Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2087179574', 'doi': 'https://doi.org/10.1042/bj20030284', 'title': 'Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent', 'display_name': 'Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent', 'publication_year': 2003, 'publication_date': '2003-07-11', 'ids': {'openalex': 'https://openalex.org/W2087179574', 'doi': 'https://doi.org/10.1042/bj20030284', 'mag': '2087179574', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12879903', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1223521'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj20030284', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc1223521?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5055713674', 'display_name': 'Hélène Munier‐Lehmann', 'orcid': 'https://orcid.org/0000-0001-7579-8561'}, 'institutions': [{'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}, {'id': 'https://openalex.org/I4210130154', 'display_name': 'Laboratoire de Chimie', 'ror': 'https://ror.org/02gaw1s20', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I100532134', 'https://openalex.org/I113428412', 'https://openalex.org/I1294671590', 'https://openalex.org/I203339264', 'https://openalex.org/I4210128300', 'https://openalex.org/I4210130154']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Hélène MUNIER-LEHMANN', 'raw_affiliation_strings': ['Laboratoire de Chimie Structurale des Macromolécules, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Chimie Structurale des Macromolécules, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France', 'institution_ids': ['https://openalex.org/I157536573', 'https://openalex.org/I4210130154']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038740680', 'display_name': 'Viviane Chenal‐Francisque', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Viviane CHENAL-FRANCISQUE', 'raw_affiliation_strings': ['Laboratoire des Yersinia, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire des Yersinia, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France', 'institution_ids': ['https://openalex.org/I157536573']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085194744', 'display_name': 'Mihaela Ionescu', 'orcid': 'https://orcid.org/0000-0002-8019-118X'}, 'institutions': [{'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}, {'id': 'https://openalex.org/I4210130154', 'display_name': 'Laboratoire de Chimie', 'ror': 'https://ror.org/02gaw1s20', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I100532134', 'https://openalex.org/I113428412', 'https://openalex.org/I1294671590', 'https://openalex.org/I203339264', 'https://openalex.org/I4210128300', 'https://openalex.org/I4210130154']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Mihaela IONESCU', 'raw_affiliation_strings': ['Laboratoire de Chimie Structurale des Macromolécules, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Chimie Structurale des Macromolécules, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France', 'institution_ids': ['https://openalex.org/I157536573', 'https://openalex.org/I4210130154']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064377146', 'display_name': 'P. Christova', 'orcid': 'https://orcid.org/0000-0002-9466-9527'}, 'institutions': [{'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}, {'id': 'https://openalex.org/I4210130154', 'display_name': 'Laboratoire de Chimie', 'ror': 'https://ror.org/02gaw1s20', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I100532134', 'https://openalex.org/I113428412', 'https://openalex.org/I1294671590', 'https://openalex.org/I203339264', 'https://openalex.org/I4210128300', 'https://openalex.org/I4210130154']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Petya CHRISTOVA', 'raw_affiliation_strings': ['Laboratoire de Chimie Structurale des Macromolécules, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Chimie Structurale des Macromolécules, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France', 'institution_ids': ['https://openalex.org/I157536573', 'https://openalex.org/I4210130154']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015913873', 'display_name': 'Jeannine Foulon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jeannine FOULON', 'raw_affiliation_strings': ['Laboratoire des Yersinia, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire des Yersinia, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France', 'institution_ids': ['https://openalex.org/I157536573']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019717952', 'display_name': 'Élisabeth Carniel', 'orcid': 'https://orcid.org/0000-0001-5647-4844'}, 'institutions': [{'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Elisabeth CARNIEL', 'raw_affiliation_strings': ['Laboratoire des Yersinia, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire des Yersinia, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France', 'institution_ids': ['https://openalex.org/I157536573']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045645139', 'display_name': 'Octavian Bârzu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}, {'id': 'https://openalex.org/I4210130154', 