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119], 'the': [18, 60, 103, 151, 155, 160, 196, 213], 'mechanism(s)': [19], 'which': [21, 32], 'NAC': [22, 63, 75, 98, 128, 176, 194], 'exerts': [23], 'neuroprotection': [24], 'unclear.': [26], 'Gene': [27], 'expression': [28], 'endothelin-1': [30], '(ET-1),': [31], 'contributes': [33], 'to': [34, 149], 'cerebral': [35], 'blood': [36], 'flow': [37], 'decline': [38], 'injury,': [42], 'partially': [44], 'regulated': [45], 'reactive': [47], 'oxygen': [48], 'species,': [49], 'and': [50, 83, 112, 159, 184, 201], 'thus': [51], 'a': [52], 'potential': [53], 'target': [54], 'NAC.': [56], 'We': [57], 'therefore': [58], 'examined': [59], 'effect': [61, 101], 'on': [64, 102], 'tumor': [65], 'necrosis': [66], 'factor': [67], '(TNF)-α-induced': [68], 'ET-1': [69, 84, 131, 145, 167, 178, 219], 'production': [70], 'cerebrovascular': [72], 'endothelial': [73], 'cells.': [74], 'dose': [76], 'dependently': [77], 'inhibited': [78, 166, 195], 'TNF-α-induced': [79, 197, 218], 'preproET-1': [80], 'mRNA': [81], 'upregulation': [82, 88, 132, 168, 179], 'protein': [85, 161, 186], 'secretion,': [86], 'while': [87, 205], 'inducible': [90], 'nitric': [91], 'oxide': [92], 'synthase': [93], '(iNOS)': [94], 'was': [95], 'unaffected.': [96], 'Intriguingly,': [97], 'had': [99], 'no': [100], 'initial': [104], 'activation': [105, 142], '(i.e.,': [106], 'IκB': [107], 'degradation,': [108], 'nuclear': [109, 171], 'p65': [110, 172], 'translocation,': [111, 173], 'Ser536': [113], 'phosphorylation)': [114], 'NF-κB': [116, 123], 'TNF-α.': [118], 'transient': [120], 'inhibition': [121, 181], 'DNA': [124], 'binding': [125], 'suggested': [126], 'that': [127, 175, 210], 'may': [129], 'inhibit': [130], 'inhibiting': [134], '(a)': [135], 'parallel': [136], 'pathway(s)': [137], 'necessary': [138], 'for': [139], 'full': [140], 'transcriptional': [141], 'NF-κB-mediated': [144], 'gene': [146], 'expression.': [147], 'Similar': [148], 'NAC,': [150], 'MEK1/2': [152], 'inhibitor': [153, 157, 163], 'U0126,': [154], 'p38': [156], 'SB203580,': [158], 'kinase': [162, 187, 203], 'H-89': [164], 'selectively': [165], 'without': [169], 'affecting': [170], 'suggesting': [174], 'inhibits': [177], 'via': [180], 'mitogen-': [183], 'stress-activated': [185], '(MSK).': [188], 'Supporting': [189], 'this': [190], 'notion,': [191], 'cotreatment': [192], 'with': [193], 'rise': [198], 'MSK1': [200], 'MSK2': [202, 211], 'activity,': [204], 'siRNA': [206], 'knock-down': [207], 'experiments': [208], 'showed': [209], 'predominant': [214], 'isoform': [215], 'involved': [216], 'upregulation.': [220]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2087578886', 'counts_by_year': [{'year': 2021, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-09-17T16:07:06.002679', 'created_date': '2016-06-24'}