NF-κB Transcription Factor p50 Critically Regulates Tissue Factor in Deep Vein Thrombosis

Name: Work Video:
Duration: 3 min 30 s
Yi-Dan Li; Bu-Qing Ye; Sheng-Xi Zheng; Jin-Tao Wang; Jianguo Wang; Ming Chen; Ji-Guo Liu; Xin-Hui Pei; Lijing Wang; Zhixin Lin; Kalpna Gupta; Nigel Mackman; Arne Slungaard; Nigel S. Key; Jian-Guo Geng
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2509, 2588, 2604, 2615, 2649, 2668, 2696, 2780, 2811, 2819, 2859, 2942, 3038, 3136, 3169, 3182, 3392, 3424, 3656, 3672, 3720, 3821, 3834, 3840, 3923, 3934, 4001, 4364], 'recapitulated': [90, 231], 'by': [91, 106, 232, 247, 518, 818, 1239, 1483, 1543, 1677, 1712, 1746, 1962, 2401, 2448, 2478, 2608, 2791, 3041, 3058, 3103, 3106, 3152, 3171, 3223, 3311, 3332, 3486, 3692, 3804, 3823, 4343], 'an': [92, 233, 399, 1950, 2058, 3446, 4100], 'anti-murine': [93, 234], 'antibody': [95, 236, 1833, 2691, 3950, 3958, 3966], 'vivo.': [97, 238, 1254, 1342], 'Our': [98, 239], 'findings': [99, 240], 'thus': [100, 241, 1321], 'indicate': [101, 242, 4199], 'regulation': [103, 244, 1236, 4209], 'essential': [112, 253, 4206], 'for': [113, 134, 254, 275, 567, 574, 581, 588, 628, 646, 1466, 1673, 1698, 1716, 1795, 1853, 2124, 2184, 2202, 2214, 2230, 2503, 2540, 2621, 2637, 2673, 2710, 2786, 2800, 2854, 3065, 3097, 3148, 3165, 3178, 3229, 3328, 3635, 3715, 3794, 3816, 4003, 4025, 4207, 4225, 4438], 'pathogenesis': [115, 256, 952, 1144], 'deep': [117, 258, 295, 1386], 'vein': [118, 259, 296, 301, 306, 1387, 1549, 1556], 'thrombosis': [119, 260, 409, 859, 1388], 'suggest': [121, 262], 'specific': [123, 264, 3120], 'inhibitors': [124, 265], 'p50,': [126, 267, 1320], 'such': [127, 268, 653, 867, 1069, 1206], 'as': [128, 269, 654, 871, 1070, 1207, 1212, 1562, 1949, 1966, 2912, 3210, 3212, 3232, 3930], 'Andro,': [129, 270, 292], 'may': [130, 271, 526], 'be': [131, 272, 527], 'therapeutically': [132, 273], 'valuable': [133, 274], 'preventing': [135, 276, 1332], 'perhaps': [137, 278], 'treating': [138, 279], 'thrombosis.': [140, 281, 534], 'Tissue': [282, 3718, 3832], '(TF)': [284], '3The': [285], 'abbreviations': [286], 'used': [287, 1794, 1948, 4024], 'are:': [288], 'TF,': [289, 636, 863, 3920], 'factor;': [291, 333], 'Andrographolide;': [293], 'DVT,': [294, 3409], 'thrombosis;': [297], 'HUVEC,': [298], 'umbilical': [300, 1548], 'cells;': [303, 308], 'PVEC,': [304], 'pulmonary': [305, 1555], 'TNF-α,': [309, 3160, 4080, 4390], 'tumor': [310, 655], 'necrosis': [311, 656], 'factor-α;': [312], 'LPS,': [313, 3157, 4079, 4389], 'lipopolysaccharide;': [314], 'PMA,': [315], 'phorbol': [316, 679], '12-myristate': [317, 680], '13-acetate;': [318], 'VCAM-1,': [319], 'vascular': [320, 664, 692, 1226, 1367], 'cell': [321, 783, 868, 1836, 2881], 'adhesion': [322, 869], 'molecule': [323], '1;': [324], 'DMSO,': [325, 1666, 3141], 'dimethyl': [326], 'sulfoxide;': [327], 'Ab,': [328, 4053], 'antibody;': [329], 'mTF,': [330, 1957], 'murine': [331, 1554, 1659, 1787, 1798, 1869, 2456, 3134, 4067, 4072, 4116, 4216], 'shRNA,': [334, 2372], 'short': [335], 'hairpin': [336], 'RNA;': [337], 'ChIP,': [338], 'immunoprecipitation.': [340], 'key': [343], 'trigger': [344], 'blood': [346, 1431], '(1Tilley': [348], 'R.': [349, 1079, 2130, 3073, 3504, 3506], 'Mackman': [350, 1168, 1186, 1820, 4479], 'N.': [351, 470, 547, 877, 1169, 1187, 1499, 1821, 1878, 1976, 2134, 3275, 3353, 3886, 4466, 4480], 'Semin.': [352], 'Thromb.': [353, 370, 471, 485, 498, 548, 878, 1189, 1629, 4467], 'Hemostasis.': [354, 371, 499], '2006;': [355, 417, 2768, 3078], '32:': [356], '5-10Crossref': [357], 'PubMed': [358, 375, 393, 420, 476, 490, 503, 553, 729, 744, 762, 883, 900, 915, 933, 965, 980, 998, 1090, 1110, 1179, 1195, 1288, 1306, 1450, 1524, 1587, 1608, 1634, 1827, 1903, 2001, 2143, 2289, 2750, 2771, 3081, 3263, 3300, 3378, 3518, 3552, 3590, 3874, 3911, 4192, 4267, 4305, 4323, 4472], 'Scopus': [359, 376, 394, 421, 477, 491, 504, 554, 730, 745, 763, 884, 901, 916, 934, 966, 981, 999, 1091, 1111, 1196, 1289, 1307, 1451, 1525, 1588, 1609, 1635, 1828, 1904, 2002, 2144, 2290, 2751, 2772, 3082, 3264, 3301, 3379, 3519, 3553, 3591, 3875, 3912, 4193, 4268, 4306, 4324, 4473], '(70)': [360], 'Google': [361, 378, 396, 423, 479, 493, 506, 556, 732, 747, 765, 886, 903, 918, 936, 968, 983, 1001, 1093, 1113, 1133, 1180, 1198, 1291, 1309, 1453, 1527, 1590, 1611, 1637, 1649, 1731, 1830, 1906, 2004, 2146, 2292, 2753, 2774, 3084, 3266, 3303, 3381, 3521, 3555, 3593, 3877, 3914, 4195, 4270, 4308, 4326, 4475], 'Scholar,': [362, 379, 480, 494, 733, 748, 887, 904, 919, 969, 984, 1181, 1292, 1591, 1612, 1638, 2754, 3267, 3522, 3556, 3878, 4309, 4476], '2Polgar': [363], 'J.': [364, 366, 369, 411, 497, 1084, 1104, 1128, 1170, 1283, 1444, 1602, 2137, 2284, 2745, 3076, 3258, 3509, 3541, 3579, 3869, 4187, 4262, 4300, 4481], 'Matuskova': [365], 'Wagner': [367, 3535], 'D.D.': [368, 3524, 3536, 3574], '2005;': [372, 390], '3:': [373], '1590-1596Crossref': [374], '(245)': [377], '3Del': [380], 'Conde': [381], 'I.': [382], 'Shrimpton': [383], 'C.N.': [384], 'Thiagarajan': [385], 'P.': [386, 1083, 1183, 3532, 3570], 'López': [387], 'J.A.': [388, 2760], 'Blood.': [389, 2767], '106:': [391], '1604-1611Crossref': [392], '(837)': [395], 'Scholar)': [397, 1310, 1907, 4271], 'important': [400], 'determinant': [401], 'hypercoagulable': [404], 'state': [405], 'associated': [406], '(4Steffel': [410], 'Luscher': [412], 'T.F.': [413], 'Tanner': [414], 