Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2087267008', 'doi': 'https://doi.org/10.1111/j.1432-1033.1990.tb15280.x', 'title': 'Ribofuranosyl‐benzimidazole derivatives as inhibitors of casein kinase‐2 and casein kinase‐1', 'display_name': 'Ribofuranosyl‐benzimidazole derivatives as inhibitors of casein kinase‐2 and casein kinase‐1', 'publication_year': 1990, 'publication_date': '1990-01-01', 'ids': {'openalex': 'https://openalex.org/W2087267008', 'doi': 'https://doi.org/10.1111/j.1432-1033.1990.tb15280.x', 'mag': '2087267008', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2105215'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1432-1033.1990.tb15280.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1990.tb15280.x', 'source': {'id': 'https://openalex.org/S4210214924', 'display_name': 'European Journal of Biochemistry', 'issn_l': '0014-2956', 'issn': ['0014-2956', '0945-5795', '1432-1033'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1990.tb15280.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005096585', 'display_name': 'Flavio Meggio', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Flavio MEGGIO', 'raw_affiliation_strings': ['Department of Biological Chemistry University of Padova, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Chemistry University of Padova, Italy.', 'institution_ids': ['https://openalex.org/I138689650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009003036', 'display_name': 'David Shugar', 'orcid': 'https://orcid.org/0000-0003-4917-4602'}, 'institutions': [{'id': 'https://openalex.org/I4654613', 'display_name': 'University of Warsaw', 'ror': 'https://ror.org/039bjqg32', 'country_code': 'PL', 'type': 'education', 'lineage': ['https://openalex.org/I4654613']}, {'id': 'https://openalex.org/I4210128244', 'display_name': 'Institute of Biochemistry and Biophysics, Polish Academy of Sciences', 'ror': 'https://ror.org/034tvp782', 'country_code': 'PL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210128244', 'https://openalex.org/I99542240']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'David SHUGAR', 'raw_affiliation_strings': ['Department of Biophysics, Institute of Experimental Physics, University of Warsaw and Institute of Biochemistry and Biophysics, Academy of Sciences, Warsaw, Poland'], 'affiliations': [{'raw_affiliation_string': 'Department of Biophysics, Institute of Experimental Physics, University of Warsaw and Institute of Biochemistry and Biophysics, Academy of Sciences, Warsaw, Poland', 'institution_ids': ['https://openalex.org/I4654613', 'https://openalex.org/I4210128244']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052547325', 'display_name': 'Lorenzo A. Pinna', 'orcid': 'https://orcid.org/0000-0002-8856-4956'}, 'institutions': [{'id': 'https://openalex.org/I138689650', 'display_name': 'University of Padua', 'ror': 'https://ror.org/00240q980', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I138689650']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Lorenzo A. PINNA', 'raw_affiliation_strings': ['Department of Biological Chemistry University of Padova, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Chemistry University of Padova, Italy.', 'institution_ids': ['https://openalex.org/I138689650']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.734, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 115, 'citation_normalized_percentile': {'value': 0.988989, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '187', 'issue': '1', 'first_page': '89', 'last_page': '94'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11617', 'display_name': 'Enzyme Production and Characterization', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11617', 'display_name': 'Enzyme Production and Characterization', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13725', 'display_name': 'Pineapple and bromelain studies', 'score': 0.9909, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13326', 'display_name': 'Biochemical and Structural Characterization', 'score': 0.9896, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/casein-kinase-2', 'display_name': 'Casein kinase 2', 'score': 0.5498337}, {'id': 'https://openalex.org/keywords/ribose', 'display_name': 'Ribose', 'score': 0.42168394}, {'id': 'https://openalex.org/keywords/benzimidazole', 'display_name': 'Benzimidazole', 'score': 0.41205966}], 'concepts': [{'id': 'https://openalex.org/C118716', 'wikidata': 'https://www.wikidata.org/wiki/Q5514725', 