Title: Mammary and extramammary paget's disease. An immunocytochemical and ultrastructural study
Abstract: CancerVolume 59, Issue 6 p. 1173-1183 ArticleFree Access Mammary and extramammary paget's disease. An immunocytochemical and ultrastructural study Nelson G. Ordóñez MD, Corresponding Author Nelson G. Ordóñez MD Department of Pathology, University of Texas M. D. Anderson Hospital, and the Tumor Institute, Houston, TexasDepartment of Pathology, University of Texas M. D. Anderson Hospital, 6723 Bertner Avenue, Houston, Texas 77030===Search for more papers by this authorHazel Awalt MD, Hazel Awalt MD Department of Pathology, University of Texas M. D. Anderson Hospital, and the Tumor Institute, Houston, TexasSearch for more papers by this authorBruce Mackay MD, PhD, Bruce Mackay MD, PhD Department of Pathology, University of Texas M. D. Anderson Hospital, and the Tumor Institute, Houston, TexasSearch for more papers by this author Nelson G. Ordóñez MD, Corresponding Author Nelson G. Ordóñez MD Department of Pathology, University of Texas M. D. Anderson Hospital, and the Tumor Institute, Houston, TexasDepartment of Pathology, University of Texas M. D. Anderson Hospital, 6723 Bertner Avenue, Houston, Texas 77030===Search for more papers by this authorHazel Awalt MD, Hazel Awalt MD Department of Pathology, University of Texas M. D. Anderson Hospital, and the Tumor Institute, Houston, TexasSearch for more papers by this authorBruce Mackay MD, PhD, Bruce Mackay MD, PhD Department of Pathology, University of Texas M. D. Anderson Hospital, and the Tumor Institute, Houston, TexasSearch for more papers by this author First published: 15 March 1987 https://doi.org/10.1002/1097-0142(19870315)59:6<1173::AID-CNCR2820590624>3.0.CO;2-RCitations: 99AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Twenty-one cases of Paget's disease have been studied using histochemical, ultrastructural, and immunohistochemical methods. Eight of the tumors involved the nipple, and 13 were extramammary (11 vulvar and two anal). The antibodies used were directed against different classes of cytokeratin proteins, epithelial membrane antigen, carcinoembryonic antigen, gross cystic disease fluid protein-15, and S-100 protein. The findings of this study provide conclusive evidence that Paget's cells, regardless of their location, are adenocarcinoma cells. Intracytoplasmic mucin is scanty in Paget's cells within the nipple, but typically plentiful in the extramammary sites where the cells are frequently signet-ring cells. The common mechanism for the evolution of Paget's disease is extension of cells from an underlying carcinoma, but the possibility that some cases, particularly in the vulva, develop from intraepithelial precursors cannot be excluded. Cancer 59:1173-1184, 1987. References 1 Paget J. Disease of the mammary areola preceding cancer of the mammary gland. St. Bartholomew's Hosp Rep 1974; 10: 87– 89. 2 Crocker HR. Paget's disease affecting the scrotum and penis. 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