'F.C.': [415], 'Circulation.': [416], '113:': [418], '722-731Crossref': [419], '(417)': [422], 'Scholar).': [424, 507, 557, 766, 937, 1002, 1199, 1454, 1528, 1650, 1732, 1831, 2005, 2147, 2293, 2775, 3085, 3304, 3382, 3594, 3915], '47-kDa': [428], 'membrane': [429], 'glycoprotein': [430], 'forms': [432, 532], 'cell-surface': [434], 'complex': [435, 456, 2957, 2980, 3003], 'VII/VIIa': [439], 'proteolytically': [441], 'activates': [442], 'IX': [444], 'to': [445, 449, 463, 599, 685, 802, 858, 1013, 1022, 1039, 1136, 1328, 1418, 1433, 1487, 1702, 1741, 1782, 1952, 1956, 2218, 2384, 2489, 2522, 2861, 3117, 3184, 3187, 3201, 3421, 3472, 3642, 3686, 4124, 4146, 4157, 4373], 'IXa': [446], 'X': [448], 'Xa.': [450], 'The': [451, 535, 558, 697, 938, 1148, 1473, 1529, 2205, 2224, 2317, 2323, 2341, 2418, 2917, 3609, 3637, 3779], 'consequent': [452], 'activation': [453, 468, 4162], 'prothrombinase': [455], 'generates': [457], 'thrombin,': [458], 'turn': [461], 'leads': [462], 'fibrin': [464], 'formation': [465], 'platelet': [467, 1750], '(5Mackman': [469, 546, 876, 4465], 'Haemostasis.': [472, 486, 549, 879, 1630, 1645, 1727, 4468], '1997;': [473, 550, 880, 1192, 4469], '78:': [474, 551, 881, 4470], '747-754Crossref': [475, 552, 882, 4471], '(249)': [478, 555, 885, 4474], '6Key': [481], 'N.S.': [482, 1280, 1628, 2281, 2742, 2764, 3255, 3866, 4184, 4259, 4297], 'Bach': [483, 1621], 'R.R.': [484, 1622], '2001;': [487, 1631], '85:': [488, 1632], '375-376Crossref': [489], '(19)': [492], '7Morrissey': [495], 'J.H.': [496], '2003;': [500, 1516, 1895, 1993, 3292, 3370, 3544, 3582, 3903], '1:': [501], '878-880Crossref': [502], '(22)': [505], 'Very': [508], 'low': [509, 671], 'or': [510, 1671, 1690, 1847, 2212, 2471, 2928, 3146, 3199, 3412, 3784, 3971], 'undetectable': [511], 'levels': [512, 525], 'are': [515, 625, 643, 683, 793, 815], 'constitutively': [516], 'expressed': [517, 1940], 'resting': [519], 'monocytes/macrophages,': [523], 'although': [524], 'dramatically': [528, 4083], 'increased': [529, 4084], 'certain': [531], 'regulated': [540], 'principally': [541], 'at': [542, 1765, 1850, 2043, 2121, 2179, 2193, 2439, 2543, 2797, 2874, 2936, 3062, 3094, 3325, 3403, 3712, 3771, 3791], 'transcriptional': [544, 943, 1235, 4208], 'level': [545, 634, 3984], 'promoter': [559, 3122, 4464], 'contains': [563], 'five': [564, 704, 770], 'binding': [565, 1327, 2550, 2613, 2694, 3689], 'sites': [566, 573, 580, 624, 642, 3989], 'specificity': [568], 'protein': [569, 2531, 2947], '1': [570, 1034, 2061, 2090, 2500, 2504, 2566, 2573, 2783, 2838, 2842, 2846, 3020, 3033, 3098, 3194, 3795], '(Sp1),': [571], 'three': [572, 3825], 'epidermal': [575], 'growth': [576, 666], 'response-1': [577], '(Egr-1),': [578], 'two': [579], 'activator': [582], 'protein-1': [583], '(AP-1),': [584], 'one': [586], 'NF-κB.': [589], 'Notably,': [590, 4121, 4393], 'there': [591], 'has': [592, 703, 1249], 'been': [593, 1251], 'non-conservative': [595], 'change': [596], 'guanine': [598], 'cytosine': [600], 'oligonucleotide': [603, 1325], 'sequence': [604, 1867, 2324, 2333, 2342, 2350, 2445], 'promoter,': [613], 'namely': [614], 'TF-κB': [616, 2623, 4446], 'site.': [617], 'It': [618], 'currently': [620], 'believed': [621], 'Sp1': [623], 'mainly': [626], 'responsible': [627], 'constitutive': [629], 'basal': [633], 'whereas': [637], 'Egr-1,': [638], 'AP-1,': [639], 'chiefly': [644], 'accountable': [645], 'inducible': [647], 'TF.': [650, 4090], 'Several': [651], 'agonists,': [652], 'factor-α': [657], '(TNF-α),': [658], 'interleukin-1β,': [659], 'CD40,': [660], 'bacterial': [661], 'lipopolysaccharides': [662], '(LPS),': [663], 'factor,': [667], 'oxidized': [668], 'acetylated': [670], 'density': [672, 4005], 'lipoprotein': [673], '(LDL),': [674], 'hypoxia,': [675], 'shear': [676, 2862], 'stress,': [677], '13-acetate': [681], '(PMA),': [682], 'known': [684, 1767], 'induce': [686, 3408], 'family': [698], 'cellular': [705, 771, 4353], 'members,': [706], 'called': [707], 'p105/p50': [708], '(NF-κB1),': [709], 'p100/p52': [710], '(NF-κB2),': [711], 'p65': [712, 1210, 2699, 2926], '(RelA),': [713], 'RelB': [714], 'c-Rel': [716, 2304, 2326, 3202], '(8Ghosh': [717, 953], 'S.': [718, 752, 889, 923, 954, 988, 1099, 1507, 1886, 1984, 3283, 3361, 3498, 3894], 'May': [719, 890, 955], 'M.J.': [720, 891, 956, 3572], 'Kopp': [721, 892, 957], 'E.B.': [722, 893, 958, 1121], 'Annu.': [723, 894, 959], 'Rev.': [724, 739, 895, 910, 960, 975], 'Immunol.': [725, 740, 896, 911, 961, 976, 1129, 1284, 1603, 2138, 2285, 2746, 3077, 3259, 3870, 4188, 4263, 4301], '1998;': [726, 897, 962, 1087, 2140], '16:': [727, 898, 963], '225-260Crossref': [728, 899, 964], '(4657)': [731, 902, 967], '9Li': [734, 905, 970], 'Q.': [735, 906, 971], 'Verma': [736, 907, 972], 'I.M.': [737, 908, 973], 'Nat.': [738, 909, 974], '2002;': [741, 912, 977, 3512], '2:': [742, 913, 978], '725-773Crossref': [743, 914, 979], '(3407)': [746, 917, 982], '10Hayden': [749, 920, 985], 'M.S.': [750, 921, 986, 2136], 'Ghosh': [751, 922, 987], 'Cell.': [753, 924, 989, 1515, 1894, 1992, 3291, 3369, 3902], '2008;': [754, 925, 990], '132:': [755, 926, 991], '344-362Abstract': [756, 927, 992], 'Full': [757, 759, 928, 930, 993, 995, 1176, 1519, 1521, 1898, 1900, 1996, 1998, 3295, 3297, 3373, 3375, 3515, 3547, 3549, 3585, 3587, 3906, 3908], 'Text': [758, 760, 929, 931, 994, 996, 1177, 1520, 1522, 1899, 1901, 1997, 1999, 3296, 3298, 3374, 3376, 3516, 3548, 