Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2087026392', 'doi': 'https://doi.org/10.1002/jgm.1500', 'title': 'Gene therapy strategies for hemophilia: benefits versus risks', 'display_name': 'Gene therapy strategies for hemophilia: benefits versus risks', 'publication_year': 2010, 'publication_date': '2010-09-16', 'ids': {'openalex': 'https://openalex.org/W2087026392', 'doi': 'https://doi.org/10.1002/jgm.1500', 'mag': '2087026392', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20848668'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jgm.1500', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S91057606', 'display_name': 'The Journal of Gene Medicine', 'issn_l': '1099-498X', 'issn': ['1099-498X', '1521-2254'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005234120', 'display_name': 'Inge Petrus', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802017950', 'display_name': 'Vlaams Instituut voor Biotechnologie', 'ror': 'https://ror.org/03xrhmk39', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802017950']}, {'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Inge Petrus', 'raw_affiliation_strings': ['Free University of Brussels, Vesalius Research Center, Flanders Institute of Biotechnology (VIB) & University of Leuven, Belgium.'], 'affiliations': [{'raw_affiliation_string': 'Free University of Brussels, Vesalius Research Center, Flanders Institute of Biotechnology (VIB) & University of Leuven, Belgium.', 'institution_ids': ['https://openalex.org/I2802017950', 'https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012452525', 'display_name': 'Marinee Chuah', 'orcid': 'https://orcid.org/0000-0001-8569-0175'}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}, {'id': 'https://openalex.org/I2802017950', 'display_name': 'Vlaams Instituut voor Biotechnologie', 'ror': 'https://ror.org/03xrhmk39', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802017950']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Marinee Chuah', 'raw_affiliation_strings': ['Free University of Brussels, Vesalius Research Center, Flanders Institute of Biotechnology (VIB) & University of Leuven, Belgium.'], 'affiliations': [{'raw_affiliation_string': 'Free University of Brussels, Vesalius Research Center, Flanders Institute of Biotechnology (VIB) & University of Leuven, Belgium.', 'institution_ids': ['https://openalex.org/I99464096', 'https://openalex.org/I2802017950']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076188773', 'display_name': 'Thierry VandenDriessche', 'orcid': 'https://orcid.org/0000-0003-4230-745X'}, 'institutions': [{'id': 'https://openalex.org/I2802017950', 'display_name': 'Vlaams Instituut voor Biotechnologie', 'ror': 'https://ror.org/03xrhmk39', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I2802017950']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Thierry VandenDriessche', 'raw_affiliation_strings': ['Free University of Brussels, Vesalius Research Center, Flanders Institute of Biotechnology (VIB) & University of Leuven, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Free University of Brussels, Vesalius Research Center, Flanders Institute of Biotechnology (VIB) & University of Leuven, Belgium', 'institution_ids': ['https://openalex.org/I2802017950']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4070, 'currency': 'USD', 'value_usd': 4070, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.115, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 44, 'citation_normalized_percentile': {'value': 0.338654, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '12', 'issue': '10', 'first_page': '797', 'last_page': '809'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11491', 'display_name': 'CAR-T cell therapy research', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/clotting-factor', 'display_name': 'Clotting factor', 'score': 0.7956046}, {'id': 'https://openalex.org/keywords/factor-ix', 'display_name': 'Factor IX', 'score': 0.73967075}, {'id': 'https://openalex.org/keywords/bleeding-diathesis', 'display_name': 'Bleeding diathesis', 'score': 0.55128735}], 'concepts': [{'id': 'https://openalex.org/C111599444', 'wikidata': 'https://www.wikidata.org/wiki/Q213901', 'display_name': 'Genetic enhancement', 'level': 3, 'score': 0.9234365}, {'id': 'https://openalex.org/C2992139802', 'wikidata': 'https://www.wikidata.org/wiki/Q179217', 'display_name': 'Clotting factor', 'level': 2, 'score': 0.7956046}, {'id': 'https://openalex.org/C2781221834', 'wikidata': 'https://www.wikidata.org/wiki/Q425360', 