Regulation of Raf-Akt Cross-talk

Name: Work Video:
Duration: 3 min 30 s
Karin Moelling; Karen Schad; Magnus Bosse; Sven Zimmermann; Marc Schweneker
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1432, 1936, 2252, 2310, 3075, 3921, 4134, 4157, 4824, 4837, 5231, 5416], 'line': [21, 181, 2311], 'MCF-7.': [22, 182], 'High': [23, 59, 183, 219, 3294, 4349], 'Raf': [24, 75, 184, 235, 1441, 1737, 2009, 2075, 2536, 2570, 2602, 2721, 2746, 3267, 3480, 4251, 4270, 4284, 4302, 4366, 4450, 4591], 'activity': [25, 37, 77, 185, 197, 237, 990, 1207, 1288, 1385, 1408, 2085, 3060, 3105, 3233, 3272, 3306, 3324, 3338, 3359, 3362, 3416, 3442, 3454, 3486, 3523, 3909, 3930, 4017, 4271, 4285, 4296, 4304, 4368, 4531, 4645, 4873, 4894, 4918, 4972, 4983, 4997, 5413, 5428], 'induces': [26, 186], 'growth': [27, 63, 187, 223, 321, 366, 448, 1503, 1940, 2972, 3069, 3814, 4112, 4203, 4274, 4515, 5111], 'arrest': [28, 188, 3070, 3815, 4275, 4516], 'differentiation': [30, 190, 1362, 1377, 1387, 1497, 1546, 1552, 1846, 1903, 4158, 4288, 4701], 'these': [32, 192, 1103, 4241, 4508, 4588], 'cells,': [33, 193, 1242, 1834, 3803, 4291, 4613], 'whereas': [34, 82, 194, 242, 1382, 1565, 1766, 2242], 'high': [35, 195, 2966, 2989, 3119, 3140, 3591, 3939, 3973, 3988, 4269, 4283, 4301, 4889], 'PI3K/Akt': [36, 111, 196, 271, 3263, 4732], 'correlates': [38, 198], 'with': [39, 199, 1090, 1263, 1278, 1430, 1537, 1845, 2088, 2331, 2403, 2420, 2425, 2567, 2599, 2697, 2764, 2963, 2982, 3116, 3139, 3221, 3253, 3257, 3366, 3497, 3590, 3603, 3675, 3730, 3807, 3972, 4061, 4124, 4287, 5007, 5201, 5276], 'survival': [41, 201, 2016, 4753, 5390, 5417], 'proliferation.': [43, 203, 3493, 4523], 'Here': [44, 204, 2276], 'we': [45, 205, 1073, 1105, 2277, 3102, 3229, 3595, 3677, 3733, 3784, 4243, 4569, 5353], 'show': [46, 206, 3698, 3734, 4313], 'Raf-Akt': [49, 209, 3466, 3744, 4316, 4511, 4904], 'is': [51, 143, 211, 303, 409, 412, 494, 701, 714, 721, 754, 774, 1047, 1082, 1225, 3100, 3218, 3339, 3428, 3443, 3770, 4011, 4318, 4338, 4552, 4576, 4632, 4637, 4667, 4741, 4832, 4874, 4895, 4958, 4973, 5000, 5235, 5263, 5449], 'regulated': [52, 212, 4319], 'a': [54, 99, 214, 259, 387, 413, 440, 460, 876, 983, 1017, 1062, 1067, 1203, 1235, 1421, 1431, 1436, 1505, 1509, 1517, 1558, 1710, 2363, 2389, 2792, 2799, 2808, 2949, 3055, 3149, 3159, 3222, 3274, 3299, 3516, 3597, 3604, 3753, 3938, 3986, 4012, 4100, 4194, 4246, 4278, 4293, 4321, 4357, 4529, 4607, 4615, 4698, 4879, 4991, 4993, 5027, 5141, 5153, 5398, 5425], 'concentration-': [55, 215, 4322], 'ligand-dependent': [57, 217, 4324], 'manner.': [58, 218, 4605], 'doses': [60, 84, 220, 244, 3120, 3141, 3295, 3499, 3581, 3592, 3737, 3974, 4063, 4350, 4525], 'of': [61, 80, 85, 137, 153, 221, 240, 245, 297, 313, 377, 407, 442, 469, 512, 579, 709, 725, 734, 739, 747, 752, 782, 878, 883, 889, 991, 1088, 1120, 1223, 1231, 1238, 1245, 1272, 1276, 1284, 1293, 1317, 1350, 1363, 1368, 1372, 1423, 1487, 1512, 1520, 1539, 1553, 1563, 1576, 1596, 1904, 2073, 2082, 2149, 2230, 2232, 2249, 2271, 2281, 2365, 2498, 2512, 2675, 2707, 2767, 2912, 2922, 2927, 2953, 2968, 2978, 3026, 3061, 3074, 3106, 3121, 3128, 3134, 3142, 3152, 3163, 3169, 3206, 3214, 3216, 3262, 3279, 3296, 3303, 3319, 3363, 3375, 3380, 3401, 3426, 3436, 3476, 3487, 3500, 3520, 3530, 3551, 3582, 3593, 3601, 3689, 3707, 3738, 3748, 3788, 3827, 3868, 3882, 3890, 3950, 3975, 4015, 4052, 4064, 4073, 4155, 4256, 4264, 4289, 4335, 4343, 4345, 4351, 4377, 4467, 4490, 4526, 4532, 4611, 4621, 4652, 4702, 4717, 4731, 4756, 4761, 4869, 4899, 4916, 4995, 5032, 5144, 5149, 5211, 5225, 5261, 5271, 5361, 5375, 5378, 5391, 5429, 5446, 5469], 'insulin-like': [62, 222, 320, 447], 'factor': [64, 224, 322, 449, 4204, 5112], 'I': [65, 225, 323, 450], '(IGF-I)': [66, 226], 'activate': [67, 227, 817, 4354, 5115], 'Akt': [68, 228, 758, 773, 818, 874, 1097, 1123, 1194, 1369, 1407, 1439, 1524, 1566, 1713, 1776, 2011, 2542, 3130, 3164, 3171, 3427, 3441, 3453, 3574, 4074, 4103, 4249, 4355, 4469, 4550, 4574, 4631, 4827], 'quickly': [69, 229], 'strongly': [71, 231, 3925], 'enough': [72, 232, 4556, 4579], 'to': [73, 133, 146, 233, 293, 306, 730, 776, 787, 1227, 1258, 1281, 1527, 1591, 1726, 1902, 1960, 2362, 2522, 2569, 2578, 2597, 2601, 2729, 2798, 2916, 2994, 3024, 3067, 3148, 3310, 3341, 3371, 3491, 3507, 3525, 3587, 3797, 3799, 3932, 3943, 4049, 4363, 4390, 4455, 4557, 4580, 4598, 4640, 4696, 4727, 4819, 4902, 5099, 5203, 5206, 5221, 5255, 5269, 5305, 5315, 5367, 5388, 5394, 5409, 5414, 5420], 'suppress': [74, 234], 'kinase': [76, 236, 326, 332, 338, 342, 415, 463, 524, 757, 814, 994, 1532, 2084, 2091, 2152, 2261, 2676, 2722, 2732, 2735, 2747, 2750, 2913, 2933, 3173, 3227, 3238, 3305, 3323, 3337, 3394, 3522, 3538, 3906, 3929, 3961, 4303, 4367, 4451, 4474, 4485, 4537, 4644, 4748, 5016, 5412, 5431], 'via': [78, 238, 353, 691, 707, 3031, 3746, 4076, 5308], 'phosphorylation': [79, 239, 500, 708, 820, 886, 1064, 1098, 1562, 2804, 3126, 3154, 3199, 3205, 3213, 3550, 3600, 3747, 3867, 3891, 5317], 'Ser-259,': [81, 241, 2539, 3552, 4480], 'low': [83, 243, 2964, 2984, 3117, 3498, 3513, 3518, 3580, 3736, 4062, 4985, 5108, 5426], 'IGF-I': [86, 246, 704, 1266, 2291, 2407, 2969, 2985, 2990, 3007, 3143, 3256, 3297, 3501, 3514, 3542, 3583, 3976, 4128, 4986], 'do': [87, 247, 3740, 4710], 'not': [88, 114, 248, 274, 1403, 3446, 3545, 3554, 3558, 3741, 3885, 3896, 3901, 3947, 4107, 4543, 4577, 4594, 4638, 4648, 4711, 4833], 'trigger': [89, 115, 249, 275, 688, 3742], 'this': [90, 250, 1427, 3098, 3196, 3560, 3701, 4336, 4547], 'but': [92, 107, 252, 267, 4554], 'are': [93, 253, 581, 3396, 4388], 'still': [94, 254], 'mitogenic.': [95, 255], 'Phorbol': [96, 256], '12-myristate': [97, 257, 345], '13-acetate,': [98, 258], 'differentiation-inducing': [100, 260, 4718], 'stimulus,': [101, 261, 2074], 'potently': [102, 262, 3457], 'activates': [103, 110, 263, 270, 453, 521], 'pathway': [106, 266, 525, 699, 1356, 1375, 3034, 3064, 3490, 3757, 3760], 'only': [108, 268, 1042, 1397, 1516, 1568, 4633, 4964, 5234], 'weakly': [109, 