Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2086253706', 'doi': 'https://doi.org/10.1371/journal.pgen.1000206', 'title': 'Zebrafish eda and edar Mutants Reveal Conserved and Ancestral Roles of Ectodysplasin Signaling in Vertebrates', 'display_name': 'Zebrafish eda and edar Mutants Reveal Conserved and Ancestral Roles of Ectodysplasin Signaling in Vertebrates', 'publication_year': 2008, 'publication_date': '2008-10-02', 'ids': {'openalex': 'https://openalex.org/W2086253706', 'doi': 'https://doi.org/10.1371/journal.pgen.1000206', 'mag': '2086253706', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18833299', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2542418'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pgen.1000206', 'pdf_url': 'https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000206&type=printable', 'source': {'id': 'https://openalex.org/S103870658', 'display_name': 'PLoS Genetics', 'issn_l': '1553-7390', 'issn': ['1553-7390', '1553-7404'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000206&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051035625', 'display_name': 'Matthew P. Harris', 'orcid': 'https://orcid.org/0000-0002-7201-4693'}, 'institutions': [{'id': 'https://openalex.org/I4210112458', 'display_name': 'Max Planck Institute for Developmental Biology', 'ror': 'https://ror.org/022jc0g24', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210112458']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Matthew P. Harris', 'raw_affiliation_strings': ['Max-Planck-Institute for Developmental Biology Tubingen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck-Institute for Developmental Biology Tubingen, Germany', 'institution_ids': ['https://openalex.org/I4210112458']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005479991', 'display_name': 'Nicolas Rohner', 'orcid': 'https://orcid.org/0000-0003-3248-2772'}, 'institutions': [{'id': 'https://openalex.org/I4210112458', 'display_name': 'Max Planck Institute for Developmental Biology', 'ror': 'https://ror.org/022jc0g24', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210112458']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Nicolas Rohner', 'raw_affiliation_strings': ['Max-Planck-Institute for Developmental Biology Tubingen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck-Institute for Developmental Biology Tubingen, Germany', 'institution_ids': ['https://openalex.org/I4210112458']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088617574', 'display_name': 'Heinz Schwarz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210112458', 'display_name': 'Max Planck Institute for Developmental Biology', 'ror': 'https://ror.org/022jc0g24', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210112458']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Heinz Schwarz', 'raw_affiliation_strings': ['Max-Planck-Institute for Developmental Biology Tubingen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck-Institute for Developmental Biology Tubingen, Germany', 'institution_ids': ['https://openalex.org/I4210112458']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027233485', 'display_name': 'Simon Perathoner', 'orcid': 'https://orcid.org/0000-0003-4779-7259'}, 'institutions': [{'id': 'https://openalex.org/I4210112458', 'display_name': 'Max Planck Institute for Developmental Biology', 'ror': 'https://ror.org/022jc0g24', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210112458']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Simon Perathoner', 'raw_affiliation_strings': ['Max-Planck-Institute for Developmental Biology Tubingen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck-Institute for Developmental Biology Tubingen, Germany', 'institution_ids': ['https://openalex.org/I4210112458']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034613333', 'display_name': 'Peter Konstantinidis', 'orcid': 'https://orcid.org/0000-0003-2949-5302'}, 'institutions': [{'id': 'https://openalex.org/I4210112458', 'display_name': 'Max Planck Institute for Developmental Biology', 'ror': 'https://ror.org/022jc0g24', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210112458']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Peter Konstantinidis', 'raw_affiliation_strings': ['Max-Planck-Institute for Developmental Biology Tubingen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck-Institute for Developmental Biology Tubingen, Germany', 