Publication Information

{'id': 'https://openalex.org/W2087846852', 'doi': 'https://doi.org/10.1002/hep.510280639', 'title': 'Is ursodeoxycholate an antiapoptotic drug?', 'display_name': 'Is ursodeoxycholate an antiapoptotic drug?', 'publication_year': 1998, 'publication_date': '1998-12-01', 'ids': {'openalex': 'https://openalex.org/W2087846852', 'doi': 'https://doi.org/10.1002/hep.510280639', 'mag': '2087846852', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9828243'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/hep.510280639', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.510280639', 'source': {'id': 'https://openalex.org/S156174673', 'display_name': 'Hepatology', 'issn_l': '0270-9139', 'issn': ['0270-9139', '1527-3350'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.510280639', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5114688178', 'display_name': 'Eugenia M. Guicciardi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eugenia M. Guicciardi', 'raw_affiliation_strings': ['Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN'], 'affiliations': [{'raw_affiliation_string': 'Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN', 'institution_ids': ['https://openalex.org/I4210125099']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5004470985', 'display_name': 'Gregory J. Gores', 'orcid': 'https://orcid.org/0000-0003-3151-009X'}, 'institutions': [{'id': 'https://openalex.org/I4210125099', 'display_name': 'Mayo Clinic in Arizona', 'ror': 'https://ror.org/03jp40720', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723', 'https://openalex.org/I4210125099']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gregory J. Gores', 'raw_affiliation_strings': ['Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN'], 'affiliations': [{'raw_affiliation_string': 'Division of Gastroenterology and Hepatology Mayo Clinic Rochester MN', 'institution_ids': ['https://openalex.org/I4210125099']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.513, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.748477, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': '28', 'issue': '6', 'first_page': '1721', 'last_page': '1723'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11465', 'display_name': 'Drug-Induced Hepatotoxicity and Protection', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11465', 'display_name': 'Drug-Induced Hepatotoxicity and Protection', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11834', 'display_name': 'Liver Diseases and Immunity', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ursodeoxycholic-acid', 'display_name': 'Ursodeoxycholic acid', 'score': 0.565407}], 'concepts': [{'id': 'https://openalex.org/C41260117', 'wikidata': 'https://www.wikidata.org/wiki/Q668064', 'display_name': 'Hepatology', 'level': 2, 'score': 0.8392714}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.69826394}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6432225}, {'id': 'https://openalex.org/C2780965833', 'wikidata': 'https://www.wikidata.org/wiki/Q241374', 'display_name': 'Ursodeoxycholic acid', 'level': 2, 'score': 0.565407}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.54332614}, {'id': 'https://openalex.org/C512399662', 'wikidata': 'https://www.wikidata.org/wiki/Q3505712', 'display_name': 'Family medicine', 'level': 1, 'score': 0.36749816}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D002756', 'descriptor_name': 'Cholagogues and Choleretics', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D014580', 'descriptor_name': 'Ursodeoxycholic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002756', 'descriptor_name': 'Cholagogues and Choleretics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007425', 'descriptor_name': 'Intracellular Membranes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007425', 'descriptor_name': 'Intracellular Membranes', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D007425', 'descriptor_name': 'Intracellular Membranes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014580', 'descriptor_name': 