Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling

Name: Work Video:
Duration: 3 min 30 s
Xiaofeng Li; Yazhuo Zhang; Heeseog Kang; Wenzhong Liu; Peng Liu; Jianghong Zhang; Stephen E. Harris; Dianqing Wu
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'sclerostin-mediated': [40, 200, 243, 403, 2321, 4490, 5930], 'antagonism': [41, 244, 2322, 4992, 5811, 5931], 'be': [43, 182, 246, 385, 1903, 2233, 3478, 3943, 4302, 4338, 4521, 4956, 5505, 5715, 5772, 5858, 5942, 5955, 5963, 6103], 'reversed': [44, 247, 3296, 5773], 'overexpression': [46, 249], 'co-receptor': [49, 252], 'low': [50, 253, 498, 1479], 'density': [51, 254, 499], 'lipoprotein': [52, 255, 500], 'receptor-related': [53, 256, 501], 'protein': [54, 257, 819, 2118, 3371], '(LRP)': [55, 258], '5.': [56, 259], 'addition,': [58, 261, 1361, 5516, 6045], 'bound': [63, 266, 6031], 'LRP5': [65, 79, 268, 282, 1019, 1366, 1486, 1785, 2295, 2691, 3217, 3244, 3295, 3321, 3345, 3376, 3522, 3530, 3546, 3578, 3595, 3615, 3769, 3857, 3881, 3922, 3925, 3931, 4133, 4143, 4180, 4240, 4349, 4390, 4465, 4480, 4503, 5736, 5739, 6063], 'as': [66, 68, 80, 269, 271, 283, 670, 796, 2114, 2300, 2361, 2449, 2480, 2769, 2813, 2923, 3381, 3563, 4249, 4293, 4500, 4623, 5023, 5959, 5970], 'well': [67, 270, 792], 'LRP6': [69, 272, 1929, 1937, 2297, 3378, 3452, 3467], 'identified': [71, 274, 710, 4614], 'first': [73, 276, 663, 784, 942, 3552, 3648, 3713, 3908, 3935, 4325, 5686], 'two': [74, 88, 277, 291, 785, 3545, 3555, 3624, 3714, 3855, 3880, 3903, 5687], 'YWTD-EGF': [75, 278, 3556, 3651, 3664, 3715, 3865, 3874, 3911, 3936, 4326, 5688], 'repeat': [76, 89, 279, 292, 3557, 3652, 3665, 3716, 3866, 3875, 3912, 3937, 4327, 5689], 'domains': [77, 90, 280, 293, 3717, 3867, 3913, 5690], 'being': [81, 284], 'responsible': [82, 285, 1021, 1982, 3532], 'for': [83, 93, 108, 286, 296, 311, 529, 1022, 1934, 1983, 2465, 2725, 2747, 2894, 2927, 3047, 3060, 3466, 3521, 3533, 3600, 3620, 3670, 3787, 3916, 4189, 4313, 4512, 4942, 5141, 5312, 5500, 5697, 5722, 5965], 'binding.': [85, 288], 'Although': [86, 289, 5924], 'these': [87, 290, 2642, 3330, 3623, 3879, 3924, 5325], 'are': [91, 294, 527, 1020, 1184, 1981, 3531, 3561, 3632, 3914, 4765, 5605, 5694], 'required': [92, 295, 3669, 3915, 5696, 5964, 6118], 'transduction': [94, 297, 530, 5698], 'signals,': [98, 301], 'did': [101, 304, 3172, 3310, 3813, 3883, 3892], 'not': [102, 305, 940, 2232, 3173, 3311, 3589, 3814, 3884, 3898, 4458, 4901, 4911, 4997, 5310, 5513, 5933], 'appear': [103, 306], 'compete': [105, 308, 1931, 3783], 'with': [106, 141, 176, 309, 344, 379, 1186, 1932, 1968, 2334, 2441, 2569, 2690, 2701, 2717, 2734, 2981, 3005, 3013, 3030, 3039, 3055, 3071, 3092, 3324, 3388, 3469, 3784, 3945, 4129, 4134, 4345, 4366, 4461, 4476, 4780, 4904, 5674, 5720, 5853, 5981, 6071], 'binding': [109, 312, 812, 1935, 3367, 3453, 3504, 3535, 3541, 3575, 3610, 3672, 3788, 3794, 3817, 3835, 3918, 4347, 4361, 4383, 4444, 4914, 5724, 5732], 'LRP5.': [111, 314, 4916, 4972], 'Examination': [112, 315], 'expression': [115, 143, 152, 318, 346, 355, 1423, 2306, 2311, 2640, 3293, 4601, 4606, 4633, 4674, 4686, 4701, 4722, 4742, 4777, 4881, 5776], 'Wnt7b,': [119, 322, 4615, 4886], 'an': [120, 189, 323, 392, 676, 1000, 1009, 1026, 1703, 1984, 2924, 2984, 3022, 3115, 3262, 3464, 3843, 5971], 'autocrine': [121, 324, 4190, 4943], 'Wnt,': [123, 326, 3188, 4944], 'during': [124, 327, 2312, 4607, 4635, 4681], 'primary': [125, 328, 1471, 4608, 4636], 'calvarial': [126, 329, 2805, 4609, 4682], 'osteoblast': [127, 138, 330, 341, 1704, 1775, 2806, 4610, 4639, 4683], 'differentiation': [128, 139, 331, 342, 2847, 4640], 'revealed': [129, 332, 3512], 'is': [132, 335, 412, 647, 1771, 2106, 3346, 3668, 3728, 4253, 4299, 4321, 4469, 4778, 4787, 4947, 5132, 5309, 5498, 5587, 5592, 5672, 5712, 5754, 5851, 6067, 6117], 'expressed': [133, 336, 1772, 2108, 3323, 3347, 4255, 4303, 4523, 4788], 'at': [134, 184, 337, 387, 2434, 2562, 2744, 3050, 3063, 3168, 3348, 3634, 3822, 4690, 4757], 'late': [135, 338, 4758], 'stages': [136, 339, 4759], 'coinciding': [140, 343], 'osteogenic': [145, 348, 2313, 2846, 4703], 'marker': [146, 349, 4704], 'osteocalcin': [147, 350, 4705, 4753], 'trailing': [149, 352], 'after': [150, 353, 2308, 2474, 2579, 5231], 'Wnt7b.': [154, 357], 'Given': [155, 358, 5533], 'plethora': [157, 360], 'evidence': [159, 362, 997, 5704], 'indicating': [160, 363], 'stimulates': [165, 368], 'osteogenesis,': [166, 369], 'believe': [168, 371, 2316, 5584], 'mass': [173, 376, 1190, 2332, 5604], 'phenotype': [174, 377, 1790], 'associated': [175, 378, 1185, 2333, 3944], 'may': [181, 384, 1786, 1911, 3771, 4233, 4309, 4337, 4797, 4900, 4926, 4985, 5941, 5954, 5962, 6102], 'attributed,': [183, 386], 'least': [185, 388], 'part,': [187, 390], 'increase': [190, 393, 1001, 1010, 3314, 4234, 4986], 'resulting': [195, 398, 4138], 'from': [196, 399, 927, 2808, 2995, 4245, 4930, 5986], 'reduction': [198, 401, 2319, 3608, 4441], 'antagonism.': [202, 405], 'family': [408], 'secretory': [410], 'glycoproteins': [411], 'one': [413, 4118, 4957], 'major': [416], 'families': [417], 'developmentally': [419], 'important': [420, 425, 677], 'molecules': [422, 707, 786, 2643, 5803], 'plays': [424, 675], 'roles': [426], 'induction,': [429], 'generation': [430], 'cell': [432, 437, 2348, 2354, 3264, 4145], 'polarity,': [433], 'specification': [435], 'fate': [438], '(1Moon': [439], 'R.T.': [440], 'Kimelman': [441, 2787], 'D.': [442, 722, 754, 829, 908, 962, 1049, 1112, 1295, 1324, 1547, 1610, 1815, 1851, 2020, 2086, 2134, 2383, 2406, 2408, 2494, 2496, 2520, 2788, 2790, 2829, 3397, 3432, 3487, 3692, 3754, 4049, 4078, 4166, 4211, 4277, 4423, 4539, 4660, 4817, 5040, 5158, 5250, 5348, 5411, 5648, 5786, 5831, 5875, 5912, 6001], 'BioEssays.': [443, 581], '1998;': [444, 474, 569, 607, 619, 695, 2671], '20:': [445], '536-545Crossref': [446], 'PubMed': [447, 460, 477, 572, 585, 596, 610, 622, 640, 698, 734, 776, 840, 867, 888, 921, 974, 989, 1167, 1277, 1307, 1355, 1415, 1464, 1520, 1665, 1688, 1761, 1827, 1858, 1888, 1957, 2039, 2096, 2152, 2184, 2220, 2277, 2390, 2420, 2508, 2532, 2674, 2796, 2837, 2943, 3408, 3439, 3498, 3699, 3761, 4031, 4061, 4109, 4173, 4218, 4284, 4430, 4557, 4593, 4667, 4835, 4871, 5058, 5090, 5126, 5176, 5208, 5268, 5300, 5466, 5486, 5578, 5666, 5797, 5844, 5888, 5919, 6017, 6094], 'Scopus': [448, 461, 478, 573, 586, 597, 611, 623, 641, 699, 735, 777, 841, 868, 889, 922, 975, 