269, 3754], 'does': [113, 273, 4542, 4647], 'cross-talk.': [117, 277, 3772, 4905], 'Thus,': [118, 278, 3377, 3464, 4506], 'herein': [120, 280], 'analyzed': [121, 281, 2163, 2278, 3103, 4121, 4162], 'parameters': [122, 282], 'such': [123, 283, 362, 585, 810, 895, 1548, 3810, 4655, 4720, 4839, 4990], 'as': [124, 284, 363, 504, 506, 586, 811, 896, 1549, 1847, 2269, 2590, 2814, 3348, 3570, 3811, 4656, 4674, 4721, 4840, 4961, 5258], 'ligand': [125, 285, 2296, 3782, 3789, 4257, 4883, 5358], 'type,': [126, 286, 4825, 4884], 'concentration,': [127, 287, 4882, 5359], 'time': [129, 289, 2391, 2998, 3330, 3412, 3450, 3616, 3999, 4463, 4886, 4967, 5364], 'course': [130, 290], 'may': [131, 151, 291, 311, 2012, 4381, 4593, 4724, 5097, 5219, 5253, 5303, 5385], 'contribute': [132, 292, 5220, 5314, 5366], 'cellular': [135, 148, 295, 308, 360, 1312, 1600, 1740, 2069, 2888, 4153, 4260, 4273, 5226, 5248], 'response': [136, 296, 1255, 4521], 'either': [138, 298, 2404, 3562], 'proliferation': [139, 299, 470, 1257, 1538, 1741, 1937, 2272, 3001, 4562], 'or': [140, 300, 705, 950, 1053, 1370, 1409, 1496, 1574, 1770, 1993, 2119, 2159, 2415, 2421, 2543, 2577, 3250, 3258, 3695, 3880, 4094, 4262, 4843, 5104, 5109], 'differentiation.': [141, 301, 4265], 'This': [142, 302, 1419, 1534, 3333, 3620, 3963, 4694, 4723, 4957, 5024, 5138], 'highly': [144, 304, 1068], 'relevant': [145, 305, 5245], 'understanding': [147, 307], 'transformation': [149, 309, 1743], 'be': [152, 312, 437, 2078, 2122, 2256, 3456, 4697, 4725, 4820, 5256], 'use': [154, 314], 'areas': [156, 316], 'like': [157, 317, 4375], 'tissue': [158, 318, 2357], 'engineering.': [159, 319], 'extracellular': [324, 443], 'signal-regulated': [325], 'insulin-receptor': [327], 'substrate': [328], '1': [329, 456, 815, 2092, 2460, 2469, 2472, 2476, 2920], 'c-Jun': [330], 'N-terminal': [331], 'mitogen-activated': [333, 335], 'protein': [334, 336, 341, 514, 813, 2496, 2513, 2528, 2734, 2930, 3278, 4747], 'kinase/ERK': [337], 'B': [343, 3407, 3912, 3979], 'phorbol': [344, 3808, 4830, 5277], '13-acetate': [346], '12-O-tetradecanoylphorbol-13-acetate': [347], 'vascular': [348, 1448, 4209], 'smooth': [349, 1449, 4210], 'muscle': [350, 1450, 1490, 4156, 4211], 'Signal': [351], 'transduction': [352, 5205, 5243], 'activated': [354, 438, 722, 1523, 2541, 2545, 4635], 'Ras': [355, 408], 'mediates': [356, 4752], 'several': [357, 890, 3668, 3683], 'apparently': [358, 3468], 'conflicting': [359], 'responses': [361, 690, 5227], 'proliferation,': [364], 'apoptosis,': [365], 'arrest,': [367], 'differentiation,': [368], 'senescence,': [370], 'depending': [371, 1492, 5228], 'on': [372, 382, 501, 507, 694, 821, 1102, 1117, 1198, 1415, 1493, 1593, 2067, 2251, 2300, 2538, 2791, 2937, 3704, 3765, 3780, 3870, 3957, 4092, 4131, 4207, 4253, 4822, 4871, 4881, 5013, 5034, 5146, 5215, 5229], 'duration': [374], 'strength': [376, 3706], 'external': [379], 'stimulus': [380, 3057, 4610], 'type.': [385, 5232], 'For': [386, 1016, 2527], 'recent': [388], 'review': [389, 1019], 'see': [390, 1020, 2738], 'Kolch': [391], '(1Kolch': [392], 'W.': [393, 606], 'Biochem.': [394, 3183, 4945], 'J.': [395, 479, 539, 568, 642, 760, 1174, 1465, 1662, 1690, 1695, 1747, 1750, 1800, 1911, 1914, 1947, 2054, 2095, 2135, 2167, 2207, 2653, 2867, 3085, 3088, 3629, 3651, 3716, 3852, 3855, 4028, 4224, 4766, 4928, 4931, 5046, 5068, 5124, 5433, 5455], '2000;': [396, 1698, 1826, 1890, 2032, 5182, 5338], '351:': [397], '289-305Crossref': [398], 'PubMed': [399, 430, 488, 544, 572, 600, 617, 653, 667, 768, 803, 847, 868, 917, 945, 972, 1011, 1036, 1132, 1159, 1185, 1216, 1342, 1476, 1620, 1647, 1673, 1706, 1761, 1810, 1870, 1893, 1927, 1954, 1988, 2035, 2061, 2114, 2142, 2182, 2222, 2611, 2638, 2664, 2825, 2852, 2878, 3043, 3190, 3636, 3662, 3723, 3840, 4039, 4145, 4188, 4235, 4410, 4429, 4444, 4501, 4689, 4785, 4810, 4862, 4952, 5053, 5079, 5131, 5190, 5295, 5346], 'Scopus': [400, 431, 545, 573, 601, 618, 654, 668, 769, 804, 869, 918, 946, 973, 1012, 1037, 1133, 1160, 1186, 1217, 1343, 1477, 1621, 1648, 1674, 1762, 1811, 1871, 1894, 1928, 1955, 1989, 2036, 2062, 2115, 2143, 2183, 2223, 2612, 2639, 2665, 2826, 2853, 2879, 3044, 3191, 3637, 3663, 3724, 3841, 4040, 4146, 4189, 4236, 4411, 4430, 4445, 4502, 4690, 4786, 4811, 4863, 4953, 5054, 5080, 5132, 5191, 5296, 5347], '(1218)': [401], 'Google': [402, 433, 489, 547, 575, 603, 620, 639, 656, 670, 685, 771, 806, 848, 871, 920, 948, 975, 1014, 1039, 1135, 1162, 1188, 1219, 1345, 1479, 1623, 1650, 1676, 1707, 1764, 1813, 1829, 1873, 1896, 1930, 1957, 1991, 2038, 2064, 2117, 2145, 2185, 2202, 2225, 2614, 2641, 2667, 2828, 2855, 2881, 3046, 3093, 3193, 3639, 3665, 3726, 3843, 3860, 4042, 4148, 4191, 4238, 4413, 4432, 4447, 4504, 4692, 4788, 4813, 4865, 4936, 4955, 5056, 5082, 5134, 5193, 5298, 5349, 5440], 'Scholar).': [403, 490, 576, 772, 807, 872, 976, 1015, 1040, 1189, 1220, 1480, 1830, 1897, 1931, 2065, 2146, 2203, 2668, 2882, 3047, 3094, 3727, 3861, 4043, 4149, 4239, 4448, 4505, 4693, 4814, 4956, 5095, 5194, 5299, 5350, 5441], 'A': [404, 1898, 4329, 4738, 5021], 'downstream': [405, 750, 1045, 3343, 3373, 5147], 'effector': [406], 'Raf-1.': [410, 1239, 5401], 'Raf-1': [411, 491, 518, 1050, 1079, 1089, 1121, 1197, 1206, 1224, 1384, 1531, 3135, 3217, 3226, 3304, 3322, 3336, 3391, 3521, 3767, 3871, 3905, 3928, 3960, 4093, 4105, 4473, 4484, 4533, 4582, 4643, 5015, 5151, 5411], 'serine/threonine': [414, 502, 756], '(2Moelling': [416], 'K.': [417, 623, 1127, 1148, 1150, 1173, 1211, 1331, 1333, 1464, 1615, 1636, 1638, 1661, 1977, 1979, 1998, 2097, 2606, 2627, 2629, 2652, 2820, 2841, 2843, 2866, 3038, 3835, 4140, 4177, 4179, 4223, 4420, 4496, 4684, 5435], 'Heimann': [418], 'B.': [419, 2048, 2177, 2217, 5171, 5284, 5327, 5462], 'Beimling': [420], 'P.': [421, 533, 556, 610, 832, 836, 857, 1002, 2044, 2127, 2133, 4851], 'Rapp': [422, 536, 559, 611, 628, 2051], 'U.R.': [423, 537, 612, 2052], 'Sander': [424], 'T.': [425, 1688, 1857, 2101, 5085], 'Nature.': [426, 540, 613, 1007, 1866, 2138, 