'display_name': 'Factor IX', 'level': 2, 'score': 0.73967075}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6736061}, {'id': 'https://openalex.org/C32470452', 'wikidata': 'https://www.wikidata.org/wiki/Q2298489', 'display_name': 'Viral vector', 'level': 4, 'score': 0.57396173}, {'id': 'https://openalex.org/C2776217217', 'wikidata': 'https://www.wikidata.org/wiki/Q611571', 'display_name': 'Bleeding diathesis', 'level': 3, 'score': 0.55128735}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.44013107}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.43029603}, {'id': 'https://openalex.org/C43953973', 'wikidata': 'https://www.wikidata.org/wiki/Q7917858', 'display_name': 'Vectors in gene therapy', 'level': 5, 'score': 0.41270375}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.37504774}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.36511594}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.26732057}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19914734}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.15538922}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.12346515}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.10169619}], 'mesh': [{'descriptor_ui': 'D005164', 'descriptor_name': 'Factor IX', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D005169', 'descriptor_name': 'Factor VIII', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015316', 'descriptor_name': 'Genetic Therapy', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D006467', 'descriptor_name': 'Hemophilia A', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000256', 'descriptor_name': 'Adenoviridae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000256', 'descriptor_name': 'Adenoviridae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002986', 'descriptor_name': 'Clinical Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000229', 'descriptor_name': 'Dependovirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000229', 'descriptor_name': 'Dependovirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004285', 'descriptor_name': 'Dogs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005164', 'descriptor_name': 'Factor IX', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005169', 'descriptor_name': 'Factor VIII', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015316', 'descriptor_name': 'Genetic Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006467', 'descriptor_name': 'Hemophilia A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006467', 'descriptor_name': 'Hemophilia A', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012190', 'descriptor_name': 'Retroviridae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012190', 'descriptor_name': 'Retroviridae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jgm.1500', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S91057606', 'display_name': 'The Journal of Gene Medicine', 'issn_l': '1099-498X', 'issn': ['1099-498X', '1521-2254'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20848668', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.74, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 197, 'referenced_works': ['https://openalex.org/W1487084354', 'https://openalex.org/W1514924602', 'https://openalex.org/W1515467810', 'https://openalex.org/W1519383882', 'https://openalex.org/W1533835843', 'https://openalex.org/W1586940012', 'https://openalex.org/W1587940136', 'https://openalex.org/W1588659566', 'https://openalex.org/W1637867377', 'https://openalex.org/W1964241088', 'https://openalex.org/W1966225115', 'https://openalex.org/W1969921794', 'https://openalex.org/W1971410862', 'https://openalex.org/W1971743740', 'https://openalex.org/W1972852573', 'https://openalex.org/W1972875347', 'https://openalex.org/W1975528602', 'https://openalex.org/W1976329054', 'https://openalex.org/W1978519692', 'https://openalex.org/W1980491559', 'https://openalex.org/W1980890790', 'https://openalex.org/W1981721989', 'https://openalex.org/W1983120627', 'https://openalex.org/W1983335647', 'https://openalex.org/W1985656844', 'https://openalex.org/W1986965660', 'https://openalex.org/W1987328341', 'https://openalex.org/W1988639136', 'https://openalex.org/W1988849266', 'https://openalex.org/W1991340891', 'https://openalex.org/W1992033402', 'https://openalex.org/W1992117647', 'https://openalex.org/W1993774764', 'https://openalex.org/W1993870540', 'https://openalex.org/W1994852532', 'https://openalex.org/W1998290936', 'https://openalex.org/W1998712648', 