990, 1168, 1278, 1308, 1356, 1416, 1465, 1521, 1666, 1689, 1762, 1828, 1859, 1889, 1958, 2040, 2097, 2153, 2185, 2221, 2278, 2391, 2421, 2509, 2533, 2675, 2797, 2838, 2944, 3409, 3440, 3499, 3700, 3762, 4032, 4062, 4110, 4174, 4219, 4285, 4431, 4558, 4594, 4668, 4836, 4872, 5059, 5091, 5127, 5177, 5209, 5269, 5301, 5467, 5487, 5579, 5667, 5798, 5845, 5889, 5920, 6018, 6095], '(278)': [449], 'Google': [450, 463, 480, 575, 588, 599, 613, 625, 643, 701, 737, 779, 843, 870, 891, 924, 977, 992, 1170, 1280, 1310, 1358, 1418, 1467, 1523, 1668, 1691, 1764, 1830, 1861, 1891, 1960, 2042, 2099, 2155, 2187, 2223, 2280, 2393, 2423, 2511, 2535, 2677, 2799, 2840, 2946, 3411, 3442, 3501, 3702, 3764, 4034, 4064, 4112, 4176, 4221, 4287, 4433, 4560, 4596, 4670, 4838, 4874, 5061, 5093, 5129, 5179, 5211, 5271, 5303, 5469, 5489, 5581, 5669, 5800, 5847, 5891, 5922, 6020, 6097], 'Scholar,': [451, 464, 576, 589, 600, 614, 626, 738, 844, 871, 892, 978, 1281, 1311, 1831, 2043, 2156, 2188, 2394, 2512, 3412, 4035, 4065, 4561, 4839, 5062, 5094, 5180, 5272, 5470, 5892], '2Peifer': [452], 'M.': [453, 580, 630, 852, 902, 1051, 1069, 1114, 1124, 1145, 1147, 1203, 1383, 1488, 1549, 1567, 1612, 1622, 1643, 1645, 2047, 2056, 2072, 2136, 2142, 2162, 2166, 2204, 2261, 2821, 3957, 4541, 4547, 4577, 4819, 4825, 4855, 5042, 5048, 5068, 5072, 5110, 5160, 5166, 5186, 5190, 5252, 5258, 5278, 5282, 5350, 5368, 5413, 5423, 5444, 5446, 5562, 5825, 5869], 'Polakis': [454], 'P.': [455, 578, 716, 831, 910, 1073, 1260, 1432, 1571, 2018, 2024, 2054, 2066, 2076, 2211, 2268, 3399, 3489, 4014, 4584, 4862, 5117, 5372, 5569, 5788, 5833, 5877], 'Science.': [456], '2000;': [457], '287:': [458], '1606-1609Crossref': [459], '(1154)': [462], '3Wodarz': [465], 'A.': [466, 561, 683, 720, 724, 833, 873, 877, 879, 914, 1090, 1102, 1110, 1134, 1235, 1239, 1251, 1291, 1588, 1600, 1608, 1632, 1811, 1876, 1945, 2168, 2195, 2252, 3401, 3491, 3989, 3993, 4005, 4045, 4568, 4846, 5074, 5101, 5192, 5284, 5389, 5401, 5409, 5433, 5553, 5790, 5837, 5881, 6082], 'Nusse': [467, 562], 'R.': [468, 563, 591, 1153, 1227, 1387, 1492, 1651, 1882, 1951, 2660, 2667, 3981, 5452, 6088], 'Annu.': [469, 564], 'Rev.': [470, 565], 'Cell': [471, 566, 883, 1410, 1515, 2336, 2468], 'Dev.': [472, 567, 606, 730], 'Biol.': [473, 568, 858, 884, 964, 985, 1411, 1516, 1854, 2174, 2386, 2410, 2498, 2522, 2670, 3435, 3695, 3757, 4169, 4214, 4280, 4426, 4663, 5080, 5198, 5290, 5656, 5915, 6007], '14:': [475, 570], '59-88Crossref': [476, 571], '(1758)': [479, 574], 'Scholar).': [481, 644, 702, 780, 925, 993, 1359, 1468, 1765, 1862, 1961, 2100, 2281, 2424, 2536, 2678, 2800, 3443, 3502, 3703, 4113, 4177, 4288, 4434, 4597, 4671, 4875, 5130, 5212, 5304, 5490, 5670, 5801, 5848, 5923, 6021], 'Both': [482, 802], 'genetic': [483], 'biochemical': [485], 'studies': [486, 2102], 'indicate': [487], 'frizzled': [489], '(Fz)': [490], 'LRP5/6': [492, 814, 3364, 5778, 5802], '1The': [493], 'abbreviations': [494], 'used': [495, 2459, 2922, 2970, 5943], 'are:': [496], 'LRP,': [497], 'protein;': [502, 510], 'HBM,': [503], 'mass;': [506], 'BMP,': [507], 'morphogenetic': [509, 2117], 'LEF,': [511], 'lymphoid': [512, 552], 'enhancing': [513, 553], 'factor;': [514], 'Dkk,': [515], 'Dickkopf;': [516], 'AP,': [517], 'alkaline': [518, 1706], 'phosphatase;': [519], 'HEK,': [520], 'kidney;': [523], 'CM,': [524, 2341, 2554, 5521], 'conditioned': [525], 'medium.': [526], 'co-receptors': [528], 'eventually': [536], 'stabilization': [540], 'β-catenin': [542, 1672], 'regulation': [544], 'transcription': [547, 549], 'through': [548], 'regulators': [550], 'including': [551, 1178], 'factor': [554], '(LEF)-1': [555], 'T-cell': [557], 'factors': [558], '(TCF)': [559], '(3Wodarz': [560], '4Pandur': [577], 'Kuhl': [579, 851], '2001;': [582, 593, 837, 859, 885, 1159, 1657, 2031, 2093, 2940, 3405, 3495, 5458, 5794], '23:': [583], '207-210Crossref': [584], '(33)': [587], '5Nusse': [590], 'Nature.': [592, 694, 836, 917, 3404, 3494, 5793, 5840, 5884], '411:': [594, 838, 3406, 3496, 5795], '255-256Crossref': [595], '(62)': [598], '6Gumbiner': [601], 'B.M.': [602, 904, 5827, 5871], 'Curr.': [603, 857], 'Opin.': [604], 'Genet.': [605, 1268, 1346, 2030, 2092, 4022, 4100], '8:': [608], '430-435Crossref': [609], '(51)': [612], '7Dale': [615], 'T.C.': [616], 'Biochem.': [617, 1681, 5479], 'J.': [618, 900, 956, 963, 1055, 1067, 1201, 1266, 1285, 1287, 1302, 1318, 1339, 1344, 1409, 1452, 1457, 1514, 1553, 1565, 1680, 1805, 1807, 1822, 1839, 1841, 1845, 1996, 2026, 2028, 2064, 2148, 2160, 2173, 2214, 2271, 2371, 2373, 2377, 2402, 2409, 2490, 2497, 2516, 2521, 2665, 2779, 2786, 2792, 2830, 3420, 3422, 3426, 3680, 3682, 3686, 3742, 3744, 3748, 3955, 4020, 4039, 4041, 4056, 4072, 4093, 4098, 4154, 4156, 4160, 4199, 4201, 4205, 4265, 4267, 4271, 4411, 4413, 4417, 4553, 4587, 4648, 4650, 4654, 4831, 4865, 5054, 5066, 5079, 5120, 5172, 5184, 5197, 5264, 5276, 5289, 5354, 5366, 5478, 5572, 5655, 5823, 5867, 5900, 5902, 5906, 6006], '329:': [620], '209-223Crossref': [621], '(440)': [624], '8He': [627], 'X.': [628, 634, 856, 1225, 1245, 1678, 1837, 2369, 3418, 3678, 3740, 3979, 3999, 4152, 4197, 4263, 4409, 4646, 5476, 5898], 'Semenov': [629], 'Tamai': [631, 847], 'K.': [632, 746, 758, 848, 1053, 1108, 1221, 1297, 1551, 1606, 1817, 2082, 2140, 3975, 4051, 4545, 4823, 5046, 5164, 5256, 5352, 5407], 'Zeng': [633], 'Development': [635, 1883, 1952, 6089], '(Camb.).': [636, 1884, 1953, 6090], '2004;': [637, 1758, 1855, 2217, 2274, 2387, 3436, 3696, 3758, 4170, 4215, 4281, 4427, 4590, 4664, 4868, 5123, 5575, 5916, 6009], '131:': [638], '1663-1677Crossref': [639], '(886)': [642], 'also': [648, 1924, 3090, 3252, 3270, 3517, 4439, 4470, 5002, 5320, 5695, 5771], 'regulated': [649], 'a': [651, 671, 816, 1894, 1904, 2115, 2234, 2301, 2647, 2756, 2912, 2931, 2996, 3031, 3084, 3155, 3228, 3451, 3594, 3605, 3614, 4226, 4294, 4379, 4616, 4735, 4746, 4799, 5024, 5137, 5594, 5623, 5938, 6104, 6108], 'number': [652], 'naturally': [654], 'occurring': [655], 'antagonists': [656, 797, 4247, 4932, 4961, 5010], 'include': [658], 'Dickkopf': [659], '(Dkk)': [660], 'molecules.': [661, 2638], 'Dkk': [664, 706, 3671, 5808], '(Xenopus': [665], 'Dkk1)': [666], 'was': [667, 1368, 1923, 2457, 2539, 2644, 2753, 2870, 2886, 2900, 2921, 2954, 2969, 3135, 3236, 3474, 3572, 4182, 4727, 5019, 5620], 'initially': [668], 'discovered': [669], 'antagonist': [673, 1719, 1897, 2120, 2237, 5026, 5597], 