4440], '1984;': [427], '312:': [428], '558-561Crossref': [429], '(149)': [432], 'Scholar)': [434, 849, 949, 1708, 1765, 1958, 1992, 2226, 5135], 'by': [439, 703, 723, 779, 819, 885, 982, 1588, 1908, 2086, 2157, 2164, 2258, 2290, 2493, 2556, 3052, 3071, 3158, 3165, 3264, 3291, 3325, 3350, 3459, 3612, 3823, 3952, 3970, 4083, 4276, 4340, 4476, 4661, 4829, 4897, 4919, 4998, 5017, 5041, 5107, 5117, 5160, 5418], 'variety': [441, 877], 'stimuli,': [444], 'among': [445], 'them': [446, 5262, 5396], '(IGF-I)1': [451], 'type': [455, 2072, 4135, 4255], 'IGF': [457], 'surface': [458], 'receptor,': [459], 'receptor': [461, 711], 'tyrosine': [462, 508], 'mainly': [464], 'implicated': [465], 'induction': [468, 2231, 3826, 4489, 4651], '(3Stewart': [471], 'A.J.': [472], 'Johnson': [473], 'M.D.': [474, 5167, 5323], 'May': [475], 'F.E.': [476], 'Westley': [477], 'B.R.': [478], 'Biol.': [480, 596, 764, 838, 864, 1032, 1175, 1466, 1663, 1696, 1751, 1889, 1923, 1950, 2031, 2057, 2654, 2868, 3632, 3652, 3719, 4029, 4225, 4858, 5049, 5069, 5127, 5181, 5291, 5337], 'Chem.': [481, 1176, 1467, 1664, 1697, 1752, 2655, 2869, 3653, 4030, 4226, 5070], '1990;': [482, 597], '265:': [483], '21172-21178Abstract': [484], 'Full': [485, 664, 842, 844, 940, 942, 1180, 1182, 1471, 1473, 1668, 1670, 1701, 1703, 1756, 1758, 1805, 1807, 2659, 2661, 2873, 2875, 3657, 3659, 4034, 4036, 4230, 4232, 5074, 5076, 5185, 5187, 5341, 5343], 'Text': [486, 665, 843, 845, 941, 943, 1181, 1183, 1472, 1474, 1669, 1671, 1702, 1704, 1757, 1759, 1806, 1808, 2660, 2662, 2874, 2876, 3658, 3660, 4035, 4037, 4231, 4233, 5075, 5077, 5186, 5188, 5342, 5344], 'PDF': [487, 666, 846, 944, 1184, 1475, 1672, 1705, 1760, 1809, 2663, 2877, 3661, 4038, 4234, 5078, 5189, 5345], 'activation': [492, 1367, 1511, 1519, 3302, 3382, 3425, 3475, 3519, 3575, 3984, 4051, 4072, 4344, 4397, 4452, 4475, 4551, 4575, 4592, 4730, 4750, 4755, 4828, 5101], 'itself': [493], 'complex': [495], 'involves': [497], 'membrane': [498, 778, 4393, 4458], 'recruitment,': [499], 'residues': [503], 'well': [505], 'residues,': [509], 'binding': [511, 724, 781, 1230], '14-3-3': [513, 1233], 'family': [515, 899], 'members.': [516], 'Activated': [517], 'phosphorylates': [519, 3479], 'MEK-ERK': [523, 1374], '(4Kyriakis': [526], 'J.M.': [527], 'App': [528], 'H.': [529, 925, 931, 1745, 1855, 2103], 'Zhang': [530, 2098], 'X.F.': [531], 'Banerjee': [532], 'Brautigan': [534], 'D.L.': [535], 'Avruch': [538], '1992;': [541, 636, 661, 682], '358:': [542], '417-421Crossref': [543], '(977)': [546], 'Scholar,': [548, 604, 621, 640, 657, 671, 921, 1136, 1163, 1624, 1651, 1874, 2039, 2186, 2615, 2642, 2829, 2856, 3640, 3844, 4414, 4433, 4789, 5057, 5083], '5Alessi': [549], 'D.R.': [550, 794, 824, 1000, 4401], 'Saito': [551], 'Y.': [552, 933], 'Campbell': [553], 'D.G.': [554], 'Cohen': [555, 835, 1001], 'Sithanandam': [557], 'G.': [558, 608, 659, 912, 1780, 2137], 'U.': [560, 629, 647, 2108, 4804], 'Ashworth': [561], 'A.': [562, 649, 675, 798, 1916, 2042, 2110, 2125, 3083, 3850, 4405, 4770, 4772, 4776, 4778, 4795, 4806, 4926, 5163, 5319, 5447, 5463], 'Marshall': [563, 4438, 5176, 5332], 'C.J.': [564, 3180, 4439, 4942], 'Cowley': [565], 'S.': [566, 648, 965, 1125, 1142, 1167, 1209, 1325, 1458, 1613, 1630, 1655, 1918, 1945, 1971, 2002, 2109, 2194, 2604, 2621, 2646, 2818, 2835, 2860, 3036, 3627, 3714, 3833, 4138, 4171, 4217, 4494, 4682, 4805, 5044, 5122], 'EMBO': [567], '1994;': [569, 3187, 4426, 4441, 4782, 4949], '13:': [570, 5093], '1610-1619Crossref': [571], '(468)': [574], 'Downstream': [577], 'effectors': [578, 2267, 5148], 'ERKs': [580], 'nuclear': [582], 'transcription': [583], 'factors': [584, 4374], 'Myc': [587], 'Elk': [589], '(6Siegfried': [590], 'Z.': [591], 'Ziff': [592], 'E.B.': [593], 'Mol.': [594, 862, 1030, 1887, 1921, 1948, 2029, 2055, 3630, 3717, 4856, 5047, 5125], 'Cell.': [595, 660, 863, 936, 1031, 1888, 1922, 1949, 2030, 2056, 3631, 3718, 4857, 5048, 5126], '10:': [598, 766, 5183, 5339], '6073-6078Crossref': [599], '(18)': [602], '7Kolch': [605], 'Heidecker': [607], 'Lloyd': [609], '1991;': [614], '349:': [615], '426-428Crossref': [616], '(355)': [619], '8Alexandropoulos': [622], 'Qureshi': [624], 'S.A.': [625, 1790], 'Bruder': [626], 'J.T.': [627], 'Foster': [630], 'D.A.': [631, 5288], 'Cell': [632, 678, 763, 1822, 4780, 5290], 'Growth': [633, 679, 1823, 2951], '&': [634, 680, 1824], 'Differ.': [635, 681, 1825], '3:': [637, 683], '731-737PubMed': [638], '9Blenis': [641], 'Proc.': [643, 2104, 4800], 'Natl.': [644, 2105, 4801], 'Acad.': [645, 2106, 4802], 'Sci.': [646, 2107, 4803, 5090], '1993;': [650], '90:': [651], '5889-5892Crossref': [652], '(1158)': [655], '10Thomas': [658], '68:': [662], '3-6Abstract': [663], '(231)': [669], '11Crews': [672], 'C.M.': [673], 'Alessandrini': [674], 'Erikson': [676], 'R.L.': [677], '135-142PubMed': [684], 'Scholar),': [686, 1346, 1677, 2118, 3194, 3666, 4192], 'which': [687, 1072, 1843, 3146, 3478, 3527, 3609, 3804, 4481, 4658, 5036, 5267, 5312, 5422], 'biological': [689, 879, 1254, 3793, 4520], 'direct': [692, 780, 1044], 'impact': [693], 'gene': [695, 5272], 'expression.': [696], 'Another': [697], 'important': [698, 4384], 'triggered': [702], 'insulin': [706, 710, 2158, 2239, 4890], 'substrate,': [712], 'IRS-1,': [713], 'pathway.': [719, 1418], 'PI3K': [720, 735, 753, 1273, 1735, 3174, 3403, 3461, 3680, 4757, 4870, 4907, 5033, 5096, 5145], 'its': [726, 783, 1410, 2083, 3232, 3271, 3342, 4479, 4734], 'p85': [727], 'regulatory': [728, 1086], 'subunit': [729], 'tyrosine-phosphorylated': [731], 'IRS-1.': [732], 'Activation': [733], 'increases': [736, 3321], 'amounts': [738, 2511], 'membrane-localized': [740], '3,4-bisphosphate': [742], '3,4,5-triphosphate.': [745], 'One': [746, 5260], 'crucial': [749], 'targets': [751, 891, 1055, 1060, 3344], '(12Downward': [759], 'Curr': [761], 'Opin': [762], '1998;': [765, 969, 1867, 2179, 2219], '262-267Crossref': [767], '(1188)': [770], 'recruited': [775, 4389], 'pleckstrin': [784], 'homology': [785], 'domain': [786, 1087], 'PI3K-produced': [789], 