Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2087478312', 'doi': 'https://doi.org/10.1002/asia.200600185', 'title': 'Identification of Potent, Selective Protein Kinase C Inhibitors Based on a Phorbol Skeleton', 'display_name': 'Identification of Potent, Selective Protein Kinase C Inhibitors Based on a Phorbol Skeleton', 'publication_year': 2006, 'publication_date': '2006-08-17', 'ids': {'openalex': 'https://openalex.org/W2087478312', 'doi': 'https://doi.org/10.1002/asia.200600185', 'mag': '2087478312', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17441066'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/asia.200600185', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S188582317', 'display_name': 'Chemistry - An Asian Journal', 'issn_l': '1861-471X', 'issn': ['1861-471X', '1861-4728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054360758', 'display_name': 'Kenzo Yamatsugu', 'orcid': 'https://orcid.org/0000-0002-4260-414X'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenzo Yamatsugu', 'raw_affiliation_strings': ['Graduate School of Pharmaceutical Sciences The University of Tokyo Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Fax: (+81)\u2009356-84-5206'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Pharmaceutical Sciences The University of Tokyo Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Fax: (+81)\u2009356-84-5206', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025380528', 'display_name': 'Rie Motoki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Rie Motoki', 'raw_affiliation_strings': ['Graduate School of Pharmaceutical Sciences The University of Tokyo Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Fax: (+81)\u2009356-84-5206'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Pharmaceutical Sciences The University of Tokyo Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Fax: (+81)\u2009356-84-5206', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088288669', 'display_name': 'Motomu Kanai', 'orcid': 'https://orcid.org/0000-0003-1977-7648'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Motomu Kanai', 'raw_affiliation_strings': ['Graduate School of Pharmaceutical Sciences The University of Tokyo Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Fax: (+81)\u2009356-84-5206'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Pharmaceutical Sciences The University of Tokyo Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Fax: (+81)\u2009356-84-5206', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012101296', 'display_name': 'Masakatsu Shibasaki', 'orcid': 'https://orcid.org/0000-0001-8862-582X'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masakatsu Shibasaki', 'raw_affiliation_strings': ['Graduate School of Pharmaceutical Sciences The University of Tokyo Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Fax: (+81)\u2009356-84-5206'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Pharmaceutical Sciences The University of Tokyo Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Fax: (+81)\u2009356-84-5206', 'institution_ids': ['https://openalex.org/I74801974']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4220, 'currency': 'USD', 'value_usd': 4220, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.268, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.627036, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': '1', 'issue': '3', 'first_page': '314', 'last_page': '321'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13230', 'display_name': 'Synthesis and Reactivity of Heterocycles', 'score': 0.9895, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/phorbol', 'display_name': 'Phorbol', 'score': 0.44651428}], 'concepts': [{'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.8942513}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.51589096}, {'id': 'https://openalex.org/C2780043322', 'wikidata': 'https://www.wikidata.org/wiki/Q2705359', 'display_name': 'Phorbol', 'level': 4, 'score': 0.44651428}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.42682827}, {'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.42624345}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.40923718}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.399403}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.34263727}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31965044}], 'mesh': [{'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010703', 'descriptor_name': 'Phorbol Esters', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020816', 'descriptor_name': 'Amino Acid Motifs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002626', 'descriptor_name': 'Chemistry, Pharmaceutical', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D002626', 'descriptor_name': 'Chemistry, Pharmaceutical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020128', 'descriptor_name': 'Inhibitory Concentration 50', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009682', 'descriptor_name': 'Magnetic Resonance Spectroscopy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008956', 'descriptor_name': 'Models, Chemical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010703', 'descriptor_name': 'Phorbol