Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2088872576', 'doi': 'https://doi.org/10.1158/1535-7163.targ-13-a278', 'title': 'Abstract A278: ARQ 087, a multi-tyrosine kinase inhibitor with potent in vitro and in vivo activity in FGFR2 driven models.', 'display_name': 'Abstract A278: ARQ 087, a multi-tyrosine kinase inhibitor with potent in vitro and in vivo activity in FGFR2 driven models.', 'publication_year': 2013, 'publication_date': '2013-11-01', 'ids': {'openalex': 'https://openalex.org/W2088872576', 'doi': 'https://doi.org/10.1158/1535-7163.targ-13-a278', 'mag': '2088872576'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.targ-13-a278', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068642499', 'display_name': 'Daniel T. Dransfield', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121633', 'display_name': 'Arqule (United States)', 'ror': 'https://ror.org/02nftnt56', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121633']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel Dransfield', 'raw_affiliation_strings': ['ArQule Inc., Woburn, MA'], 'affiliations': [{'raw_affiliation_string': 'ArQule Inc., Woburn, MA', 'institution_ids': ['https://openalex.org/I4210121633']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100628090', 'display_name': 'Jennifer Lee', 'orcid': 'https://orcid.org/0000-0001-6873-6629'}, 'institutions': [{'id': 'https://openalex.org/I4210121633', 'display_name': 'Arqule (United States)', 'ror': 'https://ror.org/02nftnt56', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121633']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jennifer Lee', 'raw_affiliation_strings': ['ArQule Inc., Woburn, MA'], 'affiliations': [{'raw_affiliation_string': 'ArQule Inc., Woburn, MA', 'institution_ids': ['https://openalex.org/I4210121633']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069559870', 'display_name': 'Carol Waghorne', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121633', 'display_name': 'Arqule (United States)', 'ror': 'https://ror.org/02nftnt56', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121633']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carol Waghorne', 'raw_affiliation_strings': ['ArQule Inc., Woburn, MA'], 'affiliations': [{'raw_affiliation_string': 'ArQule Inc., Woburn, MA', 'institution_ids': ['https://openalex.org/I4210121633']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007296799', 'display_name': 'Cathy Bull', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121633', 'display_name': 'Arqule (United States)', 'ror': 'https://ror.org/02nftnt56', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121633']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cathy Bull', 'raw_affiliation_strings': ['ArQule Inc., Woburn, MA'], 'affiliations': [{'raw_affiliation_string': 'ArQule Inc., Woburn, MA', 'institution_ids': ['https://openalex.org/I4210121633']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007307218', 'display_name': 'Ronald E. Savage', 'orcid': 'https://orcid.org/0000-0001-5374-7106'}, 'institutions': [{'id': 'https://openalex.org/I4210121633', 'display_name': 'Arqule (United States)', 'ror': 'https://ror.org/02nftnt56', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121633']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ronald E. Savage', 'raw_affiliation_strings': ['ArQule Inc., Woburn, MA'], 'affiliations': [{'raw_affiliation_string': 'ArQule Inc., Woburn, MA', 'institution_ids': ['https://openalex.org/I4210121633']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033457775', 'display_name': 'Xiaolan Zhao', 'orcid': 'https://orcid.org/0000-0002-8302-6905'}, 'institutions': [{'id': 'https://openalex.org/I4210121633', 'display_name': 'Arqule (United States)', 'ror': 'https://ror.org/02nftnt56', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121633']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiaolan Zhao', 'raw_affiliation_strings': ['ArQule Inc., Woburn, MA'], 'affiliations': [{'raw_affiliation_string': 'ArQule Inc., Woburn, MA', 'institution_ids': ['https://openalex.org/I4210121633']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044818161', 'display_name': 'Shipeng Yuan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121633', 'display_name': 'Arqule (United States)', 'ror': 'https://ror.org/02nftnt56', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121633']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shipeng Yuan', 