'phospholipids': [790], '(13Franke': [791, 4398], 'T.F.': [792, 961, 4399], 'Kaplan': [793, 4400], 'Cantley': [795, 4402], 'L.C.': [796, 4403], 'Toker': [797, 4404], 'Science.': [799, 913, 968, 1128, 1155, 1212, 1338, 1616, 1643, 1984, 2607, 2634, 2821, 2848, 3039, 3836, 4141, 4184, 4406, 4425, 4497, 4685], '1997;': [800, 839, 914, 937, 2139, 4407, 4807], '275:': [801, 1699, 4408], '665-668Crossref': [802, 4409], '(1305)': [805, 4412], 'Upstream': [808], 'kinases': [809, 4380], '3-phosphoinositide-dependent': [812], '(PDK1)': [816], 'Thr-308': [822], '(14Alessi': [823], 'James': [825], 'S.R.': [826, 923], 'Sownes': [827], 'C.P.': [828], 'Holmes': [829], 'A.B.': [830, 1694], 'Gaffney': [831], 'Reece': [833], 'C.': [834, 908, 1138, 1321, 1626, 1684, 1967, 2046, 2131, 2190, 2617, 2831, 4167, 4774], 'Curr.': [837, 5180, 5336], '7:': [840], '261-269Abstract': [841], 'Ser-473': [851], '(15Andjelkovic': [852, 4846], 'M.': [853, 906, 1004, 1169, 1171, 1460, 1462, 1657, 1659, 1778, 1821, 2000, 2005, 2188, 2648, 2650, 2862, 2864, 3087, 3854, 4219, 4221, 4422, 4847, 4930], 'Maira': [854, 4848], 'S.M.': [855, 4849], 'Cron': [856, 4850], 'Parker': [858, 4852], 'P.J.': [859, 1865, 4853], 'Hemmings': [860, 1005, 2047, 4854, 5464], 'B.A.': [861, 1006, 1140, 1323, 1628, 1969, 2619, 2833, 4169, 4855], '1999;': [865, 1129, 1156, 1213, 1339, 1617, 1644, 1951, 1985, 2608, 2635, 2822, 2849, 3040, 3090, 3633, 3654, 3720, 3837, 3857, 4031, 4142, 4185, 4498, 4686, 4859, 4933, 5050, 5071, 5092, 5128, 5292], '19:': [866, 1952, 3634, 3721, 4860, 5051, 5129], '5061-5072Crossref': [867, 4861], '(101)': [870, 4864], 'Active': [873], 'causes': [875, 4614], 'effects,': [880], 'including': [881], 'suppression': [882], 'apoptosis': [884, 2089, 4713], 'inactivation': [888, 1244], 'along': [892], 'pro-apoptotic': [893], 'Bcl-2': [898], 'member': [900], 'BAD': [901], '(16del': [902], 'Peso': [903], 'L.': [904, 1144, 1327, 1632, 1973, 2099, 2192, 2623, 2837, 4173], 'Gonzalez-Garcia': [905], 'Page': [907], 'Herrera': [909], 'R.': [910, 1146, 1329, 1634, 1792, 1975, 2169, 2209, 2625, 2839, 4175], 'Nunez': [911], '278:': [915], '687-689Crossref': [916], '(1987)': [919], '17Datta': [922], 'Dudek': [924], 'Tao': [926], 'X.': [927], 'Masters': [928], 'S.,': [929], 'Fu,': [930], 'Gotoh': [932], 'Greenberg': [934], 'M.E.': [935], '91:': [938], '231-241Abstract': [939], '(4946)': [947], 'caspase-9': [951], '(18Cardone': [952], 'M.H.': [953, 5175, 5331], 'Roy': [954], 'N.': [955], 'Stennicke': [956], 'H.R.': [957], 'Salvesen': [958], 'G.S.': [959], 'Franke': [960], 'Stanbridge': [962], 'E.': [963, 2129, 2196], 'Frisch': [964], 'Reed': [966], 'J.C.': [967], '282:': [970], '1318-1321Crossref': [971], '(2735)': [974], 'Moreover,': [977, 4150], 'it': [978, 2120, 4079, 4636], 'regulates': [979], 'glucose': [980], 'uptake': [981], 'largely': [984], 'uncharacterized': [985], 'mechanism': [986, 4334, 5408], 'controls': [988, 3484], 'glycogen': [992], 'synthase': [993], '3': [995, 3309, 3314, 4584, 4672], '(GSK3)': [996], '(19Cross': [997], 'D.A.E.': [998], 'Alessi': [999], 'Andjelkovich': [1003], '1995;': [1008], '378:': [1009], '785-789Crossref': [1010], '(4376)': [1013], 'comprehensive': [1018], 'Scheid': [1021], 'Woodgett': [1023, 1026], '(20Scheid': [1024], 'M.P.': [1025], 'J.R.': [1027], 'Nat.': [1028], 'Rev.': [1029], '2001;': [1033, 1177, 1468, 1665, 1753, 1802, 1924, 2058, 2111, 2199, 2656, 2870, 4227], '2:': [1034], '760-768Crossref': [1035], '(540)': [1038], 'Whereas': [1041], 'one': [1043, 4132], 'target': [1046, 1094, 3131], 'known': [1048], 'for': [1049, 1057, 1739, 1839, 1935, 2015, 2399, 2432, 2535, 2540, 2544, 2754, 2903, 2959, 3247, 3941, 4332, 4669, 4677, 4700, 4763, 5246, 5457, 5465], 'many': [1051], 'proven': [1052], 'putative': [1054], 'exist': [1056], 'Akt.': [1058], 'The': [1059, 1221, 1298, 2147, 2246, 2308, 2385, 2720, 2749, 2787, 2932, 3284, 3357, 3982, 4867, 4980, 5209, 5442], 'share': [1061], 'characteristic': [1063], 'sequence': [1065], 'within': [1066, 1077, 1095, 4663], 'conserved': [1069], 'motif': [1070, 1099], '(RXRXX(S/T)),': [1071], 'previously': [1075, 2816, 3012, 4120, 4680, 5028], 'characterized': [1076, 2227], 'sequence.': [1080], 'It': [1081, 3048], 'located': [1083], 'Ser-259': [1091, 1199, 3133, 3153, 3207, 3215, 3749, 3869], 'being': [1092], '(RQRSTS259).': [1100], 'Based': [1101], 'findings': [1104, 3589, 4007, 4877], 'established': [1108, 3775], 'PI3K-Akt': [1114, 1305, 1355, 1513, 3113, 3320, 3759, 3894, 3951, 4116, 4624, 4900], 'level': [1119, 3561, 3940, 3989, 5374], '(21Zimmermann': [1124, 1208, 1612, 2603, 2817, 3035, 3832, 4137, 4493, 4681], 'Moelling': [1126, 1149, 1172, 1210, 1332, 1463, 1614, 1637, 1660, 1978, 2605, 2628, 2651, 2819, 2842, 2865, 3037, 3834, 4139, 4178, 4222, 4495, 4683, 5434], '286:': [1130, 1157, 1214, 1340, 1618, 1645, 1986, 2609, 2636, 2823, 2850, 3041, 3838, 4143, 4186, 4499, 4687], '1741-1744Crossref': [1131, 1215, 1619, 2610, 2824, 3042, 3839, 4144, 4500, 4688], '(909)': [1134, 1218, 1622, 2613, 2827, 3045, 3842, 4147, 4503, 4691], '22Rommel': [1137, 1625, 2616, 2830], 'Clarke': [1139, 1322, 1627, 1968, 2618, 2832, 4168], 'Zimmermann': [1141, 1166, 1324, 1457, 1629, 1654, 1970, 2620, 2645, 2834, 2859, 4170, 4216], 'Nuñez': [1143, 1326, 1631, 1972, 2622, 2836, 4172], 'Rossman': [1145, 1328, 1633, 1974, 2624, 2838, 4174], 'Reid': [1147, 1330, 1635, 1976, 2626, 2840, 4176], 'Yancopoulos': [1151, 1334, 1639, 1980, 2630, 2844, 4180], 'G.D.': [1152, 1335, 1640, 1981, 2631, 2845, 4181], 'Glass': [1153, 1336, 1641, 1982, 2632, 2846, 4182], 'D.J.': [1154, 1337, 1642, 1983, 2633, 2847, 4183], '1738-1741Crossref': [1158, 1341, 1646, 1987, 2637, 2851, 4187], '(663)': [1161, 1344, 1649, 1990, 2640, 2854, 4190], '23Reusch': [1164, 1652, 2643, 2857], 'H.P.': [1165, 1456, 1653, 2644, 2858, 4215], 'Schaefer': [1168, 1459, 1656, 2647, 2861, 4218], 'Paul': [1170, 1461, 1658, 2649, 2863, 4220], '276:': [1178, 1469, 1666, 1754, 2657, 2871, 4228], '33630-336377Abstract': [1179, 1470, 1667, 2658, 