3550, 3586, 3588, 3907, 3909], 'PDF': [761, 932, 997, 1178, 1523, 1902, 2000, 3299, 3377, 3517, 3551, 3589, 3910], '(3722)': [764, 935, 1000], 'members': [772], 'In': [781, 1042], 'all': [782], 'types': [784], 'except': [785], 'B': [786], 'lymphocytes': [787], 'plasma': [789, 1752, 1807, 1811], 'cells,': [790], 'complexes': [792, 2587, 2941, 3037], 'typically': [794], 'localized': [795], 'cytoplasm,': [798], 'where': [799], 'they': [800, 2810], 'bind': [801], 'IκB': [803, 813, 819, 835], 'inhibitory': [804], 'proteins,': [805], 'including': [806, 862, 1243], 'IκBα,': [807], 'IκBβ,': [808], 'IκB∊.': [810], 'Upon': [811], 'stimulation,': [812], 'proteins': [814, 836, 1330, 2508], 'rapidly': [816], 'phosphorylated': [817], 'kinase': [820, 2656], 'α': [821], 'β': [823, 3735], '(IKKα': [824], '-β)': [826], 'degraded': [828], 'via': [829], 'ubiquitin-proteasome': [831], 'pathway.': [832], 'Degradation': [833], 'exposes': [837], 'nuclear': [839, 1329, 2507, 2530], 'localization': [840], 'signal': [841], 'on': [842, 2640, 2671, 2713, 2852, 3384, 4457], 'Once': [846], 'translocated': [847], 'into': [848, 1923, 2429], 'nucleus,': [849], 'triggers': [851], 'various': [854, 864, 1065, 4344], 'targeting': [855, 2302], 'genes': [856], 'critical': [857, 1138], 'inflammation,': [861, 1068], 'cytokines/chemokines,': [865], 'molecules': [870], 'E-selectin': [872], '(CD62E)': [873], 'VCAM-1': [875], '8Ghosh': [888], 'different': [939], 'subunits': [940], 'apparently': [945], 'have': [946, 1058, 1256], 'distinctive': [947], 'roles': [948], 'development': [950, 3800], 'For': [1003, 1832, 2610, 2690, 3644, 3916, 3982], 'instance,': [1004], 'p65-/-/p50-/-': [1005], 'c-Rel-/-/p65-/-': [1007], 'manifest': [1009, 1019, 1030], 'embryonic': [1010], 'death': [1011, 1032], 'due': [1012, 1021, 1038], 'extensive': [1014], 'liver': [1015], 'apoptosis;': [1016], 'p52-/-/p50-/-': [1017], 'osteopetrosis': [1020], 'failure': [1023], 'osteoclast': [1025], 'maturation;': [1026], 'relB-/-/p50-/-': [1028], 'premature': [1031], 'within': [1033, 3388], 'month': [1035], 'after': [1036, 3986], 'birth': [1037, 1049], 'multiorgan': [1040], 'inflammation.': [1041], 'contrast,': [1043], 'p50-/-/rel-/-': [1044], 'grow': [1046], 'normally': [1047], 'from': [1048, 1326, 1349, 1428, 1472, 1737, 2312, 2405, 2590, 2658, 3206, 3220, 3465, 4356, 4369, 4428], 'without': [1050], 'obvious': [1051], 'phenotypic': [1052], 'alterations.': [1053], 'However,': [1054, 1200], 'significantly': [1060], 'inflammatory': [1062, 1146, 4347], 'response': [1063], 'models': [1066], 'asthma': [1071], '(11Yang': [1072], 'L.': [1073, 1075, 1503, 1620, 1882, 1980, 3279, 3357, 3502, 3890], 'Cohn': [1074], 'Zhang': [1076, 1498, 1877, 1975, 3072, 3274, 3352, 3885], 'D.H.': [1077], 'Homer': [1078], 'Ray': [1080, 1082], 'A.': [1081, 1125, 1276, 1618, 1626, 1815, 2132, 2277, 2738, 2766, 3251, 3496, 3500, 3538, 3862, 4180, 4255, 4293], 'Exp.': [1085, 1445], 'Med.': [1086, 1446], '188:': [1088], '1739-1750Crossref': [1089], '(295)': [1092], 'Scholar),': [1094, 1114, 1134, 4196], 'arthritis': [1095], '(12Campbell': [1096], 'I.K.': [1097], 'Gerondakis': [1098], "O'Donnell": [1100], 'K.': [1101], 'Wicks': [1102], 'I.P.': [1103], 'Clin.': [1105], 'Investig.': [1106], '2000;': [1107, 1605], '105:': [1108], '1799-1806Crossref': [1109], '(154)': [1112], 'autoimmune': [1116], 'encephalomyelitis': [1117], '(13Hilliard': [1118], 'B.': [1119, 1493, 1872, 1970, 3269, 3347, 3880], 'Samoilova': [1120], 'Liu': [1122], 'T.S.': [1123, 1819], 'Rostami': [1124], 'Chen': [1126, 1508, 1887, 1985, 3284, 3362, 3895], 'Y.': [1127, 1495, 1511, 1874, 1890, 1972, 1988, 3271, 3287, 3349, 3365, 3882, 3898], '1999;': [1130], '163:': [1131], '2937-2943PubMed': [1132], 'attesting': [1135], 'role': [1139], 'disorders.': [1147], 'p65/c-Rel': [1152, 1245], 'reportedly': [1153], 'regulates': [1154, 1362], 'monocytes': [1159, 1425, 1532, 4064], 'monocytic': [1161, 2010], 'THP-1': [1162, 2011, 2360], 'vitro': [1165, 1339], '(14Parry': [1166], 'G.C.': [1167, 1185, 4478], 'Biol.': [1171, 1191, 4482], 'Chem.': [1172, 4483], '1994;': [1173, 4484], '269:': [1174, 4485], '20823-20825Abstract': [1175], '15Oeth': [1182], 'Parry': [1184], 'Arterioscler.': [1188], 'Vasc.': [1190, 3542], '17:': [1193, 1304, 4321], '365-374Crossref': [1194], '(128)': [1197], 'whether': [1201, 1355], 'other': [1202], 'factors,': [1205, 1242], '(presumably': [1211], 'heterodimer),': [1215], 'modulate': [1216], 'monocytes/macrophages': [1224, 4409], 'remains': [1229], 'undetermined.': [1230], 'Furthermore,': [1231], 'importance': [1233], 'heterodimers,': [1248], 'not': [1250, 4135, 4152, 4414], 'investigated': [1252, 1354], 'We': [1255, 1373], 'recently': [1257], 'reported': [1258], '(16Xia': [1259, 2260, 2721, 3234, 3845, 4163, 4238, 4276], 'Y.F.': [1260, 2261, 2722, 3235, 3846, 4164, 4239, 4277], 'Ye': [1261, 2262, 2723, 3236, 3847, 4165, 4240, 4278], 'B.Q.': [1262, 2263, 2724, 3237, 3848, 4166, 4241, 4279], 'Li': [1263, 2264, 2725, 3070, 3238, 3849, 4167, 4242, 4280], 'Y.D.': [1264, 2265, 2726, 3239, 3850, 4168, 4243, 4281], 'Wang': [1265, 1295, 2266, 2727, 3240, 3851, 4169, 4244, 4282, 4312], 'J.G.': [1266, 1282, 1300, 1513, 1566, 1892, 1990, 2267, 2283, 2728, 2744, 2756, 2762, 3241, 3257, 3289, 3367, 3852, 3868, 3900, 4170, 4186, 4245, 4261, 4283, 4299, 4317], 'He': [1267, 2268, 2729, 3242, 3853, 4171, 4246, 4284], 'X.J.': [1268, 2269, 2730, 3243, 3854, 4172, 