'raw_affiliation_strings': ['ArQule Inc., Woburn, MA'], 'affiliations': [{'raw_affiliation_string': 'ArQule Inc., Woburn, MA', 'institution_ids': ['https://openalex.org/I4210121633']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015924611', 'display_name': 'Edward Chang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121633', 'display_name': 'Arqule (United States)', 'ror': 'https://ror.org/02nftnt56', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121633']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Edward Chang', 'raw_affiliation_strings': ['ArQule Inc., Woburn, MA'], 'affiliations': [{'raw_affiliation_string': 'ArQule Inc., Woburn, MA', 'institution_ids': ['https://openalex.org/I4210121633']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006194586', 'display_name': 'Enkeleda Nakuci', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121633', 'display_name': 'Arqule (United States)', 'ror': 'https://ror.org/02nftnt56', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121633']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Enkeleda Nakuci', 'raw_affiliation_strings': ['ArQule Inc., Woburn, MA'], 'affiliations': [{'raw_affiliation_string': 'ArQule Inc., Woburn, MA', 'institution_ids': ['https://openalex.org/I4210121633']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041253361', 'display_name': 'Sudharshan Eathiraj', 'orcid': 'https://orcid.org/0000-0002-7260-8846'}, 'institutions': [{'id': 'https://openalex.org/I4210121633', 'display_name': 'Arqule (United States)', 'ror': 'https://ror.org/02nftnt56', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121633']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sudharshan Eathiraj', 'raw_affiliation_strings': ['ArQule Inc., Woburn, MA'], 'affiliations': [{'raw_affiliation_string': 'ArQule Inc., Woburn, MA', 'institution_ids': ['https://openalex.org/I4210121633']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058333660', 'display_name': 'Susan Cornell-Kennon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121633', 'display_name': 'Arqule (United States)', 'ror': 'https://ror.org/02nftnt56', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121633']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Susan Cornell-Kennon', 'raw_affiliation_strings': ['ArQule Inc., Woburn, MA'], 'affiliations': [{'raw_affiliation_string': 'ArQule Inc., Woburn, MA', 'institution_ids': ['https://openalex.org/I4210121633']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018984165', 'display_name': 'Xiubin Gu', 'orcid': 'https://orcid.org/0009-0004-8698-7842'}, 'institutions': [{'id': 'https://openalex.org/I4210121633', 'display_name': 'Arqule (United States)', 'ror': 'https://ror.org/02nftnt56', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121633']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiubin Gu', 'raw_affiliation_strings': ['ArQule Inc., Woburn, MA'], 'affiliations': [{'raw_affiliation_string': 'ArQule Inc., Woburn, MA', 'institution_ids': ['https://openalex.org/I4210121633']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030442342', 'display_name': 'Syed Muhammad Adnan Ali', 'orcid': 'https://orcid.org/0000-0002-1783-4437'}, 'institutions': [{'id': 'https://openalex.org/I4210121633', 'display_name': 'Arqule (United States)', 'ror': 'https://ror.org/02nftnt56', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121633']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Syed Ali', 'raw_affiliation_strings': ['ArQule Inc., Woburn, MA'], 'affiliations': [{'raw_affiliation_string': 'ArQule Inc., Woburn, MA', 'institution_ids': ['https://openalex.org/I4210121633']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5013780845', 'display_name': 'Chang-Rung Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210121633', 'display_name': 'Arqule (United States)', 'ror': 'https://ror.org/02nftnt56', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121633']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chang-Rung Chen', 'raw_affiliation_strings': ['ArQule Inc., Woburn, MA'], 'affiliations': [{'raw_affiliation_string': 'ArQule Inc., Woburn, MA', 'institution_ids': ['https://openalex.org/I4210121633']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.258, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.518181, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 78}, 'biblio': {'volume': '12', 'issue': '11_Supplement', 'first_page': 'A278', 'last_page': 