'display_name': "GTP'", 'level': 3, 'score': 0.6973268}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.55912054}, {'id': 'https://openalex.org/C143910341', 'wikidata': 'https://www.wikidata.org/wiki/Q21102140', 'display_name': 'Casein kinase 2', 'level': 5, 'score': 0.5498337}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.5385325}, {'id': 'https://openalex.org/C205744416', 'wikidata': 'https://www.wikidata.org/wiki/Q18248555', 'display_name': 'Casein kinase 2, alpha 1', 'level': 5, 'score': 0.5205577}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.51959133}, {'id': 'https://openalex.org/C180526460', 'wikidata': 'https://www.wikidata.org/wiki/Q356240', 'display_name': 'Adenylate kinase', 'level': 3, 'score': 0.49920583}, {'id': 'https://openalex.org/C160110348', 'wikidata': 'https://www.wikidata.org/wiki/Q5048387', 'display_name': 'Casein kinase 1', 'level': 4, 'score': 0.49269727}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46713164}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.43112993}, {'id': 'https://openalex.org/C2779461342', 'wikidata': 'https://www.wikidata.org/wiki/Q59817493', 'display_name': 'Ribose', 'level': 3, 'score': 0.42168394}, {'id': 'https://openalex.org/C2778484023', 'wikidata': 'https://www.wikidata.org/wiki/Q415190', 'display_name': 'Benzimidazole', 'level': 2, 'score': 0.41205966}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.4070468}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37526795}, {'id': 'https://openalex.org/C82495950', 'wikidata': 'https://www.wikidata.org/wiki/Q14911732', 'display_name': 'Cyclin-dependent kinase 2', 'level': 4, 'score': 0.23764989}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001562', 'descriptor_name': 'Benzimidazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001562', 'descriptor_name': 'Benzimidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047388', 'descriptor_name': 'Casein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012266', 'descriptor_name': 'Ribose', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012266', 'descriptor_name': 'Ribose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003313', 'descriptor_name': 'Zea mays', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D003313', 'descriptor_name': 'Zea mays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1432-1033.1990.tb15280.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1990.tb15280.x', 'source': {'id': 'https://openalex.org/S4210214924', 'display_name': 'European Journal of Biochemistry', 'issn_l': '0014-2956', 'issn': ['0014-2956', '0945-5795', '1432-1033'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2105215', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1432-1033.1990.tb15280.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1990.tb15280.x', 'source': {'id': 'https://openalex.org/S4210214924', 'display_name': 'European Journal of Biochemistry', 'issn_l': '0014-2956', 'issn': ['0014-2956', '0945-5795', '1432-1033'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1493502158', 'https://openalex.org/W1523300862', 'https://openalex.org/W1537623701', 'https://openalex.org/W1552709225', 'https://openalex.org/W1575085169', 'https://openalex.org/W1607978009', 'https://openalex.org/W1636259902', 'https://openalex.org/W1653386228', 'https://openalex.org/W1677175288', 'https://openalex.org/W1751152537', 'https://openalex.org/W1882341539', 'https://openalex.org/W1968369188', 'https://openalex.org/W1978302948', 'https://openalex.org/W1992092364', 'https://openalex.org/W2000450250', 'https://openalex.org/W2002309183', 'https://openalex.org/W2019423132', 'https://openalex.org/W2020010697', 'https://openalex.org/W2026595489', 'https://openalex.org/W2031584044', 'https://openalex.org/W2032379967', 'https://openalex.org/W2041906712', 'https://openalex.org/W2046348745', 'https://openalex.org/W2057001882', 'https://openalex.org/W2065870515', 'https://openalex.org/W2071317316', 'https://openalex.org/W2078037215', 'https://openalex.org/W2079524391', 'https://openalex.org/W2080860517', 'https://openalex.org/W2090895724', 'https://openalex.org/W2091919541', 'https://openalex.org/W2094484458', 'https://openalex.org/W2165022312', 'https://openalex.org/W2282047028', 'https://openalex.org/W2341373405', 'https://openalex.org/W2419359586', 'https://openalex.org/W4300941830', 'https://openalex.org/W638826392', 'https://openalex.org/W73888249'], 'related_works': ['https://openalex.org/W4290303882', 