Title: Short??Term Effects of Radiographic Contrast Media on Monolayer Cell Cultures and Hepatocytes
Abstract: Nordby A, Halgunset J, Thorstensen K, Haugen OA. Short-term effects of radiographic contrast media on monolayer cell cultures and hepatocytes. Invest Radiol 1987;22:603-607. Short-term effects of nine different contrast media, saline, sucrose, and mannitol on monolayer cell cultures and isolated rat hepatocytes were studied. Conventional high osmolal ionic contrast media (Na-metrizoate, Na-iothalamate, meglumine/Na-diatrizoate, meglumine-calcium-metrizoate) and the new, low-osmolal, nonionic (metrizamide, iopamidol, iohexol) and ionic dimer (meglumine/Na-ioxaglate) were tested. Dilutions of different contrast media at the same final osmolality produced similar effects on cultured cells and on isolated hepatocytes as assessed by the leakage of cytoplasmic lactatedehydrogenase. This short-term toxicity seemed to be a function of the osmolality and of the exposure time. The effect of saline, sucrose, and mannitol was equal to that of contrast media at the same osmolality.
Publication Year: 1987
Publication Date: 1987-07-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 10
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