4247, 4285], 'Lin': [1269, 2270, 2731, 3244, 3855, 4173, 4248, 4286], 'X.': [1270, 1272, 1501, 1880, 1978, 2271, 2273, 2732, 2734, 3245, 3247, 3277, 3355, 3856, 3858, 3888, 4174, 4176, 4249, 4251, 4287, 4289], 'Yao': [1271, 2272, 2733, 3246, 3857, 4175, 4250, 4288], 'Ma': [1273, 2274, 2735, 3248, 3859, 4177, 4252, 4290], 'D.': [1274, 2275, 2736, 3249, 3492, 3494, 3860, 4178, 4253, 4291], 'Slungaard': [1275, 1625, 2276, 2737, 2765, 3250, 3861, 4179, 4254, 4292], 'Hebbel': [1277, 1623, 2278, 2739, 3252, 3863, 4181, 4256, 4294], 'R.P.': [1278, 1582, 1624, 2279, 2740, 3253, 3864, 4182, 4257, 4295], 'Key': [1279, 1627, 2280, 2741, 2763, 3254, 3865, 4183, 4258, 4296], 'Geng': [1281, 1299, 1512, 1891, 1989, 2282, 2743, 2761, 3256, 3288, 3366, 3867, 3899, 4185, 4260, 4298, 4316], '2004;': [1285, 2286, 2747, 3260, 3871, 4189, 4264, 4302], '173:': [1286, 2287, 2748, 3261, 3872, 4190, 4265, 4303], '4207-4217Crossref': [1287, 2288, 2749, 3262, 3873, 4191, 4266, 4304], '(344)': [1290, 2291, 2752, 3265, 3876, 4194, 4269, 4307], '18Wang': [1293, 4310], 'Y.J.': [1294, 4311], 'J.T.': [1296, 4313], 'Fan': [1297, 4314], 'Q.X.': [1298, 4315], 'Cell': [1301, 2857, 4318], 'Res.': [1302, 3511, 3581, 4319], '2007;': [1303, 4320], '933-941Crossref': [1305, 4322], '(77)': [1308, 4325], '(Andro)': [1313], 'covalently': [1314], 'modifies': [1315], 'cysteine': [1317], '62': [1318], 'blocking': [1322], 'NF-κB-activated': [1333], 'inflammation': [1334], 'neointimal': [1336], 'hyperplasia': [1337], 'Using': [1343], 'Andro': [1344, 1672, 2213, 3147, 3650, 4039, 4104, 4133, 4155, 4235, 4398, 4434, 4443, 4456], 'primary': [1346], 'isolated': [1348, 1427, 4355, 4368, 4427], 'mice,': [1352, 4358, 4431], 'critically': [1361], 'activated': [1371, 4113, 4220, 4404], 'further': [1374, 1960, 4415], 'assessed': [1375], 'functional': [1377], 'significance': [1378], 'modulation': [1382], 'TF-mediated': [1384], 'experimental': [1385], '(DVT)': [1389], 'mice.': [1391], 'Isolation': [1392], 'Primary': [1394], 'Cells—The': [1395], 'ethical': [1396], 'review': [1397], 'boards': [1398], 'Chinese': [1401], 'Academy': [1402], 'Sciences': [1404], 'University': [1407], 'Minnesota': [1409], 'approved': [1410], 'these': [1411, 4197], 'studies.': [1412], 'Informed': [1413], 'consent': [1414], 'was': [1415, 1533, 1538, 1710, 1921, 1939, 1947, 2065, 2245, 2366, 2398, 2421, 2446, 2461, 2532, 2883, 2910, 2920, 3056, 3101, 3115, 3309, 3458, 3463, 3483, 3598, 3611, 3630, 3639, 3678, 3690, 3789, 3801, 4023, 4035, 4143], 'provided': [1416], 'according': [1417, 1432, 1486, 1740, 2383, 2488, 2521], 'Declaration': [1420], 'Helsinki.': [1422], 'Human': [1423, 1547, 1707, 4449], 'adherent': [1424, 4063], 'fresh': [1429], 'previously': [1435, 1489, 1563], 'published': [1436, 1490], 'protocol': [1437], '(19Mercurio': [1438], 'A.M.': [1439], 'Schwarting': [1440], 'G.A.': [1441, 1578, 1580], 'Robbins': [1442], 'P.W.': [1443], '1984;': [1447, 1646, 1728], '160:': [1448], '1114-1125Crossref': [1449], '(90)': [1452], 'C57BL/6J': [1455], '(C57),': [1456], 'B6;129P2-Nfkb1tm1Bal/J': [1457], '(p50': [1458], 'mice),': [1460], 'B6129PF2/J': [1462], '(B6,': [1463], 'background': [1464], 'control': [1465, 2336, 2352, 2629, 2681], 'mice)': [1469], 'purchased': [1471, 2311], 'Jackson': [1474], 'Laboratory': [1475], '(Bar': [1476], 'Harbor,': [1477], 'ME).': [1478], 'Murine': [1479], 'macrophages': [1480, 1660, 2457, 3135, 4074, 4383, 4426], 'obtained': [1482], 'peritoneal': [1484, 4073, 4382], 'lavage,': [1485], 'method': [1491], '(20Wang': [1492, 1871, 1969, 3346], 'Xiao': [1494, 1873, 1971, 3270, 3348, 3881], 'Ding': [1496, 1875, 1973, 3272, 3350, 3883], 'B.B.': [1497, 1876, 1974, 3273, 3351, 3884], 'Yuan': [1500, 1879, 1977, 3276, 3354, 3887], 'Gui': [1502, 1881, 1979, 3278, 3356, 3889], 'Qian': [1504, 1883, 1981, 3280, 3358, 3891], 'K.X.': [1505, 1884, 1982, 3281, 3359, 3892], 'Duan': [1506, 1885, 1983, 3282, 3360, 3893], 'Z.': [1509, 1888, 1986, 3285, 3363, 3896], 'Rao': [1510, 1889, 1987, 3286, 3364, 3897], 'Cancer': [1514, 1893, 1991, 3290, 3368, 3901], '4:': [1517, 1896, 1994, 3293, 3371, 3904], '19-29Abstract': [1518, 1897, 1995, 3294, 3372, 3905], '(341)': [1526, 1905, 2003, 3302, 3380, 3913], 'purity': [1530], 'routinely': [1534], '>95%': [1535], 'viability': [1537], 'greater': [1539], 'than': [1540], '>96%': [1541], 'measured': [1542, 3634], 'trypan': [1544], 'blue': [1545], 'exclusion.': [1546], '(HUVECs)': [1552], '(PVECs)': [1559], 'cultured': [1561, 2021], 'described': [1564, 1967, 3233, 3931], '(17Geng': [1565], 'Bevilacqua': [1567], 'M.P.': [1568], 'Moore': [1569], 'K.L.': [1570], 'McIntyre': [1571], 'T.M.': [1572], 'Prescott': [1573], 'S.M.': [1574], 'Kim': [1575], 'J.M.': [1576], 'Bliss': [1577], 'Zimmerman': [1579], 'McEver': [1581], 'Nature.': [1583], '1990;': [1584], '343:': [1585], '757-760Crossref': [1586], '(840)': [1589], '21Marelli-Berg': [1592], 'F.M.': [1593], 'Peek': [1594], 'E.': [1595], 'Lidington': [1596], 'E.A.': [1597], 'Stauss': [1598], 'H.J.': [1599], 'Lechler': [1600], 'R.I.': [1601], 'Methods.': [1604, 2139], '244:': [1606], '205-215Crossref': [1607], '(169)': [1610], '22Ozcan': [1613], 'M.': [1614], 'Morton': [1615], 'C.T.': [1616], 'Solovey': [1617], 'Dandelet': [1619], '250-255Crossref': [1633], '(14)': [1636], '23Janson': [1639], 'T.L.': [1640, 1722], 'Stormorken': [1641, 1723], 'H.': [1642, 1644, 1724, 1726], 'Prydz': [1643, 1725], '14:': [1647, 