'A278'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12287', 'display_name': 'Fibroblast Growth Factor Research', 'score': 0.9671, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12287', 'display_name': 'Fibroblast Growth Factor Research', 'score': 0.9671, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C82867764', 'wikidata': 'https://www.wikidata.org/wiki/Q24780051', 'display_name': 'Fibroblast growth factor receptor', 'level': 4, 'score': 0.6873884}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.662443}, {'id': 'https://openalex.org/C49418065', 'wikidata': 'https://www.wikidata.org/wiki/Q14914258', 'display_name': 'Fibroblast growth factor receptor 1', 'level': 4, 'score': 0.65701896}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.57917076}, {'id': 'https://openalex.org/C66400584', 'wikidata': 'https://www.wikidata.org/wiki/Q5446458', 'display_name': 'Fibroblast growth factor receptor 4', 'level': 5, 'score': 0.56742096}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.5439709}, {'id': 'https://openalex.org/C2778820342', 'wikidata': 'https://www.wikidata.org/wiki/Q906415', 'display_name': 'Tyrosine-kinase inhibitor', 'level': 3, 'score': 0.4426965}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42595965}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.42420584}, {'id': 'https://openalex.org/C74373430', 'wikidata': 'https://www.wikidata.org/wiki/Q24727126', 'display_name': 'Fibroblast growth factor', 'level': 3, 'score': 0.40378588}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.38315254}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.32949436}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.30570322}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.30392888}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.30298227}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.26823246}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.24570909}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18920633}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.targ-13-a278', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.74, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4302090160', 'https://openalex.org/W4248721660', 'https://openalex.org/W4241983134', 'https://openalex.org/W4205487352', 'https://openalex.org/W2358034211', 'https://openalex.org/W2357666146', 'https://openalex.org/W2353864019', 'https://openalex.org/W2095813250', 'https://openalex.org/W2080073026', 'https://openalex.org/W1972710202'], 'abstract_inverted_index': {'Abstract': [0], 'Fibroblast': [1], 'growth': [2, 239], 'factors': [3], '(FGF)': [4], 'and': [5, 23, 39, 75, 130, 148, 152, 162, 198, 225, 250, 298, 300, 320, 329, 343, 362, 385, 443, 461], 'their': [6], 'receptors': [7, 35, 184], '(FGFR)': [8], 'play': [9], 'important': [10], 'roles': [11], 'in': [12, 48, 81, 137, 142, 164, 196, 220, 253, 280, 292, 304, 333, 339, 341, 344, 360, 363, 366, 390, 441, 444, 447], 'cell': [13, 15, 17, 19, 61, 66, 238, 247], 'proliferation,': [14], 'differentiation,': [16], 'migration,': [18], 'survival,': [20], 'protein': [21], 'synthesis,': [22], 'angiogenesis.': [24], 'The': [25, 235], 'FGFR': [26, 43, 98, 181, 323], 'family': [27, 182], 'consists': [28], 'of': [29, 42, 51, 97, 176, 183, 192, 217, 237, 263, 316, 318, 454], 'four': [30], 'genes': [31], 'encoding': [32], 'tyrosine': [33], 'kinase': [34, 356, 437], '(FGFR1,': [36], 'FGFR2,': [37, 125], 'FGFR3,': [38, 129], 'FGFR4).': [40], 'Dysregulation': [41], 'signaling': [44], 'has': [45, 90], 'been': [46], 'implicated': [47], 'a': [49, 92, 106, 116, 171, 190, 305, 379, 435], 'number': [50], 'developmental': [52], 'syndromes': [53], 'as': [54, 56, 83, 105, 167], 'well': [55, 168], 'cancers,': [57], 'e.g.,': [58], 'squamous': [59], 'non-small': [60], 'lung': [62, 67], 'cancer': [63, 68], '(NSCLC),': [64], 'small': [65], '(SCLC),': [69], 'gastric,': [70], 'liver,': [71], 'breast,': [72], 'ovarian,': [73], 'endometrial,': [74], 'bladder': [76], 'carcinomas,': [77], 'fueling': [78], 'significant': [79], 'interest': [80], 'FGFRs': [82], 'targets': [84], 'for': [85, 108], 'therapeutic': [86], 'intervention.': [87], 'ArQule,': [88], 'Inc.': [89], 'discovered': [91], 'novel,': [93], 'ATP': [94], 'competitive': [95], 'class': [96], 'inhibitors': [99], 'from': [100], 'which': [101], 'ARQ': [102, 113, 155, 207, 212, 244, 283, 288, 336, 350, 433], '087': [103, 114, 156, 213, 284, 289, 337, 351], 'emerged': [104], 'candidate': [107], 