Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2087578870', 'doi': 'https://doi.org/10.1016/s0304-3940(00)01593-7', 'title': 'Spinal kappa-opioid system plays an important role in suppressing morphine withdrawal syndrome in the rat', 'display_name': 'Spinal kappa-opioid system plays an important role in suppressing morphine withdrawal syndrome in the rat', 'publication_year': 2000, 'publication_date': '2000-12-01', 'ids': {'openalex': 'https://openalex.org/W2087578870', 'doi': 'https://doi.org/10.1016/s0304-3940(00)01593-7', 'mag': '2087578870', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11078933'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0304-3940(00)01593-7', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S203050076', 'display_name': 'Neuroscience Letters', 'issn_l': '0304-3940', 'issn': ['0304-3940', '1872-7972'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5087607230', 'display_name': 'Cai‐Lian Cui', 'orcid': 'https://orcid.org/0000-0002-8638-8258'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Cai-Lian Cui', 'raw_affiliation_strings': ['Neuroscience Research Institute, Peking University, 38 Xue-Yuan Road, 100083, PR, Beijng, China.'], 'affiliations': [{'raw_affiliation_string': 'Neuroscience Research Institute, Peking University, 38 Xue-Yuan Road, 100083, PR, Beijng, China.', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009474140', 'display_name': 'Liu-Zhen Wu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liu-Zhen Wu', 'raw_affiliation_strings': ['Neuroscience Research Institute, Peking University, 38 Xue-Yuan Road, Beijng 100083, PR China'], 'affiliations': [{'raw_affiliation_string': 'Neuroscience Research Institute, Peking University, 38 Xue-Yuan Road, Beijng 100083, PR China', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108492457', 'display_name': 'Ji-Sheng Han', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ji-Sheng Han', 'raw_affiliation_strings': ['Neuroscience Research Institute, Peking University, 38 Xue-Yuan Road, Beijng 100083, PR China'], 'affiliations': [{'raw_affiliation_string': 'Neuroscience Research Institute, Peking University, 38 Xue-Yuan Road, Beijng 100083, PR China', 'institution_ids': ['https://openalex.org/I20231570']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2940, 'currency': 'USD', 'value_usd': 2940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.353, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 26, 'citation_normalized_percentile': {'value': 0.792491, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '295', 'issue': '1-2', 'first_page': '45', 'last_page': '48'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10196', 'display_name': 'Pain Mechanisms and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10196', 'display_name': 'Pain Mechanisms and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13047', 'display_name': 'Pharmacological Receptor Mechanisms and Effects', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dynorphin', 'display_name': 'Dynorphin', 'score': 0.77810323}, {'id': 'https://openalex.org/keywords/κ-opioid-receptor', 'display_name': 'κ-opioid receptor', 'score': 0.692646}], 'concepts': [{'id': 'https://openalex.org/C2777389121', 'wikidata': 'https://www.wikidata.org/wiki/Q81225', 'display_name': 'Morphine', 'level': 2, 'score': 0.8176134}, {'id': 'https://openalex.org/C151077648', 'wikidata': 'https://www.wikidata.org/wiki/Q324076', 'display_name': 'Dynorphin', 'level': 5, 'score': 0.77810323}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.7091568}, {'id': 'https://openalex.org/C184389661', 'wikidata': 'https://www.wikidata.org/wiki/Q14897645', 'display_name': 'κ-opioid receptor', 'level': 4, 'score': 0.692646}, {'id': 'https://openalex.org/C2781063702', 'wikidata': 'https://www.wikidata.org/wiki/Q427523', 'display_name': 'Opioid', 'level': 3, 'score': 0.6053252}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.54699194}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.49399716}, {'id': 'https://openalex.org/C2779886867', 'wikidata': 'https://www.wikidata.org/wiki/Q421797', 'display_name': 'Opioid receptor', 'level': 4, 'score': 0.49126166}, {'id': 'https://openalex.org/C2778750930', 'wikidata': 'https://www.wikidata.org/wiki/Q4540629', 'display_name': '(+)-Naloxone', 'level': 4, 'score': 0.47968435}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.45908988}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.45833117}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41654074}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3656927}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.3398933}, {'id': 'https://openalex.org/C88016717', 'wikidata': 'https://www.wikidata.org/wiki/Q417189', 'display_name': 'Opioid peptide', 'level': 4, 'score': 0.20694646}], 'mesh': [{'descriptor_ui': 'D019900', 'descriptor_name': '3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D018712', 'descriptor_name': 'Analgesics, Non-Narcotic', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000701', 'descriptor_name': 'Analgesics, Opioid', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D009020', 'descriptor_name': 'Morphine', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D017473', 'descriptor_name': 'Receptors, Opioid, kappa', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013375', 'descriptor_name': 'Substance Withdrawal Syndrome', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D019900', 'descriptor_name': '3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019900', 'descriptor_name': '3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018712', 'descriptor_name': 'Analgesics, Non-Narcotic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018712', 'descriptor_name': 'Analgesics, Non-Narcotic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000701', 'descriptor_name': 'Analgesics, Opioid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009020', 'descriptor_name': 'Morphine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009271', 'descriptor_name': 'Naltrexone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009271', 'descriptor_name': 'Naltrexone', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D009271', 'descriptor_name': 'Naltrexone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009292', 'descriptor_name': 'Narcotic Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009292', 'descriptor_name': 'Narcotic Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017473', 'descriptor_name': 'Receptors, Opioid, kappa', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D017473', 'descriptor_name': 'Receptors, Opioid, kappa', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013375', 'descriptor_name': 'Substance Withdrawal Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0304-3940(00)01593-7', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S203050076', 'display_name': 'Neuroscience Letters', 'issn_l': '0304-3940', 'issn': ['0304-3940', '1872-7972'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11078933', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.8, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W1487700558', 'https://openalex.org/W1918878012', 'https://openalex.org/W1953292148', 'https://openalex.org/W1965846441', 'https://openalex.org/W1966685420', 'https://openalex.org/W1969269001', 'https://openalex.org/W1972414190', 'https://openalex.org/W1975832950', 'https://openalex.org/W1986545657', 'https://openalex.org/W1999254855', 'https://openalex.org/W2006503862', 'https://openalex.org/W2010531200', 'https://openalex.org/W2021043804', 'https://openalex.org/W2028850215', 'https://openalex.org/W2029699230', 'https://openalex.org/W2035228140', 'https://openalex.org/W2039170232', 'https://openalex.org/W2040725197', 'https://openalex.org/W2042190640', 'https://openalex.org/W2049883950', 'https://openalex.org/W2081919543', 'https://openalex.org/W2097088407', 'https://openalex.org/W2253141778', 'https://openalex.org/W2266566487'], 'related_works': ['https://openalex.org/W4301394033', 'https://openalex.org/W4281618241', 'https://openalex.org/W2938871845', 'https://openalex.org/W2296746676', 'https://openalex.org/W2287941853', 'https://openalex.org/W2145721166', 'https://openalex.org/W2138928848', 'https://openalex.org/W2013691204', 'https://openalex.org/W1987316018', 'https://openalex.org/W1581994435'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2087578870', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-05T11:47:40.221113', 'created_date': '2016-06-24'}