2872, 4229], '(140)': [1187, 1478, 1675, 2666, 2880, 4237], 'directly': [1195, 4477], 'phosphorylated': [1196, 2537], 'resulted': [1201], 'decrease': [1204, 3223, 3439], 'inhibition': [1222, 1271, 1371, 1411, 3261, 3318, 4898, 4915], 'due': [1226, 3023, 3370, 4726, 4901], 'phosphorylation-dependent': [1229], 'protein,': [1234], 'negative': [1236], 'regulator': [1237], 'In': [1240, 1314, 1831, 3585, 3673, 3728, 3795, 4266, 4299, 4546, 5351], 'MCF-7': [1241, 2154, 2274, 2309, 2350, 2960, 3243, 3505, 3802, 4267, 4327, 4612, 4678, 4703, 4708, 5195], 'between': [1248, 1300, 1438, 1579, 1712, 2304, 4102, 4248, 5238], 'two': [1250, 2283, 2306, 3108, 4125, 4151, 4199, 4347, 4379, 5380], 'switched': [1252], 'from': [1256, 1453, 2317, 2887, 3966, 5397], 'cycle': [1260, 2253, 3076], 'arrest.': [1261, 4113], 'Stimulation': [1262, 2587], '100': [1264, 2341, 2345, 2405, 2416, 3254], 'ng/ml': [1265, 2406, 2413, 2417, 3255], 'concomitant': [1269, 3260], 'pharmacological': [1270], '(and': [1274], 'indirectly': [1275], 'Akt)': [1277], 'LY294002': [1279, 3531, 3556, 3613, 3883, 3899, 3953, 4920, 4999, 5018], 'led': [1280, 1901, 3147, 4048], 'an': [1282, 2891, 3167, 3235, 3535, 3824, 4383, 4559, 4603, 5309], 'increase': [1283, 3151, 3197, 3334], 'Raf-1-kinase': [1285], 'ERK': [1287, 1841, 2266, 2546, 2579, 2731, 3352, 3358, 3381, 3393, 3415, 3572, 3691, 3908, 3983, 4016, 4096, 4295, 4536, 4872, 4893, 4917, 4971, 4982, 4996, 5100, 5116, 5316], 'because': [1289, 1522, 4078, 4386, 4826], 'inhibitory': [1291, 2247, 3763], 'effect': [1292, 2248, 3764], 'was': [1296, 1307, 1396, 1525, 1567, 2321, 2387, 2588, 2752, 2762, 2805, 2885, 3003, 3268, 3282, 3289, 3528, 3610, 3895, 3995, 4080, 4297, 4305, 4659, 4675], 'suppressed.': [1297], 'also': [1308, 1444, 1723, 2013, 3495, 3577, 3712, 4047, 4742, 4751, 4909, 4988, 5038, 5157, 5198], 'demonstrated': [1309, 3349, 4959], 'other': [1311, 1589, 4836], 'systems.': [1313], 'work': [1316, 1604], 'Rommelet': [1318], 'al.': [1319, 1680], '(22Rommel': [1320, 1966, 4166], 'relative': [1348], 'contributions': [1349], 'activities': [1357, 3395, 4625], 'were': [1358, 2352, 2374, 2397, 2430, 2491, 2501, 2514, 2533, 2554, 2562, 2595, 2670, 2789, 2812, 2901, 2935, 2944, 3245, 3576, 3805, 4161], 'assessed': [1359], 'during': [1360, 3614, 4110, 4396], 'myotube': [1361, 1380], 'C2C12': [1364], 'cells.': [1365, 1541, 1555, 1718, 2275, 4328, 4704], 'Enforced': [1366], 'promoted': [1376], 'therefore': [1379], 'formation,': [1381], 'enforced': [1383], 'blocked': [1386], 'precursor': [1390], 'myoblast': [1391], 'stage.': [1392, 1498], 'Intriguingly,': [1393], 'observed': [1398, 1963, 3596, 4573, 4743, 4834, 5040], 'post-differentiation': [1400], 'myotubes': [1401, 1965], 'myoblasts,': [1405], 'where': [1406, 4292, 4746], 'had': [1412, 3954, 4088], 'no': [1413, 3018, 3438, 3762, 3771, 3955, 4089, 4566, 5008, 5011], 'influence': [1414, 3903, 3956, 4091, 4868, 5012, 5031, 5143], 'suggests': [1420], 'regulation': [1422, 3688, 4337], 'cross-talk,': [1425], 'particular': [1428], 'case': [1429], 'stage': [1433, 4263], 'specificity.': [1434, 2748], 'Recently,': [1435], 'has': [1442, 1584, 1848, 2161, 3049, 3622, 3761, 3916, 5037, 5156], 'been': [1443, 1586, 1724, 1849, 2162, 2957, 3050, 3623, 3671, 3917, 4119, 4596, 5039, 5158, 5199], 'neonatal': [1447, 4208], '(VSM)': [1451, 4212], 'cells': [1452, 1483, 1611, 1734, 1769, 1943, 2155, 2351, 2373, 2955, 2961, 2980, 3137, 3244, 3506, 4213, 4268, 4679, 4709, 4845, 5196, 5392], 'rat': [1454, 1832], '(23Reusch': [1455, 4214], 'Early': [1481], 'passage': [1482], 'expressed': [1484, 4306, 4668], 'various': [1485, 3874, 3920, 5212, 5470], 'levels': [1486], 'α-actin': [1488], 'myosin': [1491, 1550], 'their': [1494, 2971, 5406], 'developmental': [1495], 'showed': [1500, 1709, 2237, 3017, 4069], 'platelet-derived': [1502, 4202], 'factor,': [1504], 'potent': [1506, 4578], 'mitogen,': [1507], 'induced': [1508, 1545, 1557, 2240, 3515, 3865, 4272, 4660], 'sustained': [1510, 1840, 3996], 'allowed': [1515, 3504], 'transient': [1518], 'Ras-Raf-MEK-ERK,': [1521], 'able': [1526, 4639], 'phosphorylate': [1528], 'terminate': [1530], 'activity.': [1533], 'correlated': [1536, 1844, 4286], 'VSM': [1540, 1554, 1610, 4290], 'Thrombin': [1542, 1556], 'turn': [1544], 'markers': [1547], 'indicating': [1551, 2264], 'strong': [1559, 3424, 3474, 4013, 4361, 4555], 'biphasic': [1561, 4294], 'ERK-1/2,': [1564], 'partially': [1569], 'transiently': [1571], 'phosphorylated.': [1572], 'Cross-talk': [1573], 'description': [1575], 'balance': [1578, 5237], 'PKB/Akt': [1580], 'groups': [1590], 'depend': [1592, 3703], 'kind': [1595], 'agonist': [1597], 'background.': [1601], 'Besides': [1602], 'done': [1605], 'MCF-7,': [1607], 'C2C12,': [1608], 'Guan': [1678], 'et': [1679, 2205], '(24Guan': [1681], 'K.-L.': [1682], 'Figueroa': [1683], 'Brtva': [1685], 'T.R.': [1686], 'Zhu': [1687], 'Taylor': [1689], 'Barber': [1691], 'T.D.': [1692], 'Vojtek': [1693], '27354-27359Abstract': [1700], 'B-Raf': [1715, 1835], 'HEK293': [1717, 4844], 'However,': [1719, 3512], 'both': [1720, 2983, 3693, 4387], 'act': [1727], 'parallel.': [1729], 'Hence,': [1730], 'intestinal': [1732], 'epithelial': [1733], 'synergized': [1738, 1838], '(25Sheng': [1744], 'Shao': [1746], 'DuBois': [1748], 'R.N.': [1749], '14498-14504Abstract': [1755], '(97)': [1763], 'certain': [1767], 'tumor': [1768], 'primary': [1771, 2530], 'tumors': [1772], 'featured': [1773], 'constitutively': [1774], 'overexpressed': [1775], '(26Sun': [1777], 'Wang': [1779], 'Paciga': [1781], 'J.E.': [1782], 'Feldman': [1783], 'R.I.': [1784], 'Yuan': [1785], 'Z.-Q.,': [1786], 'Ma,': [1787], 'X.