1729], '440-444PubMed': [1648, 1730], 'Measurement': [1651], 'Activity—HUVECs,': [1654], 'monocytes,': [1656, 3131], 'PVECs,': [1657, 3132], 'treated': [1662, 3137, 3924], 'plain': [1664, 2468, 3139], 'buffer,': [1665, 3140], '15': [1668, 3143, 3830], 'μm': [1669, 1692, 2175, 3144, 3163, 3338], '4H-Andro': [1670, 3145, 3648, 4098], '12': [1674, 2215, 3149], 'h': [1675, 2216, 3067, 3150, 3330, 3660], 'followed': [1676, 3105, 3151, 3222, 3331, 3822], 'stimulation': [1678, 3153], '0.5': [1680, 2081, 2111, 2561, 2569, 2988, 3155], 'μg/ml': [1681, 1842, 2041, 2501, 2583, 3156, 3195, 3940, 3953, 3973], 'LPS': [1682, 2502], '(serotype': [1683], '055:B5;': [1684], 'Sigma),': [1685], '1,000': [1686, 2221, 3158], 'units/ml': [1687, 2037, 2222, 3159], 'TNF-α': [1688, 2785], '(Pierce),': [1689], '0.1': [1691, 3049, 3162], 'PMA': [1693, 3164, 4082], '(Calbiochem,': [1694], 'San': [1695, 3761], 'Diego,': [1696, 3762], 'CA)': [1697, 2434, 2520, 2636, 3763], '4': [1699, 1775, 2033, 2923, 2937, 3066, 3166, 3772], 'h,': [1700, 2505, 3099], 'prior': [1701, 2217], 'measurements': [1703], 'activity.': [1706], 'determined': [1711, 1736, 2251], 'one-stage': [1713], 'clotting': [1714, 1747], 'measurement': [1717, 1796, 2231], 'prothrombin': [1719], 'time': [1720], '(23Janson': [1721], 'concentrations': [1734], 'prothormbin': [1738], 'time,': [1739], 'standard': [1743], 'curve': [1744], 'generated': [1745], 'poor': [1751], 'using': [1753, 1801, 2235, 2252, 2373, 2410, 2864, 3119, 3618, 4006], 'serial': [1755], 'dilution': [1756], 'commercial': [1758], '(Innovin™,': [1760], 'Sysmex': [1761], 'Corporation,': [1762], 'Kobe,': [1763], 'Japan)': [1764, 3402], 'concentration': [1768], '4-channel': [1771], 'instrument': [1773], '(Start': [1774], 'analyzer;': [1776], 'Diagnostica': [1777], 'Stago,': [1778], 'Asniéres,': [1779], 'France).': [1780], 'Due': [1781], 'lack': [1784], 'standard,': [1789], 'relative': [1790], 'units': [1792], 'activity,': [1800, 4132], 'mixture': [1803], '10%': [1805, 2028, 3695], 'rat': [1806, 3785, 3954, 3962], '90%': [1809], '(24Andrews': [1812], 'B.S.': [1813, 3564], 'Rehemtulla': [1814], 'Fowler': [1816], 'B.J.': [1817], 'Edgington': [1818], 'Gene': [1822, 2297], '(Amst.).': [1823], '1991;': [1824], '98:': [1825], '265-269Crossref': [1826], '(41)': [1829], 'inhibition': [1834], 'experiments,': [1835, 2612, 2693, 3647], 'lysates': [1837, 2858, 4147], 'preincubated': [1839, 2616, 2697], '0.2': [1841], 'rabbit': [1844, 1954, 3723, 3728, 3747, 3941, 3975, 4050, 4125], 'preimmune': [1845, 3724], 'IgG': [1846, 3228, 3725, 3786], 'anti-mTF': [1848, 3196, 3729, 3942, 4051, 4126], 'Ab': [1849, 3198, 3218, 3730, 3738, 3750, 3756, 3787, 3943, 3980, 4128], '24': [1851, 3329], '°C': [1852, 2045, 2123, 2195, 2799, 2938, 3064, 3096, 3327, 3714, 3773, 3793], '30': [1854, 2541, 2638, 2711, 2787, 3716], 'min.': [1855, 2802, 2856, 3180, 3717, 3818, 3831], 'Generation': [1856], 'Anti-murine': [1858], 'Ab—A': [1860], 'cDNA': [1861, 2305, 2309, 2388, 2391, 2477], 'fragment': [1862], 'encoding': [1863, 2392], '46–249-amino': [1865], 'acid': [1866], '(mTF;': [1908], 'entire': [1910, 2444], 'extracellular': [1911], 'portion': [1912], 'mTF': [1914, 1938], 'truncated': [1915], 'just': [1916], 'before': [1917, 1968, 2642, 2715, 3661], 'transmembrane': [1919], 'domain)': [1920], 'inserted': [1922], 'pET-30a(+)': [1925], 'vector': [1926, 2086, 2319, 2470], 'His': [1929], 'tag': [1930, 2438, 3214], '(Novagen,': [1931], 'EMD': [1932], 'Biosciences,': [1933], 'Darmstadt,': [1934], 'Germany)': [1935], 'recombinant': [1937], 'Escherichia': [1942], 'coli.': [1943], 'After': [1944, 2148, 3086, 3797], 'purification,': [1945], 'it': [1946, 4142], 'immunogen': [1951], 'generate': [1953], 'antisera': [1955], 'purified': [1961], 'Protein': [1963], 'A': [1964, 2948, 3455, 4029], 'chromatography': [1965], 'Transfection': [2006, 2243], 'Luciferase': [2008, 2237], 'Assay—Human': [2009], '(TIB-202;': [2013], 'American': [2014], 'Type': [2015], 'Culture': [2016], 'Collection,': [2017], 'Manassas,': [2018], 'VA)': [2019], 'RPMI': [2023, 2152, 2169], '1640': [2024, 2153, 2170], 'medium': [2025, 2154, 2171], 'supplemented': [2026, 2114, 2172, 3812], 'heat-inactivated': [2029], 'fetal': [2030, 2156], 'calf': [2031], 'serum,': [2032], 'mm': [2034, 2095, 2100, 2103, 2106, 2109, 2112, 2554, 2559, 2562, 2567, 2570, 2829, 2834, 2839, 2889, 2894, 2903, 2961, 2966, 2975, 2984, 2998, 3007, 3021, 3029, 3034, 3701], 'l-glutamine,': [2035], '100': [2036, 2040], 'penicillin,': [2038], 'streptomycin': [2042], '37': [2044, 2122, 2194, 2798, 3713, 3792], 'presence': [2048, 2198], '5%': [2050, 2200, 2564, 2595], 'CO2.': [2051], 'Following': [2052, 2803], 'washing': [2053, 2149, 2804, 2958, 2981, 3004, 3824], 'twice': [2054, 2805, 3026], 'phosphate-buffered': [2056, 2808], 'saline,': [2057, 2809], 'aliquot': [2059, 2358, 2454, 3110], '×': [2062, 2181, 2363, 2817, 2871], '106': [2063, 2364, 2459], 'transfected': [2066, 2160, 2206, 2367, 2462], 'plasmids': [2068], '1.5': [2070], 'μg': [2071, 2082, 2117, 2370, 2465, 2527, 2924, 3090], 'pL2,': [2073], 'p2584,': [2074], 'p2586,': [2075], 'p2587,': [2076], 'p2442,': [2077], 'p2447': [2079], 'pCMVβ': [2085], '(Clontech),': [2087], 'respectively,': [2088], 'ml': [2091, 2166], 'STBE': [2093], '(25': [2094], 'Tris-HCl,': [2096, 2830, 2890, 2962, 3008, 3030, 3702], 'pH': [2097, 2556, 2831, 2891, 2963, 2986, 3009, 3031, 3703], '7.4,': [2098], '5': [2099, 