'advancement': [109], 'into': [110], 'clinical': [111, 375, 393], 'development.': [112], 'is': [115, 352, 383, 388], 'potent': [117, 215, 359, 440], 'multi-kinase': [118], 'inhibitor': [119, 357, 438], 'with': [120, 201, 206, 242, 358, 439], 'pan-FGFR': [121], 'activity': [122, 365, 446], 'against': [123], 'FGFR1,': [124, 160], 'mutant': [126], 'FGFR2': [127, 149, 193, 218, 264, 270, 319, 367, 448], '(N549H),': [128], 'FGFR4': [131], 'kinases,': [132], 'all': [133, 228], 'exhibiting': [134], 'IC50': [135], 'values': [136], 'the': [138, 174, 180, 261, 321, 386, 455], 'low': [139], 'nanomolar': [140], 'range': [141], 'biochemical': [143], 'assays.': [144, 347], 'Ki': [145], 'versus': [146], 'FGFR1': [147], 'were': [150], '2.8nM': [151], '0.68nM,': [153], 'respectively.': [154], 'inhibited': [157, 301], 'ectopically': [158], 'expressed': [159], '2,': [161], '3': [163], 'COS-1': [165], 'cells': [166, 178], 'as,': [169], 'to': [170, 204, 230, 257, 260, 335], 'varying': [172], 'extent,': [173], 'proliferation': [175, 187], 'BaF3': [177], 'expressing': [179], '(FGFR2≫FGFR1/FGFR3≫FGFR4).': [185], 'Cell': [186, 266], 'studies': [188], 'suggested': [189], 'correlation': [191], 'mRNA': [194], 'amplification': [195], 'gastric': [197], 'other': [199], 'cancers': [200], 'associated': [202, 241], 'sensitivity': [203], 'treatment': [205, 338], '087.': [208], 'Along': [209], 'these': [210], 'lines,': [211], 'demonstrated': [214, 229], 'inhibition': [216, 236, 315], 'phosphorylation': [219, 317], 'NCI-H716,': [221], 'Kato': [222], 'III,': [223], 'SNU-16': [224], 'MFM223': [226], 'cells;': [227], 'be': [231, 258], 'driven': [232, 268, 368, 449], 'by': [233, 269], 'FGFR2.': [234], 'was': [240, 331], 'an': [243, 308, 353], '087-induced': [245], 'G1': [246, 281], 'cycle': [248], 'arrest': [249], 'subsequent': [251], 'induction': [252], 'apoptosis': [254, 276], 'that': [255], 'appears': [256], 'related': [259], 'levels': [262], 'protein.': [265], 'lines': [267], 'activating': [271], 'mutations': [272], 'did': [273, 278], 'not': [274], 'undergo': [275], 'but': [277], 'accumulate': [279], 'following': [282], 'treatment.': [285], 'In': [286, 312, 348], 'vivo,': [287], 'induced': [290], 'regressions': [291], 'FGFR2-driven': [293], 'xenograft': [294], 'models': [295], '(SNU-16,': [296], 'NCI-H716': [297], 'BaF3/FGFR2)': [299], 'tumor': [302], 'progression': [303], 'model': [306], 'harboring': [307], 'FGFR2-activating': [309], 'mutation': [310], '(AN3CA).': [311], 'addition,': [313], 'concentration-dependent': [314], 'downstream': [322], 'pathway': [324], 'signals': [325], '(FRS2α,': [326], 'MEK,': [327], 'ERK,': [328], 'AKT)': [330], 'evident': [332], 'response': [334], 'both': [340], 'vitro': [342, 361, 442], 'vivo': [345, 364, 445], 'pharmacodynamic': [346], 'summary,': [349], 'orally': [354], 'bioavailable': [355], 'models,': [369], 'possessing': [370], 'good': [371], 'drug-like': [372], 'properties.': [373], 'A': [374], 'development': [376], 'plan': [377], 'including': [378], 'patient': [380], 'selection': [381], 'strategy': [382], 'defined': [384], 'drug': [387], 'currently': [389], 'Phase': [391], 'I': [392], 'studies.': [394], 'Citation': [395, 402], 'Information:': [396], 'Mol': [397, 472], 'Cancer': [398, 462, 473], 'Ther': [399, 474], '2013;12(11': [400, 475], 'Suppl):A278.': [401], 'Format:': [403], 'Daniel': [404], 'Dransfield,': [405], 'Jennifer': [406], 'Lee,': [407], 'Carol': [408], 'Waghorne,': [409], 'Cathy': [410], 'Bull,': [411], 'Ronald': [412], 'E.': [413], 'Savage,': [414], 'Xiaolan': [415], 'Zhao,': [416], 'Shipeng': [417], 'Yuan,': [418], 'Edward': [419], 'Chang,': [420], 'Enkeleda': [421], 'Nakuci,': [422], 'Sudharshan': [423], 'Eathiraj,': [424], 'Susan': [425], 'Cornell-Kennon,': [426], 'Xiubin': [427], 'Gu,': [428], 'Syed': [429], 'Ali,': [430], 'Chang-Rung': [431], 'Chen.': [432], '087,': [434], 'multi-tyrosine': [436], 'models.': [450], '[abstract].': [451], 'In:': [452], 'Proceedings': [453], 'AACR-NCI-EORTC': [456], 'International': [457], 'Conference:': [458], 'Molecular': [459], 'Targets': [460], 'Therapeutics;': [463], '2013': [464], 'Oct': [465], '19-23;': [466], 'Boston,': [467], 'MA.': [468], 'Philadelphia': [469], '(PA):': [470], 'AACR;': [471], 'Suppl):Abstract': [476], 'nr': [477], 'A278.': [478]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2088872576', 'counts_by_year': [{'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-08T12:46:58.495849', 'created_date': '2016-06-24'}