-L.': [1788], 'Shelley': [1789], 'Jove': [1791], 'Tsichlis': [1793, 4798], 'P.N.': [1794, 4799], 'Nicosia': [1795], 'S.V.': [1796], 'Cheng': [1797], 'J.Q.': [1798], 'Am.': [1799], 'Pathol.': [1801], '159:': [1803], '431-437Abstract': [1804], '(405)': [1812], 'Scholar,27Mirza': [1814], 'A.M.': [1815], 'Kohn': [1816], 'A.D.': [1817], 'Roth': [1818], 'R.A.': [1819, 5280], 'McMahon': [1820, 3086, 3853, 4929], '11:': [1827], '279-292PubMed': [1828], 'PC12': [1833], 'c-Raf': [1837], 'activity,': [1842, 3228, 4097], 'described': [1850, 2815], 'earlier': [1851], '(28York': [1852], 'R.D.': [1853, 1876, 2018], 'Yao': [1854], 'Dillon': [1856], 'Ellig': [1858], 'C.L.': [1859], 'Eckert': [1860], 'S.P.': [1861], 'McCleskey': [1862, 1883, 2025], 'E.W.': [1863, 1884, 2026], 'Stork': [1864, 1885, 2027], '392:': [1868], '622-626Crossref': [1869], '(757)': [1872], '29York': [1875], 'Molliver': [1877, 2019], 'D.C.': [1878, 2020], 'Grewal': [1879, 2021], 'S.S.': [1880, 2022], 'Stenberg': [1881, 2023], 'P.E.': [1882, 2024], 'P.J.S.': [1886, 2028], '20:': [1891, 2033], '8069-8083Crossref': [1892, 2034], '(203)': [1895, 2037], 'similar': [1899, 1959, 4739], 'synergy': [1900], 'megakaryocytes': [1905], '(UT7': [1906], 'cells)': [1907, 4160], 'thrombopoietin': [1909], '(30Garcia': [1910], 'de': [1912, 4767], 'Gunzburg': [1913], 'Eychène': [1915], 'Gisselbrecht': [1917], 'Porteu': [1919], 'F.': [1920, 2050], '21:': [1925, 2059], '2659-2670Crossref': [1926], '(81)': [1929], 'Ras-Raf': [1932, 5118], 'dominated': [1934], 'epidermal': [1939], 'factor-stimulated': [1941], 'COS': [1942], '(31Wennstrom': [1944, 3626, 5043, 5121], 'Downward': [1946, 2134, 3628, 3715, 5045, 5123], '4279-4288Crossref': [1953, 3635, 3722, 5052, 5130], '(254)': [1956, 3638, 3725, 5055, 5133], 'situation': [1962, 4740], '3T3L1': [1994], 'preadipocytes.': [1995], '2K.': [1996], 'Moelling,': [1997], 'Schad,': [1999], 'Bosse,': [2001], 'Zimmermann,': [2003], 'Schweneker,': [2006], 'unpublished': [2007], 'observations.': [2008], 'synergize': [2014], '(29York': [2017], '32von': [2040], 'Gise': [2041], 'Lorenz': [2043], 'Wellbrock': [2045], 'Berberich-Siebelt': [2049], 'Troppmair': [2053], '2324-2336Crossref': [2060], '(160)': [2063], 'Depending': [2066], 'background': [2070, 4261], 'alone': [2076], 'antiapoptotic': [2079], 'even': [2080, 4057], 'independently': [2081], 'interaction': [2087], 'signal-regulating': [2090], '(ASK-1)': [2093], '(33Chen': [2094], 'Fujii': [2096], 'Roberts': [2100, 5088], 'Fu': [2102], '98:': [2112], '7783-7788Crossref': [2113], '(270)': [2116], 'proapoptotic': [2123], '(34Kauffmann-Zeh': [2124], 'Rodriguez-Viciana': [2126], 'Ulrich': [2128], 'Gilbert': [2130], 'Coffer': [2132], 'Evan': [2136], '385:': [2140], '544-548Crossref': [2141], '(1073)': [2144], 'role': [2148, 4385], 'MAP': [2151, 2260], 'stimulated': [2156, 2398, 3138, 3246, 3755, 3926], 'TPA/PMA': [2160], 'others': [2165, 3053, 5042, 5161], '(35Alblas': [2166], 'Slager-Davidov': [2168, 2208], 'Steenbergh': [2170, 2210], 'P.H.': [2171, 2211], 'Sussenbach': [2172, 2212], 'J.S.': [2173, 2213, 5179, 5335], 'van': [2174, 2214], 'der': [2175, 2215], 'Burg': [2176, 2216], 'Oncogene.': [2178, 2218, 5436], '16:': [2180, 2220], '131-139Crossref': [2181, 2221], '(78)': [2184, 2224], '36Bartucci': [2187], 'Morelli': [2189], 'Mauro': [2191], 'Ando′': [2193], 'Surmacz': [2195], 'Cancer': [2197], 'Res.': [2198, 3185, 4781, 4947], '61:': [2200], '6747-6754PubMed': [2201], 'Alblas': [2204], 'al.(35Alblas': [2206], 'kinetics': [2229, 2280, 3369, 4342, 4620], 'immediate': [2233, 3472], 'early': [2234, 3615, 4395], 'genes': [2235], 'JNK': [2241], 'TPA': [2243, 2250], 'did': [2244, 3544, 3557, 3884, 3900, 4106], 'not.': [2245], 'entry': [2254], 'could': [2255], 'reverted': [2257], 'inhibitor': [2262, 3029, 3168, 3404, 3462, 3830, 4087, 4280], 'PD98059,': [2263], 'function': [2268], 'inhibitors': [2270, 3077, 4492, 4601, 4654], 'pathways,': [2284], 'PI3K-Akt,': [2287], 'upon': [2288], 'stimulation': [2289, 2371, 3115, 3496, 3971, 3993, 4123, 5275], 'PMA': [2293, 2418, 3014, 3862, 3924, 3992, 4010, 4045, 4662], 'using': [2294, 2503, 2807, 2890, 2948, 3351, 3565], 'different': [2295, 4126, 4152, 4200], 'concentrations.': [2297], 'focused': [2299], 'analyzing': [2301], 'pathways.': [2307, 4348], '(human': [2312], 'mammary': [2313], 'gland': [2314], 'carcinoma;': [2315], 'purchased': [2316], 'ATCC,': [2318], 'Manassas,': [2319], 'VA)': [2320], 'maintained': [2322], "Dulbecco's": [2324, 2381], 'modified': [2325, 2382], "Eagle's": [2326, 2383], 'medium/F-12': [2327], 'medium': [2328, 2386], '(Invitrogen)': [2329], 'supplemented': [2330, 2696], '5%': [2332], 'charcoal-treated': [2333], 'fetal': [2334], 'calf': [2335], 'serum': [2336], '(Seratec': [2337], 'Co.,': [2338], 'Goettingen,': [2339], 'Germany),': [2340], 'units/ml': [2342], 'penicillin,': [2343], 'mg/ml': [2346], 'streptomycin': [2347], '(both': [2348], 'Invitrogen).': [2349], 'seeded': [2353], 'onto': [2354], '100-mm': [2355], 'Falcon': [2356], 'culture': [2358], 'dishes': [2359], 'grown': [2361], 'confluency': [2364], 'about': [2366, 2975, 3326], '75%.': [2367], '24': [2368, 2976], 'h': [2369, 2393, 2977], 'before': [2370, 2394, 3625], 'starved': [2375], 'phenol': [2377], 'red-': [2378], 'serum-free': [2380], 'medium/F-12.': [2384], 'changed': [2388], 'second': [2390], '12': [2392], 'stimulation.': [2395], 'Cells': [2396, 2429, 2811], 'indicated': [2401], 'times': [2402], '(Calbiochem,': [2408], 'San': [2409], 'Diego,': [2410], 'CA),': [2411], '10': [2412, 2433, 2478, 2698, 2765, 2925, 3251, 3385], 'IGF-I,': [2414, 3594, 3801], '(Calbiochem)': [2419], 'without': [2422, 3259], 'prior': [2423], 'incubation': [2424], '20': [2426, 2689, 2917], 'μmLY294002': [2427], '(Calbiochem).': [2428], 'lysed': [2431, 2813], 'min': [2434, 2756, 2905, 3252, 3312, 3386, 3435, 3945, 4665], 'radioimmunoprecipitation': [2436], 'assay': [2437, 3239, 3539], 'buffer': [2438, 2677, 2771], '(20': [2439], 'mm': [2440, 2445, 2448, 2463, 2467, 2470, 2473, 2679, 2684, 2687, 2690, 2694, 2773], 'Tris-HCl,': [2441, 2680, 2774], 'pH': [2442, 2681, 2775], '7.5,': [2443, 2682], '135': [2444], 'NaCl,': [2446, 2685], '2': [2447, 2686, 4370], 'EDTA,': [2449], '1%': [2450], 'Triton': [2451], 'X-100,': [2452], '0.1%': [2453], 'SDS,': [2454, 2780], '0.5%': [2455], 'sodium': [2456], 'deoxycholate,': [2457], '10%': [2458, 2517, 2793], 'glycerol,': [2459, 2778], 