2165, 3179], 'KCl,': [2101, 2560], '0.7': [2102], 'CaCl2,': [2104], '137': [2105], 'NaCl,': [2107, 2895, 2967, 2990, 3707], '0.6': [2108], 'Na2HPO4,': [2110], 'MgCl2)': [2113], '150': [2116, 2965], 'DEAE-Dextran': [2119], '(Sigma)': [2120, 3788, 3809], '20': [2125, 2553, 3089, 3420, 3952], 'min': [2126, 2542, 2639, 2712, 2788], '(25Mack': [2127], 'K.D.': [2128], 'Wei': [2129], 'Elbagarri': [2131], 'Abbey': [2133], 'McGrath': [2135], '211:': [2141], '79-86Crossref': [2142], '(53)': [2145], 'once': [2150, 2952], '(without': [2155], 'bovine': [2157, 2575, 3696, 3768], 'serum),': [2158], 'resuspended': [2163, 2820], 'complete': [2168], '50': [2174, 2558, 2582, 3700], 'β-mercaptoethanol': [2176], 'plated': [2178], '2': [2180, 2464, 2974, 2997, 3659], '105': [2182], 'cells/ml': [2183], 'each': [2185, 3991], 'well': [2186, 3211], '6-well': [2189], 'culture': [2191], 'plate': [2192], 'CO2': [2201], '48': [2203], 'h.': [2204, 3167, 3796], 'incubated': [2209, 2533, 2851, 2921, 3721, 3936], 'DMSO': [2211, 4093], 'treatment': [2219, 3646, 4057], 'TNF-α.': [2223], 'lysed': [2227, 3170], 'assayed': [2229], 'luciferase': [2233], 'activities': [2234, 2250], 'Assay': [2238], 'System': [2239], '(Promega,': [2240], 'Madison,': [2241], 'WI).': [2242], 'efficiency': [2244], 'normalized': [2246, 3641], 'β-galactosidase': [2249], 'Luminescent': [2254], 'β-Gal': [2255], 'Detection': [2256], 'Kit': [2257, 2377, 2485, 2515], 'II': [2258, 3734], '(Clontech)': [2259], 'Short': [2294], 'Hairpin': [2295], 'RNA-mediated': [2296], 'Suppression—The': [2298], 'sequences': [2299], 'shRNAs': [2301], 'Open': [2313], 'Biosystems': [2314], '(Huntsville,': [2315], 'AL).': [2316], 'empty': [2318], '(mock)': [2320], 'pLKO.1.': [2322], 'shRNA': [2327, 2337, 2345, 2353], 'was:': [2328, 2338, 2346, 2354], '5′-CCGGCCACCTATATAGATGCAGCATCTCGAGATGCTGCATCTATATAGGTGGTTTTTG-3′': [2329], '(TRCN0000039983)': [2330], 'non-inhibitory,': [2335], '5′-CCGGCCAGGAAGTTAGTGAATCTATCTCGAGATAGATTCACTAACTTCCTGGTTTTTG-3′': [2339], '(TRCN0000039986).': [2340], '5′-CCGGCCAGAGTTTACATCTGATGATCTCGAGATCATCAGATGTAAACTCTGGTTTTT-3′': [2347], '(TRCN00006518),': [2348], '5′-CCGGCGAATGACAGAGGCGTGTATACTCGAGTATACACGCCTCTGTCATTCGTTTTT-3′': [2355], '(TRCN000006521).': [2356], 'An': [2357, 3109], '(1': [2362, 2816], 'cells)': [2365, 2460], '3': [2369], 'electroporation': [2374, 2479], 'Nucleofector': [2376], 'V': [2378], '(Amaxa': [2379, 2486], 'Inc.,': [2380, 2634, 2686], 'Gaithersburg,': [2381], 'MD)': [2382], "manufacturer's": [2386, 2491, 2524], 'protocol.': [2387, 2492], 'Cloning—The': [2389], 'full-length': [2390], 'mouse': [2393, 2407, 2475, 3945], '(1–430': [2395], 'amino': [2396], 'acids)': [2397], 'directly': [2399, 3484, 4145], 'amplified': [2400], 'polymerase': [2402], 'chain': [2403, 3736], 'reaction': [2404], 'lung': [2408], 'cDNAs,': [2409], 'forward': [2411], 'primer': [2412, 2416], '5′-CTGAGGATCCATGGCAGACGATGATCCCTAC-3′': [2413], 'reverse': [2415], '5′-CTGCCTCGAGCTAATGGGTGACCCCTGCGTT-3′.': [2417], 'PCR': [2419, 3118], 'product': [2420], 'digested': [2422], 'BamHI': [2424], 'XhoI': [2426], 'ligated': [2428, 3599], 'pCMV-3Tag-1A': [2430, 2469], '(Stratagene,': [2431], 'La': [2432], 'Jolla,': [2433], 'FLAG': [2437, 3213], 'its': [2440], 'N': [2441], 'terminus.': [2442], 'Its': [2443], 'verified': [2447], 'nucleotide': [2449], 'sequencing.': [2450], 'Mouse': [2451, 2482], 'Macrophage': [2452, 2483], 'Transfection—An': [2453], '(1×': [2458], 'plasmid': [2473], 'Nucleofetor': [2484], 'Inc.)': [2487, 2709, 2935], 'Electrophoretic': [2493], 'Mobility': [2494], 'Shift': [2495], 'Assay—HUVECs': [2496], 'prepared': [2510], 'Nuclear': [2513], 'Extract': [2514], '(AY2002,': [2516], 'Panomics,': [2517], 'Redwood': [2518], 'City,': [2519], 'instructions.': [2525], 'Five': [2526], 'radiolabeled': [2535, 2646, 2719], 'DNA': [2536, 2592, 2632, 2863, 3100, 3114], 'probes': [2537, 2720], '(50': [2538, 2828], 'fmol)': [2539], 'room': [2544], 'temperature': [2545], 'total': [2548], '20-μl': [2549], 'reaction,': [2551], 'containing': [2552, 3766], 'HEPES,': [2555], '7.9,': [2557], 'EDTA,': [2563, 2835], 'glycerol,': [2565], 'dithiothreitol,': [2568], 'phenylmethylsulfonyl': [2571, 2840], 'fluoride,': [2572, 2841], 'mg/ml': [2574, 2843, 2847], 'serum': [2576, 3697, 3769], 'albumin,': [2577], '0.1%': [2578, 2968, 2991, 3814], 'Nonidet': [2579], 'P-40,': [2580], 'poly(dI-dC)·poly(dI-dC).': [2585], 'Protein-DNA': [2586], 'separated': [2589], 'free': [2591], 'probe': [2593], 'through': [2594], 'non-denaturing': [2596], 'polyacrylamide': [2597], 'gel': [2598], '0.5×': [2600], 'TBE': [2601], 'buffer.': [2602], 'Gels': [2603], 'dried': [2605], 'analyzed': [2607, 4002], 'autoradiography.': [2609], 'competition': [2611, 2666], 'reactions': [2614, 2695], 'unlabeled': [2618], 'double-stranded': [2619], 'oligonucleotides': [2620, 2672], 'consensus': [2624, 2676], '(5′-GTCCCGGAGTTTCCTACCGGG-3′)': [2626], 'mutant': [2628, 2680], '(5′-GTCCCGGAGTTAGATACCGGG-3′;': [2630], 'Integrated': [2631], 'Technologies,': [2633], 'Coralville,': [2635], 'ice': [2641, 2714, 2853], 'addition': [2644, 2717], 'probes.': [2647], 'Oligonucleotides': [2648], 'end-labeled': [2650], '[γ-32P]ATP': [2652], 'T4': [2654], 'polynucleotide': [2655], '(both': [2657, 3205, 3219], 'GE': [2659], 'Healthcare': [2660], 'Life': [2661], 'Sciences,': [2662], 'Piscataway,': [2663], 'NJ).': [2664], 'Identical': [2665], 'experiments': [2667], 