Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2086715796', 'doi': 'https://doi.org/10.1210/en.2008-0640', 'title': 'Role of Aging Versus the Loss of Estrogens in the Reduction in Vascular Function in Female Rats', 'display_name': 'Role of Aging Versus the Loss of Estrogens in the Reduction in Vascular Function in Female Rats', 'publication_year': 2008, 'publication_date': '2008-09-11', 'ids': {'openalex': 'https://openalex.org/W2086715796', 'doi': 'https://doi.org/10.1210/en.2008-0640', 'mag': '2086715796', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18787021', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2630896'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/en.2008-0640', 'pdf_url': 'https://academic.oup.com/endo/article-pdf/150/1/212/9001349/endo0212.pdf', 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/endo/article-pdf/150/1/212/9001349/endo0212.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5036776589', 'display_name': 'James P. Stice', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James P. Stice', 'raw_affiliation_strings': ['Molecular and Cellular Cardiology (J.P.S., A.A.K.), University of California, Davis, Davis, California 95616'], 'affiliations': [{'raw_affiliation_string': 'Molecular and Cellular Cardiology (J.P.S., A.A.K.), University of California, Davis, Davis, California 95616', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049514965', 'display_name': 'Jason P. Eiserich', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jason P. Eiserich', 'raw_affiliation_strings': ['Cardiovascular Division, Pulmonary Division (J.P.E.), Department of Medicine, University of California, Davis, Davis, California 95616'], 'affiliations': [{'raw_affiliation_string': 'Cardiovascular Division, Pulmonary Division (J.P.E.), Department of Medicine, University of California, Davis, Davis, California 95616', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5091215873', 'display_name': 'Anne A. Knowlton', 'orcid': 'https://orcid.org/0000-0001-6410-3525'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}, {'id': 'https://openalex.org/I2799886695', 'display_name': 'Veterans Health Administration', 'ror': 'https://ror.org/05eq41471', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A. A. Knowlton', 'raw_affiliation_strings': ['Molecular and Cellular Cardiology (J.P.S., A.A.K.), University of California, Davis, Davis, California 95616', 'Veterans Affairs Medical Center (A.A.K.), Sacramento, California 95655'], 'affiliations': [{'raw_affiliation_string': 'Molecular and Cellular Cardiology (J.P.S., A.A.K.), University of California, Davis, Davis, California 95616', 'institution_ids': ['https://openalex.org/I84218800']}, {'raw_affiliation_string': 'Veterans Affairs Medical Center (A.A.K.), Sacramento, California 95655', 'institution_ids': ['https://openalex.org/I2799886695']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3400, 'currency': 'USD', 'value_usd': 3400, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.928, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 41, 'citation_normalized_percentile': {'value': 0.921009, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '150', 'issue': '1', 'first_page': '212', 'last_page': '219'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10694', 'display_name': "Effects of Hormones on Menopausal Women's Health", 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10694', 'display_name': "Effects of Hormones on Menopausal Women's Health", 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10155', 'display_name': 'Role of Nitric Oxide in Health and Disease', 'score': 0.9928, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Mechanisms of Estrogen Receptor Signaling', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sodium-nitroprusside', 'display_name': 'Sodium nitroprusside', 'score': 0.76307416}, {'id': 'https://openalex.org/keywords/soluble-guanylyl-cyclase', 'display_name': 'Soluble guanylyl cyclase', 'score': 0.7039014}, {'id': 'https://openalex.org/keywords/phenylephrine', 'display_name': 'Phenylephrine', 'score': 0.6545131}, {'id': 'https://openalex.org/keywords/vascular-function', 'display_name': 'Vascular Function', 'score': 0.540303}, {'id': 'https://openalex.org/keywords/estrogen', 'display_name': 'Estrogen', 'score': 0.539393}, {'id': 'https://openalex.org/keywords/vascular-tissue', 'display_name': 'Vascular