Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2086307279', 'doi': 'https://doi.org/10.1021/ac3022532', 'title': 'Characterization of the Mechanodynamic Response of Cardiomyocytes with Atomic Force Microscopy', 'display_name': 'Characterization of the Mechanodynamic Response of Cardiomyocytes with Atomic Force Microscopy', 'publication_year': 2012, 'publication_date': '2012-12-22', 'ids': {'openalex': 'https://openalex.org/W2086307279', 'doi': 'https://doi.org/10.1021/ac3022532', 'mag': '2086307279', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23265281'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/ac3022532', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S191963794', 'display_name': 'Analytical Chemistry', 'issn_l': '0003-2700', 'issn': ['0003-2700', '1520-6882'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://ir.nctu.edu.tw:443/bitstream/11536/21228/1/000314676100025.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058891664', 'display_name': 'Wei‐Tien Chang', 'orcid': 'https://orcid.org/0000-0002-1880-7932'}, 'institutions': [{'id': 'https://openalex.org/I16733864', 'display_name': 'National Taiwan University', 'ror': 'https://ror.org/05bqach95', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I16733864']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Wei-Tien Chang', 'raw_affiliation_strings': ['National Taiwan University Hospital and College of Medicine , Taipei 100 , Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'National Taiwan University Hospital and College of Medicine , Taipei 100 , Taiwan.', 'institution_ids': ['https://openalex.org/I16733864']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067547603', 'display_name': 'David S. Yu', 'orcid': 'https://orcid.org/0000-0002-2781-5379'}, 'institutions': [{'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'David Yu', 'raw_affiliation_strings': ['Department of Applied Chemistry and\rInstitute of Molecular Science, National Chiao Tung University, 1001 University Road, Hsinchu 30010, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Applied Chemistry and\rInstitute of Molecular Science, National Chiao Tung University, 1001 University Road, Hsinchu 30010, Taiwan', 'institution_ids': ['https://openalex.org/I148366613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102319159', 'display_name': 'Yu-Cheng Lai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Yu-Cheng Lai', 'raw_affiliation_strings': ['Department of Applied Chemistry and\rInstitute of Molecular Science, National Chiao Tung University, 1001 University Road, Hsinchu 30010, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Applied Chemistry and\rInstitute of Molecular Science, National Chiao Tung University, 1001 University Road, Hsinchu 30010, Taiwan', 'institution_ids': ['https://openalex.org/I148366613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090165722', 'display_name': 'Kuen-You Lin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Kuen-You Lin', 'raw_affiliation_strings': ['Department of Applied Chemistry and\rInstitute of Molecular Science, National Chiao Tung University, 1001 University Road, Hsinchu 30010, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Applied Chemistry and\rInstitute of Molecular Science, National Chiao Tung University, 1001 University Road, Hsinchu 30010, Taiwan', 'institution_ids': ['https://openalex.org/I148366613']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076383452', 'display_name': 'Ian Liau', 'orcid': 'https://orcid.org/0000-0002-1373-1289'}, 'institutions': [{'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Ian Liau', 'raw_affiliation_strings': ['Department of Applied Chemistry and\rInstitute of Molecular Science, National Chiao Tung University, 1001 University Road, Hsinchu 30010, Taiwan'], 'affiliations': [{'raw_affiliation_string': 'Department of Applied Chemistry and\rInstitute of Molecular Science, National Chiao Tung University, 1001 University Road, Hsinchu 30010, Taiwan', 'institution_ids': ['https://openalex.org/I148366613']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.638, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 42, 'citation_normalized_percentile': {'value': 0.911314, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '85', 'issue': '3', 'first_page': '1395', 'last_page': '1400'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10923', 'display_name': 'Force Microscopy Techniques and Applications', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/3107', 'display_name': 'Atomic and Molecular Physics, and Optics'}, 'field': {'id': 'https://openalex.org/fields/31', 'display_name': 'Physics and Astronomy'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11472', 'display_name': 'Analytical