Publication Information

{'id': 'https://openalex.org/W2086770428', 'doi': 'https://doi.org/10.1006/abbi.1993.1170', 'title': 'Suppression of Cytochrome P450 Cyp1A-1 Induction in Murine Hepatoma 1c1c7-Cells by 12-O-Tetradecanoylphorbol-13-Acetate and Inhibitors of Protein Kinase C', 'display_name': 'Suppression of Cytochrome P450 Cyp1A-1 Induction in Murine Hepatoma 1c1c7-Cells by 12-O-Tetradecanoylphorbol-13-Acetate and Inhibitors of Protein Kinase C', 'publication_year': 1993, 'publication_date': '1993-03-01', 'ids': {'openalex': 'https://openalex.org/W2086770428', 'doi': 'https://doi.org/10.1006/abbi.1993.1170', 'mag': '2086770428', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7681664'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1006/abbi.1993.1170', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S153476765', 'display_name': 'Archives of Biochemistry and Biophysics', 'issn_l': '0003-9861', 'issn': ['0003-9861', '1096-0384'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108106149', 'display_name': 'John J. Reiners', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J.J. Reiners', 'raw_affiliation_strings': ['Institute of Chemical Toxicology, Wayne State University, Detroit, Michigan, 48201'], 'affiliations': [{'raw_affiliation_string': 'Institute of Chemical Toxicology, Wayne State University, Detroit, Michigan, 48201', 'institution_ids': ['https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059379184', 'display_name': 'Alfred Schöller', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A. Scholler', 'raw_affiliation_strings': ['Wayne State Univ, Inst Chem Toxicol, Detroit, MI 48201, USA and Univ Texas, MD Anderson Canc Ctr, Dept Carcinogenesis, Div Sci Pk Res, Smithville, TX 78957, USA'], 'affiliations': [{'raw_affiliation_string': 'Wayne State Univ, Inst Chem Toxicol, Detroit, MI 48201, USA and Univ Texas, MD Anderson Canc Ctr, Dept Carcinogenesis, Div Sci Pk Res, Smithville, TX 78957, USA', 'institution_ids': ['https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055198828', 'display_name': 'P. Bischer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'P. Bischer', 'raw_affiliation_strings': ['Wayne State Univ, Inst Chem Toxicol, Detroit, MI 48201, USA and Univ Texas, MD Anderson Canc Ctr, Dept Carcinogenesis, Div Sci Pk Res, Smithville, TX 78957, USA'], 'affiliations': [{'raw_affiliation_string': 'Wayne State Univ, Inst Chem Toxicol, Detroit, MI 48201, USA and Univ Texas, MD Anderson Canc Ctr, Dept Carcinogenesis, Div Sci Pk Res, Smithville, TX 78957, USA', 'institution_ids': ['https://openalex.org/I185443292']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111732965', 'display_name': 'A R Cantu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A.R. Cantu', 'raw_affiliation_strings': ['Wayne State Univ, Inst Chem Toxicol, Detroit, MI 48201, USA and Univ Texas, MD Anderson Canc Ctr, Dept Carcinogenesis, Div Sci Pk Res, Smithville, TX 78957, USA'], 'affiliations': [{'raw_affiliation_string': 'Wayne State Univ, Inst Chem Toxicol, Detroit, MI 48201, USA and Univ Texas, MD Anderson Canc Ctr, Dept Carcinogenesis, Div Sci Pk Res, Smithville, TX 78957, USA', 'institution_ids': ['https://openalex.org/I185443292']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5086890450', 'display_name': 'Amy Pavone', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A. Pavone', 'raw_affiliation_strings': ['Wayne State Univ, Inst Chem Toxicol, Detroit, MI 48201, USA and Univ Texas, MD Anderson Canc Ctr, Dept Carcinogenesis, Div Sci Pk Res, Smithville, TX 78957, USA'], 'affiliations': [{'raw_affiliation_string': 'Wayne State Univ, Inst Chem Toxicol, Detroit, MI 48201, USA and Univ Texas, MD Anderson Canc Ctr, Dept Carcinogenesis, Div Sci Pk Res, Smithville, TX 78957, USA', 'institution_ids': ['https://openalex.org/I185443292']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3090, 'currency': 'USD', 'value_usd': 3090, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.335, 'has_fulltext': False, 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.879751, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '301', 'issue': '2', 'first_page': '449', 'last_page': '454'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11752', 'display_name': 'Cancer Treatment and Pharmacology', 'score': 0.9839, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9818, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/staurosporine', 'display_name': 'Staurosporine', 'score': 0.8682628}, {'id': 'https://openalex.org/keywords/12-o-tetradecanoylphorbol-13-acetate', 'display_name': '12-O-Tetradecanoylphorbol-13-acetate', 'score': 0.83805484}, {'id': 