Title: A novel antibacterial and antifungal phenolic compound from the endophytic fungus<i>Pestalotiopsis mangiferae</i>
Abstract: Abstract A novel phenolic compound, 4-(2,4,7-trioxa-bicyclo[4.1.0]heptan-3-yl) phenol (1), was isolated from Pestalotiopsis mangiferae, an endophytic fungus associated with Mangifera indica Linn. The structure of the compound was elucidated on the basis of comprehensive spectral analysis (UV, IR, 1H-, 13C- and 2D-NMR, as well as HRESI–MS). Compound (1) shows potent antibacterial and antifungal activity against Bacillus subtilis, Klebsiella pneumoniae, Escherichia coli, Micrococcus luteus, Pseudomonas aeruginosa and Candida albicans. The transmission electron microscope study for the mode of inhibition of compound (1) on bacterial pathogens revealed the destruction of bacterial cells by cytoplasm agglutination with the formation of pores in cell wall membranes. Keywords: Pestalotiopsis mangiferae endophytic fungusantibacterialantifungalphenol derivatesmode of action Acknowledgements Kamalraj Subban is grateful to the University Grants Commission, under the Rajiv Gandhi National Fellowship scheme (no. F.14-2(SC)/2007(SA-III)), Government of India, for financial support. Kamalraj Subban and Muthumary Johnpaul are thankful to Prof. R. Rengasamy, Director, CAS in Botany, for providing facilities and also thankful to the Indian Institute of Technology for the TEM analysis. Ramesh Subramani is grateful to Prof. William Aalbersberg, Director, Institute of Applied Sciences, The University of the South Pacific, for providing facilities. Authors are sincerely thankful to Rohitesh Kumar and Pritesh Prasad, USP, Fiji for their assistance in structure elucidation, and also Mukesh Sharma, The Australian National University for structure novelty confirmation.
Publication Year: 2013
Publication Date: 2013-08-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 70
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