'Ursodeoxycholic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/hep.510280639', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.510280639', 'source': {'id': 'https://openalex.org/S156174673', 'display_name': 'Hepatology', 'issn_l': '0270-9139', 'issn': ['0270-9139', '1527-3350'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9828243', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/hep.510280639', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.510280639', 'source': {'id': 'https://openalex.org/S156174673', 'display_name': 'Hepatology', 'issn_l': '0270-9139', 'issn': ['0270-9139', '1527-3350'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Zero hunger', 'id': 'https://metadata.un.org/sdg/2', 'score': 0.43}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 12, 'referenced_works': ['https://openalex.org/W1922978848', 'https://openalex.org/W1976773018', 'https://openalex.org/W198432786', 'https://openalex.org/W1994642867', 'https://openalex.org/W2013465015', 'https://openalex.org/W2013605037', 'https://openalex.org/W2032049833', 'https://openalex.org/W2113999599', 'https://openalex.org/W2121541608', 'https://openalex.org/W2122409112', 'https://openalex.org/W2131085743', 'https://openalex.org/W2324587274'], 'related_works': ['https://openalex.org/W3111784698', 'https://openalex.org/W2736526246', 'https://openalex.org/W2731463817', 'https://openalex.org/W2399665111', 'https://openalex.org/W2354671543', 'https://openalex.org/W2129764344', 'https://openalex.org/W2085917729', 'https://openalex.org/W2083313791', 'https://openalex.org/W2061042644', 'https://openalex.org/W1998556725'], 'abstract_inverted_index': {'HepatologyVolume': [0], '28,': [1], 'Issue': [2], '6': [3, 310], 'p.': [4], '1721-1723': [5, 478], 'ElsewhereFree': [6], 'Access': [7], 'Is': [8], 'ursodeoxycholate': [9], 'an': [10], 'antiapoptotic': [11], 'drug?': [12], 'M.': [13, 17, 58, 62], 'Eugenia': [14, 18, 59, 63], 'Guicciardi': [15, 19, 60, 64], 'Ph.D.,': [16, 61], 'Ph.D.': [20, 65], 'Division': [21, 43, 66, 88], 'of': [22, 44, 67, 89, 129, 139, 152, 163, 247, 268, 287, 302, 328, 369, 401, 462], 'Gastroenterology': [23, 45, 68, 90, 271], 'and': [24, 46, 69, 91, 127, 131, 143, 150, 169, 201, 290, 334, 386, 440], 'Hepatology,': [25, 47, 70, 92], 'Mayo': [26, 48, 71, 93], 'Clinic,': [27, 49, 72, 94], 'Rochester,': [28, 50, 73, 95], 'MNSearch': [29, 51, 74, 96], 'for': [30, 52, 75, 97, 225, 243], 'more': [31, 53, 76, 98], 'papers': [32, 54, 77, 99], 'by': [33, 55, 78, 100, 365, 435], 'this': [34, 56, 79, 101, 164], 'authorGregory': [35, 80], 'J.': [36, 40, 81, 85], 'Gores': [37, 41, 82, 86, 354, 398], 'M.D.,': [38, 83], 'Gregory': [39, 84], 'M.D.': [42, 87], 'author': [57, 102], 'First': [103], 'published:': [104], '30': [105], 'December': [106], '2003': [107], 'https://doi.org/10.1002/hep.510280639Citations:': [108], '13AboutPDF': [109], 'ToolsRequest': [110], 'permissionExport': [111], 'citationAdd': [112], 'to': [113, 135, 158], 'favoritesTrack': [114], 'citation': [115], 'ShareShare': [116], 'Give': [117], 'accessShare': [118, 121], 'full': [119], 'text': [120], 'full-text': [122, 137, 161], 'accessPlease': [123], 'review': [124], 'our': [125], 'Terms': [126, 149], 'Conditions': [128, 151], 'Use': [130], 'check': [132], 'box': [133], 'below': [134, 157], 'share': [136, 159], 'version': [138, 162], 'article.I': [140], 'have': [141], 'read': [142], 'accept': [144], 'the': [145, 155, 244, 359, 463], 'Wiley': [146], 'Online': [147], 'Library': [148], 'UseShareable': [153], 'LinkUse': [154], 'link': [156], 'a': [160, 175, 367], 'article': [165], 'with': [166, 192, 197], 'your': [167], 'friends': [168], 'colleagues.': [170], 'Learn': [171], 'more.Copy': [172], 'URL': [173], 'Share': [174], 'linkShare': [176], 'onFacebookTwitterLinkedInRedditWechat': [177], 'References': [178], '1': [179], 'Leuschner': [180, 182], 'U,': [181, 316], 'M,': [183, 221], 'Sieratzki': [184], 'J,': [185], 'Kurtz': [186], 'W,': [187, 324], 'Hubner': [188], 'K.': [189], 'Gallstone': [190], 'dissolution': [191], 'ursodeoxycholic': [193, 269, 303], 'acid': [194, 330, 429], 'in': [195, 297, 336, 407], 