Relaxin-like factor (RLF)/insulin-like peptide 3 (INSL3) is secreted from testicular Leydig cells as a monomeric protein comprising three domains B–C–A with full biological activity in boars

Name: Work Video:
Duration: 3 min 30 s
Itaru Minagawa; Masafumi Fukuda; H. Ishige; Hiroshi Kohriki; Masatoshi Shibata; Enoch Y. Park; Tatsuo Kawarasaki; Tetsuya Kohsaka
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'reverse-phase': [81], 'HPLC.': [82], 'MS/MS': [83], '(tandem': [84], 'MS)': [85], 'analysis': [86, 128, 138], 'trypsinized': [89], 'sample': [90], 'provided': [91], '66%': [92], 'sequence': [93, 141], 'coverage': [94, 142], 'and': [95, 106, 133, 146], 'revealed': [96], 'distinct': [98], 'consisting': [101], 'B-,': [104], 'C-': [105], 'A-domains': [107], 'deduced': [108], 'previously': [109], 'from': [110, 183, 199], 'cDNA.': [113], 'Moreover,': [114], 'N-terminal': [116], 'four': [119], 'amino': [120], 'acid': [121], 'residues': [122], 'longer': [123], 'than': [124], 'predicted': [125], 'previously.': [126], 'MS': [127], 'intact': [131], 'molecule': [132], 'PMF': [134], '(peptide': [135], 'mass': [136], 'fingerprinting)': [137], 'at': [139], '100%': [140], 'confirmed': [143], 'this': [144], 'indicated': [147], 'existence': [149], 'three': [151], 'site-specific': [152], 'disulfide': [153], 'bonds.': [154], 'retained': [156], 'bioactivity': [158], 'HEK': [160], '(human': [161], 'embryonic': [162], 'kidney)-293': [163], 'cells': [164, 185, 202], 'expressing': [165], 'RXFP2': [166], '(relaxin/insulin-like': [167], 'receptor': [170, 173], '2),': [171], 'RLF/INSL3.': [175], 'Furthermore,': [176], 'found': [179], 'to': [180], 'be': [181], 'secreted': [182, 198], 'into': [186], 'venous': [188], 'blood.': [189], 'Collectively,': [190], 'these': [191], 'results': [192], 'indicate': [193], 'B-C-A': [205]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2088706000', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-13T04:20:18.528739', 'created_date': '2016-06-24'}
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