Esters', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010703', 'descriptor_name': 'Phorbol Esters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/asia.200600185', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S188582317', 'display_name': 'Chemistry - An Asian Journal', 'issn_l': '1861-471X', 'issn': ['1861-471X', '1861-4728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17441066', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W138541567', 'https://openalex.org/W1502447505', 'https://openalex.org/W1576671418', 'https://openalex.org/W1588018069', 'https://openalex.org/W1594286037', 'https://openalex.org/W1641731911', 'https://openalex.org/W1706568612', 'https://openalex.org/W1749394363', 'https://openalex.org/W1965965826', 'https://openalex.org/W1970864285', 'https://openalex.org/W1973454785', 'https://openalex.org/W1983655279', 'https://openalex.org/W1984952358', 'https://openalex.org/W1990993700', 'https://openalex.org/W1993211567', 'https://openalex.org/W2001746740', 'https://openalex.org/W2008272325', 'https://openalex.org/W2011314898', 'https://openalex.org/W2020163457', 'https://openalex.org/W2020858581', 'https://openalex.org/W2024610170', 'https://openalex.org/W2030205108', 'https://openalex.org/W2034919226', 'https://openalex.org/W2049556290', 'https://openalex.org/W2051163797', 'https://openalex.org/W2052750950', 'https://openalex.org/W2057689943', 'https://openalex.org/W2061957367', 'https://openalex.org/W2068085280', 'https://openalex.org/W2070997780', 'https://openalex.org/W2075868187', 'https://openalex.org/W2076488165', 'https://openalex.org/W2076839780', 'https://openalex.org/W2082862688', 'https://openalex.org/W2085547973', 'https://openalex.org/W2092579332', 'https://openalex.org/W2114788827', 'https://openalex.org/W2115544008', 'https://openalex.org/W2117029515', 'https://openalex.org/W2119892971', 'https://openalex.org/W2127133626', 'https://openalex.org/W2137882621', 'https://openalex.org/W2161798777', 'https://openalex.org/W2163421864', 'https://openalex.org/W2952245557', 'https://openalex.org/W4247904703', 'https://openalex.org/W93019692'], 'related_works': ['https://openalex.org/W2091930564', 'https://openalex.org/W2084059091', 'https://openalex.org/W2082018395', 'https://openalex.org/W2078679345', 'https://openalex.org/W2029870587', 'https://openalex.org/W2022445643', 'https://openalex.org/W2002902845', 'https://openalex.org/W1983556646', 'https://openalex.org/W1975286344', 'https://openalex.org/W1963527569'], 'abstract_inverted_index': {'The': [0, 113], 'elucidation': [1], 'of': [2, 5, 22, 39, 55, 79, 84, 101, 149], 'specific': [3], 'functions': [4], 'protein': [6], 'kinase': [7], 'C': [8], '(PKC)': [9], 'subtypes': [10], 'in': [11, 77], 'physiological': [12], 'processes': [13], 'is': [14, 88], 'an': [15, 173], 'important': [16], 'challenge': [17], 'for': [18, 35, 154], 'the': [19, 40, 51, 68, 82, 85, 99, 110, 145, 155, 160, 166, 185], 'future': [20], 'development': [21], 'new': [23, 102, 193], 'drug': [24], 'targets.': [25], 'Subtype-selective': [26], 'PKC': [27, 43, 64, 69, 92, 125, 164], 'agonists': [28], 'and': [29, 104, 123, 134, 165, 190, 199], 'antagonists': [30], 'are': [31, 72, 152], 'useful': [32], 'biological': [33], 'tools': [34], 'this': [36, 95], 'purpose.': [37], 'Most': [38], 'currently': [41], 'used': [42], 'modulators': [44, 65], 'elicit': [45], 'their': [46], 'activities': [47], 'through': [48], 'binding': [49, 53, 161, 188, 194], 'to': [50, 74, 90], 'ATP': [52], 'site': [54], 'PKC,': [56], 'which': [57], 'shares': [58], 'many': [59], 'features': [60], 'with': [61, 129], 'other': [62], 'kinases.': [63], 'that': [66, 108], 'target': [67, 109], 'regulatory': [70, 86, 111, 126], 'domain': [71, 87, 127], 'considered': [73], 'be': [75, 182], 'advantageous': [76], 'terms': [78], 'selectivity,': [80], 'because': [81], 'structure': [83], 'intrinsic': [89], 'each': [91], 'subtype.': [93], 'In': [94], 'paper,': [96], 'we': [97], 'describe': [98], 'identification': [100], 'potent': [103, 122, 156], 'conventional': [105], 'PKC-selective': [106], 'inhibitors': [107, 114], 'domain.': [112], 'contain': [115], 'a': [116, 119, 130, 135, 140, 192], 'phorbol': [117, 167, 197], 'skeleton,': [118], 'naturally': [120], 'occurring': [121], 'selective': [124], 'binder,': [128], 'perfluorinated': [131], 'alkyl': [132], 'group': [133], 'polyether': [136], 'hydrophilic': [137], 'chain': [138], 'on': [139], 'terephthaloyl': [141], 'aromatic': [142, 175], 'ring': [143, 176], 'at': [144, 177], 'C12': [146], 'position.': [147], 'Both': [148], 'these': [150], 'substituents': [151], 'essential': [153], 'inhibitory': [157], 'activity.': [158], 'Specifically,': [159], 'affinity': [162], 'between': [163, 196], 'ester': [168], 'analogues': [169], 'was': [170], 'improved': [171], 'by': [172, 184], 'electron-deficient': [174], 'C12.': [178], 'This': [179], 'finding': [180], 'cannot': [181], 'explained': [183], 'previously': [186], 'proposed': [187], 'model': [189], 'suggests': [191], 'mode': [195], 'esters': [198], 'PKC.': [200]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2087478312', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-10T18:04:44.929333', 'created_date': '2016-06-24'}