'mmdithiothreitol,': [2461], '25': [2462, 2466], 'β-glycerol': [2464, 2691], 'phosphate,': [2465, 2692], 'NaF,': [2468], 'Na3VO4,': [2471], 'phenylmethylsulfonyl': [2474], 'fluoride,': [2475], 'mmbenzamidine,': [2477], 'μm': [2479, 2699, 2918], 'pepstatin,': [2480], 'Trasylol': [2481], '(500,000': [2482], 'Kallikrein®': [2483], 'inactivator': [2484], 'units)': [2485], '1:1000,': [2486], '5': [2487, 2693, 2705, 3311], 'μg/ml': [2488, 2713], 'leupeptin).': [2489], 'Lysates': [2490], 'cleared': [2492, 2593], 'centrifugation,': [2494], 'concentrations': [2497, 2967, 3008, 4891, 5113], 'supernatants': [2500], 'determined': [2502, 2958], 'Protein': [2505], 'Assay': [2506], 'Kit': [2507], 'II': [2508], '(Bio-Rad).': [2509], 'Equal': [2510], 'separated': [2515, 2790, 2936], 'SDS-polyacrylamide': [2518, 2794], 'gels': [2519, 2943], 'transferred': [2521, 2797], 'nitrocellulose': [2523, 2800], 'membranes': [2524], '(Amersham': [2525, 2559, 2709], 'Biosciences).': [2526, 2560], 'detection,': [2529], 'antibodies': [2531, 2553, 2568, 2600, 3354, 3569], 'used': [2532], 'specific': [2534, 2893, 5427], '(Cell': [2547], 'Signaling': [2548], 'Technologies,': [2549], 'Beverly,': [2550], 'MA).': [2551], 'Primary': [2552], 'detected': [2555, 3624, 5159], 'enhanced': [2557], 'chemiluminescence': [2558], 'Membranes': [2561], 'stripped,': [2563], 'blocked,': [2564], 'reprobed': [2566], '(R19120;': [2571], 'BD': [2572], 'Biosciences,': [2573], 'Franklin': [2574], 'Lakes,': [2575], 'NJ)': [2576], '(C14;': [2580], 'Santa': [2581, 2584, 2896], 'Cruz': [2582, 2897], 'Biotechnology,': [2583, 2717], 'Cruz,': [2585], 'CA).': [2586], 'performed': [2589, 2753, 2902], 'described,': [2591], 'lysates': [2594, 2889], 'subjected': [2596], 'immunoprecipitation': [2598], 'Beads': [2669], 'resuspended': [2671], '30': [2673, 2755, 2758, 2907, 2910, 4664], 'μl': [2674, 2766, 2911], '(50': [2678], '50': [2683], 'dithiothreitol,': [2688], 'MnCl2)': [2695], 'ATP': [2700], '(Roche': [2701], 'Diagnostics,': [2702], 'Basel,': [2703], 'Switzerland),': [2704], 'μCi': [2706, 2921], '[γ-32P]ATP': [2708], 'Biosciences),': [2710], '27.8': [2712], 'unactivated': [2714], 'MEK1': [2715], '(Upstate': [2716], 'Charlottesville,': [2718], 'VA).': [2719], 'prefers': [2723], 'Mn2+': [2724], 'over': [2725, 3873, 3997], 'Mg2+,': [2726], 'contrast': [2728, 3586, 3796], 'C': [2736, 4749], '(2,': [2737], 'Upstate': [2739], 'Biotechnology': [2740], 'Catalogue': [2741], '2001),': [2742], 'thus': [2743], 'increasing': [2744], 'reaction': [2751, 2761], 'at': [2757, 2906, 3005, 3328, 3579, 3606, 3819, 3937, 4460, 4670, 4965, 5372], '°C,': [2759], 'stopped': [2763], '4×': [2768], 'SDS': [2769], 'sample': [2770], '(250': [2772], '6.8,': [2776], '40%': [2777], '8%': [2779], '0.4%': [2781], 'bromphenol': [2782], 'blue,': [2783], '200': [2784], 'μl/ml': [2785], 'β-mercaptoethanol).': [2786], 'proteins': [2788], 'gel': [2795], 'membrane,': [2801], 'MEK': [2803, 3280], 'assayed': [2806, 3533], 'PhosphorImager': [2809, 3292], '(AmershamBiosciences).': [2810], 'Subsequently,': [2883], 'ERK-2': [2884, 2892], 'precipitated': [2886], 'antibody': [2894], '(C-14,': [2895], 'Biotechnology).': [2898], 'Kinase': [2899], 'reactions': [2900, 2934], '15': [2904], '°C': [2908], 'buffer,': [2914], 'adjusted': [2915], 'ATP,': [2919], '[γ-32P]ATP,': [2923], 'μg': [2926], 'myelin': [2928], 'basic': [2929], '(Sigma).': [2931], '12.5%': [2938], 'SDS-gels.': [2939], 'Finally,': [2940], 'dried': [2942], 'exposed': [2945], 'quantified': [2947, 3290], 'PhosphorImager.': [2950], 'properties': [2952], 'proliferating': [2954, 4309], 'treated': [2962, 3806], 'medium.': [2973], 'After': [2974, 3241, 3773], 'treatment': [2979, 4046], 'incubated': [2981], '(10': [2986, 3502], 'ng/ml)': [2987, 2992, 3016, 3503, 3864], '(100': [2991, 3015, 3144, 3863], 'started': [2993], 'proliferate.': [2995], 'At': [2996, 3410, 3448, 4888], 'later': [2997, 3411, 4462, 4966], 'points,': [2999], 'rate': [3002], 'higher': [3004, 3006, 3397], '(not': [3009], 'shown).': [3010, 3447, 3948], 'As': [3011, 3915], 'shown,': [3013], 'growth-promoting': [3019], 'effects': [3020, 5307], '(Fig.1)': [3021], 'presumably': [3022], 'expression': [3025, 5273], 'cell-cycle': [3028, 3829, 4279, 4491, 4600, 4653], 'p21cip1': [3030, 3831], 'proliferative': [3056], 'keeps': [3058], 'under': [3065, 4507, 4984], 'control': [3066, 3099], 'prevent': [3068], 'ERK-dependent': [3072, 3825, 4514, 4604], 'up-regulation': [3073], '(37Chen': [3078, 4921], 'D.': [3079, 3846, 4416, 4922], 'Heath': [3080, 3847, 4923], 'V.': [3081, 3848, 4924], "O'Garra": [3082, 3849, 4925], 'Johnston': [3084, 3851, 4927], 'Immunol.': [3089, 3856, 4932], '163:': [3091, 3858, 4934], '5796-5805PubMed': [3092, 3859, 4935], 'To': [3095], 'investigate': [3096], 'how': [3097], 'achieved': [3101], 'after': [3114, 3433, 3471, 3991, 4122], 'IGF-I.': [3122, 4065], 'Fig.2A': [3123], 'shows': [3124], 'state': [3127], 'site': [3132], 'ng/ml),': [3145], 'rapid': [3150], '(lane': [3155, 3200, 3209, 3387], '3),': [3156], 'visualized': [3157], 'phospho-specific': [3160], 'antibody.': [3161], 'Inhibition': [3162, 3949], 'LY294002,': [3166], 'upstream': [3172], '(38Sanchez-Margalet': [3175], 'V': [3176, 4938], 'Goldfine': [3177, 4939], 'I.D.': [3178, 4940], 'Vlahos': [3179, 4941], 'Sung': [3181, 4943], 'C.K.': [3182, 4944], 'Biophys.': [3184, 4946], 'Commun.': [3186, 4948], '204:': [3188, 4950], '446-452Crossref': [3189, 4951], '(122)': [3192, 4954], 'suppresses': [3195], '4).': [3201], 'Over': [3202], 'time,': [3203], 'diminishes': [3208], '5).': [3210, 3316], 'Because': [3211, 4449, 4565, 4630], 'increased': [3212, 4896], 'usually': [3219], 'associated': [3220], 'next': [3230], 'measured': [3231, 3578, 4001], 'vitro': [3237, 3537], '(Fig.2B).': [3240], 'starvation,': [3242], '3,': [3248, 5020], '5,': [3249], 'LY294002.': [3265, 3463, 4084], 'Endogenous': [3266], 'immunoprecipitated,': [3269], 'toward': [3273, 4522], 'glutathione': [3275], 'S-transferase': [3276], 'fusion': [3277, 