'display_name': 'Laboratoire de Chimie', 'ror': 'https://ror.org/02gaw1s20', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I100532134', 'https://openalex.org/I113428412', 'https://openalex.org/I1294671590', 'https://openalex.org/I203339264', 'https://openalex.org/I4210128300', 'https://openalex.org/I4210130154']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Octavian BÂRZU', 'raw_affiliation_strings': ['Laboratoire de Chimie Structurale des Macromolécules, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Chimie Structurale des Macromolécules, Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France', 'institution_ids': ['https://openalex.org/I157536573', 'https://openalex.org/I4210130154']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.511, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 25, 'citation_normalized_percentile': {'value': 0.77404, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '373', 'issue': '2', 'first_page': '515', 'last_page': '522'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12232', 'display_name': 'Yersinia bacterium, plague, ectoparasites research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12232', 'display_name': 'Yersinia bacterium, plague, ectoparasites research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12817', 'display_name': 'Pharmacological Effects of Natural Compounds', 'score': 0.9888, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10120', 'display_name': 'Bacterial Genetics and Biotechnology', 'score': 0.9784, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/yersinia-pestis', 'display_name': 'Yersinia pestis', 'score': 0.90298426}, {'id': 'https://openalex.org/keywords/wild-type', 'display_name': 'Wild type', 'score': 0.4348222}], 'concepts': [{'id': 'https://openalex.org/C2778222588', 'wikidata': 'https://www.wikidata.org/wiki/Q153875', 'display_name': 'Yersinia pestis', 'level': 4, 'score': 0.90298426}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.72477686}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.6765351}, {'id': 'https://openalex.org/C60987743', 'wikidata': 'https://www.wikidata.org/wiki/Q1460232', 'display_name': 'Virulence', 'level': 3, 'score': 0.6423227}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.54390633}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.52653843}, {'id': 'https://openalex.org/C180526460', 'wikidata': 'https://www.wikidata.org/wiki/Q356240', 'display_name': 'Adenylate kinase', 'level': 3, 'score': 0.4869934}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.47795343}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.47230032}, {'id': 'https://openalex.org/C207583985', 'wikidata': 'https://www.wikidata.org/wiki/Q128723', 'display_name': 'Wild type', 'level': 4, 'score': 0.4348222}, {'id': 'https://openalex.org/C22744801', 'wikidata': 'https://www.wikidata.org/wiki/Q172778', 'display_name': 'Plasmid', 'level': 3, 'score': 0.41734478}, {'id': 'https://openalex.org/C2778910516', 'wikidata': 'https://www.wikidata.org/wiki/Q380136', 'display_name': 'Enterobacteriaceae', 'level': 4, 'score': 0.41073507}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.35965425}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2780108}], 'mesh': [{'descriptor_ui': 'D000263', 'descriptor_name': 'Adenylate Kinase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015010', 'descriptor_name': 'Yersinia pestis', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D015010', 'descriptor_name': 'Yersinia pestis', 'qualifier_ui': 'Q000472', 'qualifier_name': 'pathogenicity', 'is_major_topic': True}, {'descriptor_ui': 'D000263', 'descriptor_name': 'Adenylate Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019943', 'descriptor_name': 'Amino Acid Substitution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015139', 'descriptor_name': 'Blotting, Southern', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003114', 'descriptor_name': 'Colony-Forming Units Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016297', 'descriptor_name': 'Mutagenesis, Site-Directed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009703', 'descriptor_name': 'Nucleoside-Phosphate Kinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009703', 'descriptor_name': 'Nucleoside-Phosphate Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011489', 'descriptor_name': 'Protein Denaturation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017510', 'descriptor_name': 'Protein Folding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014508', 'descriptor_name': 'Urea', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014508', 'descriptor_name': 'Urea', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014774', 'descriptor_name': 'Virulence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015010', 'descriptor_name': 'Yersinia pestis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015010', 'descriptor_name': 'Yersinia pestis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj20030284', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1223521', 'pdf_url': 'https://europepmc.org/articles/pmc1223521?