tissue', 'score': 0.42565188}], 'concepts': [{'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.89293593}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.8814479}, {'id': 'https://openalex.org/C2779395532', 'wikidata': 'https://www.wikidata.org/wiki/Q7916469', 'display_name': 'Vascular smooth muscle', 'level': 3, 'score': 0.7868415}, {'id': 'https://openalex.org/C2779610285', 'wikidata': 'https://www.wikidata.org/wiki/Q27108300', 'display_name': 'Sodium nitroprusside', 'level': 3, 'score': 0.76307416}, {'id': 'https://openalex.org/C2778827303', 'wikidata': 'https://www.wikidata.org/wiki/Q7558945', 'display_name': 'Soluble guanylyl cyclase', 'level': 4, 'score': 0.7039014}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.6983909}, {'id': 'https://openalex.org/C2777952589', 'wikidata': 'https://www.wikidata.org/wiki/Q421910', 'display_name': 'Phenylephrine', 'level': 3, 'score': 0.6545131}, {'id': 'https://openalex.org/C8264082', 'wikidata': 'https://www.wikidata.org/wiki/Q7113259', 'display_name': 'Ovariectomized rat', 'level': 3, 'score': 0.62497175}, {'id': 'https://openalex.org/C2777622882', 'wikidata': 'https://www.wikidata.org/wiki/Q417619', 'display_name': 'Nitric oxide synthase', 'level': 3, 'score': 0.6064745}, {'id': 'https://openalex.org/C120770815', 'wikidata': 'https://www.wikidata.org/wiki/Q14859627', 'display_name': 'Vasodilation', 'level': 2, 'score': 0.5523124}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.44691074}, {'id': 'https://openalex.org/C166397571', 'wikidata': 'https://www.wikidata.org/wiki/Q968604', 'display_name': 'Vascular tissue', 'level': 2, 'score': 0.42565188}, {'id': 'https://openalex.org/C2777164284', 'wikidata': 'https://www.wikidata.org/wiki/Q277954', 'display_name': 'Estrogen', 'level': 2, 'score': 0.41630065}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.29039708}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.28136587}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.15746301}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2992686903', 'wikidata': 'https://www.wikidata.org/wiki/Q208453', 'display_name': 'Smooth muscle', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C173803235', 'wikidata': 'https://www.wikidata.org/wiki/Q419566', 'display_name': 'Guanylate cyclase', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D001808', 'descriptor_name': 'Blood Vessels', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D004967', 'descriptor_name': 'Estrogens', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': True}, {'descriptor_ui': 'D007537', 'descriptor_name': 'Isometric Contraction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001808', 'descriptor_name': 'Blood Vessels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001808', 'descriptor_name': 'Blood Vessels', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D004967', 'descriptor_name': 'Estrogens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007537', 'descriptor_name': 'Isometric Contraction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D010052', 'descriptor_name': 'Ovariectomy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016133', 'descriptor_name': 'Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011914', 'descriptor_name': 'Rats, Inbred BN', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014661', 'descriptor_name': 'Vasoconstriction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014661', 'descriptor_name': 'Vasoconstriction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D014664', 'descriptor_name': 'Vasodilation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014664', 'descriptor_name': 'Vasodilation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/en.2008-0640', 'pdf_url': 'https://academic.oup.com/endo/article-pdf/150/1/212/9001349/endo0212.pdf', 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2630896', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630896', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18787021', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/en.2008-0640', 'pdf_url': 'https://academic.oup.com/endo/article-pdf/150/1/212/9001349/endo0212.pdf', 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.57}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1919879546', 'https://openalex.org/W1969995183', 'https://openalex.org/W1979932219', 'https://openalex.org/W1983714057', 