'carried': [2669, 3802], 'out': [2670, 3803], '(5′-AGTTGAGGGGACTTTCCCAGGC-3′)': [2678], '(5′-AGTTGAGGCGACTTTCCCAGGC-3′;': [2682], 'Santa': [2683, 2687], 'Cruz': [2684, 2707, 2933], 'Biotechnology,': [2685, 2708, 2934], 'Cruz,': [2688], 'CA).': [2689], 'supershift': [2692, 2704], '(sc-372x)': [2700], '(sc-7178x)': [2703], 'antibodies': [2705], '(Santa': [2706, 2932], '26Wang': [2755], 'Mahmud': [2757], 'S.A.': [2758], 'Thompson': [2759], '107:': [2769], '558-565Crossref': [2770], '(129)': [2773], 'Chromatin': [2776], 'Immunoprecipitation': [2777], '(ChIP)—Confluent': [2778], 'HUVECs': [2779, 2815, 4059, 4150], 'ng/ml': [2784], 'fixed': [2790, 3310], '1%': [2792, 2836, 2970, 2993, 3014, 3016, 3322, 3767], 'formaldehyde': [2793], '(37%': [2794], 'stock;': [2795], 'Calbiochem)': [2796], '10': [2801, 2833, 2855, 2872, 2885, 3028, 3741, 3817, 3939], 'ice-cold': [2807], 'scraped': [2812], 'pelleted.': [2814], '106)': [2818], '200': [2822], 'μl': [2823], 'SDS': [2825, 3047], 'lysis': [2826], 'buffer': [2827, 2959, 2982, 3005, 3045, 3175], '8.1,': [2832, 2892, 2964, 2987, 3010], 'SDS,': [2837, 2897, 2969, 2992], 'aprotinin,': [2844], 'pepstatin': [2848], 'A)': [2849], 'sonicated': [2860], 'Microson': [2866], 'xL': [2867], '2000': [2868], 'sonicator': [2869], '(3': [2870], 's': [2873], '30%': [2875], 'maximum': [2878], 'potency).': [2879], 'Sonicated': [2880], 'supernatant': [2882, 2909, 2919], 'diluted': [2884, 3444], 'times': [2886, 3826], '16.7': [2888], '167': [2893], '0.01%': [2896], '1.1%': [2898], 'Triton': [2899, 2971, 2994], 'X-100,': [2900, 2972], '1.2': [2902], 'EDTA.': [2904, 3035], 'One': [2905], 'percent': [2906], 'saved': [2911], 'input': [2914], 'material': [2915], 'control.': [2916], 'remaining': [2918], '(sc-372)': [2927], '(sc-7178)': [2930], 'Abs': [2931, 3200], 'overnight.': [2939], 'Immune': [2940, 3036], 'collected': [2943], 'salmon': [2945], 'sperm-saturated': [2946], 'sequentially': [2950], 'washed': [2951, 3025], 'low-salt': [2955], 'immune': [2956, 2979, 3002], '(20': [2960, 2983], 'EDTA),': [2976, 2999, 3022], 'high-salt': [2978], 'Tris,': [2985], 'm': [2989, 3012, 3050, 3706], 'X-100': [2995], 'LiCl': [3001], '(10': [3006, 3726, 3731], '0.25': [3011], 'LiCl,': [3013], 'IGEPAL-CA630,': [3015], 'deoxycholic': [3017], 'acid,': [3018, 3319], 'finally': [3024, 3841], '8.0,': [3032], 'then': [3039, 3612, 3640, 3935], 'extracted': [3040, 3102], '500-μl': [3043], 'elution': [3044], '(1%': [3046], 'NaHCO3),': [3051], 'protein-DNA': [3054], 'cross-linking': [3055], 'reverted': [3057], 'heating': [3059], 'samples': [3061], '65': [3063], '(27Nandiwada': [3068], 'S.L.': [3069], 'W.': [3071], 'Mueller': [3074], 'D.L.': [3075], '177:': [3079], '401-413Crossref': [3080], '(17)': [3083], 'digestion': [3087], 'proteinase': [3092], 'K': [3093], '45': [3095], 'phenol-chloroform': [3104], 'ethanol': [3107], 'precipitation.': [3108], '⅓': [3112], 'immunoprecipitated': [3113], 'subjected': [3116, 3183], 'primers:': [3123], 'forward,': [3124], '5′-GCCCTCCCTTTCCTGCCATAGA-3′': [3125], 'reverse,': [3127], '5′-CCTCCCGGTAGGAAACTCCG-3′.': [3128], 'Immunoblotting—HUVECs,': [3129], 'Cells': [3168, 4045, 4231], 'sample': [3173], 'loading': [3174], 'boiled': [3177], 'Samples': [3181], 'SDS-PAGE,': [3185], 'transferred': [3186], 'polyvinylidene': [3188], 'difluoride': [3189], 'membranes': [3190], 'detected': [3192], 'polyclonal': [3197, 3749, 3755, 4052, 4127], 'Millipore,': [3207], 'Billerica,': [3208], 'MA)': [3209], '(M2)': [3215], 'α-tubulin': [3217], 'Sigma)': [3221], 'horseradish': [3224, 3780], 'peroxidase-conjugated': [3225, 3781], 'goat': [3226, 3782], 'anti-rabbit': [3227, 3783], 'chemiluminescent': [3230], 'detection': [3231], '20Wang': [3268, 3879], 'Histology—The': [3305], 'inferior': [3306, 3480, 3627], 'vena': [3307, 3481, 3596, 3628], 'cava': [3308, 3482, 3597, 3629], 'immersion': [3312], 'Bouin': [3314], 'fixation': [3315], 'solution': [3316, 3431], '(75%': [3317], 'picric': [3318], '24%': [3320], 'formaldehyde,': [3321], 'acetic': [3323], 'acid)': [3324], '22': [3326], 'paraffin': [3333], 'embedding,': [3334], 'sectioning': [3336], '(5': [3337, 3651], 'thick),': [3339], 'hematoxylin': [3341, 3837, 3999], 'eosin': [3343], '(H&E)': [3344], 'staining': [3345, 4000, 4004], 'Leukocytes': [3383], 'endothelium': [3386], 'wall': [3391], 'counted': [3393], 'double': [3394], 'blindly': [3395], 'under': [3396], 'CX31': [3398], 'microscope': [3399], '(Olympus,': [3400], 'Tokyo,': [3401], '×1,000': [3404], 'magnification.': [3405], 'DVT': [3406], 'Model—To': [3407], 'C57,': [3410], 'B6,': [3411], '(age': [3416], '6–8': [3417], 'weeks;': [3418], 'weight': [3419, 3638], '25': [3422], 'g)': [3423], 'anesthetized': [3425], 'intraperitoneal': [3427], 'injection': [3428], 'composed': [3432], 'xylazine': [3434], '(12.5': [3435], 'mg/kg),': [3436, 3439], 'ketamine': [3437], '(125': [3438], 'atropine': [3441], '(0.025': [3442], 'mg/kg)': [3443], 'equal': [3447], 'volume': [3448], 'saline': [3450], '(0.9%': [3451], 'sodium': [3452], 'chloride': [3453], 'solution).': [3454], 'midline': [3456], 'laparotomy': [3457], 'made;': [3459], 'small': [3461], 'bowel': [3462], 'exteriorized': [3464], 'body': [3467, 3654], 'cavity': [3468], 'moved': [3470], 'slightly': [3471], 'left': [3474], 'animal,': [3477], 'approached': [3485], 'careful': [3487], 'blunt': [3488, 4339], 'dissection': [3489], '(28Myers': [3490], 'Jr.,': [3491], 