5419], '(GST-MEK)': [3281], 'assayed.': [3283], 'radioactivity': [3285], 'incorporated': [3286], 'into': [3287], 'glutathioneS-transferase-MEK': [3288], 'analysis.': [3293], 'cause': [3298, 4528, 4558], 'transient,': [3300], '∼2-fold': [3301], 'peaking': [3307], 'around': [3308, 3384], '(lanes': [3313, 3418], 'Concomitant': [3317], '50%': [3327], 'every': [3329], 'point': [3331], 'measured.': [3332], 'transmitted': [3340], 'ERK-1': [3345], '-2': [3347], 'activation-specific': [3353], '(Fig.': [3355, 3405, 3816, 3910, 3977, 4563, 5019, 5136], '2C).': [3356], 'mirrors': [3360], 'Raf-1,': [3364], 'although': [3365], 'slightly': [3367, 4461], 'delayed': [3368, 4055, 4553], 'position': [3374], 'ERK.': [3376], 'peak': [3379, 3605], 'lies': [3383], '7).': [3388], 'Both': [3389], 'presence': [3400, 3881, 4716], '2,': [3406, 3978], 'C).': [3409, 3914, 3981], 'points': [3413, 3451, 3617, 4000, 4464, 4968], 'decreased': [3417], '9–12).': [3419], 'Under': [3420, 4587], 'same': [3422, 3567], 'conditions': [3423, 4509, 4987], 'visible': [3429], 'persistent.': [3431], 'Even': [3432, 5402], '90': [3434, 3944, 4978], 'stimulation,': [3437], 'detectable': [3444, 3547], '(data': [3445, 3946], 'all': [3449, 3998], 'analyzed,': [3452], 'suppressed': [3458, 4082], 'takes': [3469], 'place': [3470, 4109], 'Akt,': [3477, 4053, 4468], 'thereby': [3482, 4487], 'negatively': [3483], 'allow': [3492], 'Interestingly': [3494], 'proliferate': [3508], '(see': [3509, 3711], 'Fig.': [3510], '1).': [3511, 4564], 'rather': [3517], '(1.5-': [3524], '2-fold),': [3526], 'independent': [3529, 5119], 'when': [3532, 4059, 4969], '(Fig.3B).': [3540], 'Low': [3541, 4524], 'concentration': [3543], 'induce': [3546, 4599], 'above': [3548], 'basal': [3549], 'unexpectedly': [3555], 'affect': [3559], '(Fig.3A).': [3563], 'By': [3564], 'phosphorylation-specific': [3568], 'above,': [3571], '(Fig.3C).': [3584], 'much': [3598], 'lower': [3599, 4530], 'ERK-1/2': [3602], '5–10': [3607], 'min,': [3608], 'inhibited': [3611], '(3–30': [3618], 'min).': [3619, 4979], 'paradox': [3621], '39Sutor': [3641, 5058], 'S.L.': [3642, 4019, 5059], 'Vroman': [3643, 4020, 5060], 'B.T.': [3644, 4021, 5061], 'Armstrong': [3645, 4022, 5062], 'E.A.': [3646, 4023, 5063], 'Abraham': [3647, 4024, 5064], 'R.T.': [3648, 4025, 5065], 'Kranitz': [3649, 4026, 5066], 'L.M.': [3650, 4027, 5067], '274:': [3655, 4032, 5072], '7002-7010Abstract': [3656, 4033, 5073], '(65)': [3664, 4041, 5081], 'explanations': [3669], 'postulated.': [3672], 'agreement': [3674], 'others,': [3676], 'conclude,': [3678], 'must': [3681], 'play': [3682, 4382], 'distinct': [3684], 'roles': [3685], 'pathway,': [3692, 5266, 5311], 'positive': [3694, 5142], 'negative.': [3696], 'here': [3699, 4960], 'incoming': [3709], 'signal': [3710, 5204, 5242], 'Ref.31Wennstrom': [3713], 'keeping': [3729], 'previous': [3731], 'findings,': [3732], 'mitogen': [3739, 4527], 'kinase,': [3768, 5152], 'i.e.there': [3769], 'having': [3774], 'depended': [3779], 'concentrations,': [3783], 'addressed': [3785], 'question': [3787], 'specificity': [3790], 'outcome.': [3794], 'exposure': [3798, 3875], 'proliferation-inducing': [3800], 'esters': [3809, 4831, 5278], 'PMA,': [3812, 4130, 4606], 'underwent': [3813], '1)': [3817], 'driven': [3818], 'least': [3820, 4671], 'part': [3822], '37Chen': [3845], 'some': [3866, 4050], '(Fig.4A)': [3872], 'periods.': [3876], 'Importantly,': [3877], 'absence': [3879, 4760], 'significantly': [3886, 3902], 'alter': [3887], 'degree': [3889], 'suggesting': [3892], 'involved.': [3897], 'Likewise,': [3898], 'nor': [3907], '4,': [3911], 'systems': [3922], 'before,': [3923], '(4-': [3931], '5-fold)': [3933], '(Fig.4B)': [3934], 'persisted': [3936], 'up': [3942], 'PMA-mediated': [3959], 'activation.': [3962], 'finding': [3964], 'differed': [3965], 'results': [3968, 4004, 4067, 4312, 5423], 'obtained': [3969], 'reached': [3985], 'very': [3987], 'immediately': [3990], '(Fig.4C).': [4002], 'These': [4003, 4815], 'confirm': [4005], 'former': [4006], 'stating': [4008], 'inducer': [4014], '(39Sutor': [4018], 'Surprisingly,': [4044], 'however,': [4054, 4817, 4963], 'reduced': [4058], 'compared': [4060], 'Our': [4066, 4311, 4876], 'further': [4068], 'PMA-induced': [4071, 4111], 'occurred': [4075], 'PI3K,': [4077], 'completely': [4081], 'Yet': [4085, 4906], 'significant': [4090], 'demonstrating': [4098], 'take': [4108, 4544], 'ligands,': [4127, 4201], 'single': [4133], '(MCF-7)': [4136], 'stages': [4154], '(C2C12': [4159], 'another': [4164], 'study': [4165], 'third': [4195], 'investigation': [4196], 'probed': [4197], 'again': [4198], 'thrombin,': [4206], 'From': [4240], 'results,': [4242], 'concluded': [4244], 'depends': [4252], 'activating': [4277], 'p21cip1.': [4281], 'Similarly,': [4282], 'induced.': [4298], 'contrast,': [4300], 'undifferentiated': [4308], 'myoblasts.': [4310], 'manner': [4325], 'possible': [4330], 'explanation': [4331], 'provided': [4339], 'mitogenic': [4352], 'stimuli': [4353], 'fast': [4358], 'sufficiently': [4360], 'way': [4362], 'down-regulate': [4364, 4641], '(Figs.': [4369, 4583, 4626], 'and5A).': [4371], 'Here,': [4372], 'spatial': [4373, 5376], 'co-localization': [4376], 'plasma': [4392, 4457], 'already': [4394], '40Stokoe': [4415], 'Macdonald': [4417], 'S.G.': [4418], 'Cadwallader': [4419], 'Symons': [4421], 'Hancock': [4423], 'J.F.': [4424], '264:': [4427], '1463-1467Crossref': [4428], '(845)': [4431], '41Leevers': [4434], 'S.J.': [4435], 'Paterson': [4436], 'H.F.': [4437], '369:': [4442], '411-414Crossref': [4443], '(885)': [4446], 'recruitment': [4454], 'occur': [4459], 'than': [4465], 'counteract': [4471, 4649], 'phosphorylating': [4478], 'inhibits': [4482], 'prevents': [4488, 4513], 'shifts': [4518], 'activities,': [4538], 'place.': [4545], 'case,': [4548], 'albeit': [4560], 'slower': [4561], 'occurs,': [4568], 'postulate': [4570], 'inhibit': [4581], '5B).': [4586], 'circumstances': [4589], 'sufficient': [4597], 'purely': [4608], 'growth-arresting': 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