'https://openalex.org/W1985178609', 'https://openalex.org/W2001114982', 'https://openalex.org/W2001644495', 'https://openalex.org/W2013798458', 'https://openalex.org/W2037365395', 'https://openalex.org/W2040837467', 'https://openalex.org/W2046234193', 'https://openalex.org/W2047968184', 'https://openalex.org/W2060441344', 'https://openalex.org/W2064601540', 'https://openalex.org/W2070463685', 'https://openalex.org/W2073634411', 'https://openalex.org/W2086416077', 'https://openalex.org/W2092236038', 'https://openalex.org/W2100605824', 'https://openalex.org/W2105169259', 'https://openalex.org/W2108747532', 'https://openalex.org/W2113431417', 'https://openalex.org/W2115631902', 'https://openalex.org/W2120670639', 'https://openalex.org/W2130666962', 'https://openalex.org/W2134402538', 'https://openalex.org/W2134487143', 'https://openalex.org/W2134812217', 'https://openalex.org/W2135728038', 'https://openalex.org/W2137623306', 'https://openalex.org/W2142086823', 'https://openalex.org/W2143152245', 'https://openalex.org/W2144948654', 'https://openalex.org/W2145306215', 'https://openalex.org/W2146307603', 'https://openalex.org/W2149136975', 'https://openalex.org/W2152312364', 'https://openalex.org/W2156491383', 'https://openalex.org/W2157520113', 'https://openalex.org/W2158855816', 'https://openalex.org/W2162042042', 'https://openalex.org/W2163691249', 'https://openalex.org/W2167671333', 'https://openalex.org/W2172217338'], 'related_works': ['https://openalex.org/W283659481', 'https://openalex.org/W2386420363', 'https://openalex.org/W2381621840', 'https://openalex.org/W2156491383', 'https://openalex.org/W2139906083', 'https://openalex.org/W1999553114', 'https://openalex.org/W1996945336', 'https://openalex.org/W1994577565', 'https://openalex.org/W1966928669', 'https://openalex.org/W1920728569'], 'abstract_inverted_index': {'Although': [0], 'aging': [1], 'is': [2], 'known': [3, 62], 'to': [4, 6, 24, 63, 77, 82, 99, 105], 'lead': [5], 'increased': [7, 93, 100], 'vascular': [8, 32, 101, 163, 191], 'stiffness,': [9], 'the': [10, 15, 21, 35, 72, 130, 146, 162, 170, 175, 180, 190], 'role': [11], 'of': [12, 17, 74, 96, 116, 144, 150], 'estrogens': [13, 75, 97], 'in': [14, 20, 34, 38, 66, 69, 80, 103, 161, 169, 177], 'prevention': [16], 'age-related': [18], 'changes': [19], 'vasculature': [22], 'remains': [23], 'be': [25, 64, 109], 'elucidated.': [26], 'To': [27], 'address': [28], 'this,': [29], 'we': [30], 'measured': [31], 'function': [33], 'thoracic': [36], 'aorta': [37], 'adult': [39], 'and': [40, 46, 56, 84, 121, 148, 155, 179, 185], 'old': [41], 'ovariectomized': [42], '(ovx)': [43], 'rats': [44], 'with': [45, 71], 'without': [47], 'immediate': [48], '17beta-estradiol': [49], '(E2)': [50], 'replacement.': [51, 114], 'In': [52], 'addition,': [53], 'aortic': [54], 'mRNA': [55], 'protein': [57], 'were': [58], 'analyzed': [59], 'for': [60], 'proteins': [61], 'involved': [65], 'vasorelaxation.': [67], 'Aging': [68], 'combination': [70], 'loss': [73], 'led': [76, 98], 'decreased': [78, 142, 181], 'vasorelaxation': [79], 'response': [81, 104], 'acetylcholine': [83], 'sodium': [85], 'nitroprusside,': [86], 'indicating': [87], 'either': [88], 'smooth': [89, 164, 192], 'muscle': [90], 'dysfunction': [91], 'and/or': [92], 'fibrosis.': [94], 'Loss': [95], 'tension': [102], 'phenylephrine,': [106], 'which': [107], 'could': [108], 'partially': [110], 'restored': [111], 'by': [112], 'E2': [113, 167], 'Levels': [115], 'endothelial': [117], 'nitric': [118, 123, 158], 'oxide': [119, 124, 159], 'synthase': [120, 125], 'inducible': [122], 'did': [126, 133], 'not': [127], 'differ': [128], 'among': [129], 'groups,': [131], 'nor': [132], 'total': [134], 'nitrite': [135], 'plus': [136], 'nitrate': [137], 'levels.': [138], 'Old': [139], 'ovx': [140, 172], 'exhibited': [141], 'expression': [143, 184], 'both': [145, 174], 'alpha': [147], 'beta-subunits': [149], 'soluble': [151], 'guanylyl': [152], 'cyclase': [153], '(sGC)': [154], 'had': [156], 'impaired': [157], 'signaling': [160, 188], 'muscle.': [165, 193], 'Immediate': [166], 'replacement': [168], 'aged': [171], 'prevented': [173], 'impairment': [176], 'vasorelaxation,': [178], 'sGC': [182, 187], 'receptor': [183], 'abnormal': [186], 'within': [189]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2086715796', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-09-09T20:42:46.908401', 'created_date': '2016-06-24'}