'Farris': [3493, 3527, 3561], 'Hawley': [3495, 3525, 3559], 'Wrobleski': [3497, 3529, 3567], 'Chapman': [3499], 'Stoolman': [3501], 'Knibbs': [3503], 'Strieter': [3505], 'Wakefield': [3507, 3539, 3577], 'T.': [3508], 'Surg.': [3510, 3543, 3580], '108:': [3513], '212-221Abstract': [3514], '(137)': [3520], '29Myers': [3523], 'A.E.': [3526, 3560], 'D.M.': [3528, 3562], 'S.K.': [3530, 3568], 'Thanaporn': [3531], 'Schaub': [3533], 'R.G.': [3534], 'Kumar': [3537], 'T.W.': [3540, 3578], '38:': [3545], '1075-1089Abstract': [3546], '(198)': [3554], '30Sullivan': [3557], 'V.V.': [3558], 'Knipp': [3563], 'Varga': [3565], 'A.J.': [3566], 'Thanapron': [3569], 'Eagleton': [3571], 'Myers': [3573], 'Fowlkes': [3575], 'J.B.': [3576], '109:': [3583], '1-7Abstract': [3584], '(69)': [3592], 'Inferior': [3595], 'below': [3600], 'renal': [3601], 'veins': [3602], 'along': [3603], 'ligation': [3605], 'side': [3607], 'branches.': [3608], 'incision': [3610], 'closed': [3613], 'two-layer': [3616], 'fashion': [3617], '5-0': [3619], 'non-reactive': [3620], 'suture': [3621], 'material.': [3622], 'On': [3623], 'day': [3624], '6,': [3625], 'removed,': [3631], 'weighed,': [3632], 'length.': [3636, 3643], 'drug': [3645], 'μg/g': [3652], 'weight)': [3655], 'intraperitoneally': [3657], 'given': [3658], 'surgery.': [3663], 'Immunohistochemical': [3664], 'Immunofluorescence': [3666], 'Staining—For': [3667], 'immunohistochemical': [3668, 3928], 'staining,': [3669, 3687], 'sections': [3671, 3719, 3833, 3922], 'subsequently': [3673], 'dewaxed': [3674], 'endogenous': [3676], 'peroxidase': [3677], 'quenched': [3679], '3%': [3681], 'H2O2': [3682, 3815], 'methanol.': [3684], 'Prior': [3685], 'nonspecific': [3688], 'blocked': [3691], 'incubation': [3693, 3805], 'albumin': [3698, 3770], '7.6,': [3704], '0.15': [3705], '0.02%': [3709], 'NaN3': [3710], '(TBS)': [3711], 'μg/ml),': [3727, 3732, 3752], 'anti-fibrin': [3733], 'monoclonal': [3737, 3949, 3957, 3965], '(clone': [3739], 'T2G1;': [3740], 'μg/ml;': [3742, 3758], 'Accurate': [3743], 'Chemical,': [3744], 'Westbury,': [3745], 'NY),': [3746], 'anti-E-selectin': [3748], '(6': [3751], 'anti-VCAM-1': [3754], '(8': [3757], 'BD': [3759], 'Pharmingen,': [3760], 'TBS': [3765, 3811, 3828], 'overnight': [3774], 'humidified': [3777], 'chamber.': [3778], 'applied': [3790], 'washing,': [3798], 'color': [3799], '0.05%': [3807], '3,3′-diaminobenzidine': [3808], 'All': [3819], 'incubations': [3820], 'over': [3829], 'counterstained': [3835], 'slides': [3839], 'mounted': [3842], 'coverslip': [3844], 'immunofluorescence': [3917], 'co-localization': [3918], 'same': [3927, 4395], 'steps': [3929], 'above.': [3932], 'They': [3933], 'simultaneously': [3937], 'anti-smooth': [3946], 'muscle': [3947], 'α-actin': [3948], '(Sigma),': [3951], 'anti-mouse': [3955, 3963], 'CD41': [3956], '(BD': [3959], 'Biosciences),': [3960], 'CD68': [3964], '(AbD': [3967], 'Serotec,': [3968], 'Oxford,': [3969], 'UK),': [3970], '16': [3972], 'biotinylated': [3974], 'anti-human': [3976], 'von': [3977], 'Willebrand': [3978], '(Sigma).': [3981], 'gray': [3983], 'analysis': [3985], 'immunostaining,': [3987], 'four': [3988, 3995], 'vessel': [3992], 'totally': [3994], 'vessels': [3996], 'no': [3998], 'NIH': [4008], 'Image': [4009], '(version': [4010], '1.6)': [4011], 'software': [4012], 'package.': [4013], 'Statistical': [4014], 'Analyses—To': [4015], 'determine': [4016], 'statistical': [4017], 'significance,': [4018], "Student's": [4019], 'unpaired': [4020], 't': [4021], 'test': [4022], 'comparison': [4026], 'between': [4027], 'groups.': [4028], 'p': [4030], 'value': [4031], '<': [4033], '0.05': [4034], 'considered': [4036], 'statistically': [4037], 'significant.': [4038], 'Suppresses': [4040], 'Stimulated': [4043], 'Endothelial': [4044, 4230], 'Activated': [4047, 4229], 'Monocytes/Macrophages—Using': [4048], 'found': [4055], '(Fig.': [4060, 4065, 4069, 4075, 4328, 4377, 4384, 4410], '1A),': [4061], '1B),': [4066], 'PVECs': [4068, 4376, 4424], '1C),': [4070], '1D)': [4076], 'Compared': [4091], '(a': [4094], 'solvent': [4095], 'control)': [4096], '(4-hydro-andrographolide,': [4099], 'inactive': [4101], 'structural': [4102], 'analog),': [4103], 'contrast': [4123], 'neutralized': [4130], 'did': [4134, 4413], 'affect': [4136], 'when': [4141], 'added': [4144], '(data': [4151], 'shown).': [4153], 'As': [4154], 'binds': [4156], 'inhibits': [4160, 4273], 'results': [4198], 'Requirement': [4222], 'Up-regulation': [4227], 'Macrophages—Given': [4233], 'targets': [4236, 4436], 'Scholar': [4327], '1,': [4329, 4411], 'A–D),': [4330], 'reasoned': [4332], 'would': [4338], 'induced': [4342], 'thrombogenic': [4345], 'agonists.': [4348], 'Indeed,': [4349], 'compared': [4350], 'counterparts': [4354], 'B6': [4357], '∼50%': [4374], '1E)': [4378], '∼70%': [4380], '1F)': [4385], 'upon': [4386], 'challenges': [4387], 'PMA.': [4392], 'dose': [4396], 'potently': [4400], 'inhibited': [4401], 'wild-type': [4405], 'A–D)': [4412], 'suppress': [4416], 'indicating': [4432], 'primarily': [4435], 'down-regulation': [4439], 'expression.': [4442], 'Antagonizes': [4444], 'Site': [4447], 'Promoter—To': [4451], 'examine': [4452], 'effect': [4454], '14Parry': [4477], '208': [4486]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2087776126', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-13T13:26:01.518767', 'created_date': '2016-06-24'}
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