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223521', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12879903', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1223521', 'pdf_url': 'https://europepmc.org/articles/pmc1223521?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1482938752', 'https://openalex.org/W1521068272', 'https://openalex.org/W1570895488', 'https://openalex.org/W1580476552', 'https://openalex.org/W1931700765', 'https://openalex.org/W1984470069', 'https://openalex.org/W1996989323', 'https://openalex.org/W2007375228', 'https://openalex.org/W2010650735', 'https://openalex.org/W2011676940', 'https://openalex.org/W2012269714', 'https://openalex.org/W2012546118', 'https://openalex.org/W2013735285', 'https://openalex.org/W2018289835', 'https://openalex.org/W2019410656', 'https://openalex.org/W2027229485', 'https://openalex.org/W2055915828', 'https://openalex.org/W2059545334', 'https://openalex.org/W2081803554', 'https://openalex.org/W2085031695', 'https://openalex.org/W2087985967', 'https://openalex.org/W2088331931', 'https://openalex.org/W2090347337', 'https://openalex.org/W2091623113', 'https://openalex.org/W2097294533', 'https://openalex.org/W2099047634', 'https://openalex.org/W2100837269', 'https://openalex.org/W2116513121', 'https://openalex.org/W2121374716', 'https://openalex.org/W2128635872', 'https://openalex.org/W2138270253', 'https://openalex.org/W2150029959', 'https://openalex.org/W2152394523', 'https://openalex.org/W2256756668', 'https://openalex.org/W2316650677', 'https://openalex.org/W2334860433', 'https://openalex.org/W2410434493', 'https://openalex.org/W2528563769', 'https://openalex.org/W2555608080', 'https://openalex.org/W2888511473'], 'related_works': ['https://openalex.org/W4242654186', 'https://openalex.org/W3111991548', 'https://openalex.org/W2970846962', 'https://openalex.org/W2480152448', 'https://openalex.org/W2372021546', 'https://openalex.org/W2349788150', 'https://openalex.org/W2329223977', 'https://openalex.org/W2145805955', 'https://openalex.org/W2114418658', 'https://openalex.org/W2098387568'], 'abstract_inverted_index': {'Nucleoside': [0], 'monophosphate': [1], 'kinases': [2], '(NMPKs)': [3], 'are': [4], 'essential': [5], 'catalysts': [6], 'for': [7], 'bacterial': [8, 192], 'growth': [9, 114, 154], 'and': [10, 67, 106, 133], 'multiplication.': [11], 'These': [12], 'enzymes': [13], 'display': [14], 'high': [15, 195], 'primary': [16], 'sequence': [17], 'identities': [18], 'among': [19], 'members': [20], 'of': [21, 30, 53, 82, 151, 155, 165, 179, 185, 201], 'the': [22, 27, 78, 141, 147, 156, 162, 186, 202], 'family': [23], 'Enterobacteriaceae.': [24], 'Yersinia': [25], 'pestis,': [26, 153], 'causative': [28], 'agent': [29], 'plague,': [31], 'belongs': [32], 'to': [33, 110, 137, 207], 'this': [34, 76], 'family.': [35], 'However,': [36], 'it': [37], 'was': [38, 86, 144, 159], 'previously': [39, 108], 'shown': [40, 109], 'that': [41], 'its': [42, 54], 'thymidylate': [43], 'kinase': [44, 80], '(TMPKyp)': [45], 'exhibits': [46], 'biochemical': [47], 'properties': [48], 'significantly': [49], 'different': [50], 'from': [51], 'those': [52], 'Escherichia': [55], 'coli': [56], 'counterpart': [57], '[Chenal-Francisque,': [58], 'Tourneux,': [59], 'Carniel,': [60], 'Christova,': [61], 'Li': [62], 'de': [63], 'la': [64], 'Sierra,': [65], 'Barzu': [66], 'Gilles': [68], '(1999)': [69], 'Eur.': [70], 'J.': [71], 'Biochem.': [72], '265,': [73], '112-119].': [74], 'In': [75, 169], 'work,': [77], 'adenylate': [79], '(AK)': [81], 'Y.': [83, 152, 181], 'pestis': [84, 182], '(AKyp)': [85], 'characterized.': [87], 'As': [88], 'with': [89], 'TMPKyp,': [90], 'AKyp': [91, 132], 'displayed': [92], 'a': [93, 112, 127, 134], 'lower': [94, 128], 'thermodynamic': [95], 'stability': [96, 129], 'than': [97, 130, 173], 'other': [98], 'studied': [99], 'AKs.': [100], 'Two': [101], 'mutations': [102], 'in': [103, 116], 'AK': [104], '(Ser129Phe': [105], 'Pro87Ser),': [107], 'induce': [111], 'thermosensitive': [113], 'defect': [115], 'E.': [117], 'coli,': [118], 'were': [119, 205], 'introduced': [120, 145], 'into': [121, 146], 'AKyp.': [122], 'The': [123], 'recombinant': [124], 'variants': [125], 'had': [126], 'wild-type': [131, 180], 'higher': [135], 'susceptibility': [136], 'proteolytic': [138], 'digestion.': [139], 'When': [140], 'Pro87Ser': [142], 'substitution': [143], 'chromosomal': [148], 'adk': [149, 203], 'gene': [150], 'mutant': [157, 204], 'strain': [158], 'altered': [160], 'at': [161], 'non-permissive': [163], 'temperature': [164], '37': [166], 'degree': [167], 'C.': [168], 'virulence': [170], 'testings,': [171], 'less': [172], '50': [174], 'colony': [175], 'forming': [176], 'units': [177], '(CFU)': [178], 'killed': [183], '100%': [184], 'mice': [187], 'upon': [188], 'subcutaneous': [189], 'infection,': [190], 'whereas': [191], 'loads': [193], 'as': [194, 196], '1.5': [197], 'x': [198], '10(4)': [199], 'CFU': [200], 'unable': [206], 'kill': [208], 'any': [209], 'animals.': [210]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2087179574', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-11T17:18:58.389894', 'created_date': '2016-06-24'}