'https://openalex.org/W2000185853', 'https://openalex.org/W2000194482', 'https://openalex.org/W2002914110', 'https://openalex.org/W2004470100', 'https://openalex.org/W2006765654', 'https://openalex.org/W2007261697', 'https://openalex.org/W2007605191', 'https://openalex.org/W2008004245', 'https://openalex.org/W2009078306', 'https://openalex.org/W2010216896', 'https://openalex.org/W2011056811', 'https://openalex.org/W2011102092', 'https://openalex.org/W2011762615', 'https://openalex.org/W2011767474', 'https://openalex.org/W2012445121', 'https://openalex.org/W2013607072', 'https://openalex.org/W2014818093', 'https://openalex.org/W2019231516', 'https://openalex.org/W2020030124', 'https://openalex.org/W2023159885', 'https://openalex.org/W2023545075', 'https://openalex.org/W2023820753', 'https://openalex.org/W2023954148', 'https://openalex.org/W2026502021', 'https://openalex.org/W2027926820', 'https://openalex.org/W2028634229', 'https://openalex.org/W2030699641', 'https://openalex.org/W2034342587', 'https://openalex.org/W2034598016', 'https://openalex.org/W2034629713', 'https://openalex.org/W2034647149', 'https://openalex.org/W2036877355', 'https://openalex.org/W2041157989', 'https://openalex.org/W2041938757', 'https://openalex.org/W2042259141', 'https://openalex.org/W2043443197', 'https://openalex.org/W2044166365', 'https://openalex.org/W2044474105', 'https://openalex.org/W2045292147', 'https://openalex.org/W2046488302', 'https://openalex.org/W2047434089', 'https://openalex.org/W2047608515', 'https://openalex.org/W2047667011', 'https://openalex.org/W2048955984', 'https://openalex.org/W2049466721', 'https://openalex.org/W2049592320', 'https://openalex.org/W2050193680', 'https://openalex.org/W2050245606', 'https://openalex.org/W2051442157', 'https://openalex.org/W2052207235', 'https://openalex.org/W2053492054', 'https://openalex.org/W2053776926', 'https://openalex.org/W2057548071', 'https://openalex.org/W2058590056', 'https://openalex.org/W2061584786', 'https://openalex.org/W2061645642', 'https://openalex.org/W2063291958', 'https://openalex.org/W2065451039', 'https://openalex.org/W2066226950', 'https://openalex.org/W2067204822', 'https://openalex.org/W2071665028', 'https://openalex.org/W2072266400', 'https://openalex.org/W2073545118', 'https://openalex.org/W2073739917', 'https://openalex.org/W2074561000', 'https://openalex.org/W2076237922', 'https://openalex.org/W2076380364', 'https://openalex.org/W2077388039', 'https://openalex.org/W2079321467', 'https://openalex.org/W2079861804', 'https://openalex.org/W2080395310', 'https://openalex.org/W2080943222', 'https://openalex.org/W2080951809', 'https://openalex.org/W2081487415', 'https://openalex.org/W2082266692', 'https://openalex.org/W2082337683', 'https://openalex.org/W2083162782', 'https://openalex.org/W2083475119', 'https://openalex.org/W2083788869', 'https://openalex.org/W2086878238', 'https://openalex.org/W2089865394', 'https://openalex.org/W2090607175', 'https://openalex.org/W2091771432', 'https://openalex.org/W2096674194', 'https://openalex.org/W2097933470', 'https://openalex.org/W2099598492', 'https://openalex.org/W2106662817', 'https://openalex.org/W2109215179', 'https://openalex.org/W2109751467', 'https://openalex.org/W2109913483', 'https://openalex.org/W2111742323', 'https://openalex.org/W2113444875', 'https://openalex.org/W2114126275', 'https://openalex.org/W2115243133', 'https://openalex.org/W2119164964', 'https://openalex.org/W2119615642', 'https://openalex.org/W2121429345', 'https://openalex.org/W2121444412', 'https://openalex.org/W2121638344', 'https://openalex.org/W2122236774', 'https://openalex.org/W2122874617', 'https://openalex.org/W2124762750', 'https://openalex.org/W2128435780', 'https://openalex.org/W2128684337', 'https://openalex.org/W2129042241', 'https://openalex.org/W2130515212', 'https://openalex.org/W2131862356', 'https://openalex.org/W2132091114', 'https://openalex.org/W2137440275', 'https://openalex.org/W2137660425', 'https://openalex.org/W2138084195', 'https://openalex.org/W2138117792', 'https://openalex.org/W2141474527', 'https://openalex.org/W2141570423', 'https://openalex.org/W2142439096', 'https://openalex.org/W2142613671', 'https://openalex.org/W2144365434', 'https://openalex.org/W2145365087', 'https://openalex.org/W2147158708', 'https://openalex.org/W2147193337', 'https://openalex.org/W2148920506', 'https://openalex.org/W2150480269', 'https://openalex.org/W2151137440', 'https://openalex.org/W2153867928', 'https://openalex.org/W2154329712', 'https://openalex.org/W2155710930', 