'patients': [196], 'chronic': [198], 'active': [199], 'hepatitis': [200], 'two': [202], 'years': [203], 'follow-up.': [204], 'A': [205], 'pilot': [206], 'study.': [207], 'Dig': [208], 'Dis': [209], 'Sci': [210], '1985;': [211], '30:': [212], '642–': [213], '649.MEDLINE': [214], '2': [215], 'Rubin': [216], 'RA,': [217], 'Kowalski': [218], 'TE,': [219], 'Khandelwal': [220], 'Malet': [222], 'PF.': [223], 'Ursodiol': [224, 242], 'hepatobiliary': [226], 'disorders.': [227], 'Ann': [228], 'Intern': [229], 'Med': [230, 258, 446], '1994;': [231, 259, 413], '121:': [232], '207–': [233], '218.MEDLINE': [234], '3': [235], 'Poupon': [236, 238, 283], 'RE,': [237], 'R,': [239, 347], 'Balkau': [240], 'B.': [241], 'long-term': [245], 'treatment': [246], 'primary': [248, 298], 'biliary': [249, 299], 'cirrhosis.': [250], 'The': [251], 'UDCA-PBC': [252], 'Study': [253], 'Group.': [254], 'N': [255], 'Engl': [256], 'J': [257, 339, 372, 410, 466], '330:': [260], '1342–': [261], '1347.MEDLINE': [262], '4': [263], 'Heuman': [264], 'DM.': [265], 'Hepatoprotective': [266], 'properties': [267], 'acid.': [270, 304], '1993;': [272], '104:': [273], '1865–': [274], '1870.MEDLINE': [275], '5': [276], 'Calmus': [277], 'Y,': [278], 'Gane': [279], 'P,': [280, 282, 318, 322], 'Rouger': [281], 'R.': [284], 'Hepatic': [285], 'expression': [286], 'class': [288, 291], 'I': [289], 'II': [292], 'major': [293], 'histocompatibility': [294], 'complex': [295], 'molecules': [296], 'cirrhosis:': [300], 'effect': [301], 'Hepatology': [305], '1990;': [306], '11:': [307], '12–': [308], '15.MEDLINE': [309], 'Benz': [311], 'C,': [312], 'Angermuller': [313], 'S,': [314], 'Tox': [315], 'Kloters-Plachky': [317], 'Riedel': [319], 'HD,': [320], 'Sauer': [321], 'Stremmel': [323], 'Stiehl': [325], 'A.': [326], 'Effect': [327], 'tauroursodeoxycholic': [329], 'on': [331], 'bile-acid-induced': [332], 'apoptosis': [333, 406, 434], 'cytolysis': [335], 'rat': [337, 408], 'hepatocytes.': [338, 409], 'Hepatol': [340], '1998;': [341, 389, 447], '28:': [342], '99–': [343], '106.MEDLINE': [344], '7': [345], 'Botla': [346], 'Spivey': [348], 'JR,': [349], 'Aguilar': [350], 'H,': [351], 'Bronk': [352, 396], 'SF,': [353, 397], 'GJ.': [355, 399], 'Ursodeoxycholate': [356], '(UDCA)': [357], 'inhibits': [358], 'mitochondrial': [360, 437], 'membrane': [361], 'permeability': [362], 'transition': [363], 'induced': [364], 'glycochenodeoxycholate:': [366], 'mechanism': [368], 'UDCA': [370], 'cytoprotection.': [371], 'Pharmacol': [373], 'Exp': [374], 'Ther': [375], '1995;': [376], '272:': [377, 470], '930–': [378], '938.MEDLINE': [379], '8': [380], 'Green': [381], 'DR,': [382], 'Reed': [383], 'JC.': [384], 'Mitochondria': [385], 'apoptosis.': [387], 'Science': [388], '281:': [390], '1309–': [391], '1312.MEDLINE': [392], '9': [393], 'Patel': [394], 'T,': [395], 'Increases': [400], 'intracellular': [402], 'magnesium': [403], 'promote': [404], 'glycodeoxycholate-induced': [405], 'Clin': [411], 'Invest': [412], '94:': [414], '2183–': [415], '2192.MEDLINE': [416], '10': [417], 'Rodrigues': [418], 'CM,': [419], 'Fan': [420], 'G,': [421], 'Wong': [422], 'PY,': [423], 'Kren': [424], 'BT,': [425], 'Steer': [426], 'CJ.': [427], 'Ursodeoxycholic': [428], 'may': [430], 'inhibit': [431], 'deoxycholic': [432], 'acid-induced': [433], 'modulating': [436], 'transmembrane': [438], 'potential': [439], 'reactive': [441], 'oxygen': [442], 'species': [443], 'production.': [444], 'Mol': [445], '4:': [448], '165–': [449], '178.MEDLINE': [450], '11': [451], 'Hsu': [452], 'YT,': [453], 'Youle': [454], 'RJ.': [455], 'Nonionic': [456], 'detergents': [457], 'induce': [458], 'dimerization': [459], 'among': [460], 'members': [461], 'Bcl-2': [464], 'family.': [465], 'Biol': [467], 'Chem': [468], '1997;': [469], '13829–': [471], '13834.MEDLINE': [472], 'Citing': [473], 'Literature': [474], 'Volume28,': [475], 'Issue6December': [476], '1998Pages': [477], 'ReferencesRelatedInformation': [479]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2087846852', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-11T11:31:26.891210', 'created_date': '2016-06-24'}