 'targeted': [121], 'therapy': [122], 'against': [123], 'inflammation.': [126], 'Finally,': [127], 'distinct': [129], 'characteristics': [130], 'compared': [135], 'to': [136], 'conventional': [137], 'addressed.': [140]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2089368195', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 7}], 'updated_date': '2024-12-10T23:25:59.515174', 'created_date': '2016-06-24'}