'role': [678, 4800], 'head': [680], 'formation': [681, 1735], '(9Glinka': [682], 'Wu': [684, 717, 824, 895, 961, 1294, 1814, 1850, 2382, 2407, 2495, 2519, 2789, 3392, 3431, 3482, 3691, 3753, 4048, 4165, 4210, 4276, 4422, 4659, 5781, 5818, 5862, 5911], 'W.': [685, 718, 825, 896, 960, 1057, 1136, 1143, 1342, 1434, 1555, 1634, 1641, 1739, 2045, 2060, 2089, 2400, 2488, 3393, 3483, 4096, 5356, 5435, 5442, 5782, 5819, 5863], 'Delius': [686, 725, 905, 5828, 5872], 'H.': [687, 726, 906, 1043, 1104, 1126, 1541, 1602, 1624, 2022, 2164, 2206, 2263, 2398, 2486, 2514, 2775, 4579, 4857, 5070, 5112, 5188, 5280, 5342, 5403, 5425, 5564, 5829, 5873], 'Monaghan': [688], 'A.P.': [689, 714], 'Blumenstock': [690], 'C.': [691, 693, 728, 744, 835, 912, 916, 1081, 1205, 1233, 1330, 1396, 1436, 1501, 1579, 2058, 2080, 2128, 2777, 3403, 3493, 3959, 3987, 4084, 4533, 4811, 5034, 5152, 5244, 5380, 5652, 5792, 5835, 5839, 5879, 5883, 5993], 'Niehrs': [692, 727, 834, 915, 3402, 3492, 5791, 5838, 5882], '391:': [696], '357-362Crossref': [697], '(1380)': [700], 'To': [703, 3177, 3351, 3525, 3777, 4352], 'date,': [704], 'four': [705], 'have': [708, 790, 3385, 3518, 3723, 3853, 3939, 4115, 4372, 4378], 'been': [709, 791, 3940, 4517, 5976], 'mammals': [712], '(10Monaghan': [713], 'Kioschis': [715], 'Zuniga': [719], 'Bock': [721], 'Poustka': [723], 'Mech.': [729], '1999;': [731, 773, 2412, 2500, 2524, 2793], '87:': [732], '45-56Crossref': [733], '(176)': [736], '11Krupnik': [739], 'V.E.': [740], 'Sharp': [741], 'J.D.': [742], 'Jiang': [743], 'Robison': [745], 'Chickering': [747], 'T.W.': [748], 'Amaravadi': [749], 'L.': [750, 954, 958, 1120, 1217, 1229, 1289, 1314, 1326, 1398, 1408, 1503, 1513, 1618, 1809, 1847, 2006, 2014, 2199, 2256, 2379, 2396, 2484, 2518, 2773, 3428, 3688, 3750, 3971, 3983, 4043, 4068, 4080, 4162, 4207, 4273, 4419, 4572, 4656, 4850, 5105, 5419, 5557, 5908], 'Brown': [751], 'D.E.': [752], 'Guyot': [753], 'Mays': [755], 'G.': [756, 875, 898, 1037, 1061, 1247, 1406, 1511, 1535, 1559, 1674, 2823, 4001, 5336, 5360, 5472, 5821, 5865], 'Leiby': [757], 'Chang': [759, 1390, 1495], 'B.': [760, 823, 894, 1087, 1092, 1096, 1130, 1132, 1149, 1213, 1241, 1450, 1585, 1590, 1594, 1628, 1630, 1647, 2084, 3391, 3481, 3967, 3995, 5386, 5391, 5395, 5429, 5431, 5448, 5780, 5817, 5861], 'Duong': [761], 'T.': [762, 1045, 1100, 1118, 1151, 1328, 1543, 1598, 1616, 1649, 1676, 1749, 2016, 2130, 4082, 4535, 4813, 5036, 5154, 5246, 5344, 5399, 5417, 5450, 5474], 'Goodearl': [763], 'A.D.': [764], 'Gearing': [765], 'D.P.': [766], 'Sokol': [767, 853, 981], 'S.Y.': [768, 982], 'McCarthy': [769], 'S.A.': [770, 881], 'Gene': [771], '(Amst.).': [772], '238:': [774], '301-313Crossref': [775], '(425)': [778], 'However,': [781, 3305, 3878, 5213, 5702], 'only': [782, 3584, 4625, 4755, 4948, 4998], '(Dkk1': [787], 'Dkk2)': [789], 'documented': [793], 'function': [795, 1016, 1176, 1977, 4400, 5968], 'signaling.': [801, 3120, 5616, 5750, 5949, 6043, 6130], 'DKK1': [803], 'DKK2': [805, 2600], 'simultaneously': [811], 'single': [817], 'transmembrane': [818], 'called': [820, 1898], 'Kremen': [821, 5815, 5850, 5925, 5960], '(12Mao': [822, 3390, 3480, 5779], 'Li': [826, 901, 1397, 1502, 1836, 1842, 1846, 2368, 2374, 2378, 2517, 3394, 3417, 3423, 3427, 3484, 3677, 3683, 3687, 3739, 3745, 3749, 4151, 4157, 4161, 4196, 4202, 4206, 4262, 4268, 4272, 4408, 4414, 4418, 4645, 4651, 4655, 5783, 5824, 5868, 5897, 5903, 5907], 'Y.': [827, 1031, 1223, 1332, 1438, 1529, 1833, 1835, 2010, 2365, 2367, 3395, 3414, 3416, 3485, 3674, 3676, 3736, 3738, 3977, 4086, 4148, 4150, 4193, 4195, 4259, 4261, 4405, 4407, 4642, 4644, 5330, 5784, 5894, 5896], 'Hoppe': [828, 907, 3396, 3486, 5785, 5830, 5874], 'Stannek': [830, 909, 3398, 3488, 5787, 5832, 5876], 'Glinka': [832, 913, 3400, 3490, 5789, 5836, 5880], '321-325Crossref': [839, 3407, 3497, 5796], '(917)': [842, 3410, 3500, 5799], '13Semenov': [845], 'M.V.': [846], 'Brott': [849], 'B.K.': [850, 980], 'S.': [854, 1039, 1059, 1063, 1219, 1243, 1537, 1557, 1561, 1849, 1874, 1943, 2002, 2070, 2381, 3430, 3690, 3752, 3973, 3997, 4164, 4209, 4275, 4421, 4658, 5338, 5358, 5362, 5910, 6080], 'He': [855], '11:': [860], '951-961Abstract': [861], 'Full': [862, 864, 969, 971, 1162, 1164, 1272, 1274, 1350, 1352, 1660, 1662, 2034, 2036, 2179, 2181, 2415, 2417, 2503, 2505, 2527, 2529, 4026, 4028, 4104, 4106, 5085, 5087, 5203, 5205, 5295, 5297, 5461, 5463, 5661, 5663, 6012, 6014], 'Text': [863, 865, 970, 972, 1163, 1165, 1273, 1275, 1351, 1353, 1661, 1663, 2035, 2037, 2180, 2182, 2416, 2418, 2504, 2506, 2528, 2530, 4027, 4029, 4105, 4107, 5086, 5088, 5204, 5206, 5296, 5298, 5462, 5464, 5662, 5664, 6013, 6015], 'PDF': [866, 973, 1166, 1276, 1354, 1664, 2038, 2183, 2419, 2507, 2531, 4030, 4108, 5089, 5207, 5299, 5465, 5665, 6016], '(605)': [869], '14Bafico': [872], 'Liu': [874, 959], 'Yaniv': [876], 'Gazit': [878], 'Aaronson': [880], 'Nat.': [882], '3:': [886], '683-686Crossref': [887], '(683)': [890], '15Mao': [893], 'Davidson': [897, 5820, 5864], 'Marhold': [899, 5822, 5866], 'Mechler': [903, 5826, 5870], 'Walter': [911, 5834, 5878], '2002;': [918, 966, 986, 1269, 1304, 1412, 1517, 1824, 2834, 4023, 4058, 5841, 5885], '417:': [919, 5842, 5886], '664-667Crossref': [920, 5843, 5887], '(889)': [923, 5846, 5890], 'Work': [926], 'our': [928, 4920, 4976, 5493, 5675, 5703], 'laboratory': [929], 'others': [931, 3384], 'further': [932, 1725, 3178, 3846, 4510, 4716], 'demonstrated': [933, 3333], 'second': [936, 3650, 3862, 3910], 'Cys-rich': [937, 943], 'domain': [938, 3666, 3938, 4328], '(but': [939], 'domain)': [944], 'Dkk1': [946, 1770, 1797, 3831, 4250, 4252, 4710, 5000, 5760, 5765], 'Dkk2': [948], 'inhibits': [949], '(16Li': [953], 'Mao': [955, 1284, 1804, 1840, 2372, 2401, 2489, 2515, 2778, 3421, 3681, 3743, 4038, 4155, 4200, 4266, 4412, 4649, 5901], 'Sun': [957], 'Chem.': [965, 2175, 2411, 2499, 2523, 5081, 5199, 5291, 5657, 6008], '277:': [967], '5977-5981Abstract': [968], '(149)': [976], '17Brott': [979], 'Mol.': [983, 1756, 1852, 2091, 2384, 2668, 3433, 3693, 3755, 4167, 4212, 4278, 4424, 4661, 5913], 'Cell.': [984, 1158, 1656, 1853, 2385, 2669, 3434, 3694, 3756, 4168, 4213, 4279, 4425, 4662, 5457, 5914], '22:': [987, 2150, 4555, 4833, 5056, 5174, 5266], '6100-6110Crossref': [988], '(191)': [991], 'A': [994, 1863], 'myriad': [995], 'demonstrates': [998], 'LRP5/6-mediated': [1003], 'Loss': [1014, 1975], 'mutations': [1017, 1978, 3932], 