Title: A comparison of the proteolytic susceptibility of several rat liver enzymes
Abstract: The susceptibility of five enzymes to proteolytic attack has been compared in rat liver extracts. The results show that enzymes with short in vivo half-lives were especially vulnerable to proteolytic attack, as measured by loss of activity in vitro, in contrast to the long-lived enzymes which were resistant to attack. Furthermore, there was a good correlation between the relative rates of inactivation in vivo and in vitro only with specific proteases such as trypsin and chymotrypsin, not with non-specific proteases such as pronase and subtilisin. This suggests that proteolytic enzymes with some degree of specificity are involved in the degradation of intracellular enzymes.
Publication Year: 1971
Publication Date: 1971-04-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 63
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