Title: Epidermal Growth Factor Receptor in Undifferentiated Carcinoma of the Nasopharynx
Abstract: To determine the expression levels of epidermal growth factor receptor (EGFR) and its prognostic value in undifferentiated carcinoma (UC) of the nasopharynx.A prospective study of 75 patients diagnosed with UC over a 4-year period in a tertiary care hospital.Postnasal space biopsies were obtained and processed, and immunohistochemical staining was performed. The over-expression of EGFR was measured, and the expression levels were statistically analyzed with the clinical and pathologic variables. Disease-free and overall survival analyses were performed.There were 62 (82.7%) specimens that showed over-expression of EGFR levels. Over-expression of EGFR correlated significantly only with primary tumor size (P =.007). Age, sex, positive smoking and family history, presence of nodal metastasis, distant metastasis, and Epstein-Barr virus serology titers were not significantly correlated with over-expression of EGFR. Both 54-month disease-free and 56-month overall survivals were not associated with EGFR over-expression.The frequency of over-expression of EGFR in UC is similar to other squamous cell carcinoma (SCC) of the head and neck region. Only primary tumor size is independently correlated with over-expression of EGFR. EGFR over-expression does not affect disease-free and overall survival.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 80
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