'osteoporosis-pseudoglioma': [1024, 1379], 'syndrome,': [1025], 'autosomal': [1027, 1985], 'recessive': [1028, 1986], 'disorder': [1029, 1989], '(18Gong': [1030, 1528, 5329], 'Slee': [1032, 1530, 5331], 'R.B.': [1033, 1531, 5332], 'Fukai': [1034, 1532, 5333], 'N.': [1035, 1237, 1300, 1533, 1820, 1870, 1939, 2049, 2158, 2172, 3991, 4054, 5064, 5078, 5182, 5196, 5274, 5288, 5334, 6076], 'Rawadi': [1036, 1534, 5335], 'Roman-Roman': [1038, 1536, 5337], 'Reginato': [1040, 1538, 5339], 'A.M.': [1041, 1539, 5340], 'Wang': [1042, 1540, 1677, 1834, 2366, 3415, 3675, 3737, 4149, 4194, 4260, 4406, 4643, 5341, 5475, 5895], 'Cundy': [1044, 1542, 5343], 'Glorieux': [1046, 1544, 5345], 'F.H.': [1047, 1545, 5346], 'Lev': [1048, 1546, 5347], 'Zacharin': [1050, 1548, 5349], 'Oexle': [1052, 1550, 5351], 'Marcelino': [1054, 1552, 5353], 'Suwairi': [1056, 1554, 5355], 'Heeger': [1058, 1556, 5357], 'Sabatakos': [1060, 1558, 5359], 'Apte': [1062, 1560, 5361], 'Adkins': [1064, 1562, 5363], 'W.N.': [1065, 1563, 5364], 'Allgrove': [1066, 1564, 5365], 'Arslan-Kirchner': [1068, 1566, 5367], 'Batch': [1070, 1568, 5369], 'J.A.': [1071, 1448, 1569, 2146, 4551, 4829, 5052, 5170, 5262, 5370, 5654, 6005], 'Beighton': [1072, 1570, 2023, 5371], 'Black': [1074, 1572, 5373], 'G.C.': [1075, 1573, 5374], 'Boles': [1076, 1574, 5375], 'R.G.': [1077, 1199, 1575, 3953, 5376], 'Boon': [1078, 1576, 5377], 'L.M.': [1079, 1283, 1577, 1803, 4037, 5378], 'Borrone': [1080, 1578, 5379], 'Brunner': [1082, 1580, 5381], 'H.G.': [1083, 1581, 5382], 'Carle': [1084, 1582, 5383], 'G.F.': [1085, 1583, 5384], 'Dallapiccola': [1086, 1584, 5385], 'De': [1088, 1335, 1586, 2200, 2257, 4089, 4573, 4851, 5106, 5387, 5558], 'Paepe': [1089, 1587, 5388], 'Floege': [1091, 1589, 5390], 'Halfhide': [1093, 1591, 5392], 'M.L.': [1094, 1157, 1264, 1334, 1442, 1592, 1655, 4018, 4088, 5393, 5456], 'Hall': [1095, 1593, 5394], 'Hennekam': [1097, 1595, 5396], 'R.C.': [1098, 1596, 5397], 'Hirose': [1099, 1597, 5398], 'Jans': [1101, 1599, 5400], 'Juppner': [1103, 1601, 5402], 'Kim': [1105, 1603, 5404], 'C.A.': [1106, 1604, 5405], 'Keppler-Noreuil': [1107, 1605, 5406], 'Kohlschuetter': [1109, 1607, 5408], 'LaCombe': [1111, 1609, 5410], 'Lambert': [1113, 1611, 1744, 5412], 'Lemyre': [1115, 1613, 5414], 'E.': [1116, 1128, 1316, 1614, 1626, 2052, 2202, 2259, 2404, 2492, 4070, 4575, 4853, 5108, 5415, 5427, 5560, 5642, 5644], 'Letteboer': [1117, 1615, 5416], 'Peltonen': [1119, 1617, 5418], 'Ramesar': [1121, 1619, 5420], 'R.S.': [1122, 1620, 2012, 5421], 'Romanengo': [1123, 1621, 5422], 'Somer': [1125, 1623, 5424], 'Steichen-Gersdorf': [1127, 1625, 5426], 'Steinmann': [1129, 1627, 5428], 'Sullivan': [1131, 1629, 5430], 'Superti-Furga': [1133, 1631, 5432], 'Swoboda': [1135, 1633, 5434], 'van': [1137, 1635, 5436], 'den': [1138, 1636, 5437], 'Boogaard': [1139, 1637, 5438], 'M.J.': [1140, 1638, 5439], 'Van': [1141, 1258, 1340, 1639, 1994, 2050, 2061, 2087, 2196, 2253, 4012, 4094, 4569, 4847, 5102, 5440, 5554], 'Hul': [1142, 1341, 1640, 2051, 2088, 4095, 5441], 'Vikkula': [1144, 1642, 5443], 'Votruba': [1146, 1644, 5445], 'Zabel': [1148, 1646, 5447], 'Garcia': [1150, 1648, 5449], 'Baron': [1152, 1650, 5451], 'Olsen': [1154, 1652, 5453], 'B.R.': [1155, 1653, 2000, 2138, 4543, 4821, 5044, 5162, 5254, 5454], 'Warman': [1156, 1333, 1654, 4087, 5455], '107:': [1160, 1658, 5459], '513-523Abstract': [1161, 1659, 5460], '(1899)': [1169, 1667, 5468], 'Scholar),': [1171, 1419, 1524, 2224, 2947, 3765, 4222, 5582, 6098], 'whereas': [1172], 'putative': [1173], 'gain': [1174], 'mutations,': [1177, 4121], 'Gly171': [1180], 'Val': [1182], 'substitution,': [1183], '(HBM)': [1191], 'phenotypes': [1192, 1374], '(19Little': [1193, 3947], 'R.D.': [1194, 3948], 'Carulli': [1195, 3949], 'J.P.': [1196, 3950], 'Del': [1197, 3951], 'Mastro': [1198, 3952], 'Dupuis': [1200, 3954], 'Osborne': [1202, 3956], 'Folz': [1204, 3958], 'Manning': [1206, 3960], 'S.P.': [1207, 3961], 'Swain': [1208, 3962], 'P.M.': [1209, 1878, 1947, 3963, 6084], 'Zhao': [1210, 1433, 1738, 2005, 3964], 'S.C.': [1211, 2663, 3965], 'Eustace': [1212, 3966], 'Lappe': [1214, 3968], 'M.M.': [1215, 3969], 'Spitzer': [1216, 3970], 'Zweier': [1218, 3972], 'Braunschweiger': [1220, 3974], 'Benchekroun': [1222, 3976], 'Hu': [1224, 3978], 'Adair': [1226, 3980], 'Chee': [1228, 3982], 'FitzGerald': [1230, 3984], 'M.G.': [1231, 3985], 'Tulig': [1232, 3986], 'Caruso': [1234, 3988], 'Tzellas': [1236, 3990], 'Bawa': [1238, 3992], 'Franklin': [1240, 3994], 'McGuire': [1242, 3996], 'Nogues': [1244, 3998], 'Gong': [1246, 1331, 4000, 4085], 'Allen': [1248, 4002], 'K.M.': [1249, 4003], 'Anisowicz': [1250, 4004], 'Morales': [1252, 4006], 'A.J.': [1253, 1745, 4007], 'Lomedico': [1254, 4008], 'P.T.': [1255, 4009], 'Recker': [1256, 1261, 4010, 4015], 'S.M.': [1257, 4011], 'Eerdewegh': [1259, 4013], 'R.R.': [1262, 4016], 'Johnson': [1263, 4017], 'Am.': [1265, 1343, 2027, 4019, 4097], 'Hum.': [1267, 1345, 2029, 2090, 4021, 4099], '70:': [1270, 4024], '11-19Abstract': [1271, 4025], '(1109)': [1279, 4033], '20Boyden': [1282, 4036], 'Belsky': [1286, 1806, 4040], 'Mitzner': [1288, 1808, 4042], 'Farhi': [1290, 1810, 4044], 'Mitnick': [1292, 1812, 4046], 'M.A.': [1293, 1813, 4047], 'Insogna': [1296, 1816, 4050], 'Lifton': [1298, 1818, 4052], 'R.P.': [1299, 1819, 4053], 'Engl.': [1301, 1821, 4055], 'Med.': [1303, 1823, 2216, 2273, 4057, 4589, 4867, 5122, 5574], '346:': [1305, 1825, 4059], '1513-1521Crossref': [1306, 1826, 4060], '(1366)': [1309, 1829, 4063], '21Van': [1312, 4066], 'Wesenbeeck': [1313, 4067], 'Cleiren': [1315, 4069], 'Gram': [1317, 4071], 'Beals': [1319, 4073], 'R.K.': [1320, 4074], 'Benichou': [1321, 4075], 'O.': [1322, 4076], 'Scopelliti': [1323, 4077], 'Key': [1325, 4079], 'Renton': [1327, 4081], 'Bartels': [1329, 4083], 'Vernejoul': [1336, 4090], 'M.C.': [1337, 4091], 'Bollerslev': [1338, 4092], '2003;': [1347, 1461, 1685, 1885, 1954, 2149, 2176, 4101, 4554, 4832, 5055, 5082, 5173, 5200, 5265, 5292, 5483, 6091], '72:': [1348, 4102], '763-771Abstract': [1349, 4103], '(490)': [1357, 4111], 'mice': [1362, 1427, 2810], 'which': [1364, 3082, 3473, 3527, 3859, 4298, 4320, 4946, 5693, 6066, 6125], 'inactivated': [1369], 'targeting': [1372], 'showed': [1373, 1473, 2103, 3148, 3197, 3271, 3450, 3604, 4440, 4628, 4678, 4745, 5629, 6050], 'similar': [1375, 3455, 3519, 4747, 5939], 'those': [1377], 'syndrome': [1380], 'patients': [1381], '(22Kato': [1382, 1487], 'Patel': [1384, 