Chemistry and Sensors', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1502', 'display_name': 'Bioengineering'}, 'field': {'id': 'https://openalex.org/fields/15', 'display_name': 'Chemical Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/contractility', 'display_name': 'Contractility', 'score': 0.874493}, {'id': 'https://openalex.org/keywords/isovolumetric-contraction', 'display_name': 'Isovolumetric contraction', 'score': 0.4227441}], 'concepts': [{'id': 'https://openalex.org/C39133596', 'wikidata': 'https://www.wikidata.org/wiki/Q5165683', 'display_name': 'Contractility', 'level': 2, 'score': 0.874493}, {'id': 'https://openalex.org/C158328960', 'wikidata': 'https://www.wikidata.org/wiki/Q1088369', 'display_name': 'Chronotropic', 'level': 4, 'score': 0.7539929}, {'id': 'https://openalex.org/C163415756', 'wikidata': 'https://www.wikidata.org/wiki/Q126473', 'display_name': 'Contraction (grammar)', 'level': 2, 'score': 0.7486291}, {'id': 'https://openalex.org/C155710745', 'wikidata': 'https://www.wikidata.org/wiki/Q575278', 'display_name': 'Inotrope', 'level': 2, 'score': 0.7217556}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6583785}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5101676}, {'id': 'https://openalex.org/C207200792', 'wikidata': 'https://www.wikidata.org/wiki/Q428914', 'display_name': 'Myocyte', 'level': 2, 'score': 0.49505034}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.49311683}, {'id': 'https://openalex.org/C2778198053', 'wikidata': 'https://www.wikidata.org/wiki/Q181754', 'display_name': 'Heart failure', 'level': 2, 'score': 0.49252233}, {'id': 'https://openalex.org/C2776050358', 'wikidata': 'https://www.wikidata.org/wiki/Q127006', 'display_name': 'Muscle contraction', 'level': 2, 'score': 0.42609072}, {'id': 'https://openalex.org/C39078644', 'wikidata': 'https://www.wikidata.org/wiki/Q17092725', 'display_name': 'Isovolumetric contraction', 'level': 4, 'score': 0.4227441}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.17242044}, {'id': 'https://openalex.org/C2777953023', 'wikidata': 'https://www.wikidata.org/wiki/Q1073121', 'display_name': 'Heart rate', 'level': 3, 'score': 0.13498056}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C57900726', 'wikidata': 'https://www.wikidata.org/wiki/Q492905', 'display_name': 'Diastole', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018625', 'descriptor_name': 'Microscopy, Atomic Force', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D009200', 'descriptor_name': 'Myocardial Contraction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D032383', 'descriptor_name': 'Myocytes, Cardiac', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001696', 'descriptor_name': 'Biomechanical Phenomena', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001696', 'descriptor_name': 'Biomechanical Phenomena', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002642', 'descriptor_name': 'Chick Embryo', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018625', 'descriptor_name': 'Microscopy, Atomic Force', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009200', 'descriptor_name': 'Myocardial Contraction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D032383', 'descriptor_name': 'Myocytes, Cardiac', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D032383', 'descriptor_name': 'Myocytes, Cardiac', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/ac3022532', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S191963794', 'display_name': 'Analytical Chemistry', 'issn_l': '0003-2700', 'issn': ['0003-2700', '1520-6882'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.886.6344', 'pdf_url': 'https://ir.nctu.edu.tw:443/bitstream/11536/21228/1/000314676100025.pdf', 'source': {'id': 'https://openalex.org/S4306400349', 'display_name': 'CiteSeer X (The Pennsylvania State University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I130769515', 'host_organization_name': 'Pennsylvania State University', 'host_organization_lineage': ['https://openalex.org/I130769515'], 'host_organization_lineage_names': ['Pennsylvania State University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23265281', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.886.6344', 'pdf_url': 'https://ir.nctu.edu.tw:443/bitstream/11536/21228/1/000314676100025.pdf', 'source': {'id': 'https://openalex.org/S4306400349', 'display_name': 'CiteSeer X (The Pennsylvania State University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I130769515', 'host_organization_name': 'Pennsylvania State University', 'host_organization_lineage': ['https://openalex.org/I130769515'], 'host_organization_lineage_names': ['Pennsylvania State University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.78, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W1758646032', 