Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2088687690', 'doi': 'https://doi.org/10.1038/bjc.1993.56', 'title': 'Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy', 'display_name': 'Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy', 'publication_year': 1993, 'publication_date': '1993-02-01', 'ids': {'openalex': 'https://openalex.org/W2088687690', 'doi': 'https://doi.org/10.1038/bjc.1993.56', 'mag': '2088687690', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8381657', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1968161'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/bjc.1993.56', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62966998', 'display_name': 'British Journal of Cancer', 'issn_l': '0007-0920', 'issn': ['0007-0920', '1532-1827'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc1968161?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5028333767', 'display_name': 'Robert Maidorn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}, {'id': 'https://openalex.org/I112260969', 'display_name': 'Ontario Institute for Cancer Research', 'ror': 'https://ror.org/043q8yx54', 'country_code': 'CA', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I112260969']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'R P Maidorn', 'raw_affiliation_strings': ['Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Canada.', 'institution_ids': ['https://openalex.org/I185261750', 'https://openalex.org/I112260969']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089801903', 'display_name': 'Edward J. Cragoe', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'E J Cragoe', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5063846121', 'display_name': 'Ian F. Tannock', 'orcid': 'https://orcid.org/0000-0002-2636-7041'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'I F Tannock', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3790, 'currency': 'EUR', 'value_usd': 4690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.708, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 80, 'citation_normalized_percentile': {'value': 0.942911, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '67', 'issue': '2', 'first_page': '297', 'last_page': '303'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12763', 'display_name': 'ATP Synthase and ATPases Research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nigericin', 'display_name': 'Nigericin', 'score': 0.9896414}, {'id': 'https://openalex.org/keywords/amiloride', 'display_name': 'Amiloride', 'score': 0.9787714}, {'id': 'https://openalex.org/keywords/intracellular-ph', 'display_name': 'Intracellular pH', 'score': 0.7226843}, {'id': 'https://openalex.org/keywords/sodium–hydrogen-antiporter', 'display_name': 'Sodium–hydrogen antiporter', 'score': 0.6260282}], 'concepts': [{'id': 'https://openalex.org/C2777330628', 'wikidata': 'https://www.wikidata.org/wiki/Q7033077', 'display_name': 'Nigericin', 'level': 3, 'score': 0.9896414}, {'id': 'https://openalex.org/C2779608910', 'wikidata': 'https://www.wikidata.org/wiki/Q419995', 'display_name': 'Amiloride', 'level': 3, 'score': 0.9787714}, {'id': 'https://openalex.org/C57181701', 'wikidata': 'https://www.wikidata.org/wiki/Q2853339', 'display_name': 'Antiporter', 'level': 3, 'score': 0.9599048}, {'id': 'https://openalex.org/C134897140', 'wikidata': 'https://www.wikidata.org/wiki/Q6058355', 'display_name': 'Intracellular pH', 'level': 3, 'score': 0.7226843}, {'id': 'https://openalex.org/C114574056', 'wikidata': 'https://www.wikidata.org/wiki/Q7553395', 'display_name': 'Sodium–hydrogen antiporter', 'level': 3, 'score': 0.6260282}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5547244}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.51397747}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.4526184}, {'id': 'https://openalex.org/C28406088', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Extracellular', 'level': 2, 'score': 0.45052725}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.42587385}, {'id': 'https://openalex.org/C99975950', 'wikidata': 'https://www.wikidata.org/wiki/Q911011', 'display_name': 'Ion transporter', 'level': 3, 'score': 0.42259702}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.396787}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.36276725}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2732209}, {'id': 'https://openalex.org/C537181965', 'wikidata': 'https://www.wikidata.org/wiki/Q658', 'display_name': 'Sodium', 'level': 2, 'score': 0.22699344}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.16677132}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000584', 'descriptor_name': 'Amiloride', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D006863', 'descriptor_name': 'Hydrogen-Ion Concentration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009374', 'descriptor_name': 'Neoplasms, Experimental', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000584', 'descriptor_name': 'Amiloride', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000584', 'descriptor_name': 'Amiloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003412', 'descriptor_name': 'Cricetulus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005470', 'descriptor_name': 'Fluorometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007424', 'descriptor_name': 'Intracellular Fluid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007424', 'descriptor_name': 'Intracellular Fluid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009374', 'descriptor_name': 'Neoplasms, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009374', 'descriptor_name': 'Neoplasms, Experimental', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012964', 'descriptor_name': 'Sodium', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D012964', 'descriptor_name': 'Sodium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012979', 'descriptor_name': 'Sodium Radioisotopes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017923', 'descriptor_name': 'Sodium-Hydrogen Exchangers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/bjc.1993.56', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62966998', 'display_name': 'British Journal of Cancer', 'issn_l': '0007-0920', 'issn': ['0007-0920', '1532-1827'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1968161', 'pdf_url': 'https://europepmc.org/articles/pmc1968161?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968161', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8381657', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1968161', 'pdf_url': 'https://europepmc.org/articles/pmc1968161?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1558696846', 'https://openalex.org/W1578086030', 'https://openalex.org/W1793737126', 'https://openalex.org/W1839358117', 'https://openalex.org/W1914697351', 'https://openalex.org/W1948560807', 'https://openalex.org/W1954857248', 'https://openalex.org/W1956944003', 'https://openalex.org/W1983768617', 'https://openalex.org/W2009156957', 'https://openalex.org/W2022128427', 'https://openalex.org/W2033936610', 'https://openalex.org/W2041585886', 'https://openalex.org/W2063671015', 'https://openalex.org/W2074061850', 'https://openalex.org/W2078450213', 'https://openalex.org/W2119434127', 'https://openalex.org/W2122880329', 'https://openalex.org/W2141597592', 'https://openalex.org/W2165884308', 'https://openalex.org/W2318996479'], 'related_works': ['https://openalex.org/W2461564378', 'https://openalex.org/W2410120624', 'https://openalex.org/W2409395677', 'https://openalex.org/W2098757654', 'https://openalex.org/W2089675043', 'https://openalex.org/W2088687690', 'https://openalex.org/W2039337816', 'https://openalex.org/W2029862011', 'https://openalex.org/W1984946268', 'https://openalex.org/W1964197368'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2088687690', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-09T16:41:57.196013', 'created_date': '2016-06-24'}