1489, 2048], 'M.S.': [1385, 1490, 5640], 'Levasseur': [1386, 1491], 'Lobov': [1388, 1493], 'I.': [1389, 1494, 2170, 2817, 5076, 5194, 5286], 'B.H.': [1391, 1496], 'Glass': [1392, 1497], 'II,': [1393, 1498], 'D.A.': [1394, 1499], 'Hartmann': [1395, 1500], 'Hwang': [1399, 1504], 'T.H.': [1400, 1505], 'Brayton': [1401, 1506], 'C.F.': [1402, 1507], 'Lang': [1403, 1508], 'R.A.': [1404, 1454, 1509], 'Karsenty': [1405, 1510], 'Chan': [1407, 1512], '157:': [1413, 1518], '303-314Crossref': [1414, 1519], '(952)': [1417, 1522], 'transgenic': [1422], 'LRP5G171V': [1425, 4365, 4968], 'resulted': [1428], 'HBM': [1430, 1789, 3946, 4895], '(23Babij': [1431], 'Small': [1435], 'Kharode': [1437, 1740], 'Yaworsky': [1439], 'P.J.': [1440, 2008], 'Bouxsein': [1441], 'Reddy': [1443], 'P.S.': [1444], 'Bodine': [1445], 'P.V.': [1446, 1737], 'Robinson': [1447], 'Bhat': [1449], 'Marzolf': [1451], 'Moran': [1453], 'Bex': [1455, 1742], 'F.': [1456], 'Bone': [1458, 2831], 'Miner.': [1459, 2832], 'Res.': [1460, 1683, 2833, 2939, 5481], '18:': [1462, 1759, 2672, 2794], '960-974Crossref': [1463], '(449)': [1466], 'Moreover,': [1469], 'osteoblasts': [1472, 4733, 4952], 'reduced': [1474], 'responsiveness': [1475], 'proliferation': [1480], 'indices': [1481], 'absence': [1484, 3805], 'Wnts': [1527, 3343, 4191, 5318], 'Scholar)': [1669, 1692, 1892, 2841], 'or': [1670, 1913, 2623, 2720, 3377, 3553, 3565, 3804, 3889, 3923, 4953, 6064], 'activated': [1671, 3278, 3340, 5506], '(24Bain': [1673], 'Muller': [1675, 5473], 'Papkoff': [1679, 5477], 'Biophys.': [1682, 5480], 'Commun.': [1684, 5482], '301:': [1686, 5484], '84-91Crossref': [1687, 5485], '(239)': [1690, 5488], 'stimulated': [1693], 'activity': [1698, 2752, 3153, 3204, 3281, 3317, 3339, 4494, 4988, 5228, 5307, 5323, 6057], 'induced': [1700, 2843], 'production': [1701], 'marker,': [1705], 'phosphatase': [1707, 3073], '(AP),': [1708], 'osteoblast-like': [1710], 'finding': [1713, 4290], 'inactivation': [1715], 'sFRP1': [1720], 'enhances': [1721, 1733], 'trabecular': [1722], 'accrual': [1724], 'supports': [1726], 'idea': [1728], '(25Bodine': [1736], 'Y.P.': [1741], 'F.J.': [1743, 2074], 'Goad': [1746], 'M.B.': [1747], 'Gaur': [1748], 'Stein': [1750], 'G.S.': [1751], 'Lian': [1752], 'J.B.': [1753], 'Komm': [1754], 'B.S.': [1755], 'Endocrinol.': [1757], '1222-1237Crossref': [1760], '(411)': [1763], 'Recently,': [1766, 5973], 'reported': [1768], 'differentiated': [1774], 'osteocytes': [1778, 2110, 4257, 4525, 4764, 4790], 'G171V': [1782, 4318, 4341, 4455, 4924, 4983], 'mutation': [1783, 4127, 4232, 4342, 4403, 4456, 4474, 4909, 4925, 4984], 'cause': [1787], 'attenuating': [1792, 4990], 'antagonistic': [1794, 3220, 5611, 5708], 'effect': [1795, 3116, 3122, 3181, 3221, 3255, 5525, 5612, 5709, 5744, 5758, 5928], 'on': [1798, 2723, 2911, 3117, 3128, 3224, 3258, 3850, 4720, 5219, 5602, 5613, 5747, 5761, 5929], '(20Boyden': [1802], '26Zhang': [1832, 3413, 5893], 'Zhang': [1838, 2370, 3419, 3679, 3741, 4153, 4198, 4264, 4410, 4647, 5899], 'Z.': [1843, 2375, 2819, 3424, 3684, 3746, 4158, 4203, 4269, 4415, 4652, 5904], 'Zheng': [1844, 2376, 3425, 3685, 3747, 4159, 4204, 4270, 4416, 4653, 5905], 'Harris': [1848, 2380, 3429, 3689, 3751, 4163, 4208, 4274, 4420, 4657, 5909], '24:': [1856, 2388, 3437, 3697, 3759, 4171, 4216, 4282, 4428, 4665, 5917], '4677-4684Crossref': [1857, 2389, 3438, 3698, 3760, 4172, 4217, 4283, 4429, 4666, 5918], '(146)': [1860, 2392, 3441, 3701, 3763, 4175, 4220, 4286, 4432, 4669, 5921], 'report': [1864, 5624, 6074], 'Itasaki': [1866], 'et': [1867, 5627], 'al.': [1868, 5628], '(27Itasaki': [1869, 1938, 6075], 'Jones': [1871, 1940, 6077], 'C.M.': [1872, 1941, 6078], 'Mercurio': [1873, 1942, 6079], 'Rowe': [1875, 1944, 2828, 6081], 'Domingos': [1877, 1946, 6083], 'Smith': [1879, 1948, 6085], 'J.C.': [1880, 1949, 1993, 2126, 4531, 4809, 5032, 5150, 5242, 5646, 5995, 6086], 'Krumlauf': [1881, 1950, 6087], '130:': [1886, 1955, 6092], '4295-4305Crossref': [1887, 1956, 6093], '(279)': [1890, 1959, 6096], 'described': [1893, 2363, 2482, 2771, 2814, 2933], 'new': [1895, 4295], 'WISE.': [1899], 'WISE': [1900, 1922, 1962, 3106], 'appears': [1901], 'context-dependent': [1905], 'regulator': [1906], 'signaling;': [1909], 'it': [1910, 2241, 4468, 5586], 'inhibit': [1912, 5541, 5730, 5947, 6035], 'stimulate': [1914, 5321], 'different': [1918], 'assays': [1919, 2477, 2764], 'Xenopus.': [1921], 'shown': [1925, 3445, 3725, 4519, 5020, 5678, 5977], 'bind': [1927, 2292, 3585, 3719, 3885], 'Wnt8': [1933], 'shares': [1963], '38%': [1964], 'amino': [1965], 'acid': [1966], 'identity': [1967], 'sclerostin,': [1969, 2598, 3108, 3183, 4945, 6033], 'SOST.': [1974, 2335], 'sclerosing': [1987], 'skeletal': [1988], '(28Brunkow': [1990], 'M.E.': [1991, 2144, 4549, 4827, 5050, 5168, 5260], 'Gardner': [1992], 'Ness': [1995], 'Paeper': [1997], 'B.W.': [1998], 'Kovacevich': [1999, 2137, 4542, 4820, 5043, 5161, 5253], 'Proll': [2001], 'Skonier': [2003, 2131, 4536, 4814, 5037, 5155, 5247, 5649, 5998], 'J.E.': [2004, 2132, 4537, 4815, 5038, 5156, 5248, 5650, 5999], 'Sabo': [2007], 'Fu': [2009], 'Alisch': [2011], 'Gillett': [2013], 'Colbert': [2015], 'Tacconi': [2017, 2075], 'Galas': [2019], 'Hamersma': [2021, 2205, 2262, 4578, 4856, 5111, 5563], 'Mulligan': [2025], '68:': [2032], '577-589Abstract': [2033], '(821)': [2041], '29Balemans': [2044], 'Ebeling': [2046], 'Olson': [2053], 'Dioszegi': [2055], 'Lacza': [2057], 'Wuyts': [2059], 'Den': [2062], 'Ende': [2063], 'Willems': [2065], 'Paes-Alves': [2067], 'A.F.': [2068], 'Hill': [2069], 'Bueno': [2071], 'Ramos': [2073], 'Dikkers': [2077], 'F.G.': [2078], 'Stratakis': [2079], 'Lindpaintner': [2081], 'Vickery': [2083], 'Foernzler': [2085], '10:': [2094], '537-543Crossref': [2095], '(943)': [2098], 'Previous': [2101], 'highly': [2107, 4254], 'might': [2112, 2231, 2242, 6034], 'act': [2113, 2299, 5022], '(BMP)': [2119], '(30Winkler': [2121, 4526, 4804, 5027, 5145, 5237], 'D.G.': [2122, 4527, 4805, 5028, 5146, 5238, 5638, 5991], 'Sutherland': [2123, 4528, 4806, 5029, 5147, 5239, 5639, 6002], 'M.K.': [2124, 4529, 4807, 5030, 5148, 5240, 6003], 'Geoghegan': [2125, 4530, 4808, 5031, 5149, 5241, 5645, 5994], 'Yu': [2127, 4532, 4810, 5033, 5151, 5243, 5651, 5992], 'Hayes': [2129, 4534, 4812, 5035, 5153, 5245], 'Shpektor': [2133, 4538, 4816, 5039, 5157, 5249, 5647, 6000], 'Jonas': [2135, 4540, 4818, 5041, 5159, 5251], 'Staehling-Hampton': [2139, 4544, 4822, 5045, 5163, 