'https://openalex.org/W2994357812', 'https://openalex.org/W2616752406', 'https://openalex.org/W2286419106', 'https://openalex.org/W2066531752', 'https://openalex.org/W2035140644', 'https://openalex.org/W2021820849', 'https://openalex.org/W1978302948', 'https://openalex.org/W1513535321', 'https://openalex.org/W1483181891'], 'abstract_inverted_index': {'5,6-Dichloro-1-(beta-D-ribofuranosyl)benzimidazole': [0], '(DiCl-RB)': [1], 'is': [2, 86, 112, 120, 139, 254, 265, 289, 299], 'a': [3, 21, 58, 296], 'powerful': [4], 'inhibitor': [5, 122], 'of': [6, 23, 26, 38, 40, 43, 100, 129, 140, 163, 189, 238, 244, 263, 267, 283, 291, 303], 'casein': [7], 'kinase-2': [8], '(CK-2)': [9], '[Zandomeni,': [10], 'R.': [11], 'et': [12], 'al.': [13], '(1986)': [14], 'J.': [15], 'Biol.': [16], 'Chem.': [17], '261,': [18], '3414-3420].': [19], 'Here': [20], 'series': [22], '17': [24], 'analogues': [25, 288], 'DiCl-RB': [27, 72, 132], 'has': [28, 197], 'been': [29, 198], 'employed': [30], 'for': [31, 183, 200], 'studying': [32], 'the': [33, 36, 51, 63, 82, 94, 101, 106, 109, 141, 147, 150, 164, 184, 190, 216, 242, 268, 280, 286, 307], 'specificity': [34], 'and': [35, 133, 171, 176, 194, 224, 247], 'mode': [37], 'action': [39], 'this': [41], 'family': [42], 'CK-2': [44, 130, 259, 310], 'inhibitors.': [45], 'The': [46, 160], 'two': [47], 'halogen': [48], 'substituents': [49], 'on': [50], 'benzene': [52], 'ring': [53], 'are': [54, 173], 'shown': [55], 'to': [56, 146, 234, 260, 273], 'play': [57], 'prominent': [59], 'role': [60], 'in': [61], 'inhibition,': [62], '5,6-dibromo': [64], 'derivative': [65, 84], '(DiBr-RB)': [66], 'being': [67, 153], 'fivefold': [68], 'more': [69], 'effective': [70], 'than': [71, 157, 187, 209], '(Ki': [73, 275], '=': [74, 276], '2': [75, 177], 'microM,': [76, 178], 'with': [77, 144, 155, 158, 169, 271, 294, 309, 314], 'GTP': [78, 156], 'as': [79, 88, 90, 124, 126, 256, 258], 'substrate),': [80], 'whereas': [81], 'difluoro': [83], '(DiF-RB)': [85], 'nearly': [87, 255], 'ineffective': [89], 'unsubstituted': [91], '1-(beta-D-ribofuranosyl)benzimidazole.': [92], 'On': [93], 'other': [95, 208], 'hand,': [96], 'although': [97], 'some': [98], 'modifications': [99], 'ribose': [102, 304], 'group': [103], 'significantly': [104], 'decrease': [105], 'inhibitory': [107, 202, 281], 'efficiency,': [108], 'sugar': [110], 'moiety': [111], 'not': [113], 'strictly': [114], 'required,': [115], 'since': [116], 'dichlorobenzimidazole': [117], 'itself': [118], '(DiCl-Bz)': [119], 'an': [121, 181], 'almost': [123, 239], 'good': [125], 'DiCl-RB.': [127], 'Inhibition': [128, 262], 'by': [131, 134, 221, 285, 301], 'its': [135, 201], 'analogues,': [136], 'DiCl-Bz': [137], 'included,': [138], 'competitive': [142, 269], 'type': [143, 270], 'respect': [145, 272], 'nucleotide': [148], 'substrate,': [149], 'Ki': [151, 161, 308], 'values': [152, 162], 'lower': [154], 'ATP.': [159], 'most': [165], 'potent': [166], 'inhibitor,': [167], 'DiBr-RB,': [168], 'ATP': [170, 193, 274], 'GTP,': [172], '6': [174], 'microM': [175], 'respectively,': [179], 'denoting': [180], 'affinity': [182], 'enzyme': [185], 'higher': [186], 'that': [188, 292, 313], 'physiological': [191], 'substrates,': [192], 'GTP.': [195], 'DiBr-RB': [196, 235], 'assayed': [199], 'capacity': [203], 'toward': [204], 'several': [205], 'protein': [206, 214, 218, 228], 'kinase': [207, 219], 'CK-2.': [210, 250], 'Protein': [211], 'kinase-C,': [212], 'cAMP-dependent': [213], 'kinase,': [215], 'Ser/Thr': [217], 'expressed': [220], 'Pseudorabies': [222], 'virus,': [223], 'four': [225], 'different': [226], 'tyrosine': [227], 'kinases': [229], 'from': [230], 'spleen,': [231], 'proved': [232], 'insensitive': [233], 'concentrations': [236], 'capable': [237], 'entirely': [240], 'suppressing': [241], 'activity': [243], 'rat': [245], 'liver': [246], 'maize': [248], 'seedling': [249], 'Casein': [251], 'kinase-1': [252], 'however': [253], 'sensitive': [257], 'DiBr-RB.': [261], 'CK-1': [264, 284], 'also': [266], '14': [277], 'microM).': [278], 'Although': [279], 'spectrum': [282], 'various': [287], 'reminiscent': [290], 'observed': [293], 'CK-2,': [295], 'remarkable': [297], 'difference': [298], 'revealed': [300], "5'-phosphorylation": [302], 'which': [305], 'increases': [306], 'while': [311], 'decreasing': [312], 'CK-1.': [315]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2087267008', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-09T08:40:11.885899', 'created_date': '2016-06-24'}