'https://openalex.org/W2157210697', 'https://openalex.org/W2158522626', 'https://openalex.org/W2159050641', 'https://openalex.org/W2159397356', 'https://openalex.org/W2159428320', 'https://openalex.org/W2160641725', 'https://openalex.org/W2160690575', 'https://openalex.org/W2162290849', 'https://openalex.org/W2162794473', 'https://openalex.org/W2163902333', 'https://openalex.org/W2164389688', 'https://openalex.org/W2165615022', 'https://openalex.org/W2165909566', 'https://openalex.org/W2169219209', 'https://openalex.org/W2172109879', 'https://openalex.org/W2172643117', 'https://openalex.org/W2175016040', 'https://openalex.org/W2176536964', 'https://openalex.org/W2211341420', 'https://openalex.org/W2272922409', 'https://openalex.org/W2283037005', 'https://openalex.org/W2320147764', 'https://openalex.org/W2323613689', 'https://openalex.org/W2325885736', 'https://openalex.org/W2394989160', 'https://openalex.org/W2398240417', 'https://openalex.org/W2410909283', 'https://openalex.org/W2417899292', 'https://openalex.org/W2418309151', 'https://openalex.org/W2461900811', 'https://openalex.org/W32440674', 'https://openalex.org/W4250253384', 'https://openalex.org/W4250446838', 'https://openalex.org/W85311522'], 'related_works': ['https://openalex.org/W67249329', 'https://openalex.org/W4236112554', 'https://openalex.org/W3216150095', 'https://openalex.org/W2464963141', 'https://openalex.org/W2396323037', 'https://openalex.org/W2317999314', 'https://openalex.org/W2130075432', 'https://openalex.org/W2038407495', 'https://openalex.org/W1990754903', 'https://openalex.org/W1514924602'], 'abstract_inverted_index': {'Abstract': [0], 'Hemophilia': [1, 38], 'is': [2], 'an': [3, 43], 'inherited': [4], 'bleeding': [5, 140], 'disorder': [6], 'caused': [7], 'by': [8, 35, 170], 'a': [9, 51, 62, 68, 83], 'deficiency': [10], 'of': [11, 24, 116, 130, 138, 196], 'functional': [12, 69], 'clotting': [13, 56, 160], 'factors': [14], 'VIII': [15], 'or': [16, 71, 182], 'IX': [17], 'in': [18, 32, 55, 61, 135, 142, 166, 177, 185], 'the': [19, 25, 76, 114, 139, 154, 173, 191, 197], 'blood': [20], 'plasma.': [21], 'The': [22], 'drawbacks': [23], 'classical': [26], 'protein': [27], 'substitution': [28], 'therapy': [29, 49, 200], 'fueled': [30], 'interest': [31], 'alternative': [33], 'treatments': [34], 'gene': [36, 48, 73, 96, 118, 171, 199], 'therapy.': [37], 'has': [39, 163], 'been': [40, 92, 111, 164, 206], 'recognized': [41], 'as': [42, 148, 150], 'ideal': [44], 'target': [45, 78], 'disease': [46], 'for': [47, 85, 94, 113, 202], 'because': [50], 'relatively': [52], 'modest': [53], 'increase': [54], 'factor': [57, 161], 'levels': [58, 184], 'can': [59], 'result': [60], 'significant': [63], 'therapeutic': [64, 180], 'benefit.': [65], 'Consequently,': [66], 'introducing': [67], 'FVIII': [70, 181], 'FIX': [72, 183], 'copy': [74], 'into': [75], 'appropriate': [77], 'cells': [79], 'could': [80], 'ultimately': [81], 'provide': [82], 'cure': [84], 'hemophilic': [86, 167], 'patients.': [87, 187], 'Several': [88, 129], 'cell': [89], 'types': [90], 'have': [91, 110, 133, 205], 'explored': [93], 'hemophilia': [95, 117, 143, 203], 'therapy,': [97, 119, 172], 'including': [98, 120], 'hepatocytes,': [99], 'muscle,': [100], 'endothelial': [101], 'and': [102, 107, 125, 145, 193], 'hematopoietic': [103], 'cells.': [104], 'Both': [105], 'nonviral': [106], 'viral': [108, 127], 'vectors': [109], 'considered': [112], 'development': [115], 'transposons,': [121], 'γ‐retroviral,': [122], 'lentiviral,': [123], 'adenoviral': [124], 'adeno‐associated': [126], 'vectors.': [128], 'these': [131, 186], 'strategies': [132, 201], 'resulted': [134], 'stable': [136], 'correction': [137], 'diathesis': [141], 'A': [144], 'B': [146], 'murine': [147], 'well': [149], 'canine': [151], 'models,': [152], 'paving': [153], 'way': [155], 'towards': [156], 'clinical': [157], 'trials.': [158], 'Although': [159], 'expression': [162], 'detected': [165], 'patients': [168], 'treated': [169], 'challenge': [174], 'now': [175], 'lies': [176], 'obtaining': [178], 'prolonged': [179], 'This': [188], 'review': [189], 'highlights': [190], 'benefits': [192], 'potential': [194], 'risks': [195], 'different': [198], 'that': [204], 'developed.': [207], 'Copyright': [208], '©': [209], '2010': [210], 'John': [211], 'Wiley': [212], '&': [213], 'Sons,': [214], 'Ltd.': [215]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2087026392', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2025-01-17T21:34:16.583789', 'created_date': '2016-06-24'}