5255], 'Appleby': [2141, 4546, 4824, 5047, 5165, 5257], 'Brunkow': [2143, 4548, 4826, 5049, 5167, 5259], 'Latham': [2145, 4550, 4828, 5051, 5169, 5261, 5653, 6004], 'EMBO': [2147, 2791, 4552, 4830, 5053, 5171, 5263], '6267-6276Crossref': [2151, 4556, 4834, 5057, 5175, 5267], '(903)': [2154, 4559, 4837, 5060, 5178, 5270], '31Kusu': [2157, 5063, 5181, 5273], 'Laurikkala': [2159, 5065, 5183, 5275], 'Imanishi': [2161, 5067, 5185, 5277], 'Usui': [2163, 5069, 5187, 5279], 'Konishi': [2165, 5071, 5189, 5281], 'Miyake': [2167, 5073, 5191, 5283], 'Thesleff': [2169, 5075, 5193, 5285], 'Itoh': [2171, 5077, 5195, 5287], '278:': [2177, 5083, 5201, 5293], '24113-24117Abstract': [2178, 5084, 5202, 5294], '(217)': [2186, 5092, 5210, 5302], '32Van': [2189, 4562, 4840, 5095], 'Bezooijen': [2190, 2247, 4563, 4841, 5096, 5548], 'R.L.': [2191, 2248, 4564, 4842, 5097, 5549], 'Roelen': [2192, 2249, 4565, 4843, 5098, 5550], 'B.A.': [2193, 2250, 4566, 4844, 5099, 5551], 'Visser': [2194, 2251, 4567, 4845, 5100, 5552], 'Der': [2197, 2254, 4570, 4848, 5103, 5555], 'Wee-Pals': [2198, 2255, 4571, 4849, 5104, 5556], 'Wilt': [2201, 2258, 4574, 4852, 5107, 5559], 'Karperien': [2203, 2260, 4576, 4854, 5109, 5561], 'Papapoulos': [2207, 2264, 4580, 4858, 5113, 5565], 'S.E.': [2208, 2265, 4581, 4859, 5114, 5566], 'Ten': [2209, 2266, 4582, 4860, 5115, 5567], 'Dijke': [2210, 2267, 4583, 4861, 5116, 5568], 'Lowik': [2212, 2269, 4585, 4863, 5118, 5570], 'C.W.': [2213, 2270, 4586, 4864, 5119, 5571], 'Exp.': [2215, 2272, 4588, 4866, 5121, 5573], '199:': [2218, 2275, 4591, 4869, 5124, 5576], '805-814Crossref': [2219, 2276, 4592, 4870, 5125, 5577], '(711)': [2222, 2279, 4595, 4873, 5128, 5580], 'but': [2225, 3588, 5001], 'another': [2226, 3186, 4707, 5813], 'study': [2227], 'suggested': [2228, 2450, 4918], 'functional': [2235], 'BMP': [2236, 5025, 5220, 5313, 5508, 5546, 5988], 'speculated': [2239], 'modulate': [2243, 6041], '(32Van': [2246, 5547], 'now': [2286], 'clearly': [2287, 3332], 'demonstrate': [2288], 'can': [2291, 3718, 4620, 5319, 5770], 'both': [2294, 3577, 3710, 3906], 'antagonist.': [2303, 5972], 'Because': [2304, 3100, 3160, 4178, 4453], 'occurs': [2307], 'peak': [2309], 'Wnt7b': [2310, 2968, 4605, 4677, 4688, 4721, 4725], 'differentiation,': [2314, 4761], 'contributes': [2326, 4891], 'increases': [2329], 'Culture,': [2337], 'Transfection,': [2338], 'Preparation': [2339], 'Luciferase': [2343, 2476], 'Assay—Human': [2344], '(HEK)': [2347], 'line': [2349, 2355], 'were': [2357, 2432, 2470, 2478, 2557, 2575, 2601, 2617, 2627, 2655, 2688, 2699, 2730, 2742, 2765, 2811, 2861, 2979, 2999, 3011, 3036, 3069, 3089, 3190, 3322, 3379, 3927, 5221], 'maintained': [2358], 'transfected': [2360, 2440, 2568, 2689], 'previously': [2362, 2481, 2770, 2815, 2934, 3386, 3475, 3724, 4116, 4373, 4518, 4613], '(26Zhang': [2364, 3673, 3735, 4147, 4192, 4258, 4404, 4641], '33Li': [2395], 'Yuan': [2397, 2485, 2774], 'Xie': [2399, 2487], 'McMahon': [2403, 2491], 'Sussman': [2405, 2493, 2783], '274:': [2413, 2501, 2525], '129-134Abstract': [2414, 2502], '(257)': [2422, 2510], 'For': [2425, 2548, 2881], 'luciferase': [2426], 'assays,': [2427], '24-well': [2430, 2686], 'plates': [2431, 2687], 'seeded': [2433, 2558], '5': [2435], '×': [2436, 2564], '104': [2437], 'cells/well': [2438, 2566], '0.5': [2442], 'μg': [2443, 2571], 'DNA/well': [2444], 'using': [2445, 2605, 2755, 2872, 2903, 2983, 3021, 3137, 5520], 'Lipofectamine': [2446], 'Plus': [2447], '(Invitrogen),': [2448], 'manufacturer.': [2453], 'LacZ': [2455], 'plasmid': [2456], 'usually': [2458], 'make': [2461], 'DNA': [2462, 2610, 2620, 2913], 'concentrations': [2463], 'equal': [2464], 'each': [2466, 2928, 3785], 'transfection.': [2467, 2475, 2580], 'extracts': [2469], 'collected': [2471, 2576], '24': [2472], 'h': [2473, 2578, 5530], 'performed': [2479], '(33Li': [2483], '34Yuan': [2513], '30419-30423Abstract': [2526], '(98)': [2534], 'Luminescence': [2537], 'intensity': [2538, 2543], 'normalized': [2540, 2955], 'against': [2541, 2956], 'fluorescence': [2542], 'green': [2545, 3094], 'fluorescent': [2546], 'protein.': [2547], 'preparation': [2549], 'DKK1-AP-': [2551], 'sclerostin-AP-containing': [2553], 'HEK': [2555, 3144, 3193, 5510], '6': [2560, 3248, 3302, 5529], 'well-plates': [2561], '4': [2563], '105': [2565], '1': [2570], 'DNA/well.': [2572], 'Conditioned': [2573], 'media': [2574], '48': [2577], 'Construction': [2581], 'Expression': [2583, 3267], 'Plasmids': [2584], 'Mutagenesis—The': [2586], 'wild-type': [2587, 4389, 4502, 4971], 'mutant': [2589, 2637, 3596, 3616, 3770, 4181, 4940], 'forms': [2590], 'LRP5,': [2593, 3851, 5692], 'LRP6,': [2594], 'Wnt1,': [2596, 3189], 'DKK1,': [2597], 'generated': [2602, 2812], 'PCR': [2604, 2867, 2883, 2899, 2908], 'fidelity': [2608], 'thermostable': [2609], 'polymerase': [2611], 'Pfu': [2612], 'Ultra': [2613], '(Stratagene).': [2614], 'Nucleotide': [2615], 'sequences': [2616, 3849], 'verified': [2618], 'sequencing.': [2621], 'Hemagglutinin': [2622], 'FLAG': [2624], 'epitope': [2625], 'tags': [2626], 'introduced': [2628], 'C': [2631], 'termini': [2632], 'full-length': [2635, 2964], 'driven': [2645], 'cytomegalovirus': [2648], 'promoter.': [2649], 'LEF-1': [2651, 6054], 'reporter': [2652, 3140, 3279, 5495, 6055], 'constructs': [2654], 'kindly': [2656], 'provided': [2657], 'Dr.': [2659], 'Grosschedl': [2661, 2666], '(35Hsu': [2662], 'Galceran': [2664], '4807-4818Crossref': [2673], '(340)': [2676], 'DKK1-AP': [2679, 2719], 'Sclerostin-AP': [2681], 'Binding': [2682], 'Assay—HEK': [2683], 'its': [2693, 4135, 4632, 5600, 5610], 'mutants.': [2694], 'One': [2695, 4334], 'day': [2696, 4691], 'later,': [2697], 'washed': [2700, 2731, 3037], 'cold': [2702], 'washing': [2703, 2736], 'buffer': [2704, 2737], "(Hank's": [2705], 'buffered': [2706], 'salt': [2707], 'solution': [2708], 'containing': [2709, 3125, 3597, 3617], 'bovine': [2710], 'serum': [2711], 'albumin': [2712], 'NaN3)': [2714], 'incubated': [2716, 3070], 'sclerostin-AP': [2721, 3369, 3449, 3462, 3506, 3514, 3543, 3582, 3612, 3796, 3819, 3837, 3888, 4363, 4446, 5734], 'CM': [2722, 3124, 3147, 3162], 'ice': [2724], '2': [2726, 2864, 3211, 3288], 'h.': [2727], 'Then,': [2728, 3008], 'three': [2732], 'times': [2733], 'lysed.': [2739], 'lysates': [2741], 'heated': [2743], '65': [2745, 3064], '°C': [2746, 3052], '10': [2748], 'min,': [2749], 'AP': [2751, 2759, 5227, 5306, 5322], 'determined': [2754, 3136, 3476, 5223], 