'institution_ids': ['https://openalex.org/I4210112458']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5072765144', 'display_name': 'Christiane Nüsslein–Volhard', 'orcid': 'https://orcid.org/0000-0002-7688-1401'}, 'institutions': [{'id': 'https://openalex.org/I4210112458', 'display_name': 'Max Planck Institute for Developmental Biology', 'ror': 'https://ror.org/022jc0g24', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210112458']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Christiane Nüsslein-Volhard', 'raw_affiliation_strings': ['Max-Planck-Institute for Developmental Biology Tubingen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Max-Planck-Institute for Developmental Biology Tubingen, Germany', 'institution_ids': ['https://openalex.org/I4210112458']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2655, 'currency': 'USD', 'value_usd': 2655, 'provenance': 'doaj'}, 'apc_paid': {'value': 1882, 'currency': 'EUR', 'value_usd': 2029, 'provenance': 'openapc'}, 'fwci': 3.81, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 207, 'citation_normalized_percentile': {'value': 0.999983, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '4', 'issue': '10', 'first_page': 'e1000206', 'last_page': 'e1000206'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11919', 'display_name': 'dental development and anomalies', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11919', 'display_name': 'dental development and anomalies', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10268', 'display_name': 'Developmental Biology and Gene Regulation', 'score': 0.9188, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hypohidrotic-ectodermal-dysplasia', 'display_name': 'Hypohidrotic ectodermal dysplasia', 'score': 0.8443455}, {'id': 'https://openalex.org/keywords/genetic-screen', 'display_name': 'Genetic screen', 'score': 0.51672953}, {'id': 'https://openalex.org/keywords/loss-function', 'display_name': 'Loss function', 'score': 0.49469897}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.91412103}, {'id': 'https://openalex.org/C2776878037', 'wikidata': 'https://www.wikidata.org/wiki/Q169444', 'display_name': 'Zebrafish', 'level': 3, 'score': 0.90584093}, {'id': 'https://openalex.org/C2777230673', 'wikidata': 'https://www.wikidata.org/wiki/Q1077955', 'display_name': 'Hypohidrotic ectodermal dysplasia', 'level': 3, 'score': 0.8443455}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.72094136}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.6746396}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.52493554}, {'id': 'https://openalex.org/C207177822', 'wikidata': 'https://www.wikidata.org/wiki/Q5050812', 'display_name': 'Genetic screen', 'level': 4, 'score': 0.51672953}, {'id': 'https://openalex.org/C105951970', 'wikidata': 'https://www.wikidata.org/wiki/Q1036748', 'display_name': 'Loss function', 'level': 4, 'score': 0.49469897}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.4563033}, {'id': 'https://openalex.org/C180754005', 'wikidata': 'https://www.wikidata.org/wiki/Q80726', 'display_name': 'Allele', 'level': 3, 'score': 0.44094598}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.4348597}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.37611434}], 'mesh': [{'descriptor_ui': 'D004476', 'descriptor_name': 'Ectodermal Dysplasia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D053331', 'descriptor_name': 'Ectodysplasins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D053339', 'descriptor_name': 'Edar Receptor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019143', 'descriptor_name': 'Evolution, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015027', 'descriptor_name': 'Zebrafish', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': True}, {'descriptor_ui': 'D029961', 'descriptor_name': 'Zebrafish Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019521', 'descriptor_name': 'Body Patterning', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004476', 'descriptor_name': 'Ectodermal Dysplasia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004476', 'descriptor_name': 'Ectodermal Dysplasia', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053331', 'descriptor_name': 'Ectodysplasins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053331', 'descriptor_name': 'Ectodysplasins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053339', 'descriptor_name': 'Edar Receptor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053339', 'descriptor_name': 