'https://openalex.org/W1964426508', 'https://openalex.org/W1985249510', 'https://openalex.org/W1989240471', 'https://openalex.org/W1990392771', 'https://openalex.org/W1995660049', 'https://openalex.org/W1995773789', 'https://openalex.org/W2002958873', 'https://openalex.org/W2027519251', 'https://openalex.org/W2041961852', 'https://openalex.org/W2050028594', 'https://openalex.org/W2064816775', 'https://openalex.org/W2065761480', 'https://openalex.org/W2065959795', 'https://openalex.org/W2067335193', 'https://openalex.org/W2077382855', 'https://openalex.org/W2079305884', 'https://openalex.org/W2101099004', 'https://openalex.org/W2118722808', 'https://openalex.org/W2119614155', 'https://openalex.org/W2132433042', 'https://openalex.org/W2151937301', 'https://openalex.org/W2166672630', 'https://openalex.org/W2461980944'], 'related_works': ['https://openalex.org/W576616620', 'https://openalex.org/W2950547776', 'https://openalex.org/W2413198329', 'https://openalex.org/W2348741148', 'https://openalex.org/W2330616315', 'https://openalex.org/W2092878964', 'https://openalex.org/W2085011369', 'https://openalex.org/W1971564964', 'https://openalex.org/W1515908635', 'https://openalex.org/W140326142'], 'abstract_inverted_index': {'Coordinated': [0], 'and': [1, 21, 69, 94, 111, 139, 160], 'synchronous': [2], 'contraction': [3, 13, 72, 144], 'of': [4, 14, 26, 30, 38, 45, 52, 61, 80, 132, 142, 152, 181, 204, 208, 229], 'cardiomyocytes': [5, 15, 31, 63, 182], 'ensures': [6], 'a': [7], 'normal': [8], 'cardiac': [9, 217], 'function': [10], 'while': [11], 'deranged': [12], 'can': [16], 'lead': [17], 'to': [18, 56, 105, 212, 222], 'heart': [19, 39], 'failure': [20, 40], 'circulatory': [22], 'dysfunction.': [23], 'Detailed': [24], 'assessment': [25], 'the': [27, 36, 65, 77, 81, 84, 92, 95, 107, 113, 122, 137, 156, 173, 179, 187, 205], 'contractile': [28, 66, 109, 123, 157, 167], 'property': [29], 'not': [32, 176], 'only': [33, 177], 'helps': [34], 'elucidate': [35], 'pathophysiology': [37], 'but': [41, 183], 'also': [42, 184], 'facilitates': [43], 'development': [44], 'novel': [46], 'therapies.': [47], 'Herein,': [48], 'we': [49, 135], 'report': [50], 'application': [51], 'atomic': [53], 'force': [54], 'microscopy': [55], 'determine': [57], 'essential': [58], 'mechanodynamic': [59, 206], 'characteristics': [60], 'self-beating': [62], 'including': [64], 'amplitude,': [67, 158], 'force,': [68, 159], 'frequency.': [70], 'The': [71, 150], 'was': [73, 88, 98], 'continuously': [74], 'measured': [75], 'on': [76, 116], 'same': [78], 'point': [79], 'cell': [82], 'surface;': [83], 'result': [85], 'assessed': [86], 'postintervention': [87], 'then': [89], 'compared': [90], 'with': [91], 'baseline,': [93], 'fractional': [96], 'change': [97], 'obtained.': [99], 'We': [100, 189], 'employed': [101], 'short-time': [102], 'Fourier': [103], 'transform': [104], 'analyze': [106], 'time-varying': [108], 'properties': [110], 'calculate': [112], 'spectrogram,': [114, 174], 'based': [115], 'which': [117], 'subtle': [118], 'dynamic': [119], 'changes': [120], 'in': [121, 172, 197], 'rhythmicity': [124], 'were': [125], 'delicately': [126], 'illustrated.': [127], 'To': [128], 'demonstrate': [129], 'potential': [130], 'applications': [131], 'this': [133], 'approach,': [134], 'examined': [136], 'inotropic': [138], 'chronotropic': [140], 'responses': [141], 'cardiomyocyte': [143], 'induced': [145], 'by': [146], 'various': [147], 'pharmacological': [148], 'interventions.': [149], 'administration': [151], 'epinephrine': [153], 'significantly': [154], 'increased': [155], 'frequency': [161], 'whereas': [162], 'esmolol': [163], 'markedly': [164], 'decreased': [165], 'these': [166], 'properties.': [168], 'As': [169], 'uniquely': [170], 'illustrated': [171], 'doxorubicin': [175], 'impaired': [178], 'contractility': [180], 'drastically': [185], 'compromised': [186], 'rhythmicity.': [188], 'envision': [190], 'that': [191, 200, 215, 225], 'our': [192], 'approach': [193], 'should': [194], 'be': [195], 'useful': [196], 'research': [198], 'fields': [199], 'require': [201], 'detailed': [202], 'evaluation': [203], 'response': [207], 'cardiomyocytes,': [209], 'for': [210], 'example,': [211], 'screen': [213], 'drugs': [214], 'possess': [216], 'activity': [218], 'or': [219, 221], 'cardiotoxicity,': [220], 'assess': [223], 'chemicals': [224], 'could': [226], 'direct': [227], 'differentiation': [228], 'stem': [230], 'cells': [231], 'into': [232], 'functioning': [233], 'cardiomyocytes.': [234]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2086307279', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 4}], 'updated_date': '2025-01-05T07:15:19.058775', 'created_date': '2016-06-24'}