'https://openalex.org/keywords/calphostin-c', 'display_name': 'Calphostin C', 'score': 0.675399}, {'id': 'https://openalex.org/keywords/calphostin', 'display_name': 'Calphostin', 'score': 0.48862606}, {'id': 'https://openalex.org/keywords/tetradecanoylphorbol-acetate', 'display_name': 'Tetradecanoylphorbol Acetate', 'score': 0.4716044}], 'concepts': [{'id': 'https://openalex.org/C2779084600', 'wikidata': 'https://www.wikidata.org/wiki/Q5957181', 'display_name': 'Staurosporine', 'level': 4, 'score': 0.8682628}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.85884684}, {'id': 'https://openalex.org/C2777168633', 'wikidata': 'https://www.wikidata.org/wiki/Q416716', 'display_name': '12-O-Tetradecanoylphorbol-13-acetate', 'level': 5, 'score': 0.83805484}, {'id': 'https://openalex.org/C2780245509', 'wikidata': 'https://www.wikidata.org/wiki/Q5023913', 'display_name': 'Calphostin C', 'level': 4, 'score': 0.675399}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.54286116}, {'id': 'https://openalex.org/C132154277', 'wikidata': 'https://www.wikidata.org/wiki/Q5381545', 'display_name': 'Enzyme inducer', 'level': 3, 'score': 0.53943723}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.50143695}, {'id': 'https://openalex.org/C2781168148', 'wikidata': 'https://www.wikidata.org/wiki/Q5023911', 'display_name': 'Calphostin', 'level': 4, 'score': 0.48862606}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4882803}, {'id': 'https://openalex.org/C2909761558', 'wikidata': 'https://www.wikidata.org/wiki/Q416716', 'display_name': 'Tetradecanoylphorbol Acetate', 'level': 4, 'score': 0.4716044}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.46649265}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.4255374}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.38510182}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.38351434}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36751965}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.26202595}, {'id': 'https://openalex.org/C3017695315', 'wikidata': 'https://www.wikidata.org/wiki/Q37713691', 'display_name': 'Phorbol ester', 'level': 4, 'score': 0.10964033}], 'mesh': [{'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D008114', 'descriptor_name': 'Liver Neoplasms, Experimental', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D009281', 'descriptor_name': 'Naphthalenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D013755', 'descriptor_name': 'Tetradecanoylphorbol Acetate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019307', 'descriptor_name': '1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000470', 'descriptor_name': 'Alkaloids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000470', 'descriptor_name': 'Alkaloids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004790', 'descriptor_name': 'Enzyme Induction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004790', 'descriptor_name': 'Enzyme Induction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007546', 'descriptor_name': 'Isoquinolines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007546', 'descriptor_name': 'Isoquinolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008114', 'descriptor_name': 'Liver Neoplasms, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011083', 'descriptor_name': 'Polycyclic Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011083', 'descriptor_name': 'Polycyclic Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011493', 'descriptor_name': 'Protein Kinase C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019311', 'descriptor_name': 'Staurosporine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013755', 'descriptor_name': 'Tetradecanoylphorbol Acetate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1006/abbi.1993.1170', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S153476765', 'display_name': 'Archives of Biochemistry and Biophysics', 'issn_l': '0003-9861', 'issn': ['0003-9861', '1096-0384'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7681664', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.54, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2408854342', 'https://openalex.org/W2380026795', 'https://openalex.org/W2285160624', 'https://openalex.org/W2235827406', 'https://openalex.org/W2091237014', 'https://openalex.org/W2086770428', 'https://openalex.org/W2073796934', 'https://openalex.org/W2066072901', 'https://openalex.org/W2037800788', 'https://openalex.org/W1985134565'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2086770428', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-16T00:07:24.174205', 'created_date': '2016-06-24'}