'Edar Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004817', 'descriptor_name': 'Epidermis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004817', 'descriptor_name': 'Epidermis', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D004817', 'descriptor_name': 'Epidermis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012863', 'descriptor_name': 'Skeleton', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014714', 'descriptor_name': 'Vertebrates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014714', 'descriptor_name': 'Vertebrates', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014714', 'descriptor_name': 'Vertebrates', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D014714', 'descriptor_name': 'Vertebrates', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015027', 'descriptor_name': 'Zebrafish', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015027', 'descriptor_name': 'Zebrafish', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015027', 'descriptor_name': 'Zebrafish', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D029961', 'descriptor_name': 'Zebrafish Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029961', 'descriptor_name': 'Zebrafish Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pgen.1000206', 'pdf_url': 'https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000206&type=printable', 'source': {'id': 'https://openalex.org/S103870658', 'display_name': 'PLoS Genetics', 'issn_l': '1553-7390', 'issn': ['1553-7390', '1553-7404'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/64d31abaac334fe0805c685c5ccd1db9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2542418', 'pdf_url': 'https://europepmc.org/articles/pmc2542418?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542418', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18833299', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pgen.1000206', 'pdf_url': 'https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000206&type=printable', 'source': {'id': 'https://openalex.org/S103870658', 'display_name': 'PLoS Genetics', 'issn_l': '1553-7390', 'issn': ['1553-7390', '1553-7404'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/14', 'display_name': 'Life below water', 'score': 0.4}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 65, 'referenced_works': ['https://openalex.org/W1482347863', 'https://openalex.org/W1522354953', 'https://openalex.org/W1528098230', 'https://openalex.org/W1548753322', 'https://openalex.org/W1570514184', 'https://openalex.org/W1602743992', 'https://openalex.org/W1891643707', 'https://openalex.org/W1968757757', 'https://openalex.org/W1973062643', 'https://openalex.org/W1976122633', 'https://openalex.org/W1978609814', 'https://openalex.org/W1981198027', 'https://openalex.org/W1981937147', 'https://openalex.org/W1988699784', 'https://openalex.org/W1990797650', 'https://openalex.org/W1991382572', 'https://openalex.org/W1997650783', 'https://openalex.org/W2003781078', 'https://openalex.org/W2005695901', 'https://openalex.org/W2007853906', 'https://openalex.org/W2010131461', 'https://openalex.org/W2016547423', 'https://openalex.org/W2017857362', 'https://openalex.org/W2018395541', 'https://openalex.org/W2020600328', 'https://openalex.org/W2022111741', 'https://openalex.org/W2023112637', 'https://openalex.org/W2024844633', 'https://openalex.org/W2035112815', 'https://openalex.org/W2036850921', 'https://openalex.org/W2048319852', 'https://openalex.org/W2048619570', 'https://openalex.org/W2050348484', 'https://openalex.org/W2062632483', 'https://openalex.org/W2067435927', 'https://openalex.org/W2070560929', 'https://openalex.org/W2072930288', 'https://openalex.org/W2083653513', 'https://openalex.org/W2086020230', 'https://openalex.org/W2090311609', 'https://openalex.org/W2094026255', 'https://openalex.org/W2096819604', 'https://openalex.org/W2101024791', 'https://openalex.org/W2105505995', 'https://openalex.org/W2106010587', 'https://openalex.org/W2108244474', 'https://openalex.org/W2112994343', 'https://openalex.org/W2113162350', 'https://openalex.org/W2120951751', 'https://openalex.org/W2123938765', 'https://openalex.org/W2124935184', 'https://openalex.org/W2137119500', 'https://openalex.org/W2140149931', 'https://openalex.org/W2140854466', 'https://openalex.org/W2144271871', 'https://openalex.org/W2145032231', 'https://openalex.org/W2151527805', 'https://openalex.org/W2156866331', 'https://openalex.org/W2160867220', 