'Tropix': [2757], 'luminescence': [2758], 'assay': [2760, 3142, 5497, 5519], 'kit.': [2761], 'immunoprecipitation': [2763], 'carried': [2766, 2901], 'out': [2767, 2902], 'essentially': [2768], '(36Li': [2772], 'Weaver': [2776], 'Farr': [2780], 'III,': [2781], 'G.H.': [2782], 'D.J.': [2784], 'Jonkers': [2785], '4233-4240Crossref': [2795], '(359)': [2798], 'Primary': [2801], 'Calvarial': [2802], 'Osteoblast': [2803], 'Culture—Mouse': [2804], 'cultures': [2807], '5-day-old': [2809], '(37Kalajzic': [2816], 'Kalajzic': [2818], 'Kaliterna': [2820], 'Gronowicz': [2822], 'Clark': [2824], 'S.H.': [2825], 'Lichtler': [2826], 'A.C.': [2827], '17:': [2835], '15-25Crossref': [2836], '(329)': [2839], 'undergo': [2845], 'presence': [2850, 3241, 3803, 3810, 3829, 6060], '8': [2852, 4692], 'mm': [2853], 'β-glycerophosphate': [2854], '50': [2856, 3169], 'μg/ml': [2857], 'ascorbic': [2858], 'acid.': [2859], 'Media': [2860], 'changed': [2862], 'every': [2863], 'days.': [2865], 'Quantitative': [2866, 2898], 'Analysis—Total': [2868], 'RNA': [2869, 2885, 2985], 'isolated': [2871], 'TRIzol': [2873], 'reagent': [2874], '(Invitrogen)': [2875], 'according': [2876], "manufacturer's": [2879], 'instructions.': [2880], 'quantitative': [2882], 'analysis,': [2884], 'reverse-transcribed': [2887], 'SuperScript™': [2890], 'First-Strand': [2891], 'Synthesis': [2892], 'System': [2893], 'reverse': [2895, 4489, 5741, 5804], 'transcription-PCR': [2896], '(Invitrogen).': [2897], 'QuantiTect™': [2905], 'SYBR': [2906], 'Green': [2907], 'kit': [2909], '(Qiagen)': [2910], 'Engine': [2914], 'OPTICON™': [2915], 'instrument': [2916], '(MJ': [2917], 'Research': [2918], 'Inc.).': [2919], 'B-actin': [2920, 2958], 'internal': [2925], 'reference': [2926], 'sample.': [2929], 'Using': [2930], 'formula': [2932], '(38Pfaffl': [2935], 'M.W.': [2936], 'Nucleic': [2937], 'Acids': [2938], '29:': [2941], 'e45Crossref': [2942], '(26628)': [2945], 'relative': [2949], 'change': [2950], 'mRNA': [2952, 2959, 4726], 'levels': [2953, 4634, 4675], 'levels.': [2960, 3350], 'Situ': [2962], 'Hybridization—The': [2963], 'coding': [2965], 'region': [2966], 'synthesize': [2972], 'antisense': [2973], 'sense': [2975], 'probes.': [2976], 'probes': [2978], 'labeled': [2980], 'digoxigenin': [2982], 'Labeling': [2986], 'Kit': [2987], '(Roche': [2988], 'Applied': [2989], 'Science).': [2990], 'Sections': [2991], 'tibia': [2994], '3-week-old': [2997], 'dewaxed,': [3000], 'rehydrated,': [3001], 'fixed': [3003], 'again': [3004], '4%': [3006], 'paraformaldehyde.': [3007], 'sections': [3010, 3035, 3088], 'treated': [3012], '2%': [3014], 'glycine': [3015], 'proteinase': [3017], 'K': [3018], 'acetylated': [3020], 'acetic': [3023], 'anhydride/Tris-EDTA': [3024], 'acetate': [3025], 'solution,': [3026], 'followed': [3027, 3075], 'hybridization': [3029, 4715], 'digoxigenin-labeled': [3032], 'probe.': [3033], 'twice': [3038], '50%': [3040, 3056], 'formamide,': [3041, 3057], '5×': [3042], 'SSC,': [3043], '5%': [3045], 'SDS': [3046], '30': [3048, 3061], 'min': [3049, 3062], '70': [3051], 'once': [3054, 6030], '2×': [3058], 'SSC': [3059], '°C,': [3065], 'then': [3067, 4694], 'they': [3068, 3893], 'anti-digoxigenin-alkaline': [3072], 'antibody': [3074], 'nitro': [3077], 'blue': [3078], 'tetrazolium/4-bromo-5-chloro': [3079], 'indolyl': [3080], 'phosphate,': [3081], 'yields': [3083], 'purple-blue': [3085], 'color.': [3086], 'counterstained': [3091], 'methyl': [3093], '(nuclei)': [3095], 'orange': [3097], 'G': [3098], '(cytoplasma).': [3099], 'homology': [3103], 'shared': [3104], 'between': [3105, 4464, 4479], 'examined': [3110, 3253, 3359, 4599], 'whether': [3111, 3360, 3779], 'would': [3113, 4955], 'exert': [3114], 'Wnt3a-induced': [3129, 5633], 'activation': [3130], 'LEF-1-based': [3139], 'Sclerostin-containing': [3146], 'marked': [3149, 3607], 'inhibition': [3150, 3167, 3201, 3275, 3298, 4491, 5856], 'Wnt3a': [3152, 3812, 5727], 'dose-dependent': [3156], 'manner': [3157], '(Fig.': [3158, 3208, 3245, 3285, 3299, 3326, 3523, 3568, 3580, 3591, 3626, 3824, 3840, 4391, 4451, 4504, 4711, 4739, 4771, 5531], '1A).': [3159, 5532], 'control': [3161], 'started': [3163], 'show': [3165], 'significant': [3166], 'μl,': [3170], 'test': [3174, 4353], 'higher': [3175], 'doses.': [3176], 'confirm': [3179], 'coexpressed': [3191, 3206, 3243, 5852], 'cells,': [3194, 3308], 'up': [3198, 3272], '60%': [3200], 'Wnt-1': [3207, 3277], '1B,': [3209, 3246], 'bars': [3210, 3247, 3287, 3301], '4).': [3213, 3290], 'Interestingly,': [3214], 'coexpression': [3215], 'abolished': [3218], 'signaling,': [3226, 3357], 'slight': [3229, 6051], 'stimulation': [3230, 6052], 'Wnt1': [3232, 3316], 'even': [3237, 4897, 6111], 'observed': [3238], '8).': [3250, 3304], 'We': [3251, 3722, 4114, 4598, 4612], 'line,': [3265], 'MC3T3.': [3266], '70%': [3274], '1C,': [3286, 3300], 'Once': [3291], 'again,': [3292], 'observe': [3312], 'any': [3313], 'when': [3318, 3344, 4763], '1C).': [3327], 'Nevertheless,': [3328], 'all': [3329, 3823], 'results': [3331, 3901], 'antagonizes': [3336, 3355], 'endogenous': [3349], 'understand': [3352, 6121], 'how': [3353], 'binds': [3362, 5683], 'directly.': [3365], 'fusion': [3370], 'expressing': [3374, 3799, 4376, 4388, 4437], 'exogenous': [3375, 5775, 6062], 'measured': [3380, 3539, 3792, 4357, 5523], 'done': [3387], 'Dkk1-AP': [3389, 3508, 3516, 3571], 'As': [3444, 4370, 4917, 5677], 'Fig.': [3447, 5680], '2A,': [3448], 'curve': [3454], 'Dkk1-AP,': [3459, 3472, 3890], 'suggesting': [3460, 3766], 'has': [3463, 4516, 4964, 5136, 5975], 'affinity': [3465, 5140], 'comparable': [3468], 'sub-nanomolar': [3479], 'LRP5-expressing': [3510], 'affinities': [3520], '2B).': [3524], 'delineate': [3526, 3847], 'regions': [3528], 'sclerostin-AP,': [3537], 'mutants': [3547, 3560, 3579, 3882, 3926], 'lack': [3549, 3860], 'either': [3550, 3621, 3887, 3905], 'last': [3554], 'domains.': [3558], 'These': [3559, 3900], 'designated': [3562], 'LRP5R12': [3564, 3727, 3800, 3821, 3839], 'LRP5R34,': [3566], 'respectively': [3567], '2E).': [3569], 'Whereas': [3570], 'capable': [3573], '2D),': [3581], 'LRP5R12,': [3587, 3790], 'LRP5R34': [3590], '2C).': [3592], 'Additionally,': [3593], 'Ala': [3598, 3618], 'substitution': [3599, 3619], 'Asp111': [3601, 3629], 'Asp418': [3603, 3631], 'more': [3606, 5588], 'than': [3613, 4386, 4969], 'residues': [3625], '2G).': [3627], 'Residues': [3628], 'located': [3633, 4322], 'centers': [3636], 