Title: Thyroid Function in the Acquired Immunodeficiency Syndrome (AIDS)
Abstract: Letters and Corrections15 November 1989Thyroid Function in the Acquired Immunodeficiency Syndrome (AIDS)Kanji Sato, MD, Minoru Ozawa, MD, Hiroshi Demura, MD, Toru Fujii, MDKanji Sato, MDSearch for more papers by this author, Minoru Ozawa, MDSearch for more papers by this author, Hiroshi Demura, MDSearch for more papers by this author, Toru Fujii, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-10-857 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:In a recent issue, LoPresti and colleagues (1) reported that serum triiodothyronine (T3) is normal and reverse T3 (rT3) is decreased in emaciated patients with AIDS. This finding is highly unexpected because the T4 levels of such patients are normal or supranormal due to elevated serum thyroxine-binding globulin. Such an inappropriately increased T3/T4 and decreased rT3/T4 ratio contrasts sharply with those usually seen in patients with non-thyroidal illnesses: In these patients, the serum T3 concentration is decreased and rT3 is reciprocally increased (2). This low-T3, high-rT3 state is caused by the adaptation of iodothyronine-5′-deiodinating enzymes for energy-saving...References1. LoPresti J, Fried J, Spencer C, and Nicoloff J. Unique alterations of thyroid hormone indices in the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1989;110:970-5. LinkGoogle Scholar2. Chopra I, Hershman J, Pardridge W, and Nicoloff J. Thyroid function in non-thyroidal illnessess. Ann Intern Med. 1983;98:946-57. LinkGoogle Scholar3. Ozawa M, Sato K, Han D, Kawakami M, Tsushima T, and Shizume K. Effect of tumor necrosis factor-alpha/cachectin on thyroid hormone metabolism in mice. Endocrinology. 1988;123:1461-7. CrossrefMedlineGoogle Scholar4. Fujii T, Sato K, and Ozawa M. Effect of interleukin-1 (IL-I) on thyroid hormone metabolism in mice: stimulation by IL-I of iodothyronine 5′-deiodinating activity (type I) in the liver. Endocrinology. 1989;124:167-74. CrossrefMedlineGoogle Scholar5. Lahdevirta J, Maury G, Teppo A, and Repo H. Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am J Med. 1988;85:289-91. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Kanji Sato, MD; Minoru Ozawa, MD; Hiroshi Demura, MD; Toru Fujii, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThyroid Function in Children with Perinatal Human Immunodeficiency Virus Type 1 InfectionEndocrine Dysfunction in Children with HIV-1 InfectionHIV Wasting Syndrome: Treatment Update 15 November 1989Volume 111, Issue 10Page: 857-858KeywordsAIDSAttentionEnzymesGlobulinsThyroidTriiodothyronine ePublished: 1 December 2008 Issue Published: 15 November 1989 PDF downloadLoading ...
Publication Year: 1989
Publication Date: 1989-11-15
Language: en
Type: letter
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 4
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