'https://openalex.org/W2163429946', 'https://openalex.org/W2170173260', 'https://openalex.org/W2173390200', 'https://openalex.org/W2331991505', 'https://openalex.org/W2464281433', 'https://openalex.org/W3028418616'], 'related_works': ['https://openalex.org/W3199493936', 'https://openalex.org/W2911639489', 'https://openalex.org/W2071344712', 'https://openalex.org/W2055145510', 'https://openalex.org/W2033163523', 'https://openalex.org/W2015712858', 'https://openalex.org/W2015495529', 'https://openalex.org/W1814951489', 'https://openalex.org/W1563296473', 'https://openalex.org/W144594900'], 'abstract_inverted_index': {'The': [0, 78], 'genetic': [1, 204, 234, 281], 'basis': [2], 'of': [3, 8, 11, 33, 37, 48, 51, 55, 58, 66, 83, 116, 139, 163, 174, 184, 195, 215, 224, 227, 229, 238, 248, 256, 266, 279], 'the': [4, 31, 38, 43, 59, 64, 67, 70, 75, 87, 101, 114, 161, 172, 175, 182, 196, 225, 257, 262, 277, 284], 'development': [5, 115, 162], 'and': [6, 45, 69, 90, 122, 141, 147, 166, 177, 200, 208, 253, 264, 270, 295], 'variation': [7, 265], 'adult': [9, 34, 56, 164, 280], 'form': [10], 'vertebrates': [12], 'is': [13], 'not': [14, 150], 'well': [15, 73], 'understood.': [16], 'To': [17], 'address': [18], 'this': [19, 239], 'problem,': [20], 'we': [21, 41, 220], 'performed': [22], 'a': [23, 49, 244], 'mutant': [24], 'screen': [25], 'to': [26, 181, 211, 276], 'identify': [27], 'genes': [28, 96], 'essential': [29, 288], 'for': [30, 152, 160], 'formation': [32, 263], 'skeletal': [35, 165], 'structures': [36, 57], 'zebrafish.': [39], 'Here,': [40], 'describe': [42], 'phenotypic': [44, 144], 'molecular': [46], 'characterization': [47], 'set': [50], 'mutants': [52], 'showing': [53], 'loss': [54, 82, 228], 'dermal': [60], 'skeleton,': [61], 'such': [62, 119], 'as': [63, 72, 74, 120, 134], 'rays': [65], 'fins': [68, 176], 'scales,': [71], 'pharyngeal': [76], 'teeth.': [77, 123], 'mutations': [79, 126], 'represent': [80], 'adult-viable,': [81], 'function': [84, 231], 'alleles': [85], 'in': [86, 100, 127, 136, 187, 213, 232, 251, 261, 283, 286, 292, 296], 'ectodysplasin': [88, 91], '(eda)': [89], 'receptor': [92], '(edar)': [93], 'genes.': [94], 'These': [95], 'are': [97, 149, 157, 179], 'frequently': [98], 'mutated': [99, 135], 'human': [102, 137, 293], 'hereditary': [103], 'disease': [104, 294], 'hypohidrotic': [105], 'ectodermal': [106], 'dysplasia': [107], '(HED;': [108], 'OMIM': [109], '224900,': [110], '305100)': [111], 'that': [112, 130, 171], 'affects': [113], 'integumentary': [117, 268], 'appendages': [118, 269], 'hair': [121], 'We': [124, 169, 242], 'find': [125, 170], 'zebrafish': [128, 154, 285], 'edar': [129, 148, 230], 'affect': [131], 'similar': [132, 143], 'residues': [133], 'cases': [138], 'HED': [140], 'show': [142, 221, 254], 'consequences.': [145], 'eda': [146], 'required': [151], 'early': [153], 'development,': [155], 'but': [156], 'rather': [158], 'specific': [159], 'dental': [167], 'structures.': [168], 'defects': [173], 'scales': [178], 'due': [180], 'role': [183, 247], 'Eda': [185, 216, 249], 'signaling': [186, 193, 250], 'organizing': [188], 'epidermal': [189, 198], 'cells': [190], 'into': [191], 'discrete': [192], 'centers': [194], 'scale': [197], 'placode': [199], 'fin': [201], 'fold.': [202], 'Our': [203], 'analysis': [205], 'demonstrates': [206], 'dose-sensitive': [207], 'organ-specific': [209], 'response': [210], 'alteration': [212], 'levels': [214], 'signaling.': [217], 'In': [218], 'addition,': [219], 'substantial': [222], 'buffering': [223], 'effect': [226], 'different': [233], 'backgrounds,': [235], 'suggesting': [236], 'canalization': [237], 'developmental': [240, 258, 289], 'system.': [241], 'uncover': [243], 'previously': [245], 'unknown': [246], 'teleosts': [252], 'conservation': [255], 'mechanisms': [259], 'involved': [260, 291], 'both': [267], 'limbs.': [271], 'Lastly,': [272], 'our': [273], 'findings': [274], 'point': [275], 'utility': [278], 'screens': [282], 'identifying': [287], 'processes': [290], 'morphological': [297], 'evolution.': [298]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2086253706', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 20}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 18}, {'year': 2018, 'cited_by_count': 15}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 12}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 18}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2024-12-29T22:52:48.168944', 'created_date': '2016-06-24'}