'wider': [3639], 'openings': [3640], 'barrel-like': [3643], 'structures': [3644], 'formed': [3645], 'domains,': [3653, 3876], 'respectively,': [3654], 'correspond': [3656], 'Glu721': [3659], 'residue': [3660], 'third': [3663], 'piece': [3705], 'data': [3707], 'suggests': [3708, 5705, 6099], 'sclerostin.': [3721, 4351, 4482], 'still': [3729, 3772, 4183, 4488], 'able': [3730, 4184], 'transduce': [3732, 3894, 4186], 'retain': [3773], 'Wnt-binding': [3775], 'sequences.': [3776], 'determine': [3778], 'other': [3786, 5007, 5951], 'Wnt3A': [3807], 'CM.': [3808], 'affect': [3815, 4912], '3A).': [3825], 'contrast,': [3827, 5492], 'completely': [3832], 'blocked': [3833], '3B).': [3841, 4452], 'attempt': [3844], 'sclerostin-binding': [3848, 4332], 'constructed': [3854], 'additional': [3856], 'mutants,': [3858], 'fourth': [3864, 3873], 'first,': [3870], 'third,': [3871], 'respectively.': [3877], 'nor': [3891], '(data': [3897, 5512, 5932], 'shown).': [3899, 5514], 'suggest': [3902, 4229, 4980, 6026], 'possibilities:': [3904], 'incorrectly': [3928], 'folded.': [3929], 'Several': [3930], 'G171V,': [4122], 'interfered': [4128], 'interaction': [4131, 4463, 4478], 'chaperon': [4136], 'Mesd,': [4137], 'poor': [4140], 'transportation': [4141], 'surfaces': [4146], 'signals': [4187], 'intracellularly': [4188], 'had': [4224, 5926], 'proposed': [4225], 'hypothesis': [4227, 4921, 4978], 'retaining': [4238], 'receptor': [4241, 4929, 4941], 'inside': [4242], 'extracellular': [4246], 'such': [4248, 4335, 4959, 5958], 'because': [4251, 5725, 5764, 5809], 'antagonist,': [4297, 4709], 'known': [4300], 'osteocytes,': [4308, 4954], 'provide': [4310], 'alternative': [4311], 'explanations': [4312], 'effects': [4315, 5216, 5601, 5634, 5806], 'mutation,': [4319], 'within': [4330], 'region.': [4333], 'explanation': [4336], 'directly': [4343, 4459, 4902, 5979], 'interferes': [4344, 4475], 'possibility,': [4355], 'compared': [4359], 'Dkk1-AP.': [4369], 'shown,': [4374], 'LRP5GV': [4377, 4438, 4486], '5-fold': [4380], 'lower': [4381, 4697], 'apparent': [4382], 'Dkk-AP': [4385], '3C)': [4392], 'due': [4393, 5716], 'interference': [4396], "chaperon's": [4399], 'Similarly,': [4435, 4672], 'same': [4449, 4497], 'degree': [4450], 'does': [4457, 4910], 'interfere': [4460, 4903], 'Dkk1,': [4467], 'unlikely': [4471, 5713], 'observation': [4484, 5753, 6047], 'dose': [4498], 'range': [4499], '1,': [4505], 'B': [4506], 'C)': [4508], 'provides': [4509], 'support': [4511], 'idea.': [4514], 'Sclerostin': [4515], 'primarily': [4522, 4729, 5607], 'relation': [4603], 'differentiation.': [4611], 'stabilize': [4621], 'β-catenin,': [4622], 'drastic': [4629, 4679], 'changes': [4630, 4680], 'marrow': [4638], 'differentiation;': [4684], 'peaked': [4689], 'receded': [4695], 'levels,': [4698], 'preceding': [4699], '4A).': [4712, 4772], 'situ': [4714], 'confirms': [4717], 'conclusion': [4719], 'detected': [4728], 'early': [4731, 5542], 'undifferentiated': [4732], 'long': [4737], '4B).': [4740], 'time': [4748], 'course': [4749], 'occurred': [4756], 'presumably': [4762], 'forming': [4766], 'mineralized': [4769], 'matrix': [4770, 4795], 'pattern': [4774], 'consistent': [4779, 5673, 6068], 'previous': [4781, 5016, 6073], 'vivo': [4783], 'observations': [4784, 5536], 'buried': [4791], 'play': [4798], 'mechanical': [4802], 'loading': [4803], 'On': [4876], 'basis': [4878], 'patterns': [4882], 'postulate': [4888], 'G171V-associated': [4894], 'phenotype,': [4896], 'though': [4898], 'binding,': [4906], 'hide': [4927], 'paracrine': [4931, 4960, 5008], 'without': [4933], 'diminishing': [4934], 'ability': [4937], 'produced': [4949], 'well-differentiated': [4951], 'conceivably': [4963], 'less': [4965], 'access': [4966], 'Thus,': [4973], 'amend': [4975], 'original': [4977], 'potentially': [5006], 'present': [5011], 'bone.': [5014], 'studies,': [5017], 'It': [5131, 6022], 'convincing': [5133], 'reasonably': [5138], 'BMP6': [5142], 'BMP7': [5144], 'biological': [5215], 'merely': [5222], 'measuring': [5225], 'BMP-induced': [5226], '3–6': [5229], 'days': [5230], 'ligand': [5232], 'addition': [5233], 'readout': [5308], 'specific': [5311, 5499], 'activity.': [5314], 'fact,': [5316], 'types': [5326], '24Bain': [5471], 'cannot': [5504], 'recent': [5535], 'failed': [5539, 5728], 'responses': [5543], 'elicited': [5544], 'likely': [5589], 'biologically': [5593], 'probably': [5606], 'attributed': [5608], 'While': [5617], 'work': [5619, 6116], 'under': [5621, 6107], 'review,': [5622], 'Winkle': [5626], 'inhibited': [5632], 'C3H10T1/2': [5636], '(39Winkler': [5637], 'Ojala': [5641, 5996], 'Turcott': [5643], '2005;': [5658], '280:': [5659], '2498-2502Abstract': [5660], '(145)': [5668], 'finding.': [5676], '2,': [5681], 'signals.': [5701], 'direct': [5718], 'competition': [5719], 'LRP': [5723], '1)': [5726], '2)': [5738], 'inhibitory': [5743], 'latter': [5752], 'reminiscent': [5755], 'suppression': [5766], 'Dkk-mediated': [5810, 5855], 'requires': [5812], 'protein,': [5814], '(15Mao': [5816, 5860], 'When': [5849], 'LRP5/6,': [5854], 'restored': [5859], 'no': [5927], 'shown),': [5934], 'suspect': [5936], 'mechanism': [5940, 6123], 'words,': [5952], 'there': [5953], 'accessory': [5956], 'proteins': [5957], 'efficiently': [5969], 'noggin': [5974, 5985], 'interact': [5980], 'prevent': [5984], 'inhibiting': [5987], '(40Winkler': [5990], 'E.W.': [5997], '279:': [6010], '36293-36298Abstract': [6011], '(83)': [6019], 'seems': [6023], 'reasonable': [6024], 'noggin,': [6029], 'capacity': [6037], 'LRP5GV,': [6065], 'principle': [6070], 'partial': [6105], 'agonist': [6106], 'certain': [6109], 'circumstance': [6110], 'mammalian': [6113], 'systems.': [6114], 'Further': [6115], 'better': [6120], 'regulates': [6127]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2087560312', 'counts_by_year': [{'year': 2024, 'cited_by_count': 42}, {'year': 2023, 'cited_by_count': 63}, {'year': 2022, 'cited_by_count': 67}, {'year': 2021, 'cited_by_count': 76}, {'year': 2020, 'cited_by_count': 92}, {'year': 2019, 'cited_by_count': 69}, {'year': 2018, 'cited_by_count': 69}, {'year': 2017, 'cited_by_count': 75}, {'year': 2016, 'cited_by_count': 86}, {'year': 2015, 'cited_by_count': 89}, {'year': 2014, 'cited_by_count': 77}, {'year': 2013, 'cited_by_count': 89}, {'year': 2012, 'cited_by_count': 74}], 'updated_date': '2024-12-14T03:11:21.119117', 'created_date': '2016-06-24'}
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